Nutritional Intake and Lifestyle in Infertile Women with and without Polycystic Ovary Syndrome: A Case-control Study DOI Open Access
Sanaz Alaee, Maryam Ekramzadeh, Mohammad Samare‐Najaf

et al.

Journal of Infertility and Reproductive Biology, Journal Year: 2024, Volume and Issue: 12(4), P. 15 - 30

Published: Dec. 20, 2024

Background: Polycystic ovary syndrome (PCOS), the most common endocrine pathology in females of reproductive age worldwide, is a multifactorial disorder. Although obesity, lifestyle, depression, and nutrition are considered possible contributing factors to PCOS pathogenesis, association between nutrient intake, clinical indices, adipokines women not comprehensively elucidated. Therefore, current study aimed reveal contribution nutritional intake lifestyle pathogenesis disease. Methods: 90 infertile women, 45 with as cases without controls, aged 25–40 years were enrolled study. Different questionnaires including antioxidant food frequency (using Nut4 software), international physical activity, fast internet addiction completed by participants. Moreover, demographic characteristics, weight, height, BMI, serum levels hormones, blood glucose, malondialdehyde (MDA), chemerin, vaspin, omentin-1 measured. Results: No significant differences two groups obtained regarding (p-value>0.05). calories macronutrients did significantly differ However, androgens, AMH, LH, LH: FSH ratio, FBS, MDA higher estradiol was lower subjects compared controls (p-value<0.001). correlation parameters indicators observed (p-value<0.05). Conclusion: The findings may suggest that crucially contributes through hyperandrogenism weight gain.

Language: Английский

Association of insulin resistance surrogates with live birth outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization DOI Creative Commons
Shenghao Wu, Yanhong Wu,

Lizi Fang

et al.

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 11, 2025

Insulin resistance (IR) is a common pathophysiologic feature in patients with polycystic ovary syndrome (PCOS). However, there have been no studies investigating the association of IR surrogates pregnancy outcomes women PCOS undergoing vitro fertilization (IVF). Therefore, we explored between these factors among patients. We conducted retrospective study that included who underwent IVF at university-affiliated hospital. Blood samples and physical examinations are collected reproductive center on fasting morning 2nd to 4th day menstrual cycle prior medication. categorized participants into "Non-IR group" (HOMA-IR < 2.2) "IR ≥ 2.2). The [triglyceride-glucose-body mass index (TyG-BMI), triglyceride-glucose (TyG) homeostasis model assessment (HOMA-IR)] was evaluated by regression analysis. Moreover, also performed sensitivity analyses stratification interaction tests. primary outcome variable live birth rate. A total 543 were finally study. In all three models for fresh embryo transfer (ET) cycles, showed stable negative correlations rate (in Model III: TyG-BMI OR = 0.99, 95% CI: 0.98 ~ 0.99; TyG 0.47, 0.27 0.82; HOMA-IR 0.84, 0.72 0.97; P 0.05), this across subgroups population (all P-interaction > 0.05). relationship did not exist frozen-thawed (FET) cycles. Furthermore, our found superior predicting ET cycles [TyG-BMI: 0.64 (95% 0.58, 0.69) vs. TyG: 0.61 0.55, 0.67) HOMA-IR: 0.60 0.67)]. Our revealed (TyG-BMI, HOMA-IR) negatively associated rates FET

Language: Английский

Citations

1
The Impact of the Endocrine and Immunological Function of Adipose Tissue on Reproduction in Women with Obesity DOI Open Access
Katarzyna Mączka,

