Translational Vision Science & Technology,
Год журнала:
2025,
Номер
14(1), С. 5 - 5
Опубликована: Янв. 9, 2025
Purpose:
Previous
researches
have
suggested
an
important
association
between
gut
microbiota
(GM)
and
vascular
pathologies
such
as
atherosclerosis.
This
study
aimed
to
explore
the
196
GM
taxa
retinal
vein
occlusion
(RVO).
Methods:
used
Mendelian
randomization
(MR),
linkage
disequilibrium
score
regression
(LDSC),
polygenic
overlap
analysis.
Genome-wide
(GWAS)
data
associated
with
was
obtained
from
MiBioGen
consortium,
involving
a
large
number
of
European-ancestry
participants.
GWAS
RVO
FinnGen
consortium
another
that
also
involved
Inverse-variance
weighted
primary
approach
for
MR
estimation.
Moreover,
LDSC
analyses
were
performed
evaluate
genetic
correlation
RVO.
Results:
The
results
identified
six
taxa,
including
class
Bacilli,
order
Lactobacillales,
family
Streptococcaceae,
genus
Clostridium
innocuum
group,
Family
XIII
AD3011
Subdoligranulum
development
In
addition,
analysis
supported
Conclusions:
Our
findings
confirmed
RVO,
thereby
highlighting
effects
on
health.
Translational
Relevance:
may
provide
rationale
developing
GM-based
strategies
preventing
onset
Nutrients,
Год журнала:
2020,
Номер
12(12), С. 3719 - 3719
Опубликована: Дек. 2, 2020
Type
2
diabetes
mellitus
(T2DM)
remains
one
of
the
most
problematic
and
economic
consumer
disorders
worldwide,
with
growing
prevalence
incidence.
Over
last
years,
substantial
research
has
highlighted
intricate
relationship
among
gut
microbiota,
dysbiosis
metabolic
syndromes
development.
Changes
in
microbiome
composition
lead
to
an
imbalanced
gastrointestinal
habitat
which
promotes
abnormal
production
metabolites,
inflammatory
status,
glucose
metabolism
alteration
even
insulin
resistance
(IR).
Short-chain
fatty
acids
(SCFAs),
trimethylamine
N-oxide
(TMAO),
lipopolysaccharide,
aromatic
amino
their
affiliated
contribute
T2DM
via
different
immunologic
pathways.
In
this
narrative
review,
we
discuss
immunopathogenic
mechanism
behind
dysbiosis,
development
major
known
diabetic
microvascular
complications
(retinopathy,
neuropathy
nephropathy),
beneficial
use
pre-
pro-biotics
fecal
microbiota
transplantation
management
new
findings
future
perspectives
field.
Frontiers in Microbiology,
Год журнала:
2022,
Номер
12
Опубликована: Янв. 14, 2022
The
term
microbiome
means
not
only
a
complex
ecosystem
of
microbial
species
that
colonize
our
body
but
also
their
genome
and
the
surrounding
environment
in
which
they
live.
Recent
studies
support
existence
gut-retina
axis
involved
pathogenesis
several
chronic
progressive
ocular
diseases,
including
age-related
macular
disorders.
This
review
aims
to
underline
importance
gut
relation
health.
After
briefly
introducing
characteristics
terms
composition
functions,
role
dysbiosis,
development
or
progression
retinal
is
highlighted,
focusing
on
relationship
between
health
based
recently
investigated
axis.
BMJ Open Ophthalmology,
Год журнала:
2024,
Номер
9(1), С. e001547 - e001547
Опубликована: Янв. 1, 2024
Evidence
from
observational
studies
has
reported
possible
associations
between
the
gut
microbiome
(GM)
and
glaucoma.
However,
causal
effect
of
GM
on
glaucoma
risk
remains
to
be
determined.
Investigative Ophthalmology & Visual Science,
Год журнала:
2024,
Номер
65(5), С. 2 - 2
Опубликована: Май 1, 2024
To
identify
compositional
differences
in
the
gut
microbiome
of
nonmyopes
(NM)
and
myopes
using
16S
ribosomal
RNA
sequencing
to
investigate
whether
may
contribute
onset
or
progression
condition.
Cells,
Год журнала:
2022,
Номер
11(19), С. 3005 - 3005
Опубликована: Сен. 26, 2022
Diabetic
retinopathy
(DR),
the
leading
cause
of
blindness
in
working-age
adults,
is
one
most
common
complications
diabetes
mellitus
(DM)
featured
by
metabolic
disorders.
With
global
prevalence
diabetes,
incidence
DR
expected
to
increase.
Prompt
detection
and
targeting
anti-oxidative
stress
intervention
could
effectively
reduce
visual
impairment
caused
DR.
However,
diagnosis
treatment
often
delayed
due
absence
obvious
signs
retina
imaging.
Research
progress
supports
that
metabolomics
a
powerful
tool
discover
potential
diagnostic
biomarkers
therapeutic
targets
for
causes
oxidative
through
profiling
metabolites
diseases,
which
provides
great
opportunities
with
heterogeneity.
Thus,
this
review
summarizes
latest
advances
DR,
as
well
biomarkers,
predicts
molecular
integration
genome-wide
association
studies
(GWAS)
metabolomics.
