The triple exposure nexus of microplastic particles, plastic-associated chemicals, and environmental pollutants from a human health perspective

Environment International, Год журнала: 2024, Номер 188, С. 108736 - 108736

Опубликована: Май 10, 2024

The presence of microplastics (MPs) is increasing at a dramatic rate globally, posing risks for exposure and subsequent potential adverse effects on human health. Apart from being physical objects, MP particles contain thousands plastic-associated chemicals (i.e., monomers, chemical additives, non-intentionally added substances) captured within the polymer matrix. These are often migrating MPs can be found in various environmental matrices food chains; health effects. In addition to attributes MPs, plastic surfaces effectively bind exogenous chemicals, including pollutants (e.g., heavy metals, persistent organic pollutants). Therefore, act as vectors pollution across air, drinking water, food, further amplifying posed by exposure. Critically, fragmentation plastics environment increases risk interactions with cells, available leach adsorb transfer pollutants. This review proposes so-called triple nexus approach comprehensively map existing knowledge interconnected particles, Based data, there large gap regard cumulative nexus. Each component known induce genotoxicity, inflammation, endocrine disruption, but about long-term inter-individual lacking. Furthermore, not readily excreted organisms after ingestion they have been accumulated blood, cardiac tissue, placenta, etc. Even though number studies MPs-associated impacts rapidly, this underscores that pressing necessity achieve an integrated assessment MPs' order address future gaps.

Язык: Английский

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First evidence of microplastics in human ovarian follicular fluid: An emerging threat to female fertility

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117868 - 117868

Опубликована: Фев. 1, 2025

Язык: Английский

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The histopathological and functional consequences of microplastic exposure

Deleted Journal, Год журнала: 2025, Номер 7(1)

Опубликована: Янв. 11, 2025

As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory, nervous, digestive, respiratory, reproductive systems explains associated functional alterations. Except nervous system, main morphological involve degenerative throughout body, such as apoptosis, inflammation, fibrosis. Most were inflammatory responses microplastics, leading fibrosis subsequent impairments. Various studies confirm that stimulate cells, increased reactive oxygen species cell death. Consequently, these impair related systemic functions. review highlights fundamental organs cells due discusses limitations involving showing no changes.

Язык: Английский

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Microplastics – A Growing Concern as Carcinogens in Cancer Etiology: Emphasis on Biochemical and Molecular Mechanisms

Cell Biochemistry and Biophysics, Год журнала: 2024, Номер 82(4), С. 3109 - 3121

Опубликована: Июль 20, 2024

Язык: Английский

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Airborne Nanoplastics Exposure Inducing Irreversible Glucose Increase and Complete Hepatic Insulin Resistance

Environmental Science & Technology, Год журнала: 2024, Номер unknown

Опубликована: Фев. 6, 2024

As an emerging type of pollutant, microplastics have become a global environmental problem. Approximately, fifth the burden 2 diabetes can be attributed to air particulate pollution. However, scientific knowledge remains limited about effects airborne nanoplastics (NPs) exposure on metabolic diseases. In this experiment, whole-body system was used simulate real atmospheric environment, and three concentrations combined with actual concentration were selected explore NPs Based histological analyses, studies, gene expression, metabolites, molecular signaling mice exposed observed show phenotype systemic inflammation complete insulin resistance featuring excessive drinking eating, weight loss, elevated blood glucose, decreased triglyceride levels. After exposure, intolerant glucose tolerant insulin. addition, could result in long-term irreversible hyperglycemia. Together, research findings provide strong basis for understanding hazards nanopollution disorders.

Язык: Английский

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Intravenous hypertonic fluids as a source of human microplastic exposure

Environmental Toxicology and Pharmacology, Год журнала: 2024, Номер 107, С. 104411 - 104411

Опубликована: Март 5, 2024

Язык: Английский

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Microplastics in Freshwater Systems: A Review of Classification, Sources, and Environmental Impacts

Chemical Engineering Journal Advances, Год журнала: 2024, Номер unknown, С. 100649 - 100649

Опубликована: Сен. 1, 2024

Язык: Английский

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Microplastic residues in clinical samples: A retrospection on sources, entry routes, detection methods and human toxicity

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 173, С. 117618 - 117618

Опубликована: Март 6, 2024

Язык: Английский

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First evidence of microplastics in human ovarian follicular fluid: an emerging threat to female fertility

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Апрель 5, 2024

Abstract Plastic pollution is a pressing global issue, with over 400 million tons produced annually and projections of 1.1 billion by 2050. Microplastics (MPs), ranging from 5 mm to 1 µm, are pervasive in the environment. They found air, sea, freshwater, soils, food chains studies show that tiny MPs, smaller than 10 μm, can cross cellular membranes, posing potential health risks through oxidative stress, inflammation, immune dysfunction, neurotoxicity reprotoxicity. In recent years, research has shown microplastics have negative effects on female reproductive systems animals. However, there still lack evidence how accumulation affects human females. This study aimed examine presence ovarian follicular fluid 18 women undergoing assisted treatment whose samples were processed using patented method endorsed nationally internationally. particles <10 µm measured SEM EDX detection. Preventive measures taken avoid contamination during process. (dimensions µm) detected 14 out fluid, an average 2191 p/ml (0 - 7181p/ml) mean diameter MPs 4.48 (3.18-5.54 µm). A significant correlation was between microplastic concentration FSH (p-value <0.05), as well weak BMI, age Estradiol. There no fertilization outcomes, miscarriages, or live birth. first provide for microplastics’ treatment, representing threat function. Figure

Язык: Английский

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Breathing in danger: Mapping microplastic migration in the human respiratory system

Physics of Fluids, Год журнала: 2024, Номер 36(4)

Опубликована: Апрель 1, 2024

The abundance of air pollutants over the last few years, including concentration microplastics, has become an alarming concern across world. Initially discovered in marine life, these toxic and inflammatory particles have recently been found human lung tissues. When inhaled, harmful settle down airways and, time, lead to respiratory failures. A recent study analyzed microplastic transport behavior mouth–throat airways. However, knowledge migration bifurcating tracheobronchial is missing literature. Therefore, this first-ever analyzes detail settling patterns different sizes shapes at intensities numerical technique based on discrete phase modeling employed simulate flow a three-dimensional realistic geometry. model results indicate low velocity turbulence intensity magnitudes with smooth trachea compared left right lobes, which experience higher velocities generate secondary vortices. Lower lobes are deposition hotspots for lower rate. These shift upper rate same particle size. Moreover, size shape influence overall current study, accumulation regions breathing intensities, will contribute updated pollutant inhalation facilitate relevant treatment measures.

Язык: Английский

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