The interaction between Mediterranean diet and intestinal microbiome: relevance for preventive strategies against frailty in older individuals
Aging Clinical and Experimental Research,
Год журнала:
2024,
Номер
36(1)
Опубликована: Март 6, 2024
Age-related
changes
in
intestinal
microbiome
composition
and
function
are
increasingly
recognized
as
pivotal
the
pathophysiology
of
aging
associated
with
phenotype.
Diet
is
a
major
determinant
gut-microbiota
throughout
entire
lifespan,
several
benefits
healthy
diet
could
be
mediated
by
microbiome.
Mediterranean
(MD)
traditional
dietary
pattern
regarded
paradigm,
large
number
studies
have
demonstrated
its
promoting
aging.
MD
has
also
positive
modulatory
effect
on
microbiome,
favoring
bacterial
taxa
involved
synthesis
bioactive
compounds,
such
short-chain
fatty
acids
(SCFAs),
that
counteract
inflammation,
anabolic
resistance,
tissue
degeneration.
Intervention
conducted
older
populations
suggested
individual
response
subjects
to
MD,
terms
reduction
frailty
scores
amelioration
cognitive
function,
significantly
functionality.
In
this
context,
should
considered
when
designing
MD-based
interventions
tailored
needs
geriatric
patients.
Язык: Английский
Research Status and Trends of Gut Microbiota and Intestinal Diseases Based on Bibliometrics
Microorganisms,
Год журнала:
2025,
Номер
13(3), С. 673 - 673
Опубликована: Март 17, 2025
Gut
microbiota
plays
an
important
role
in
gut
health,
and
its
dysbiosis
is
closely
related
to
the
pathogenesis
of
various
intestinal
diseases.
The
field
diseases
has
not
yet
been
systematically
quantified
through
bibliometric
methods.
This
study
conducted
analysis
delineate
evolution
research
on
Data
were
sourced
from
Web
Science
Core
Collection
database
2009
2023
scientometrically
analyzed
using
CiteSpace.
We
have
found
that
number
annual
publications
steadily
increasing
showing
upward
trend.
China
Chinese
Academy
Sciences
are
country
institution
with
most
contributions,
respectively.
Frontiers
Microbiology
Nutrients
journals
publications,
while
Plos
One
Nature
citations.
shifted
focusing
traditional
descriptive
composition
exploring
causal
relationship
between
hotspots
trends
mainly
include
correlation
specific
diversity,
mechanism
involvement
diseases,
exploration
human
health.
provides
a
comprehensive
knowledge
map
highlights
key
areas,
outlines
potential
future
directions.
Язык: Английский
Function and therapeutic potential of Amuc_1100, an outer membrane protein of Akkermansia muciniphila: A review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142442 - 142442
Опубликована: Март 1, 2025
Язык: Английский
Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review
Frontiers in Physiology,
Год журнала:
2023,
Номер
14
Опубликована: Ноя. 28, 2023
Aquaporin-3
(AQP3)
is
a
predominant
water
channel
protein
expressed
in
the
intestine,
and
plays
important
roles
gut
physiology
pathophysiology
due
to
its
permeability
water,
glycerol
hydrogen
peroxide.
In
this
review,
we
systematically
summarized
current
understanding
of
expression
AQP3
intestine
different
species,
focused
on
potential
transport,
types
diarrhea
constipation,
intestinal
inflammation,
barrier
function,
oxidative
stress,
autophagy.
These
updated
findings
have
supported
that
may
function
as
an
target
maintaining
health
human
animals.
Язык: Английский
Comparative evaluation of fermented ginseng on alleviating antibiotic-associated diarrhea in mice
Food Science and Biotechnology,
Год журнала:
2024,
Номер
33(12), С. 2845 - 2856
Опубликована: Май 11, 2024
Язык: Английский
The Aging Stomach: Clinical Implications of H. pylori Infection in Older Adults—Challenges and Strategies for Improved Management
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12826 - 12826
Опубликована: Ноя. 28, 2024
Aging
is
a
multifactorial
biological
process
characterized
by
decline
in
physiological
function
and
increasing
susceptibility
to
various
diseases,
including
malignancies
gastrointestinal
disorders.
Helicobacter
pylori
(
Язык: Английский
Interpretable machine learning models for predicting the incidence of antibiotic- associated diarrhea in elderly ICU patients
BMC Geriatrics,
Год журнала:
2024,
Номер
24(1)
Опубликована: Май 24, 2024
Abstract
Background
Antibiotic-associated
diarrhea
(AAD)
can
prolong
hospitalization,
increase
medical
costs,
and
even
lead
to
higher
mortality
rates.
Therefore,
it
is
essential
predict
the
incidence
of
AAD
in
elderly
intensive
care
unit(ICU)
patients.
