Association of Mediterranean Diet with Cardiovascular Risk Factors and with Metabolic Syndrome in Subjects with Long COVID: BioICOPER Study
Nutrients,
Год журнала:
2025,
Номер
17(4), С. 656 - 656
Опубликована: Фев. 12, 2025
Long
COVID
has
been
associated
with
increased
cardiovascular
risk
and
chronic
low-grade
inflammation,
raising
concerns
about
its
long-term
metabolic
consequences.
Given
that
the
Mediterranean
diet
(MD)
shown
beneficial
effects
on
factors
inflammation
in
various
populations,
it
is
important
to
explore
potential
impact
individuals
COVID.
Therefore,
aim
determine
association
of
MD
(CVRF)
syndrome
(MetS)
Caucasian
subjects
diagnosed
Cross-sectional
study,
305
were
included
following
WHO
criteria.
Adherence
was
evaluated
MEDAS
(Mediterranean
Diet
Screener)
14
items
used
Prevention
study
(PREDIMED
study).
The
criteria
considered
diagnose
MetS
blood
pressure,
glycemia,
triglycerides,
HDL
cholesterol,
waist
circumference.
Other
CVRFs
tobacco
consumption,
total
LDL
body
mass
index,
baseline
uric
acid
levels.
between
CVRF
number
components
analyzed
using
multiple
regression
models
multinomial
regression.
mean
age
52.75
±
11.94
years
(men
55.74
12.22
women
51.33
11.57;
p
=
0.002),
(68%
women).
questionnaire
7.76
2.37.
presented
23.6%
(39.8%
men
15.9%
<
0.001).
In
analysis,
after
adjusting
for
average
time
from
acute
COVID-19
infection
date
inclusion
this
score
showed
a
negative
(β
-0.295;
95%
CI:
-0.496
-0.093),
BMI
-0.049;
-0.096
-0.002),
-0.210;
-0.410
-0.010),
circumference
(WC)
-0.021;
-0.037
-0.003)
positive
cholesterol
-0.018;
0.001
-0.037).
findings
suggest
higher
scores
are
lower
levels
acid,
fewer
components,
smaller
circumference,
Язык: Английский
Targeting Cytokine Dysregulation in Psoriasis: The Role of Dietary Interventions in Modulating the Immune Response
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 2895 - 2895
Опубликована: Март 22, 2025
Psoriasis
is
a
chronic
immune-mediated
skin
disease
characterized
by
cytokine
dysregulation.
Pro-inflammatory
mediators,
including
tumor
necrosis
factor-alpha
(TNF-α),
interleukin
(IL)-17,
and
IL-23,
play
pivotal
roles
in
the
pathogenesis
of
psoriasis.
Emerging
evidence
suggests
that
dietary
interventions
can
modulate
activity,
providing
complementary
approach
to
standard
therapies.
This
narrative
review
examines
impact
various
strategies,
Mediterranean
diet,
ketogenic
gluten-free
fasting-mimicking
on
profiles
clinical
outcomes
Research
insights
reveal
components
such
as
omega-3
fatty
acids,
polyphenols,
short-chain
acids
influence
immune
signaling
pathways.
These
pathways
include
nuclear
factor-kappa
B
(NF-κB)
Signal
Transducer
Activator
Transcription
3
(STAT3).
Additionally,
these
promote
anti-inflammatory
effects
mediated
gut
microbiota.
Clinical
studies
demonstrate
significant
reductions
psoriasis
severity,
improved
quality
life,
modulation
key
cytokines
associated
with
activity.
Despite
advancements,
challenges
persist
effectively
integrating
findings
into
practice.
variability
patient
responses,
adherence
issues,
need
for
robust
biomarkers
monitor
efficacy.
Future
directions
emphasize
potential
personalized
nutrition
precision
medicine
approaches
optimize
tailored
individual
genetic
predispositions.
Integrating
strategies
care
could
transform
treatment
paradigms
simultaneously
addressing
both
systemic
inflammation
comorbid
conditions.
Язык: Английский
Chronic Inflammatory Diseases and Cardiovascular Risk: Current Insights and Future Strategies for Optimal Management
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3071 - 3071
Опубликована: Март 27, 2025
Chronic
inflammation
is
a
pivotal
driver
in
the
progression
of
atherosclerosis,
significantly
contributing
to
burden
cardiovascular
disease
(CVD).
Patients
with
chronic
inflammatory
diseases,
such
as
bowel
diseases
(IBDs)
(e.g.,
ulcerative
colitis
and
Crohn's
disease),
rheumatological
disorders,
well
individuals
auto-immune
(such
systemic
lupus
erythematosus),
present
higher
risk
major
adverse
cardiac
events
(MACEs).
Despite
their
elevated
CVD
risk,
these
populations
remain
underrepresented
research,
leading
critical
underestimation
(CVR)
clinical
practice.
Furthermore,
even
recent
CVR
scores
poorly
predict
specific
populations.
This
narrative
review
examines
physiopathological
mechanisms
linking
inflammation,
immunomodulation,
thrombosis
events.
We
data
from
epidemiological
studies
trials
explore
potential
benefits
anti-inflammatory
immunomodulatory
therapies.
existing
evidence,
significant
gaps
knowledge
remain.
Future
research
mandatory,
focusing
on
innovative
strategies
for
stratification
optimization,
including
lipidomics,
proteomics,
advanced
markers,
microbiota
profiling,
imaging.
Addressing
unmet
needs
will
enhance
understanding
enabling
tailored
interventions
better
outcomes.
