BioNanoScience, Год журнала: 2025, Номер 15(2)
Опубликована: Март 17, 2025
Язык: Английский
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2023, Номер 15(4)
Опубликована: Апрель 11, 2023
Abstract Transdermal delivery of drugs offers an interesting alternative for the administration molecules that present certain troubles when delivered by oral route. It can produce systemic effects or perform a local action formulation exerts optimal controlled drug release targeted to specific cell type site. also avoids several inconveniences such as hepatic first pass effect, gastric pH‐induced hydrolysis, malabsorption because diseases surgeries, and unpleasant organoleptic properties. Nanomedicine microneedle array patches (MAPs) are two trendiest systems applied transdermal research nowadays. However, skin is protective barrier nanoparticles (NPs) cannot through intact stratum corneum . The association NPs MAPs (NPs@MAPs) work synergistically, since assist bypass outer layers, contribute system providing delivery. Vaccination tailored therapies have been proposed fields where both great potential due inherent characteristics. conception easy use could allow self‐administration therefore facilitate mass vaccination campaigns in undeveloped areas with weak healthcare services. Additionally, nanomedicine being explored platform personalize important field oncology. In this we show recent insights prove benefits NPs@MAPs analyze prospects discrete interest industry NPs@MAPs, evaluating different limiting steps restricts translation clinical practice. This article categorized under: Nanotechnology Approaches Biology > NA Therapeutic Drug Discovery
Язык: Английский
Процитировано
23
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 263, С. 130301 - 130301
Опубликована: Фев. 20, 2024
The development of a self-regulated minimally invasive system for insulin delivery can be considered as the holy grail in field diabetes mellitus. A capable releasing response to blood glucose levels would significantly improve quality life diabetic patients, eliminating need frequent finger-prick tests and providing better glycaemic control with lower risk hypoglycaemia. In this context, latest advances glucose-responsive microneedle-based transdermal are here compiled thorough analysis mechanisms challenges lying ahead their clinical translation. Two main groups systems have been developed so far: oxidase-containing phenylboronic acid-containing systems. Both strategies combination also tested two other novel under development, namely electronic closed-loop transporter-based Results from preclinical studies conducted using these different types glucose-triggered release comprehensively discussed. Altogether, both mechanistic translational perspective will provide rationale and/or guidance future trends research hotspot
Язык: Английский
Процитировано
11
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Май 13, 2024
Current research in cancer therapy focuses on personalized therapies, through nanotechnology-based targeted drug delivery systems. Particularly, controlled release with nanoparticles (NPs) can be designed to safely transport various active agents, optimizing specific organs and tumors, minimizing side effects. The use of microfluidics (MFs) this field has stood out against conventional methods by allowing precise control over parameters like size, structure, composition, mechanical/biological properties nanoscale carriers. This review compiles applications the production core-shell NPs (CSNPs) for therapy, discussing versatility inherent microchannel and/or micromixer setups showcasing how these utilized individually or combination, as well technology allows development new advances more efficient fabrication nanoformulations. Recent biological studies have achieved an effective, safe, otherwise unreliable encapsulants such small interfering RNA (siRNA), plasmid DNA (pDNA), cisplatin a result precisely tuned nanocarriers, showing that is paving way innovative strategies nanofabrication, characterized continuous high reproducibility. Finally, analyzes technical, biological, technological limitations currently prevent from becoming standard.
