Association of Mediterranean Diet with Cardiovascular Risk Factors and with Metabolic Syndrome in Subjects with Long COVID: BioICOPER Study

Nutrients, Journal Year: 2025, Volume and Issue: 17(4), P. 656 - 656

Published: Feb. 12, 2025

Long COVID has been associated with increased cardiovascular risk and chronic low-grade inflammation, raising concerns about its long-term metabolic consequences. Given that the Mediterranean diet (MD) shown beneficial effects on factors inflammation in various populations, it is important to explore potential impact individuals COVID. Therefore, aim determine association of MD (CVRF) syndrome (MetS) Caucasian subjects diagnosed Cross-sectional study, 305 were included following WHO criteria. Adherence was evaluated MEDAS (Mediterranean Diet Screener) 14 items used Prevention study (PREDIMED study). The criteria considered diagnose MetS blood pressure, glycemia, triglycerides, HDL cholesterol, waist circumference. Other CVRFs tobacco consumption, total LDL body mass index, baseline uric acid levels. between CVRF number components analyzed using multiple regression models multinomial regression. mean age 52.75 ± 11.94 years (men 55.74 12.22 women 51.33 11.57; p = 0.002), (68% women). questionnaire 7.76 2.37. presented 23.6% (39.8% men 15.9% < 0.001). In analysis, after adjusting for average time from acute COVID-19 infection date inclusion this score showed a negative (β -0.295; 95% CI: -0.496 -0.093), BMI -0.049; -0.096 -0.002), -0.210; -0.410 -0.010), circumference (WC) -0.021; -0.037 -0.003) positive cholesterol -0.018; 0.001 -0.037). findings suggest higher scores are lower levels acid, fewer components, smaller circumference,

Language: Английский

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Targeting Cytokine Dysregulation in Psoriasis: The Role of Dietary Interventions in Modulating the Immune Response

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2895 - 2895

Published: March 22, 2025

Psoriasis is a chronic immune-mediated skin disease characterized by cytokine dysregulation. Pro-inflammatory mediators, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-17, and IL-23, play pivotal roles in the pathogenesis of psoriasis. Emerging evidence suggests that dietary interventions can modulate activity, providing complementary approach to standard therapies. This narrative review examines impact various strategies, Mediterranean diet, ketogenic gluten-free fasting-mimicking on profiles clinical outcomes Research insights reveal components such as omega-3 fatty acids, polyphenols, short-chain acids influence immune signaling pathways. These pathways include nuclear factor-kappa B (NF-κB) Signal Transducer Activator Transcription 3 (STAT3). Additionally, these promote anti-inflammatory effects mediated gut microbiota. Clinical studies demonstrate significant reductions psoriasis severity, improved quality life, modulation key cytokines associated with activity. Despite advancements, challenges persist effectively integrating findings into practice. variability patient responses, adherence issues, need for robust biomarkers monitor efficacy. Future directions emphasize potential personalized nutrition precision medicine approaches optimize tailored individual genetic predispositions. Integrating strategies care could transform treatment paradigms simultaneously addressing both systemic inflammation comorbid conditions.

Language: Английский

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Chronic Inflammatory Diseases and Cardiovascular Risk: Current Insights and Future Strategies for Optimal Management

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3071 - 3071

Published: March 27, 2025

Chronic inflammation is a pivotal driver in the progression of atherosclerosis, significantly contributing to burden cardiovascular disease (CVD). Patients with chronic inflammatory diseases, such as bowel diseases (IBDs) (e.g., ulcerative colitis and Crohn's disease), rheumatological disorders, well individuals auto-immune (such systemic lupus erythematosus), present higher risk major adverse cardiac events (MACEs). Despite their elevated CVD risk, these populations remain underrepresented research, leading critical underestimation (CVR) clinical practice. Furthermore, even recent CVR scores poorly predict specific populations. This narrative review examines physiopathological mechanisms linking inflammation, immunomodulation, thrombosis events. We data from epidemiological studies trials explore potential benefits anti-inflammatory immunomodulatory therapies. existing evidence, significant gaps knowledge remain. Future research mandatory, focusing on innovative strategies for stratification optimization, including lipidomics, proteomics, advanced markers, microbiota profiling, imaging. Addressing unmet needs will enhance understanding enabling tailored interventions better outcomes.

