Опубликована: Янв. 1, 2024
Язык: Английский
BMC Pregnancy and Childbirth, Год журнала: 2025, Номер 25(1)
Опубликована: Янв. 11, 2025
Insulin resistance (IR) is a common pathophysiologic feature in patients with polycystic ovary syndrome (PCOS). However, there have been no studies investigating the association of IR surrogates pregnancy outcomes women PCOS undergoing vitro fertilization (IVF). Therefore, we explored between these factors among patients. We conducted retrospective study that included who underwent IVF at university-affiliated hospital. Blood samples and physical examinations are collected reproductive center on fasting morning 2nd to 4th day menstrual cycle prior medication. categorized participants into "Non-IR group" (HOMA-IR < 2.2) "IR ≥ 2.2). The [triglyceride-glucose-body mass index (TyG-BMI), triglyceride-glucose (TyG) homeostasis model assessment (HOMA-IR)] was evaluated by regression analysis. Moreover, also performed sensitivity analyses stratification interaction tests. primary outcome variable live birth rate. A total 543 were finally study. In all three models for fresh embryo transfer (ET) cycles, showed stable negative correlations rate (in Model III: TyG-BMI OR = 0.99, 95% CI: 0.98 ~ 0.99; TyG 0.47, 0.27 0.82; HOMA-IR 0.84, 0.72 0.97; P 0.05), this across subgroups population (all P-interaction > 0.05). relationship did not exist frozen-thawed (FET) cycles. Furthermore, our found superior predicting ET cycles [TyG-BMI: 0.64 (95% 0.58, 0.69) vs. TyG: 0.61 0.55, 0.67) HOMA-IR: 0.60 0.67)]. Our revealed (TyG-BMI, HOMA-IR) negatively associated rates FET
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9391 - 9391
Опубликована: Авг. 29, 2024
Obesity, which leads to metabolic dysregulation and body function impairment, emerges as one of the pressing health challenges worldwide. Excessive fat deposits comprise a dynamic biologically active organ possessing its own endocrine function. One mechanisms underlying pathophysiology obesity is low-grade systemic inflammation mediated by pro-inflammatory factors such free fatty acids, lipopolysaccharides, adipokines (including leptin, resistin visfatin) cytokines (TNF-α, IL-1β, Il-6), are secreted adipose tissue. Together with obesity-induced insulin resistance hyperandrogenism, exacerbated immune response has negative impact on hypothalamic–pituitary–gonadal axis at all levels directly affects reproduction. In women, it results in disrupted ovarian function, irregular menstrual cycles anovulation, contributing infertility. This review focuses abnormal intracellular communication, altered gene expression signaling pathways activated obesity, underscoring multifactorial character consequences molecular level. Extensive presentation complex interplay between adipokines, cytokines, cells neurons may serve foundation for future studies search potential sites more targeted treatment reproductive disorders related obesity.
Язык: Английский
Процитировано
6
International Journal of Gynaecology Research, Год журнала: 2025, Номер 7(1), С. 01 - 05
Опубликована: Янв. 1, 2025
The aim of the current scientific study is to measure concentrations following variables (FSH, LH, Testosterone, AMH, IR) in women with Polycystic Ovary Syndrome. was conducted from September 2023 May 2023, and specimen were composed visitors Kirkuk General Hospital specialized medical clinics city Kirkuk. included (55) ills polycystic ovary syndrome. Aged (20-40) years an average body mass index (29.078) kg/m², (45) healthy subjects (23.960) kg/m2 same age as ills. These samples distributed follows: control group females, while patient three groups according groups, first (20-26) 20 patients, second (27-33) 25 third (34-40) 10 patients. results concluded that there a significant increase (p>0.05) levels (Testosterone, IR, LH) decrease level FSH syndrome compared groups.