Olga Stasiak,

Paulina Przybysz

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9391 - 9391

Published: Aug. 29, 2024

Obesity, which leads to metabolic dysregulation and body function impairment, emerges as one of the pressing health challenges worldwide. Excessive fat deposits comprise a dynamic biologically active organ possessing its own endocrine function. One mechanisms underlying pathophysiology obesity is low-grade systemic inflammation mediated by pro-inflammatory factors such free fatty acids, lipopolysaccharides, adipokines (including leptin, resistin visfatin) cytokines (TNF-α, IL-1β, Il-6), are secreted adipose tissue. Together with obesity-induced insulin resistance hyperandrogenism, exacerbated immune response has negative impact on hypothalamic–pituitary–gonadal axis at all levels directly affects reproduction. In women, it results in disrupted ovarian function, irregular menstrual cycles anovulation, contributing infertility. This review focuses abnormal intracellular communication, altered gene expression signaling pathways activated obesity, underscoring multifactorial character consequences molecular level. Extensive presentation complex interplay between adipokines, cytokines, cells neurons may serve foundation for future studies search potential sites more targeted treatment reproductive disorders related obesity.

Language: Английский

Citations

6
Decoding immune tolerance in infertility: Exploring immune pathways and non-coding RNAs as pioneering biomarkers and therapeutic targets DOI
Harikumar Pallathadka,

Abdulrahman Qais Khaleel,

Ahmed Hjazi

et al.

Human Immunology, Journal Year: 2025, Volume and Issue: 86(3), P. 111264 - 111264

Published: Feb. 20, 2025

Language: Английский

Citations

0
Alpha-lipoic acid regulates pro-inflammatory cytokines and hormones in letrozole-induced polycystic ovary syndrome in rats DOI

Fehintoluwa Joy Femi-Olabisi,

Olawunmi Rashidat Oyerinde,

Opeyemi Faokunla

et al.

Endocrine and Metabolic Science, Journal Year: 2025, Volume and Issue: 18, P. 100245 - 100245

Published: May 3, 2025

Language: Английский

Citations

0
Evaluation of some physiological and histological variables in women with polycystic ovary syndrome in Kirkuk / Iraq DOI Creative Commons
Hasbi Ibrahim, Sami Ibrahim Abdullah,

Amera Kamal Mohammed

et al.

International Journal of Gynaecology Research, Journal Year: 2025, Volume and Issue: 7(1), P. 01 - 05

Published: Jan. 1, 2025

The aim of the current scientific study is to measure concentrations following variables (FSH, LH, Testosterone, AMH, IR) in women with Polycystic Ovary Syndrome. was conducted from September 2023 May 2023, and specimen were composed visitors Kirkuk General Hospital specialized medical clinics city Kirkuk. included (55) ills polycystic ovary syndrome. Aged (20-40) years an average body mass index (29.078) kg/m², (45) healthy subjects (23.960) kg/m2 same age as ills. These samples distributed follows: control group females, while patient three groups according groups, first (20-26) 20 patients, second (27-33) 25 third (34-40) 10 patients. results concluded that there a significant increase (p>0.05) levels (Testosterone, IR, LH) decrease level FSH syndrome compared groups.

Language: Английский

Citations

0
The role of immunity in insulin resistance in patients with polycystic ovary syndrome DOI Creative Commons
Qixuan Zhang, Zhe Yang,

Xiangyang Ou

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 22, 2025

Polycystic ovary syndrome (PCOS) is a prevalent disorder of the endocrine system with significant clinical implications, often leading to health complications related adipose tissue accumulation, including obesity, insulin resistance (IR), metabolic syndrome, and type 2 diabetes mellitus. While precise pathogenesis PCOS remains unclear, it now recognized that genetic, endocrine, dysregulations all contribute significantly its onset. The immunopathogenesis has not been extensively explored, but there growing speculation immune abnormalities may play pivotal role. This chronic inflammatory state exacerbated by factors such as obesity hyperinsulinemia. Therefore, this review aims elucidate interplay between IR in patients, controlled response orchestrated cells immunomodulatory molecules, their interactions adipocytes, hyperandrogenemia, inflammation, homeostasis.

Language: Английский

Citations

0
Distinct mechanisms of electroacupuncture and manual acupuncture in modulating hypothalamic GnRH–tanycyte unit function of polycystic ovary syndrome DOI Creative Commons
Yu Wang, Yicong Wang, Yuning Chen

et al.

