Rubia
cordifolia
Linn
is
one
of
medicinal
plants
traditionally
used
for
the
treatment
various
diseases
and
ailments
by
different
people
around
world.
This
study
involves
successively
extraction
dried
powdered
root
bark
R.
cordifolia,
evaluating
anti-bacterial
activities,
screening
phytochemicals,
isolating
characterizing
chemical
constituents
from
crude
with
best
antibacterial
activity.
Freshly
collected
was
washed
then
under
shade
at
room
temperature
grounded.
The
(175g)
extracted
(2.4L)
chloroform/methanol(1:1)
(1.2L)
methanol
solution
filtered
using
Whatman
filter
paper
concentrated
rotary
evaporator
about
400C.
chloroform/methanol
(1:1)
extract
yields
were
9.5%
3.6%,
respectively.
disc
diffusion
method
to
evaluate
activity
extracts.
Phytochemical
test
extracts
revealed
presence
alkaloids,
anthraquinones,
glycosides,
phenol,
saponins,
steroids,
tannin
terpenoids
whereas
flavonoids
absent.
A
which
have
shown
relatively
superior
good
TLC
profile.
subjected
column
chromatography
resulted
in
isolation
compound
1,3-dihydroxy-2-methoxymethyl-9,10-anthraquinone.
Characterization
isolated
performed
spectroscopic
techniques
such
as
1H-NMR,
13C-NMR
DEPT-135
comparison
previously
reported
literature.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(8), С. 1048 - 1048
Опубликована: Авг. 9, 2024
The
establishment
and
utilization
of
preclinical
animal
models
constitute
a
pivotal
aspect
across
all
facets
cancer
research,
indispensably
contributing
to
the
comprehension
disease
initiation
progression
mechanisms,
as
well
facilitating
development
innovative
anti-cancer
therapeutic
approaches.
These
have
emerged
crucial
bridges
between
basic
clinical
offering
multifaceted
support
investigations.
This
study
initially
focuses
on
importance
benefits
establishing
models,
discussing
different
types
recent
advancements
in
research.
It
then
delves
into
treatment,
studying
characteristics
stages
tumor
drugs.
By
integrating
hallmarks
we
elaborate
path
drug
provide
guidance
personalized
therapy
strategies,
including
synthetic
lethality
approaches
novel
drugs
widely
adopted
field.
Ultimately,
summarize
strategic
framework
for
selecting
safety
experiments,
tailored
experimental
modalities
species,
present
an
outlook
prospects
challenges
associated
with
models.
undoubtedly
offer
new
avenues
encompassing
protocols.
Nevertheless,
road
ahead
continues
be
lengthy
fraught
obstacles.
Hence,
encourage
researchers
persist
harnessing
advanced
technologies
refine
thereby
empowering
these
emerging
paradigms
positively
impact
patient
outcomes.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(3), С. 1751 - 1751
Опубликована: Фев. 1, 2024
Amyotrophic
lateral
sclerosis
(ALS)
is
a
rare
progressive
motor
neuron
disease
that,
due
to
its
high
complexity,
still
lacks
effective
treatments.
Development
of
new
drug
highly
costly
and
time-consuming
process,
the
repositioning
approved
drugs
can
represent
an
efficient
strategy
provide
therapeutic
opportunities.
This
particularly
true
for
diseases,
which
are
characterised
by
small
patient
populations
therefore
attract
little
commercial
interest.
Based
on
overlap
between
biological
background
cancer
neurodegeneration,
repurposing
antineoplastic
ALS
has
been
suggested.
The
objective
this
narrative
review
was
summarise
current
experimental
evidence
use
anticancer
in
ALS.
Specifically,
belonging
different
classes
were
found
act
mechanisms
involved
pathogenesis,
some
them
proved
exert
beneficial
effects
models.
However,
additional
studies
necessary
confirm
real
potential
treatment.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 9659 - 9688
Опубликована: Сен. 1, 2024
Reactive
oxygen
species
(ROS)
encompass
a
diverse
group
of
chemically
reactive
molecules
or
ions
distinguished
by
their
substantial
oxidative
potential.
Empirical
studies
have
shown
that
the
targeted
administration
high
toxic
concentrations
ROS
can
effectively
induce
tumor
cell
death
in
various
types.
