Updates in clinical dermatology, Год журнала: 2022, Номер unknown, С. 191 - 202
Опубликована: Янв. 1, 2022
Язык: Английский
American Journal of Clinical Dermatology, Год журнала: 2021, Номер 23(1), С. 37 - 50
Опубликована: Сен. 8, 2021
Granuloma annulare (GA) is an inflammatory granulomatous skin disease that can be localized (localized GA) or disseminated (generalized GA), with patch, perforating, and subcutaneous subtypes being less common variants of this benign condition. Recently, new research has emerged further elucidates GA epidemiology etiopathogenesis; importantly, therapeutic options for have also been described, although there remains a paucity randomized controlled studies. In review, we summarize recent updates on etiopathogenesis offer updated review the currently reported in literature. We hope current galvanizes studies will turn help lead to recommendation evidence-based treatments GA.
Язык: Английский
Процитировано
95
Current Opinion in Pulmonary Medicine, Год журнала: 2021, Номер 27(5), С. 439 - 447
Опубликована: Июнь 28, 2021
Purpose of review Sarcoidosis is a complex granulomatous disease unknown cause. Several drug categories are able to induce systemic indistinguishable from sarcoidosis, known as drug-induced sarcoidosis-like reaction (DISR). This inflammation can resolve if the medication discontinued. In this review, we discuss recent literature on associated with DISR, possible pathophysiology, clinical features, and treatment. Recent findings Recently, increasing reports DISR have expanded list drugs eruption. Most reported be categorized combination antiretroviral therapy, tumor necrosis factor-α antagonist, interferons, immune checkpoint inhibitors, but other also published. The proposed mechanism enhancement aberrant response which results in granuloma formation. It currently not know whether represents separate entity or triggered ‘true’ sarcoidosis. As DISRs may cause minimal symptoms, treatment always necessary benefits continuing offending should weighed against symptoms organ dysfunction. Treatment involve immunosuppressive that used for sarcoidosis Summary article, insights DISR: categories, presentation, diagnosis, Additionally, mechanisms add our knowledge pathophysiology.
Язык: Английский
Процитировано
33
Case Reports in Dermatological Medicine, Год журнала: 2024, Номер 2024(1)
Опубликована: Янв. 1, 2024
Granuloma annulare is a poorly understood dermatosis that, when generalized, can occur in up to 15 percent of patients. In these cases, treatment frustrating and experimental. We report case 60‐year‐old woman 41‐year‐old who demonstrated resolution recalcitrant, generalized granuloma (GA) following oral with upadacitinib. After showing little no response other various treatments, such as steroids, antibiotic regimens, systemic therapies, each patient was started on mg daily At 2 months, one had complete clearance all lesions while the experienced noticeable improvement. Within 4 reached total her lesions. These cases provide evidence therapeutic option that may shorten disease duration relief from cutaneous disease.
Язык: Английский
Процитировано
4
Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)
Опубликована: Апрель 29, 2025
Язык: Английский
Процитировано
0
Human Pathology, Год журнала: 2023, Номер 140, С. 144 - 172
Опубликована: Май 2, 2023
Язык: Английский
Процитировано
1
Journal of Medical Case Reports, Год журнала: 2024, Номер 18(1)
Опубликована: Июнь 20, 2024
Abstract Background Granuloma annulare is a noninfectious inflammatory granulomatous skin disease characterized by an erythematous or colored plaque. The diagnosis of granuloma may be challenging owing to its diverse morphology. In such cases, correlation between the clinical findings and histologic are necessary. Case presentation We report case after purified protein derivative administration. A 56-year-old Caucasian female patient complained mildly pruritic rashes which started on both arms lower extremities, eventually spread thighs, left popliteal region, upper back, right abdominal area. About 6 weeks prior eruption rashes, had been given tuberculin test. Biopsy specimens revealed dermal histiocytes palisading around areas mucin degenerated collagen, confirming annulare. After treatment with 0.1% topical triamcinolone acetanide 500 mg oral metronidazole, patient’s lesions resolved. Discussion Relatively little known about annulare’s exact etiology. has four variations presenting as either localized, generalized, subcutaneous, perforating patch prognosis for varies according subtypes. Proposed causal mechanisms subcutaneous include physical trauma, infections, immunizations, insect bites, diabetes mellitus, alterations in cell-mediated immune responses. likely component. Clinically, confused many other diseases. Conclusion This was reported since it rare dermatologic pathological condition that can rash disorders. Although benign self-limited disease, definitive important rule out pathologies similar appearances, cancer human immunodeficiency virus (HIV) infection. Diagnostic confirmation best made through biopsy.
Язык: Английский
Процитировано
0
Indian Journal of Dermatology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 12, 2024
Язык: Английский
Процитировано
0
Australasian Journal of Dermatology, Год журнала: 2022, Номер 63(3)
Опубликована: Май 2, 2022
Язык: Английский
Процитировано
2
Journal of Cutaneous Medicine and Surgery, Год журнала: 2022, Номер 26(5), С. 512 - 513
Опубликована: Май 19, 2022
Язык: Английский
Процитировано
2
Zeitschrift für Rheumatologie, Год журнала: 2022, Номер 81(7), С. 577 - 586
Опубликована: Июль 19, 2022
Процитировано
2