Язык: Английский
Процитировано
10
Life Sciences, Год журнала: 2024, Номер 349, С. 122671 - 122671
Опубликована: Апрель 30, 2024
Язык: Английский
Процитировано
9
Journal of Biomedical Materials Research Part B Applied Biomaterials, Год журнала: 2025, Номер 113(1)
Опубликована: Янв. 1, 2025
A new method is developed using elastic lipid nanovesicles (ELNs) loaded with ethanolic extract of Lantana camara (LC) to enhance skin permeation plant actives. The ELNs contained cholesterol, 1, 2-distearoyl-sn-glycero-3-phosphocholine, span 80, and tween 80. Firstly, 15 formulations were produced examine critical factors likely affecting formulation characteristics. In addition, surface characteristics, vesicle size, polydispersity index, zeta potential, degree deformability, % entrapment efficiency (% EE) ELN examined. As a significant parameter, was measured (using Start-M; it highly resembles human skin). influence hydrophilic-lipophilic balance (HLB), ratio vital through Start-M. particular, the LC decreased at more extensive size ranges, 400, 350-450 nm. contrast, increased significantly smaller such as 200 100 More than 75% permeated within 8 h when surfactant (span 80:tween 80; 25%:75%). Permeation studies conducted based on HLB values revealed that 78% in 12.2, an increase HLB. Cell viability assay SK-MEL-37 cells (skin cancer) reduced by ~80% 24 h, further validating formulation. Future research could investigate long-term safety therapeutic potential these clinical settings their effectiveness delivering other plant-based extracts for transdermal applications via ELNs.
Язык: Английский
Процитировано
1
Molecular Pharmaceutics, Год журнала: 2024, Номер 21(9), С. 4450 - 4464
Опубликована: Авг. 20, 2024
Microneedle (MN) patches are gaining increasing attention as a cost-effective technology for delivering drugs directly into the skin. In present study, two different 3D printing processes were utilized to produce coated MNs, namely, digital light processing (DLP) and semisolid extrusion (SSE). Donepezil (DN), cholinesterase inhibitor administered treatment of Alzheimer's disease, was incorporated coating material. Physiochemical characterization MNs confirmed successful incorporation donepezil well stability suitability materials transdermal delivery. Optical microscopy SEM studies validated uniform weight distribution precise dimensions MN arrays, while mechanical testing ensured MNs' robustness, ensuring efficient skin penetration. vitro conducted evaluate produced patches, indicating their potential use in clinical treatment. Permeation revealed significant increase DN permeation compared plain material, affirming effectiveness enhancing drug Confocal laser scanning (CLSM) elucidated API, within layers, demonstrating sustained release transcellular transport pathways. Finally, cell also on NIH3T3 fibroblasts biocompatibility safety printed objects applications.
Язык: Английский
Процитировано
6
Advanced Functional Materials, Год журнала: 2024, Номер 34(24)
Опубликована: Фев. 19, 2024
Abstract Epidermal growth factor receptor (EGFR)‐overexpressing cutaneous squamous cell carcinoma (CSCC) necessitates more effective therapies due to its elevated metastasis risk compared the conventional CSCC. While photodynamic therapy (PDT) is a promising way treat CSCC, effectively administering photosensitizers reach deeper skin malignancies remains challenge. Herein, BE‐TEL reported, transethosome formulation designed enhance and tumor permeability, for targeted treatment of EGFR‐overexpressed The co‐loaded with Erlotinib (Erb), hydrophobic EGFR inhibitor, BODIPY (BPY), photosensitizer. Upon penetration subsequent exposure 660 nm light, induces apoptosis by reactive oxygen species (ROS) generation pathway inhibition. ROS Erb‐induced metabolic oxidative stress upregulating expression NADPH oxidase 4 (NOX4) can immunogenic death (ICD) promote dendritic maturation tumor‐specific immune response. Furthermore, downregulation further mitigated recurrence. In conclusion, BE‐TEL's superior ability together combined PDT approach paves an efficient strategy against
Язык: Английский
Процитировано
5
Drug Delivery and Translational Research, Год журнала: 2024, Номер 14(12), С. 3404 - 3421
Опубликована: Март 12, 2024
