Journal of biomedical and life sciences., Год журнала: 2024, Номер 4(1), С. 1 - 14
Опубликована: Июль 16, 2024
Epigenetic studies have provided new opportunities to better understand the biological effects of poverty and racial/ethnic minority status. However, little is known about sex differences in these processes.
Язык: Английский
BMC Public Health, Год журнала: 2024, Номер 24(1)
Опубликована: Фев. 13, 2024
Abstract Background Biological aging reflects a decline in the functions and integrity of human body that is closely related to chronological aging. A variety biomarkers have been found predict biological age. age higher than (biological acceleration) indicates an accelerated state risk premature morbidity mortality. This study investigated how socioeconomic disadvantages influence Methods The data from National Health Nutrition Examination Survey (NHANES) IV, including 10 nationally representative cross-sectional surveys between 1999-2018, were utilized. analytic sample consisted N = 48,348 individuals (20-84 years). We used total 11 for estimating Our main outcome was acceleration, indexed by PhenoAge acceleration (PAA) Klemera-Doubal (KDM-A). Poverty measured as ratio family income poverty thresholds defined U.S. Census Bureau, adjusted annually inflation size (5 categories). PAA KDM-A regressed on levels, age, their interaction, education, sex, race, collection wave. Sample weights make estimates adult population. Results results showed associated with (PAA: unstandardized coefficient B 1.38 p <.001, KDM: 0.96, .026 when comparing highest lowest level categories), above beyond other covariates. association U-shaped. Importantly, there interaction levels ( <.001), effect most pronounced middle-aged categories while it modest younger elderly groups. Conclusion In US population, we positively particularly among persons.
Язык: Английский
Процитировано
8
Neurobiology of Aging, Год журнала: 2024, Номер 136, С. 23 - 33
Опубликована: Янв. 24, 2024
Язык: Английский
Процитировано
7
JAMA Network Open, Год журнала: 2024, Номер 7(3), С. e240655 - e240655
Опубликована: Март 1, 2024
Importance People who complete more education live longer lives with better health. New evidence suggests that these benefits operate through a slowed pace of biological aging. If so, measurements the aging could offer intermediate end points for studies how interventions to promote will affect healthy longevity. Objective To test hypothesis upward educational mobility is associated slower and increased Design, Setting, Participants This prospective cohort study analyzed data from 3 generations participants in Framingham Heart Study: (1) original cohort, enrolled beginning 1948; (2) Offspring 1971; (3) Gen3 2002. A 3-generation database was constructed quantify intergenerational mobility. Mobility were linked blood DNA-methylation collected 2005 2008 (n = 1652) 2009 2011 1449). Follow-up ongoing. Data analysis conducted June 2022 November 2023 using obtained National Institutes Health Genotypes Phenotypes (dbGaP). Exposure Educational measured by comparing participants’ outcomes those their parents. Main Outcomes Measures The whole-blood DunedinPACE epigenetic clock. For comparison purposes, repeated 4 other clocks. Survival follow-up 2019. Results 3101 Study; 1652 (mean [SD] age, 65.57 [9.22] years; 764 [46.2%] male) 1449 45.38 [7.83] 691 [47.7%] male). upwardly mobile terms tended have later life ( r −0.18 [95% CI, −0.23 −0.13]; P &lt; .001). pattern association similar across held within-family sibling comparisons. There 402 died over period. Upward lower mortality risk (hazard ratio, 0.89 0.81 0.98]; .01). Slower accounted approximately half this association. Conclusions Relevance study’s findings support attainment may slow Epigenetic clocks potential as near-term outcome measures intervention effects on Experimental needed confirm findings.
Язык: Английский
Процитировано
6
JAMA Network Open, Год журнала: 2024, Номер 7(7), С. e2421889 - e2421889
Опубликована: Июль 29, 2024
Importance Variation in DNA methylation at specific loci estimates biological age, which is associated with morbidity, mortality, and social experiences. Aging known as epigenetic clocks, including the Dunedin Pace of Calculated From Epigenome (DunedinPACE), were trained on data predominately from individuals European ancestry; however, limited research has explored DunedinPACE underrepresented populations experiencing health disparities. Objective To investigate associations neighborhood individual sociobehavioral factors aging a racially ethnically diverse population. Design, Setting, Participants This cohort study, part Multiethnic Cohort study conducted May 1993 to September 1996 examine racial ethnic disparities chronic diseases, integrated biospecimen self-reported collected between April 2004 November 2005 healthy Hawaii residents aged 45 76 years. These participants self-identified Japanese American, Native Hawaiian, or White background. Data analyzed January 2022 2024. Main Outcomes Measures generated monocytes enriched cryopreserved lymphocytes used derive scores 2017 June 2021. Neighborhood economic status (NSES) was estimated 1990 US Census Bureau include such educational level, occupation, income. Individual-level included body mass index (BMI), physical activity (PA), diet quality measured by Healthy Eating Index (HEI). Linear regression analysis their NSES variables. Results A total 376 (113 [30.1%] 144 [38.3%] 119 [31.6%] White; 189 [50.3%] female). Mean (SE) age 57.81 (0.38) Overall, mean significantly higher among females than males (1.28 [0.01] vs 1.25 [0.01]; P = .005); correlated negatively ( R −0.09; .08), HEI −0.11; .03), attainment −0.15; .003) positively BMI 0.31; &lt; .001); varied race ethnicity. Hawaiian exhibited score (1.31 [0.01]) compared American (1.25 .001) (1.22 participants. Controlling for sex, HEI, BMI, NSES, linear analyses revealed negative association level (β, −0.005 [95% CI, −0.013 0.002]; .03) −0.003 −0.011 0.005]; .08) participants, yet this positive 0.007; 95% −0.001 0.015; .09). Moderate vigorous PA lower only −0.006; −0.001; .005), independent NSES. Conclusions Relevance In sample adults, low rate score, individual-level affected association, findings support interventions addressing inequities.