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Feb. 5, 2025

Language: Английский

Citations

0
Ayurveda Approaches for Management of Chronic Secondary Amenorrhoea Complexed with Hormonal Replacement Resistance, PCOD, and Thyroid Dysfunction: A Comprehensive Case Analysis DOI Open Access
Anjali Verma,

Aayushi Agarwal

Journal of Drug Delivery and Therapeutics, Journal Year: 2025, Volume and Issue: 15(2), P. 1 - 6

Published: Feb. 15, 2025

Ayurvedic protocols offer a holistic approach in managing Female pathologies by targeting the underlying imbalances HPO axis. In gynecological practices, hormonal therapy is common for management of secondary amenorrhea associated with Polycystic Ovary Disease (PCOD), thyroid dysfunction, which interfere endocrinal system and hypothalamic-pituitary-ovarian (HPO) The present case involves amenorrhea, has persisted 8-10 years, compounded resistance to replacement therapy, dysfunction polycystic ovary (PCOD) from 10-11 years. Initially, menstrual cycle interval increased 4-5 months, then over period natural menstruation ceased remain responsive withdrawal bleeding about 2 years but later patient become irresponsive even after usage hormones. emphasizes individualized treatment plans that address both symptoms root causes these conditions. regimen included Shodhana Chikitsa, specifically Basti Nasya, conjunction oral medications. Over course one year, experienced gradual improvement. resumed naturally 6-month interval, followed eventually at 35-40 days improved regularity quality bleeding. This transition marked shift irregular regular cycles Ayurveda treatment. Keywords: Amenorrhoea, Ayurveda, Basti, Hormonal Withdrawal

Language: Английский

Citations

0
Diagnosis and Treatment of Adolescent Polycystic Ovary syndrome:A Review DOI Creative Commons
Ying Zhang, Kaiyu Yang, Ting‐Jun Fan

et al.

International Journal of Women s Health, Journal Year: 2025, Volume and Issue: Volume 17, P. 459 - 474

Published: Feb. 1, 2025

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder among women of reproductive age. Diagnosing adolescent PCOS challenging due to the overlap between adult diagnostic criteria and normal physiological changes in adolescence. This review examines diagnosis treatment strategies for PCOS. The should meet two primary criteria-ovulatory dysfunction biochemical or clinical hyperandrogenism-after excluding other causes. Defining these accurately aids early management However, limited research, age-specific standards remain lacking. Once diagnosed, timely interventions-such as lifestyle, exercise, dietary changes, along with targeted treatments like metformin antiandrogens-should be initiated. In addition, presents several challenges, including absence standardized medication guidelines, psychological factors that may impede adherence exercise recommendations, parental concerns about long-term effects on bone health metabolism. Therefore, additional research required establish optimal protocols enhance patients' quality life prevent complications.

Language: Английский

Citations

0
Impact of Polycystic Ovary Syndrome Hyperandrogenic Phenotypes A and Non-Hyperandrogenic D on Pregnancy Outcomes After in vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI) DOI Creative Commons

Khaldoun Khamaiseh,

Roba Bdeir,

Mohammad Abukbeer

et al.

International Journal of Women s Health, Journal Year: 2025, Volume and Issue: Volume 17, P. 561 - 569

Published: March 1, 2025

This study aims to evaluate the association between polycystic ovary syndrome (PCOS) phenotypes A and D with primary secondary pregnancy outcomes among PCOS vs non-PCOS patients after in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). retrospective cohort design using data of eligible women aged 20-40 years who had their first IVF treatment. The were obtained from medical records. either diagnosed according Rotterdam Criteria, namely or non-PCOS. Pregnancy outcome including (1) rate biochemical (2) ongoing clinical (3) miscarriage measured. Furthermore, collected on number oocytes retrieved, percentage mature oocytes, rate, (4) grade 1 embryos day 3 (5) 5. sample 149 was analyzed. For outcomes, in groups have lower oocyte maturity ratio, as well fewer comparison control. Primary significantly values group respect higher rates control group. Finally, did not differ outcomes. Patients phenotype better A. Phenotype A, affects negatively possibly due hyperandrogenism.

Language: Английский

Citations

0