Seminars in Reproductive Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 23, 2024
Abstract
The
female
lower
reproductive
tract
microbiota
is
a
complex
ecosystem
comprising
various
microorganisms
that
play
pivotal
role
in
maintaining
women's
well-being.
During
pregnancy,
the
vaginal
undergoes
dynamic
changes
are
important
for
successful
gestation.
This
review
summarizes
implications
of
cervical
mucus
plug
microenvironment
and
its
profound
impact
on
health.
Further,
symbiotic
relationship
between
microbiome
highlighted,
with
special
emphasis
how
this
natural
barrier
serves
as
guardian
against
ascending
infections.
Understanding
host–microbes
interplay
could
pave
way
innovative
approaches
to
improve
health
fertility.
Cancer and Metastasis Reviews,
Год журнала:
2023,
Номер
42(3), С. 677 - 698
Опубликована: Июль 11, 2023
Abstract
Cancer
is
a
multi-step
process
that
can
be
viewed
as
cellular
and
immunological
shift
away
from
homeostasis
in
response
to
selected
infectious
agents,
mutations,
diet,
environmental
carcinogens.
Homeostasis,
which
contributes
importantly
the
definition
of
“health,”
maintained,
part
by
production
short-chain
fatty
acids
(SCFAs),
are
metabolites
specific
gut
bacteria.
Alteration
composition
bacteria,
or
dysbiosis,
often
major
risk
factor
for
some
two
dozen
tumor
types.
Dysbiosis
characterized
diminished
levels
SCFAs
stool,
presence
“leaky
gut,”
permitting
penetration
microbes
microbial
derived
molecules
(e.g.,
lipopolysaccharides)
through
wall,
thereby
triggering
chronic
inflammation.
attenuate
inflammation
inhibiting
activation
nuclear
kappa
B,
decreasing
expression
pro-inflammatory
cytokines
such
necrosis
alpha,
stimulating
anti-inflammatory
interleukin-10
transforming
growth
beta,
promoting
differentiation
naïve
T
cells
into
regulatory
cells,
down-regulate
immune
responses
immunomodulation.
SCFA
function
epigenetically
histone
acetyltransferases
alter
multiple
genes
activity
many
signaling
pathways
Wnt,
Hedgehog,
Hippo,
Notch)
contribute
pathogenesis
cancer.
block
cancer
stem
cell
proliferation,
potentially
delaying
development
relapse
targeting
mutated
tumors
epidermal
receptor,
hepatocyte
factor,
MET)
suppressors
up-regulating
PTEN
p53).
When
administered
properly,
have
advantages
compared
probiotic
bacteria
fecal
transplants.
In
carcinogenesis,
toxic
against
but
not
surrounding
tissue
due
differences
their
metabolic
fate.
Multiple
hallmarks
also
targets
SCFAs.
These
data
suggest
may
re-establish
without
overt
toxicity
either
delay
prevent
various
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Янв. 21, 2025
Female
infertility
is
a
multifactorial
condition
influenced
by
various
genetic,
environmental,
and
lifestyle
factors.
Recent
research
has
investigated
the
significant
impact
of
gut
microbiome
dysbiosis
on
systemic
inflammation,
metabolic
dysfunction,
hormonal
imbalances,
which
can
potentially
impair
fertility.
The
gut-brain
axis,
bidirectional
communication
system
between
brain,
also
plays
role
in
regulating
reproductive
functions.
Emerging
evidence
suggests
that
influence
brain
functions
behavior,
further
emphasizing
importance
microbiota-gut-brain
axis
reproduction.
Given
their
as
major
modulator
microbiome,
diet
dietary
factors,
including
patterns
nutrient
intake,
have
been
implicated
development
management
female
infertility.
Hence,
this
review
aims
to
highlight
patterns,
such
Western
(WD)
Mediterranean
(MD),
decipher
modulatory
action
infertile
women.
By
contrasting
detrimental
effects
WD
with
therapeutic
potential
MD,
we
emphasize
pivotal
balanced
rich
nutrients
promoting
healthy
microbiome.
These
insights
underscore
targeted
interventions
modifications
promising
strategies
enhance
outcomes
subfertile
Cells,
Год журнала:
2022,
Номер
11(10), С. 1711 - 1711
Опубликована: Май 22, 2022
Male
infertility
is
an
increasing
and
serious
medical
concern,
though
the
mechanism
remains
poorly
understood.
Impaired
male
reproductive
function
affects
approximately
half
of
infertile
couples
worldwide.
Multiple
factors
related
to
environment,
genetics,
age,
comorbidities
have
been
associated
with
impaired
sperm
function.
Present-day
clinicians
rely
primarily
on
standard
semen
analysis
diagnose
potential
develop
treatment
strategies.
To
address
quality
assessment
bias
enhance
accuracy,
World
Health
Organization
(WHO)
has
recommended
standardized
testing;
however,
conventional
diagnostic
therapeutic
options
for
infertility,
including
physical
examination
analysis,
remain
ineffective
in
relieving
social
burden.
Instead,
assisted
techniques
are
becoming
primary
approach.
In
post-genomic
era,
multiomics
technologies
that
deeply
interrogate
genome,
transcriptome,
proteome,
and/or
epigenome,
even
at
single-cell
level,
besides
breakthroughs
robotic
surgery,
stem
cell
therapy,
big
data,
offer
promises
towards
solving
deterioration
factor
infertility.