Язык: Английский
Процитировано
6
Biological Psychiatry, Год журнала: 2023, Номер 95(11), С. 1038 - 1047
Опубликована: Ноя. 2, 2023
Язык: Английский
Процитировано
14
Biochemical Journal, Год журнала: 2024, Номер 481(10), С. 615 - 642
Опубликована: Май 9, 2024
Early-life adversities, whether prenatal or postnatal exposure, have been linked to adverse mental health outcomes later in life increasing the risk of several psychiatric disorders. Research on its neurobiological consequences demonstrated an association between exposure adversities and persistent alterations structure, function, connectivity brain. Consistent evidence supports idea that regulation gene expression through epigenetic mechanisms are involved embedding impact early-life experiences genome mediate social environments behavioral phenotypes. In addition, studies from rodent models humans suggest these acquired factors can be transmitted offspring following generations potentially contributing a cycle disease risk. However, one important aspects mechanisms, unlike genetic sequences fixed unchangeable, is although markings long-lasting, they nevertheless reversible. this review, we summarize our current understanding derived malnutrition, maltreatment poverty, with huge pervasive health. We also discuss about transgenerational inheritance mammals experimental data suggesting suitable pharmacological interventions could reverse modifications induced by negative experiences. regard, must accompanied efforts determine causes promote result inequity population.
Язык: Английский
Процитировано
5
Translational Psychiatry, Год журнала: 2024, Номер 14(1)
Опубликована: Июль 12, 2024
Although stress and adversity are largely universal experiences, people exposed to greater hardship at increased risk for negative health consequences. Recent studies identify accelerated biological aging as a mechanism that could explain how trauma gives rise poor health, advances in this area of study coincide with technological innovations the measurement aging, particularly epigenetic profiles consistent derived from DNA methylation. In review, we provide an overview current literature examining might accelerate specific focus on social behaviors. The most extensive evidence suggests health-compromising behaviors, smoking, may partially association between aging. there is relatively less published support role emerging points importance connection future study. Our review highlights need determine extent which associations causal processes. As consider these questions, emphasizes methodological approaches inference can help deepen our understanding result health. use methodologies will behavioral interventions slow improve among populations more often experience trauma.
Язык: Английский
Процитировано
5
Ageing Research Reviews, Год журнала: 2024, Номер 100, С. 102418 - 102418
Опубликована: Июль 14, 2024
Язык: Английский
Процитировано
5
International Journal of Hygiene and Environmental Health, Год журнала: 2025, Номер 264, С. 114521 - 114521
Опубликована: Янв. 13, 2025
Evidence on the impact of complex neighborhood environment, including air pollution, greenness, and socioeconomic deprivation (nSED) cognitive health in older adults remains scarce. Both cognition environment are associated with physical activity, but little is known about potential mediating role activity this association. Cross-sectional data Czech arm HAPIEE cohort study examined 4,178 participants (55.6% women) aged 45-69 years. Global score was constructed from memory, verbal fluency, concentration domains. The exposures, assigned to participant's addresses, include 4-year (2000-2003) average concentrations PM2.5, greenness index calculated tree crown canopy cover estimation (2000), census-based nSED characteristics. Physical other covariates were assessed by a questionnaire. Structural equation modelling used estimate standardized β coefficients for relationships between performance. After controlling range covariates, global function inversely PM2.5 (β = -0.087; 95%CI: 0.122 -0.052) -0.147; 0.182 -0.115), positively 0.036; 0.001 0.069). We identified weak statistically significant associations exposures score. Total mediation proportions ranged 3.9% 6.5% respectively. individuals; partially mediated activity.
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Авг. 26, 2024
Abstract Aging is associated with genome-wide changes in DNA methylation humans, facilitating the development of epigenetic age prediction models. However, most these models have been trained primarily on European-ancestry individuals, and none account for impact quantitative trait loci (meQTL). To address gaps, we analyzed relationships between age, genotype, CpG 3 understudied populations: central African Baka (n = 35), southern ‡Khomani San 52), Himba 51). We find that published methods yield higher mean errors cohorts compared to unaccounted-for sequence variation may be a significant factor underlying this loss accuracy. leverage information about associations genotype develop an predictor minimally influenced by meQTL, show model remains accurate across broad range genetic backgrounds. Intriguingly, also older individuals those exhibiting relatively lower acceleration our tend carry more age-reducing variants, suggesting novel mechanism which heritable factors can influence longevity.
Язык: Английский
Процитировано
4