International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137058 - 137058
Published: Nov. 3, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132123 - 132123
Published: May 17, 2024
Language: Английский
Citations
15
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122845 - 122845
Published: Oct. 17, 2024
Polysaccharide hydrogels, which can mimic the natural extracellular matrix and possess appealing physicochemical biological characteristics, have emerged as significant bioinks for 3D bioprinting. They are highly promising applications in tissue engineering regenerative medicine because of their ability to enhance cell adhesion, proliferation, differentiation a manner akin cellular environment. This review comprehensively examines fabrication methods, polysaccharide hydrogel-driven bioprinting, underscoring its potential engineering, drug delivery, medicine. To contribute pertinent knowledge future research this field, critically key aspects, including chemistry carbohydrates, manufacturing techniques, formulation bioinks, characterization polysaccharide-based hydrogels. Furthermore, explores primary advancements 3D-printed encompassing delivery systems with controlled release kinetics targeted therapy, along tissue-engineered constructs bone, cartilage, skin, vascular regeneration. The use these bioprinted hydrogels innovative fields, disease modeling screening, is also addressed. Despite notable progress, challenges, modulating properties polysaccharides, enhancing bioink printability mechanical properties, achieving long-term vivo stability, been highlighted.
Language: Английский
Citations
10
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 115504 - 115504
Published: Dec. 1, 2024
Language: Английский
Citations
6
Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 245 - 245
Published: March 26, 2025
Dermatological diseases pose a significant challenge due to their chronic nature, complex pathophysiology, and the need for effective, patient-friendly treatments. Recent advancements in liposomal gel-based formulations have played crucial role improving drug delivery, therapeutic efficacy, patient compliance. Liposomal garnered considerable attention dermatology ability encapsulate both hydrophilic lipophilic compounds, enabling controlled release enhanced skin penetration. However, challenges such as formulation complexity, stability issues, regulatory constraints remain. Similarly, are widely used ease of application, biocompatibility, retain active ingredients. they also face limitations, including restricted penetration depth, susceptibility microbial contamination, achieving sustained release. The integration technologies offers promising strategy overcome current optimize dermatological delivery. This review explores well-established therapies recent innovations, offering comprehensive overview applications treatment prevalent conditions. Ultimately, continued research is essential refine these formulations, expanding clinical utility enhancing effectiveness dermatology.
Language: Английский
Citations
0
European Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 201, P. 106858 - 106858
Published: July 20, 2024
Protein therapeutics hold immense promise for treating a wide array of diseases. However, their efficacy is often compromised by rapid degradation and clearance. The synthetic smectite clay Laponite emerges as promising candidate sustained delivery. Despite its unique properties allow to load release proteins mitigating burst extending effects, precise control over Laponite-protein interactions remains challenging since it depends on complex interplay factors whose implication not fully understood yet. aim this review article shed light issue, providing comprehensive discussion the influencing protein loading release, including physicochemical nanoclay proteins, pH, dispersion buffer, clay/protein concentration degradation. Furthermore, we thoroughly revise bioactive that have been delivered from formulations containing nanoclay, highlighting Laponite-polymer nanocomposite hydrogels, avenue currently under extensive investigation.
Language: Английский
Citations
3
Journal of Bioactive and Compatible Polymers, Journal Year: 2024, Volume and Issue: 39(3), P. 162 - 174
Published: March 17, 2024
As a microscale three-dimensional bionic model, microtissue array is promising method for disease modeling and drug screening. Digital light processing (DLP) 3D bio-printing technology with the capabilities of excellent printing speed resolution shows great potential fabricating arrays. However, outcomes arrays using DLP are limited by shortage biomaterials. In this work, we prepare hydrogel microtissues combining biphasic bio-ink consisting gelatin methacrylate (GelMA) dextran. GelMA/ dextran mixed to form bio-inks different volume ratios, which can achieve high-precision various patterns. Due presence dextran, internal porous structure in printed The pore size related proportion bio-inks, becomes smaller increase ratio. addition, adipose-derived stem cells (ADSCs) encapsulated hydrogels maintain high survival rate 98.01% after 3 days culture, larger promotes cell migration. Combining system allows multiple micro-size geometric pattern be simultaneously study, new suitable proposed, simple, accurate, high-throughput biological manufacturing developed, thus providing valuable tool screening tissue engineering.
Language: Английский
Citations
2
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137058 - 137058
Published: Nov. 3, 2024
Language: Английский
Citations
0