Язык: Английский
Процитировано
0
Frontiers in Endocrinology, Год журнала: 2025, Номер 15
Опубликована: Янв. 22, 2025
Polycystic ovary syndrome (PCOS) is a prevalent disorder of the endocrine system with significant clinical implications, often leading to health complications related adipose tissue accumulation, including obesity, insulin resistance (IR), metabolic syndrome, and type 2 diabetes mellitus. While precise pathogenesis PCOS remains unclear, it now recognized that genetic, endocrine, dysregulations all contribute significantly its onset. The immunopathogenesis has not been extensively explored, but there growing speculation immune abnormalities may play pivotal role. This chronic inflammatory state exacerbated by factors such as obesity hyperinsulinemia. Therefore, this review aims elucidate interplay between IR in patients, controlled response orchestrated cells immunomodulatory molecules, their interactions adipocytes, hyperandrogenemia, inflammation, homeostasis.
Язык: Английский
Процитировано
0
Chinese Medicine, Год журнала: 2025, Номер 20(1)
Опубликована: Фев. 5, 2025
Язык: Английский
Процитировано
0
Journal of Drug Delivery and Therapeutics, Год журнала: 2025, Номер 15(2), С. 1 - 6
Опубликована: Фев. 15, 2025
Ayurvedic protocols offer a holistic approach in managing Female pathologies by targeting the underlying imbalances HPO axis. In gynecological practices, hormonal therapy is common for management of secondary amenorrhea associated with Polycystic Ovary Disease (PCOD), thyroid dysfunction, which interfere endocrinal system and hypothalamic-pituitary-ovarian (HPO) The present case involves amenorrhea, has persisted 8-10 years, compounded resistance to replacement therapy, dysfunction polycystic ovary (PCOD) from 10-11 years. Initially, menstrual cycle interval increased 4-5 months, then over period natural menstruation ceased remain responsive withdrawal bleeding about 2 years but later patient become irresponsive even after usage hormones. emphasizes individualized treatment plans that address both symptoms root causes these conditions. regimen included Shodhana Chikitsa, specifically Basti Nasya, conjunction oral medications. Over course one year, experienced gradual improvement. resumed naturally 6-month interval, followed eventually at 35-40 days improved regularity quality bleeding. This transition marked shift irregular regular cycles Ayurveda treatment. Keywords: Amenorrhoea, Ayurveda, Basti, Hormonal Withdrawal
Язык: Английский
Процитировано
0
International Journal of Women s Health, Год журнала: 2025, Номер Volume 17, С. 459 - 474
Опубликована: Фев. 1, 2025
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder among women of reproductive age. Diagnosing adolescent PCOS challenging due to the overlap between adult diagnostic criteria and normal physiological changes in adolescence. This review examines diagnosis treatment strategies for PCOS. The should meet two primary criteria-ovulatory dysfunction biochemical or clinical hyperandrogenism-after excluding other causes. Defining these accurately aids early management However, limited research, age-specific standards remain lacking. Once diagnosed, timely interventions-such as lifestyle, exercise, dietary changes, along with targeted treatments like metformin antiandrogens-should be initiated. In addition, presents several challenges, including absence standardized medication guidelines, psychological factors that may impede adherence exercise recommendations, parental concerns about long-term effects on bone health metabolism. Therefore, additional research required establish optimal protocols enhance patients' quality life prevent complications.
Язык: Английский
Процитировано
0
Human Immunology, Год журнала: 2025, Номер 86(3), С. 111264 - 111264
Опубликована: Фев. 20, 2025
Язык: Английский
Процитировано
0
International Journal of Women s Health, Год журнала: 2025, Номер Volume 17, С. 561 - 569
Опубликована: Март 1, 2025
This study aims to evaluate the association between polycystic ovary syndrome (PCOS) phenotypes A and D with primary secondary pregnancy outcomes among PCOS vs non-PCOS patients after in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). retrospective cohort design using data of eligible women aged 20-40 years who had their first IVF treatment. The were obtained from medical records. either diagnosed according Rotterdam Criteria, namely or non-PCOS. Pregnancy outcome including (1) rate biochemical (2) ongoing clinical (3) miscarriage measured. Furthermore, collected on number oocytes retrieved, percentage mature oocytes, rate, (4) grade 1 embryos day 3 (5) 5. sample 149 was analyzed. For outcomes, in groups have lower oocyte maturity ratio, as well fewer comparison control. Primary significantly values group respect higher rates control group. Finally, did not differ outcomes. Patients phenotype better A. Phenotype A, affects negatively possibly due hyperandrogenism.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0