Numerous
bioactive
ingredients
derived
from
traditional
Chinese
medicine
(TCM),
recognized
for
ROS-inducing
properties,
demonstrated
significant
anti-tumor
activity.
Nonetheless,
clinical
application
has
been
hindered
challenges
such
as
low
solubility,
limited
bioavailability,
and
poor
selectivity.
Multifunctional
nanoformulations
possess
potential
to
overcome
these
enhance
anticancer
efficacy
active
compounds.
Through
extensive
searches
academic
databases
thorough
review
screening
relevant
literature,
this
study
aims
systematically
summarize
generalize
multiple
TCM
generation,
along
with
multifunctional
nanoformulations,
perspectives.
The
objective
is
provide
new
insights
references
fundamental
cancer
research
treatments.
Furthermore,
we
acknowledge
although
numerous
potentials,
potentially
offering
novel
strategies
therapy,
underlying
mechanisms
require
further
comprehensive
investigation.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 13461 - 13483
Опубликована: Дек. 1, 2024
Bladder
cancer
represents
one
of
the
most
prevalent
malignant
neoplasms
urinary
tract.
In
Asian
context,
it
eighth
common
in
males.
2022,
there
were
approximately
613,791
individuals
diagnosed
with
bladder
worldwide.
Despite
availability
efficacious
treatments
for
two
principal
forms
cancer,
namely
non-invasive
and
invasive
high
incidence
recurrence
following
treatment
suboptimal
outcomes
observed
patients
high-grade
advanced
disease
represent
significant
concerns
management
at
this
juncture.
Nanoparticles
have
gained
attention
their
excellent
properties,
including
stable
physical
a
porous
structure
that
can
be
loaded
variety
substances,
so
on.
The
in-depth
research
on
nanoparticles
has
led
to
emergence
as
new
class
combination
therapy,
due
advantageous
properties.
These
include
extension
drug
release
window,
enhancement
bioavailability,
improvement
targeting
ability,
reduction
local
systemic
toxicity,
simultaneous
delivery
multiple
drugs
therapy.
As
result,
become
novel
agent
system.
advent
provided
impetus
development
non-surgical
chemotherapy,
immunotherapy,
gene
therapy
phototherapy.
unique
properties
facilitated
diverse
therapeutic
modalities,
enhancing
overall
efficacy.
This
review
examines
recent
advancements
use
treatments,
encompassing
aspects
such
delivery,
efficacy,
associated
toxicity
nanoparticles,
well
challenges
encountered
clinical
applications.
Breast Cancer Targets and Therapy,
Год журнала:
2025,
Номер
Volume 17, С. 27 - 51
Опубликована: Янв. 1, 2025
Nanoparticle
technology
has
revolutionized
breast
cancer
treatment
by
offering
innovative
solutions
addressing
the
gaps
in
traditional
methods.
This
paper
aimed
to
comprehensively
explore
historical
journey
and
advancements
of
nanoparticles
treatment,
highlighting
their
transformative
impact
on
modern
medicine.
The
discussion
traces
evolution
nanoparticle-based
therapies
from
early
conceptualization
current
applications
future
potential.
We
initially
explored
context
limitations
conventional
therapies,
such
as
surgery,
radiation,
chemotherapy.
advent
nanotechnology
introduced
a
new
era
characterized
development
various
nanoparticles,
including
liposomes,
dendrimers,
gold
designed
target
cells
with
remarkable
precision.
further
described
mechanisms
action
for
passive
active
targeting,
reviewed
significant
breakthroughs
clinical
trials
that
have
validated
efficacy.
Current
been
examined,
showcasing
clinically
approved
comparing
effectiveness
article
also
discusses
latest
nanoparticle
research,
drug
delivery
systems
combination
therapy
innovations,
while
technical,
biological,
regulatory
challenges.
technical
challenges
include
efficient
targeted
tumor
sites
without
affecting
healthy
tissue;
potential
toxicity,
immune
system
activation,
or
resistance
mechanisms;
economic,
involving
high
production
scaling
costs;
regulatory,
requiring
rigorous
testing
safety,
efficacy,
long-term
effects
meet
stringent
approval
standards.
Finally,
we
emerging
trends,
personalized
medicine,
ethical
social
implications
this
technology.
In
conclusion,
through
comprehensive
analysis
case
studies,
underscores
profound