Language: Английский

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Mediterranean diet, diet quality, and adequacy to Italian dietary recommendations in southern Italian adults

Mediterranean Journal of Nutrition and Metabolism, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Aug. 30, 2024

OBJECTIVE: This study aimed to explore the relation between adherence Mediterranean diet, adequacy Italian dietary recommendations, and several domains of diet quality in a sample adults. METHODS: The habits total 1936 participants were investigated. Adherence assessed through Medi-Lite Diet Quality Index-International (DQI-I). RESULTS: global DQI-I score positively correlated with score. Negative coefficients found for protein intake calcium category, fat moderation fatty acid ratio overall balance category. More than half adherent national recommendations potatoes, cereals, red meat, other fats consumption. In contrast, on legumes, fruit, vegetables, processed meat met by about while those dairy products (milk yogurt) cheese, eggs, white rather underrepresented. Higher scores well predicted fruit legumes. CONCLUSIONS: Individuals reporting higher show better probability meeting recommendations.

Language: Английский

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Dose–Response Associations Between Diet and Risk of Rheumatoid Arthritis: A Meta-Analysis of Prospective Cohort Studies

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4050 - 4050

Published: Nov. 26, 2024

To provide a systematic and quantitative summary of dietary factors rheumatoid arthritis (RA) risk. A review meta-analysis included prospective cohort studies from 2000 to 2024 reporting relative risks (RRs) with 95% confidence intervals (CIs) for RA incidence relating 32 different exposures. Linear non-linear dose-response analyses were conducted. Thirty included, involving 2,986,747 participants 9,677 cases. analysis suggested that each 2-unit per week increase in total alcohol intake was linked 4% risk reduction (RR (95%-CI), heterogeneity (

Language: Английский

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Immune aging and infectious diseases

Chinese Medical Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract The rise in global life expectancy has led to an increase the older population, presenting significant challenges managing infectious diseases. Aging affects innate and adaptive immune systems, resulting chronic low-grade inflammation (inflammaging) function decline (immunosenescence). These changes would impair defense mechanisms, susceptibility infections reduce vaccine efficacy adults. Cellular senescence exacerbates these issues by releasing pro-inflammatory factors, further perpetuating inflammation. Moreover, comorbidities, such as cardiovascular disease diabetes, which are common adults, amplify dysfunction, while immunosuppressive medications complicate responses infections. This review explores molecular cellular mechanisms driving inflammaging immunosenescence, focusing on genomic instability, telomere attrition, mitochondrial dysfunction. Additionally, we discussed how aging-associated alterations influence bacterial, viral, parasitic evaluated emerging antiaging strategies, aimed at mitigating effects improve health outcomes aging population.

Language: Английский

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PHYSICAL FITNESS AND HEALTHY AGING

Anti-Aging Eastern Europe, Journal Year: 2024, Volume and Issue: 3(2), P. 107 - 108

Published: June 27, 2024

PHYSICAL FITNESS AND HEALTHY AGING

Language: Английский

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Adherence to the Mediterranean Diet Mitigates Inflammation and Hospital Stay in Frail Elderly Patients: A Moderation Analysis

Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2482 - 2482

Published: July 31, 2024

Understanding the interaction between dietary patterns and nutritional status in influencing health outcomes is crucial, especially vulnerable populations. Our study investigates impact of adherence to Mediterranean diet (MD) on inflammatory markers (CRP) length stay (LOS) hospitalized frail elderly patients. Methods: We conducted two-way ANOVA multiple regression analysis evaluate effects MD CRP levels LOS a cohort 117 patients aged 65 years or older. Patients with cancer acute infection were excluded. Adherence was assessed using 14-item PREDIMED questionnaire. Results: Significant interactions found for both LOS. The low-level poor exhibited higher longer hospital stays compared those high adherence. Specifically, statistically significant observed (F (1, 113) = 7.36, p 0.008) 15.4, < 0.001), indicating protective effect high-level Moderation confirmed that mitigates adverse malnutrition response Conclusions: These findings highlight importance promoting MD, particularly malnourished patients, improve reduce hospitalization duration. Further longitudinal studies are warranted establish causality explore underlying mechanisms.

Language: Английский

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