Язык: Английский
Mediterranean diet, diet quality, and adequacy to Italian dietary recommendations in southern Italian adults
Mediterranean Journal of Nutrition and Metabolism,
Год журнала:
2024,
Номер
unknown, С. 1 - 14
Опубликована: Авг. 30, 2024
OBJECTIVE:
This
study
aimed
to
explore
the
relation
between
adherence
Mediterranean
diet,
adequacy
Italian
dietary
recommendations,
and
several
domains
of
diet
quality
in
a
sample
adults.
METHODS:
The
habits
total
1936
participants
were
investigated.
Adherence
assessed
through
Medi-Lite
Diet
Quality
Index-International
(DQI-I).
RESULTS:
global
DQI-I
score
positively
correlated
with
score.
Negative
coefficients
found
for
protein
intake
calcium
category,
fat
moderation
fatty
acid
ratio
overall
balance
category.
More
than
half
adherent
national
recommendations
potatoes,
cereals,
red
meat,
other
fats
consumption.
In
contrast,
on
legumes,
fruit,
vegetables,
processed
meat
met
by
about
while
those
dairy
products
(milk
yogurt)
cheese,
eggs,
white
rather
underrepresented.
Higher
scores
well
predicted
fruit
legumes.
CONCLUSIONS:
Individuals
reporting
higher
show
better
probability
meeting
recommendations.
Язык: Английский
Dose–Response Associations Between Diet and Risk of Rheumatoid Arthritis: A Meta-Analysis of Prospective Cohort Studies
Nutrients,
Год журнала:
2024,
Номер
16(23), С. 4050 - 4050
Опубликована: Ноя. 26, 2024
To
provide
a
systematic
and
quantitative
summary
of
dietary
factors
rheumatoid
arthritis
(RA)
risk.
A
review
meta-analysis
included
prospective
cohort
studies
from
2000
to
2024
reporting
relative
risks
(RRs)
with
95%
confidence
intervals
(CIs)
for
RA
incidence
relating
32
different
exposures.
Linear
non-linear
dose-response
analyses
were
conducted.
Thirty
included,
involving
2,986,747
participants
9,677
cases.
analysis
suggested
that
each
2-unit
per
week
increase
in
total
alcohol
intake
was
linked
4%
risk
reduction
(RR
(95%-CI),
heterogeneity
(
Язык: Английский
Immune aging and infectious diseases
Chinese Medical Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
Abstract
The
rise
in
global
life
expectancy
has
led
to
an
increase
the
older
population,
presenting
significant
challenges
managing
infectious
diseases.
Aging
affects
innate
and
adaptive
immune
systems,
resulting
chronic
low-grade
inflammation
(inflammaging)
function
decline
(immunosenescence).
These
changes
would
impair
defense
mechanisms,
susceptibility
infections
reduce
vaccine
efficacy
adults.
Cellular
senescence
exacerbates
these
issues
by
releasing
pro-inflammatory
factors,
further
perpetuating
inflammation.
Moreover,
comorbidities,
such
as
cardiovascular
disease
diabetes,
which
are
common
adults,
amplify
dysfunction,
while
immunosuppressive
medications
complicate
responses
infections.
This
review
explores
molecular
cellular
mechanisms
driving
inflammaging
immunosenescence,
focusing
on
genomic
instability,
telomere
attrition,
mitochondrial
dysfunction.
Additionally,
we
discussed
how
aging-associated
alterations
influence
bacterial,
viral,
parasitic
evaluated
emerging
antiaging
strategies,
aimed
at
mitigating
effects
improve
health
outcomes
aging
population.
Язык: Английский
PHYSICAL FITNESS AND HEALTHY AGING
Anti-Aging Eastern Europe,
Год журнала:
2024,
Номер
3(2), С. 107 - 108
Опубликована: Июнь 27, 2024
PHYSICAL
FITNESS
AND
HEALTHY
AGING
Язык: Английский
Adherence to the Mediterranean Diet Mitigates Inflammation and Hospital Stay in Frail Elderly Patients: A Moderation Analysis
Nutrients,
Год журнала:
2024,
Номер
16(15), С. 2482 - 2482
Опубликована: Июль 31, 2024
Understanding
the
interaction
between
dietary
patterns
and
nutritional
status
in
influencing
health
outcomes
is
crucial,
especially
vulnerable
populations.
Our
study
investigates
impact
of
adherence
to
Mediterranean
diet
(MD)
on
inflammatory
markers
(CRP)
length
stay
(LOS)
hospitalized
frail
elderly
patients.
Methods:
We
conducted
two-way
ANOVA
multiple
regression
analysis
evaluate
effects
MD
CRP
levels
LOS
a
cohort
117
patients
aged
65
years
or
older.
Patients
with
cancer
acute
infection
were
excluded.
Adherence
was
assessed
using
14-item
PREDIMED
questionnaire.
Results:
Significant
interactions
found
for
both
LOS.
The
low-level
poor
exhibited
higher
longer
hospital
stays
compared
those
high
adherence.
Specifically,
statistically
significant
observed
(F
(1,
113)
=
7.36,
p
0.008)
15.4,
<
0.001),
indicating
protective
effect
high-level
Moderation
confirmed
that
mitigates
adverse
malnutrition
response
Conclusions:
These
findings
highlight
importance
promoting
MD,
particularly
malnourished
patients,
improve
reduce
hospitalization
duration.
Further
longitudinal
studies
are
warranted
establish
causality
explore
underlying
mechanisms.
Язык: Английский