Metabolomics
strategies
controlling
especially
interventions
at
early
stages
precise
treatments
based
on
individual
patient
variations.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2022,
Номер
12
Опубликована: Авг. 12, 2022
Glaucoma
is
a
multifactorial,
neurodegenerative
disorder
characterized
by
the
loss
of
retinal
ganglion
cells
(RGCs).
Crosstalk
between
gut
microbiota
and
host
involved
in
progression
many
diseases,
although
little
known
about
its
role
glaucoma.
To
investigated
alterations
derived
metabolites
glaucomatous
rats,
interaction
with
RGCs,
we
performed
16S
rRNA
(V1-V9)
sequencing
untargeted
metabolomic
analyses.
The
microbial
composition
differed
significantly
two
groups,
diversity
cecal
bacteria
was
dramatically
reduced
rats.
Firmicutes/Bacteroidetes
(F/B)
ratio,
Verrucomicrobia
phylum,
some
bacterial
genera
(Romboutsia,
Akkermansia,
Bacteroides)
were
increased
rat
model
compared
control,
which
showed
negative
correlation
RGCs.
Untargeted
analysis
identified
284
differentially
expressed
metabolites,
Kyoto
Encyclopedia
Genes
Genomes
pathway
enrichment
revealed
considerable
mainly
bile
secretion
pathways.
relationships
among
enriched
pathway,
microbiota,
RGCs
investigated,
glutathione
(GSH)
found
to
be
negatively
correlated
Bacteroides
F/B
positively
Reduced
GSH
level
blood
glaucoma
rats
further
established,
Romboutsia
ratio
This
finding
suggests
potential
glaucoma,
GSH,
major
antioxidant
metabolite,
related
their
effects,
indicating
for
development
microbiota-targeted
interventions
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
164, С. 114994 - 114994
Опубликована: Июнь 8, 2023
Diabetic
retinopathy
(DR)
is
the
most
common
and
detrimental
microvascular
complication
of
diabetes
mellitus.
It
has
become
one
top
causes
blindness
visual
impairment
in
working-age
population.
However,
prevention
treatment
options
for
DR
are
limited,
invasive,
expensive,
focused
on
advanced-stage
disease.
The
gut
microbiota
an
intricate
system
that
alters
body's
microenvironment,
its
dysbiosis
strongly
associated
with
DR.
Recently,
more
investigations
into
relationship
between
have
enhanced
our
understanding
how
influences
occurrence,
development,
prevention,
In
this
review,
we
summarize
changes
animals
patients
function
metabolites
anti-diabetes
drugs.
Furthermore,
discuss
potential
use
as
early
diagnostic
marker
targeting
healthy
people
diabetic
patients.
Finally,
microbiota-gut-retina
axis
presented
to
help
us
understand
mechanisms
underlying
effect
triggering
or
promoting
DR,
a
focus
key
pathways
(e.g.,
bacterial
barrier
dysfunction)
promote
inflammation,
insulin
resistance,
retinal
cell
acellular
capillary
damage,
leading
Based
these
data,
can
hope
achieve
non-invasive,
inexpensive
by
modulating
microbiota,
either
supplementation
probiotics
fecal
transplantation.
We
outline
microbiota-targeting
treatments
detail
could
prevent
progression.
Molecular Aspects of Medicine,
Год журнала:
2023,
Номер
94, С. 101221 - 101221
Опубликована: Окт. 21, 2023
Glaucoma
is
a
common
irreversible
vision
loss
disorder
because
of
the
gradual
retinal
ganglion
cells
(RGCs)
and
optic
nerve
axons.
Major
risk
factors
include
elder
age
high
intraocular
pressure
(IOP).
However,
IOP
neither
necessary
nor
sufficient
to
cause
glaucoma.
Some
non-IOP
signaling
cascades
can
mediate
RGC
degeneration.
In
addition,
gender,
diet,
obesity,
depression,
or
anxiety
also
contribute
development
Understanding
mechanism
glaucoma
crucial
for
timely
diagnosis
establishing
new
strategies
improve
current
IOP-reducing
therapies.
The
microbiota
exerts
marked
influence
on
human
body
during
homeostasis
disease.
Many
patients
have
abnormal
compositions
(dysbiosis)
in
multiple
locations,
including
ocular
surface,
cavity,
oral
stomach,
gut.
Here,
we
discuss
findings
last
ten
years
more
about
metabolite
changes
animal
models,
with
three
(aging,
depression),
patients.
Antigenic
mimicry
heat
stress
protein
(HSP)-specific
T-cell
infiltration
retina
may
be
responsible
commensal
microbes
contributing
glaucomatous
damage.
LPS-TLR4
pathway
primary
surface
dysbiosis
affecting
Microbe-derived
metabolites
affect
pathogenesis.
Homocysteine
accumulation,
inflammatory
factor
release,
direct
dissemination
link
gastric
H.
pylori
infection
anterior
chamber
viral
(such
as
cytomegalovirus)
Potential
therapeutic
protocols
targeting
antibiotics,
modified
stool
transplant.
Later
investigations
will
uncover
underlying
molecular
connecting
its
clinical
applications
management.