Abstract Several drugs can be used for treating inflammatory skin pathologies like dermatitis and psoriasis. However, the management of chronic long-term cases, topical administration is preferred over oral delivery since it prevents certain issues due to systemic side effects from occurring. Cyclosporin A (CsA) has been this purpose; however, its high molecular weight (1202 Da) restricts diffusion through structure. Here, we developed a nano-in-micro device combining lipid vesicles (LVs) dissolving microneedle array patches (DMAPs) targeted delivery. CsA-LVs allowed effective incorporation CsA in hydrophilic DMAP matrix despite hydrophobicity drug. Polymeric composed poly (vinyl alcohol) (5% w/v), pyrrolidine) (15% w/v) CsA-LV dispersion (10% v/v) led formation CsA-LVs@DMAPs with adequate mechanical properties penetrate stratum corneum barrier. The safety biocompatibility were ensured an vitro viability test using HaCaT keratinocytes L929 fibroblast cell lines. Ex vivo permeability studies Franz-diffusion setup showed drug retention Finally, challenged murine model delayed-type hypersensitivity corroborate their potential ameliorate conditions. Different findings photon emission reduction bioluminescence study, normalisation histological damage decrease cytokines point out effectivity treat these Overall, our study demonstrates that downregulate environment which paves way clinical translation use as alternative corticosteroid-based therapies. Graphical
Язык: Английский
Процитировано
5
ADMET & DMPK, Год журнала: 2024, Номер unknown
Опубликована: Апрель 29, 2024
Introduction: Berberine is a poorly water-soluble alkaloid compound showing significant anti-inflammatory characteristics. It reduces the levels of pro-inflammatory and inflammatory cytokines, including tumour necrosis factor (TNF-????, IFN-????) interleukin (IL-23, IL-12, IL-23). Diacerein significantly splenomegaly associated with psoriasis. downregulates production TNF-α IL-12. Method: This study reported development transferosomes containing berberine HCl diacerein using film hydration method followed by optimization Box-Behnken design. Sodium deoxycholate was used as an edge activator. The impact independent variables (amount phosphatidylcholine, amount activator, sonication cycles) on dependent (particle size entrapment efficiency) examined. optimized formulation characterized for polydispersity index, vesicle size, efficiency, ζ potential, spectral analysis like Fourier transform infrared, thermal analysis, X-ray diffraction, deformability, transmission electron microscopy, antioxidant assay, in-vitro release, ex-vivo skin permeation studies. Results: had particle 110.90±2.8 nm high efficiency (89.50±1.5 91.23±1.8 diacerein). Deformability, activity were 2.44, 0.296, -13.3, 38.36 %, respectively. Optimized exhibited 82.093±0.81 % 85.02±3.81 release after 24 h dissolution study. transdermal flux 0.0224 µg cm-2 h-1 (2.24 cm coefficient) 0.0462 (4.62 coefficient), respectively, diacerein. Raman treated pig confirmed that can permeate skin. No change in condition or irritation observed BALB/c mice. Formulation stored at 4 25±2 °C / 60±5 relative humidity stable 3 months. Conclusions: Thus, results demonstrated successful efficient topical delivery effective management
Язык: Английский
Процитировано
5
Cosmetics, Год журнала: 2024, Номер 11(6), С. 191 - 191
Опубликована: Ноя. 5, 2024
Skin diseases are a common health problem affecting millions of people worldwide. Effective treatment often depends on the precise delivery drugs to affected areas. One promising approach is currently transdermal drug system (TDDS), whose significant challenge poor penetration many compounds into skin due stratum corneum (SC), which acts as formidable barrier. To overcome this limitation, nanocarriers have emerged highly effective alternative. This review discusses use liposomes and ethosomes for delivery. Liposomes micro- or nanostructures consisting lipid bilayer surrounding an aqueous core. They facilitate may be advantageous site-specific targeting. Some methods treating involve incorporating such acyclovir, dithranol, tretinoin bioactive fluconazole, melanin, glycolic acid, kojic CoQ10 nanocarriers. The inability pass through narrowed intercellular channels led invention lipid-based vesicular systems ethosomes. structurally similar conventional liposomes, they prepared from phospholipids, but contain high ethanol concentration. Ethosomes noninvasive carriers that allow reach deep layers skin. Examples commonly used substances combined with in cosmetics include methotrexate, ascorbic vitamin A E, colchicine. development area rutin-loaded Encapsulating rutin significantly improves its stability enhances penetration, allowing more efficient deeper layers. In cosmetics, rutin–ethosome formulations protect oxidative stress, reduce redness, improve capillary strength, making it valuable formulation anti-aging anti-inflammatory products. results first clinical trial acyclovir–ethosome confirm require further investigation. work provides update recent advances pharmaceutical cosmetic applications, mentioning essential points commercially available formulations, trials, patents past.
Язык: Английский
Процитировано
5