Using nutrition to help recovery from infections DOI
Inês B. Moura, Anthony M. Buckley

Current Opinion in Gastroenterology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Antibiotics are a cornerstone of modern medicine, but antibiotic consumption can have depleting effects on the gut microbiota, potentially leading to gastrointestinal symptoms and other diseases, namely Clostridioides difficile infection. Because nutrition is major driver microbiota diversity function, here we explore current evidence potential diets in alleviate deleterious antibiotics consumed during infections.

Language: Английский

The interaction between Mediterranean diet and intestinal microbiome: relevance for preventive strategies against frailty in older individuals DOI Creative Commons
Andrea Ticinesi, Antonio Nouvenne,

Nicoletta Cerundolo

et al.

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: March 6, 2024

Age-related changes in intestinal microbiome composition and function are increasingly recognized as pivotal the pathophysiology of aging associated with phenotype. Diet is a major determinant gut-microbiota throughout entire lifespan, several benefits healthy diet could be mediated by microbiome. Mediterranean (MD) traditional dietary pattern regarded paradigm, large number studies have demonstrated its promoting aging. MD has also positive modulatory effect on microbiome, favoring bacterial taxa involved synthesis bioactive compounds, such short-chain fatty acids (SCFAs), that counteract inflammation, anabolic resistance, tissue degeneration. Intervention conducted older populations suggested individual response subjects to MD, terms reduction frailty scores amelioration cognitive function, significantly functionality. In this context, should considered when designing MD-based interventions tailored needs geriatric patients.

Language: Английский

Citations

12
Research Status and Trends of Gut Microbiota and Intestinal Diseases Based on Bibliometrics DOI Creative Commons
Xiao Sun, Jiancheng Zhai

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 673 - 673

Published: March 17, 2025

Gut microbiota plays an important role in gut health, and its dysbiosis is closely related to the pathogenesis of various intestinal diseases. The field diseases has not yet been systematically quantified through bibliometric methods. This study conducted analysis delineate evolution research on Data were sourced from Web Science Core Collection database 2009 2023 scientometrically analyzed using CiteSpace. We have found that number annual publications steadily increasing showing upward trend. China Chinese Academy Sciences are country institution with most contributions, respectively. Frontiers Microbiology Nutrients journals publications, while Plos One Nature citations. shifted focusing traditional descriptive composition exploring causal relationship between hotspots trends mainly include correlation specific diversity, mechanism involvement diseases, exploration human health. provides a comprehensive knowledge map highlights key areas, outlines potential future directions.

Language: Английский

Citations

0
Function and therapeutic potential of Amuc_1100, an outer membrane protein of Akkermansia muciniphila: A review DOI
Xuhui Wu, Dahai Yu, Yixuan Ma

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142442 - 142442

Published: March 1, 2025

Language: Английский

Citations

0
Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review DOI Creative Commons

Cui Zhu,

Xiaoyan Nie, Lu Qi

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 28, 2023

Aquaporin-3 (AQP3) is a predominant water channel protein expressed in the intestine, and plays important roles gut physiology pathophysiology due to its permeability water, glycerol hydrogen peroxide. In this review, we systematically summarized current understanding of expression AQP3 intestine different species, focused on potential transport, types diarrhea constipation, intestinal inflammation, barrier function, oxidative stress, autophagy. These updated findings have supported that may function as an target maintaining health human animals.

Language: Английский

Citations

8
Comparative evaluation of fermented ginseng on alleviating antibiotic-associated diarrhea in mice DOI

Qiuyang Li,

Pei Yin,

Heyu Wang

et al.

Food Science and Biotechnology, Journal Year: 2024, Volume and Issue: 33(12), P. 2845 - 2856

Published: May 11, 2024

Language: Английский

Citations

2
The Aging Stomach: Clinical Implications of H. pylori Infection in Older Adults—Challenges and Strategies for Improved Management DOI Open Access
Jarosław Skokowski, Yogesh K. Vashist, Sergii Girnyi

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12826 - 12826

Published: Nov. 28, 2024

Aging is a multifactorial biological process characterized by decline in physiological function and increasing susceptibility to various diseases, including malignancies gastrointestinal disorders. Helicobacter pylori (

Language: Английский

Citations

2
Interpretable machine learning models for predicting the incidence of antibiotic- associated diarrhea in elderly ICU patients DOI Creative Commons

Yating Cui,

Yibo Zhou,

Chao Liu

et al.

