Materials & Design,
Год журнала:
2024,
Номер
239, С. 112825 - 112825
Опубликована: Март 1, 2024
Non-alcoholic
fatty
liver
disease
(NAFLD),
or
hepatic
steatosis,
has
become
one
of
the
most
common
pathologies
among
liver-related
disorders.
The
rapid
accumulation
fat
in
this
organ,
and
consequent
increment
oxidative
stress
levels,
have
been
recognized
as
main
factors
involved
pathological
mechanism
underlying
progressive
non-alcoholic
steatohepatitis.
Experimental
epidemiological
data
shown
how
antioxidant
compounds
rich
phenolic
groups,
such
resveratrol
quercetin,
are
particular
efficient
contrasting
onset
pathology.
In
work,
an
vitro
model
NAFLD
was
established
based
on
oleic
acid-treated
HepG2
cells.
Steatotic
cells
were
treated
with
polydopamine
nanoparticles
(PDNPs),
biocompatible
polymeric
nanostructures
groups
high
power.
PDNP
treatment
to
be
effective
counteracting
hallmarks
characterizing
a
reduction
lipids
observed.
Further
analyses
showed
significant
triglyceride
cholesterol
jointly
reduced
levels
stress.
All
these
data,
corroborated
by
proteomics
gene
ontology
analysis,
suggest
PDNPs
promising
pharmaceutical
candidate
for
prevention
steatosis.
JAMA Psychiatry,
Год журнала:
2023,
Номер
80(6), С. 567 - 567
Опубликована: Апрель 26, 2023
Physical
health
and
chronic
medical
comorbidities
are
underestimated,
inadequately
treated,
often
overlooked
in
psychiatry.
A
multiorgan,
systemwide
characterization
of
brain
body
neuropsychiatric
disorders
may
enable
systematic
evaluation
brain-body
status
patients
potentially
identify
new
therapeutic
targets.
Antioxidants,
Год журнала:
2024,
Номер
13(8), С. 985 - 985
Опубликована: Авг. 14, 2024
Gut
dysbiosis,
resulting
from
an
imbalance
in
the
gut
microbiome,
can
induce
excessive
production
of
reactive
oxygen
species
(ROS),
leading
to
inflammation,
DNA
damage,
activation
immune
system,
and
epigenetic
alterations
critical
genes
involved
metabolic
pathways.
dysbiosis-induced
inflammation
also
disrupt
barrier
integrity
increase
intestinal
permeability,
which
allows
gut-derived
toxic
products
enter
liver
systemic
circulation,
further
triggering
oxidative
stress,
associated
with
diseases.
However,
specific
metabolites,
such
as
short-chain
fatty
acids
(SCFAs),
lactate,
vitamins,
modulate
stress
system
through
mechanisms,
thereby
improving
function.
microbiota
diet-induced
diseases,
obesity,
insulin
resistance,
dyslipidemia,
hypertension,
transfer
next
generation,
involving
mechanisms.
In
this
review,
we
will
introduce
key
that,
along
dysbiosis
ROS,
are
engaged
developing
Finally,
discuss
potential
therapeutic
interventions
dietary
modifications,
prebiotics,
probiotics,
postbiotics,
fecal
transplantation,
may
reduce
syndrome
by
altering
alterations.
summary,
review
highlights
crucial
role
pathogenesis
a
particular
focus
on
(including
histone
methylomics,
RNA
interference)
that
prevent
or
improve
npj Science of Food,
Год журнала:
2025,
Номер
9(1)
Опубликована: Янв. 11, 2025
Chronic
stress
disrupts
gut
microbiota
homeostasis,
contributing
to
anxiety
and
depression.
This
study
explored
the
effects
of
Limosilactobacillus
reuteri
fermented
brown
rice
(FBR)
on
using
an
ICR
mouse
chronic
mild
(CMS)
model.
Anxiety
was
assessed
through
body
weight,
corticosterone
levels,
neurotransmitter
profiles,
behavioral
tests.
A
four-week
FBR
regimen
reduced
corticosterone,
restored
neurotransmitters
like
gamma-aminobutyric
acid
(GABA)
serotonin,
improved
anxiety-related
behaviors.
Metagenomic
(16S
rRNA)
metabolomic
analyses
revealed
enhanced
amino
metabolism,
energy
short-chain
fatty
(SCFA)
production
in
FBR-treated
mice.
FBR-enriched
beneficial
bacteria,
aligning
profile
with
that
non-stressed
also
modulated
GABA
receptor-related
gene
expression,
promoting
relaxation.
Network
pharmacology
identified
quercetin,
GABA,
glutamic
acid,
phenylalanine,
ferulic
as
bioactive
compounds
neuroprotective
potential.
These
findings
highlight
FBR's
potential
a
gut-brain
axis-targeted
therapeutic
for
stress-related
disorders.
Nature Mental Health,
Год журнала:
2023,
Номер
1(10), С. 736 - 750
Опубликована: Сен. 11, 2023
Abstract
Lifestyle
factors
have
been
acknowledged
to
be
modifiable
targets
that
can
used
counter
the
increasing
prevalence
of
depression.