The
objective
this
study
was
create
a
prediction
model
that
both
interpretable
generalizable
for
predicting
ICU
Methods
We
retrospectively
analyzed
data
from
First
Medical
Center
People’s
Liberation
Army
General
Hospital
(PLAGH)
China.
utilized
machine
learning
Extreme
Gradient
Boosting
(XGBoost)
Shapley’s
additive
interpretation
method
patients
an
manner.
Results
A
total
848
adult
were
eligible
study.
XGBoost
predicted
with
area
under
receiver
operating
characteristic
curve
(ROC)
0.917,
sensitivity
0.889,
specificity
0.806,
accuracy
0.870,
F1
score
0.780.
outperformed
other
models,
including
logistic
regression,
support
vector
(AUC
=
0.809),
K-nearest
neighbor
algorithm
0.872),
plain
Bayes
0.774).
Conclusions
While
may
not
excel
absolute
performance,
demonstrates
superior
predictive
capabilities
compared
models
forecasting
categorized
based
on
their
characteristics.
Язык: Английский
The Intestinal Microbiome in Humans: Its Role for a Healthy Life and in the Onset of Diseases
Physiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 4, 2024
The
discovery
of
human
microbiota
shed
a
different
perspective
regarding
homeostasis
and
immune
regulation.
Gut
comprises
multitude
microorganisms,
its
composition
being
host-specific
evolving
throughout
the
lifetime,
subjected
to
both
endogenous
exogenous
factors.
This
subject
gained
significant
interest
after
improvement
metagenomic
metabolomic
studies.
gut
microbiome
displays
several
roles,
such
as
modulating
permeability,
digestive
processes,
metabolic
pathways,
responses.
Any
dysregulation
in
complex
symbiosis
mechanism
between
humans
intestinal
might
lead
variable
diseases.
Environmental
factors
diet
play
very
important
role
maintaining
healthy
microbiota.
In
this
chapter,
one
aims
discuss
core
subjects
how
stages
dysbiosis
can
initiation
progression
pathogenic
mechanisms
leading
diseases,
gastrointestinal
disorders
(irritable
bowel
syndrome,
inflammatory
infections
or
diarrhea
associated
with
antibiotics,
colon
cancer),
disorders,
obesity,
diabetes,
allergies.
We
underline
importance
environmental
microorganism
concentrations.
light
on
new
possible
perspectives
modulation
for
improving
health
status
host.
Язык: Английский
Preliminary Analysis of Gut Microbiome and Gastrointestinal Symptom Burden in Breast Cancer Patients Receiving Chemotherapy Compared to Healthy Controls
Biological Research For Nursing,
Год журнала:
2023,
Номер
26(2), С. 219 - 230
Опубликована: Окт. 13, 2023
Background
Alterations
in
the
naturally
occurring
bacteria
of
gut,
known
as
gastrointestinal
(GI)
microbiome,
may
influence
GI
symptoms
women
with
breast
cancer.
Objective
This
work
aims
to
describe
symptom
occurrence,
duration,
severity,
and
distress
measures
microbiome
among
cancer
receiving
chemotherapy
compared
age-
sex-matched
healthy
controls.
Interventions/Methods
22
17
control
provided
stool
specimens
data
using
modified
Memorial
Symptom
Assessment
Scale
(MSAS).
The
fecal
was
profiled
by
metagenomic
sequencing
16S
Ribosomal
RNA
(rRNA).
between
groups
alpha-diversity
(Observed
OTU
number
Shannon
index),
beta-diversity
(UniFrac
distances),
relative
abundance
select
genera.
Results
high
reports
patients
included
nausea,
diarrhea,
flatulence,
dry
mouth,
taste
change,
poor
appetite.
Indices
differential
(beta
diversity)
significantly
distinguished
Unique
bacterial
features
differentiating
2
were
Prevotella_9,
Akkermansia,
Lachnospira,
Lachnospiraceae_NK4A136,
Lachnoclostridium,
Oscillibacter.
Conclusions
Gut
are
associated
inflammation
mucus
degradation,
suggesting
potential
role
burden.
Understanding
on
gut
health
will
help
harness
enormous
a
future
diagnostic
therapeutic
agent
reduce
burden
chemotherapy.
Язык: Английский
Using nutrition to help recovery from infections
Current Opinion in Gastroenterology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 4, 2024
Antibiotics
are
a
cornerstone
of
modern
medicine,
but
antibiotic
consumption
can
have
depleting
effects
on
the
gut
microbiota,
potentially
leading
to
gastrointestinal
symptoms
and
other
diseases,
namely
Clostridioides
difficile
infection.
Because
nutrition
is
major
driver
microbiota
diversity
function,
here
we
explore
current
evidence
potential
diets
in
alleviate
deleterious
antibiotics
consumed
during
infections.
Язык: Английский