This
review
highlights
complex
etiology
especially
roles
lifestyle
environmental
factors,
discusses
advanced
technologies/methodologies
used
characterizing
its
pathophysiology.
A
comprehensive
combination
these
innovative
approaches
a
global
multi-centric
setting
fulfilling
suitable
ethical
consent
could
ensure
optimal
developmental
outcomes.
These
combinatorial
should
allow
development
markers,
molecular
stratification
classes,
personalized
Since
choices
influence
fertility,
their
integration
any
approach
required
safe,
proactive,
cost-effective,
noninvasive
precision
theranostics
affordable,
accessible,
facilitate
realizing
procreation
dream.
Journal of Endocrinological Investigation,
Год журнала:
2023,
Номер
46(6), С. 1079 - 1085
Опубликована: Янв. 12, 2023
Abstract
Background
Infertility,
which
is
defined
as
the
inability
to
conceive
after
at
least
12
months
of
regular
unprotected
sexual
intercourses,
affects
about
15–20%
couples
worldwide
and
a
male
factor
involved
in
half
cases.
The
development
assisted
reproductive
technology
(ART)
made
it
possible
also
individuals
affected
from
severe
oligospermia
or
azoospermia.
However,
impact
on
embryo
development,
implantation,
prevalence
chromosomal
abnormalities,
genetic
epigenetic
alterations,
clinical
obstetric
outcomes
still
controversial.
Purpose
This
narrative
review
examines
indications,
minimum
access
criteria,
by
individual
ART
technique
relation
factor.
Nutrients,
Год журнала:
2023,
Номер
15(1), С. 221 - 221
Опубликована: Янв. 1, 2023
The
incidence
of
Idiopathic
Recurrent
Pregnancy
Loss
(RPL)
is
doubled
in
patients
suffering
from
Celiac
Disease
(CD)
compared
to
healthy
populations.
CD
genetic
components
are
HLA
class
II
genes
known
as
HLA-DQ2
and
DQ8.
Genetically
susceptible
women
can
remain
asymptomatic
even
though
they
exposed
a
risk
RPL
the
general
population.
Furthermore,
has
been
associated
with
microbiota
alterations.
aim
this
study
evaluate
endometrial
vaginal
HLA-DQ2/DQ8
positive
negative
pregnant
women.
Endometrial
3
subgroups
were
evaluated:
15
women,
25
DQ2/DQ8
(for
total
40
women)
7
fertile
controls
previous
uncomplicated
pregnancies
(all
negative).
2
(HLA-DQ2/DQ8
negative)
showed
different
composition
Lactobacillacae
family
controls:
Lactobacillus
acidophilus
was
absent
both
samples
while
Lactobaciluus
iners,
which
favor
less
stable
microbiota,
found
only
(26.4%
22.1%
districts.
In
conclusion,
positive-RPL
negative-RPL
controls.
Acta Obstetricia Et Gynecologica Scandinavica,
Год журнала:
2023,
Номер
102(7), С. 921 - 934
Опубликована: Май 23, 2023
Despite
the
considerable
progress
made
in
assisted
reproductive
technologies
(ART),
implantation
rate
of
transferred
embryos
remains
low
and
many
cases,
reasons
for
failure
remain
unclear.
We
aimed
to
determine
potential
impact
female
male
partners'
tract
microbiome
composition
on
ART
outcome.The
couples
(n
=
97)
healthy
12)
were
recruited
into
study.
The
smaller
group
underwent
a
careful
selection
according
their
general
health
criteria.
Both
vaginal
semen
samples
subjected
16S
rDNA
sequencing
reveal
bacterial
diversity
identify
distinct
microbial
community
types.
Ethics
statement
study
was
approved
by
Review
Committee
Human
Research
Tartu
University,
Tartu,
Estonia
(protocol
no.
193/T-16)
31
May
2010.
Participation
research
voluntary.
Written
informed
consent
obtained
from
all
participants.The
men
with
Acinetobacter-associated
who
had
children
past,
highest
success
(P
<
0.05).
women
vaginosis
L.
iners-predominant
gasseri-predominant
lower
than
crispatus-predominant
or
mixed
lactic-acid-bacteria-predominant
type
15
where
both
partners
beneficial
types
superior
53%,
when
compared
rest
(25%;
P
0.023).Microbiome
disturbances
genital
tend
be
associated
couple's
infertility
as
well
levels
may
thus
need
attention
before
procedure.
incorporation
genitourinary
screening
part
diagnostic
evaluation
process
become
routine
patients
if
our
results
are
confirmed
other
studies.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Март 18, 2024
Relevant
studies
increasingly
indicate
that
female
reproductive
health
is
confronted
with
substantial
challenges.
Emerging
research
has
revealed
the
microbiome
interacts
anatomy,
histology,
and
immunity
of
tract,
which
are
cornerstone
maintaining
preventing
adverse
pregnancy
outcomes.
Currently,
precise
mechanisms
underlying
their
interaction
impact
on
physiological
functions
tract
remain
elusive,
constituting
a
prominent
area
investigation
within
field
microecology.
From
this
new
perspective,
we
explore
interactions
between
factors
affect
composition
in
as
well
personalized
medicine
approaches
managing
based
microbiome.
This
study
highlights
pivotal
role
influencing
occurrence
diseases.
These
findings
support
exploration
innovative
for
prevention,
monitoring
treatment
diseases