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 24, 2024

Abstract Background Antibiotic-associated diarrhea (AAD) can prolong hospitalization, increase medical costs, and even lead to higher mortality rates. Therefore, it is essential predict the incidence of AAD in elderly intensive care unit(ICU) patients. The objective this study was create a prediction model that both interpretable generalizable for predicting ICU Methods We retrospectively analyzed data from First Medical Center People’s Liberation Army General Hospital (PLAGH) China. utilized machine learning Extreme Gradient Boosting (XGBoost) Shapley’s additive interpretation method patients an manner. Results A total 848 adult were eligible study. XGBoost predicted with area under receiver operating characteristic curve (ROC) 0.917, sensitivity 0.889, specificity 0.806, accuracy 0.870, F1 score 0.780. outperformed other models, including logistic regression, support vector (AUC = 0.809), K-nearest neighbor algorithm 0.872), plain Bayes 0.774). Conclusions While may not excel absolute performance, demonstrates superior predictive capabilities compared models forecasting categorized based on their characteristics.

Language: Английский

Citations

1
The Intestinal Microbiome in Humans: Its Role for a Healthy Life and in the Onset of Diseases DOI Creative Commons
Bogdan Gașpar, Monica Profir,

Oana Alexandra Roşu

et al.

Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: June 4, 2024

The discovery of human microbiota shed a different perspective regarding homeostasis and immune regulation. Gut comprises multitude microorganisms, its composition being host-specific evolving throughout the lifetime, subjected to both endogenous exogenous factors. This subject gained significant interest after improvement metagenomic metabolomic studies. gut microbiome displays several roles, such as modulating permeability, digestive processes, metabolic pathways, responses. Any dysregulation in complex symbiosis mechanism between humans intestinal might lead variable diseases. Environmental factors diet play very important role maintaining healthy microbiota. In this chapter, one aims discuss core subjects how stages dysbiosis can initiation progression pathogenic mechanisms leading diseases, gastrointestinal disorders (irritable bowel syndrome, inflammatory infections or diarrhea associated with antibiotics, colon cancer), disorders, obesity, diabetes, allergies. We underline importance environmental microorganism concentrations. light on new possible perspectives modulation for improving health status host.

Language: Английский

Citations

1
Preliminary Analysis of Gut Microbiome and Gastrointestinal Symptom Burden in Breast Cancer Patients Receiving Chemotherapy Compared to Healthy Controls DOI
Jemmie Hoang, Stephanie Gilbertson‐White, Nicole Cady

et al.

Biological Research For Nursing, Journal Year: 2023, Volume and Issue: 26(2), P. 219 - 230

Published: Oct. 13, 2023

Background Alterations in the naturally occurring bacteria of gut, known as gastrointestinal (GI) microbiome, may influence GI symptoms women with breast cancer. Objective This work aims to describe symptom occurrence, duration, severity, and distress measures microbiome among cancer receiving chemotherapy compared age- sex-matched healthy controls. Interventions/Methods 22 17 control provided stool specimens data using modified Memorial Symptom Assessment Scale (MSAS). The fecal was profiled by metagenomic sequencing 16S Ribosomal RNA (rRNA). between groups alpha-diversity (Observed OTU number Shannon index), beta-diversity (UniFrac distances), relative abundance select genera. Results high reports patients included nausea, diarrhea, flatulence, dry mouth, taste change, poor appetite. Indices differential (beta diversity) significantly distinguished Unique bacterial features differentiating 2 were Prevotella_9, Akkermansia, Lachnospira, Lachnospiraceae_NK4A136, Lachnoclostridium, Oscillibacter. Conclusions Gut are associated inflammation mucus degradation, suggesting potential role burden. Understanding on gut health will help harness enormous a future diagnostic therapeutic agent reduce burden chemotherapy.

Language: Английский

Citations

3
Using nutrition to help recovery from infections DOI
Inês B. Moura, Anthony M. Buckley

Current Opinion in Gastroenterology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Antibiotics are a cornerstone of modern medicine, but antibiotic consumption can have depleting effects on the gut microbiota, potentially leading to gastrointestinal symptoms and other diseases, namely Clostridioides difficile infection. Because nutrition is major driver microbiota diversity function, here we explore current evidence potential diets in alleviate deleterious antibiotics consumed during infections.

Language: Английский

Citations

0