This
study
aims
investigate
combining
an
extensive
range
lifestyle
factors,
including
alcohol
consumption,
diet,
physical
activity,
sleep,
smoking,
sedentary
behavior
and
social
connection,
contribute
depression,
examine
underlying
neurobiological
mechanisms.
Over
nine
years
follow-up,
a
multivariate
Cox
model
was
utilized
on
287,282
participants
from
UK
Biobank
demonstrate
protective
roles
seven
combined
score
Combining
genetic
risk
category
in
197,344
participants,
we
found
healthy
decreased
depression
across
population
with
varied
risk.
Mendelian
randomization
confirmed
causal
relationship
between
A
broad
brain
regions
peripheral
biomarkers
were
related
lifestyle,
pallidum,
precentral
cortex,
triglycerides
C-reactive
protein.
Structural
equation
modeling
18,244
revealed
mechanisms
involving
structure,
immunometabolic
function,
genetics
Together,
our
findings
suggest
adherence
could
aid
prevention
The Lancet Healthy Longevity,
Год журнала:
2023,
Номер
4(11), С. e618 - e628
Опубликована: Ноя. 1, 2023
BackgroundMany
physical,
psychological,
and
cognitive
disorders
are
highly
clustered
among
populations
with
low
socioeconomic
status.
However,
the
extent
to
which
status
is
associated
different
combinations
of
these
unclear,
particularly
outside
high-income
countries.
We
aimed
evaluate
associations
in
33
countries
including
countries,
upper-middle-income
one
lower-middle-income
country.MethodsThis
cross-sectional
multi-region
study
pooled
individual-level
data
from
seven
studies
on
ageing
between
2017
2020.
Education
total
household
wealth
were
used
measure
Physical
disorder
was
defined
as
having
or
more
self-reported
chronic
conditions.
Psychological
measured
by
study-specific
instruments.
The
outcome
included
eight
categories:
no
disorders,
physical
disorder,
psychological
their
four
combinations.
Multivariable-adjusted
logistic
regression
models
estimate
odds
ratios
(ORs)
95%
CIs
for
outcomes
separately
country.FindingsAmong
167
376
individuals
aged
45
years
older,
prevalence
multimorbidity
24·5%
33·9%
8·1%
country
(India).
Lower
levels
education,
wealth,
a
combined
score
strongly
ORs
(low
vs
high
status)
physical–psychological–cognitive
12·36
(95%
CI
10·29–14·85;
p<0·0001)
23·84
(18·85–30·14;
mixed.
Participants
both
level
education
had
highest
(eg,
OR
physical-psychological–cognitive
21·21
[15·95–28·19;
p<0·0001]
37·07
[25·66–53·56;
54·96
[7·66–394·38;
country).InterpretationIn
country,
multimorbidity,
than
ten
times
greater
Equity-oriented
policies
programmes
that
reduce
social
inequalities
urgently
needed
achieve
Sustainable
Development
Goals.FundingZhejiang
University,
Fundamental
Research
Funds
Central
Universities,
Key
Laboratory
Intelligent
Preventive
Medicine
Zhejiang
Province,
Wellcome
Trust,
Medical
Council,
National
Institute
Aging,
Academy
Finland.TranslationFor
Chinese
translation
abstract
see
Supplementary
Materials
section.
Abstract
Background
Childhood
maltreatment
is
associated
with
depression
and
cardiometabolic
disease
in
adulthood.
However,
the
relationships
these
two
diseases
have
so
far
only
been
evaluated
different
samples
methodology.
Thus,
it
remains
unknown
how
effect
sizes
magnitudes
for
compare
each
other
whether
childhood
especially
co-occurrence
(“comorbidity”)
of
disease.
This
pooled
analysis
examined
association
depression,
disease,
their
comorbidity
Methods
We
carried
out
an
individual
participant
data
meta-analysis
on
13
international
observational
studies
(
N
=
217,929).
comprised
self-reports
physical,
emotional,
and/or
sexual
abuse
before
18
years.
Presence
was
established
clinical
interviews
or
validated
symptom
scales
presence
self-reported
diagnoses.
In
included
studies,
binomial
multinomial
logistic
regressions
estimated
sociodemographic-adjusted
associations
comorbidity.
then
additionally
adjusted
lifestyle
factors
(smoking
status,
alcohol
consumption,
physical
activity).
Finally,
random-effects
models
were
used
to
pool
estimates
across
differences
sex
types.
Results
progressively
higher
odds
without
(OR
[95%
CI]
1.27
[1.18;
1.37]),
2.68
[2.39;
3.00]),
between
both
conditions
3.04
[2.51;
3.68])
Post
hoc
analyses
showed
that
stronger
than
either
alone,
Associations
remained
significant
after
adjusting
factors,
present
males
females,
all
Conclusions
revealed
adults
a
history
suffer
more
often
from
non-exposed
peers.
These
are
also
three
times
likely
comorbid
may
therefore
be
clinically
relevant
indicator
connecting
poor
mental
somatic
health.
Future
research
should
investigate
potential
benefits
early
intervention
individuals
distal
health
(PROSPERO
CRD42021239288).
