Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 775 - 775
Опубликована: Фев. 26, 2023
Cancer
develops
with
unexpected
mutations
and
causes
death
in
many
patients.
Among
the
different
cancer
treatment
strategies,
immunotherapy
is
promising
benefits
of
high
specificity
accuracy,
as
well
modulating
immune
responses.
Nanomaterials
can
be
used
to
formulate
drug
delivery
carriers
for
targeted
therapy.
Polymeric
nanoparticles
clinic
are
biocompatible
have
excellent
stability.
They
potential
improve
therapeutic
effects
while
significantly
reducing
off-target
toxicity.
This
review
classifies
smart
systems
based
on
their
components.
Synthetic
polymers
pharmaceutical
industry,
including
enzyme-responsive,
pH-responsive,
redox-responsive
polymers,
discussed.
Natural
derived
from
plants,
animals,
microbes,
marine
organisms
also
construct
stimuli-responsive
biocompatibility,
low
toxicity,
biodegradability.
The
applications
or
immunotherapies
discussed
this
systemic
review.
We
summarize
strategies
mechanisms
that
give
examples
each
case.
ACS Nano,
Год журнала:
2022,
Номер
16(2), С. 3194 - 3207
Опубликована: Янв. 31, 2022
In
view
of
the
lack
a
specific
drug-sustained
release
system
that
is
responsive
to
chronic
wounds
type
II
diabetic
foot,
and
demands
for
frequent
movement
at
foot
wound,
pH/glucose
dual-responsive
metformin-released
adhesion-enhanced
self-healing
easy-removable
antibacterial
antioxidant
conductive
hemostasis
multifunctional
phenylboronic
acid
benzaldehyde
bifunctional
polyethylene
glycol-co-poly(glycerol
sebacic
acid)/dihydrocaffeic
l-arginine
cografted
chitosan
(PEGS-PBA-BA/CS-DA-LAG,
denoted
as
PC)
hydrogel
dressings
were
constructed
based
on
double
dynamic
bond
Schiff-base
phenylboronate
ester.
It
was
further
demonstrated
PC
promotes
wound
healing
by
reducing
inflammation
enhancing
angiogenesis
in
rat
model.
addition,
addition
metformin
(Met)
graphene
oxide
(GO),
well
their
synergy,
confirmed
better
promote
repair
vivo.
summary,
PC/GO/Met
hydrogels
with
stimuli-responsive
ability
easy
removability
have
shown
promoting
effect
athletic
provide
local-specific
drug
dual-response
strategy
treatment
feet.
Theranostics,
Год журнала:
2021,
Номер
11(13), С. 6370 - 6392
Опубликована: Янв. 1, 2021
As
one
of
the
most
important
cancer
treatment
strategies,
conventional
chemotherapy
has
substantial
side
effects
and
leads
easily
to
failure.
Therefore,
exploring
developing
more
efficient
methods
enhance
is
an
urgently
problem
that
must
be
solved.
With
development
nanotechnology,
nanomedicine
showed
a
good
application
prospect
in
improving
chemotherapy.
In
this
review,
we
aim
present
discussion
on
significant
research
progress
for
enhanced
First,
increased
enrichment
drugs
tumor
tissues
relying
different
targeting
ligands
promoting
tissue
penetration
are
summarized.
Second,
specific
subcellular
organelle-targeted
discussed.
Next,
combinational
strategies
reverse
multidrug
resistance
(MDR)
improve
effective
intracellular
concentration
therapeutics
Furthermore,
advantages
combination
therapy
emphasized.
Finally,
discuss
major
problems
facing
therapeutic
chemotherapy,
propose
possible
future
directions
field.
Nanoscale Research Letters,
Год журнала:
2021,
Номер
16(1)
Опубликована: Май 25, 2021
Abstract
The
increasing
prevalence
of
cancer,
a
disease
in
which
rapid
and
uncontrollable
cell
growth
causes
complication
tissue
dysfunction,
is
one
the
serious
tense
concerns
scientists
physicians.
Nowadays,
cancer
diagnosis
especially
its
effective
treatment
have
been
considered
as
biggest
challenges
health
medicine
last
century.
Despite
significant
advances
drug
discovery
delivery,
their
many
adverse
effects
inadequate
specificity
sensitivity,
usually
cause
damage
to
healthy
tissues
organs,
great
barriers
using
them.
Limitation
duration
amount
these
therapeutic
agents’
administration
also
challenging.
On
other
hand,
incidence
tumor
cells
that
are
resistant
typical
methods
treatment,
such
chemotherapy
radiotherapy,
highlights
intense
need
for
innovation,
improvement,
development
antitumor
properties.
Liposomes
suggested
suitable
candidate
delivery
nanomedicine
due
ability
store
drugs
with
different
physical
chemical
characteristics.
Moreover,
high
flexibility
potential
liposome
structure
modification
by
conjugating
various
polymers,
ligands,
molecules
pro
liposomes
not
only
enhance
pharmacological
merits
but
improve
effectiveness
anticancer
drugs.
can
increase
specificity,
durability
anti-malignant
agents
body
provide
remarkable
benefits
be
applied
nanomedicines.
We
reviewed
focusing
on
clinical
applications
treat
diverse
sorts
cancers
diseases.
How
properties
liposomal
improved
opportunity
therapy
were
discussed.
Graphic
abstract
Nanotheranostics,
Год журнала:
2023,
Номер
7(3), С. 236 - 257
Опубликована: Янв. 1, 2023
Nanomaterials
have
been
extensively
studied
in
cancer
therapy
as
vectors
that
may
improve
drug
delivery.Such
not
only
bring
numerous
advantages
such
stability,
biocompatibility,
and
cellular
uptake
but
also
shown
to
overcome
some
cancer-related
resistances.Nanocarrier
can
deliver
the
more
precisely
specific
organ
while
improving
its
pharmacokinetics,
thereby
avoiding
secondary
adverse
effects
on
target
tissue.Between
these
nanovectors,
diverse
material
types
be
discerned,
liposomes,
dendrimers,
carbon
nanostructures,
nanoparticles,
nanowires,
etc.,
each
of
which
offers
different
opportunities
for
therapy.In
this
review,
a
broad
spectrum
nanovectors
is
analyzed
application
multimodal
diagnostics
terms
mode
action
pharmacokinetics.Advantages
inconveniences
promising
including
gold
SPIONs,
semiconducting
quantum
dots,
various
phospholipid-based
polymeric
micelles,
extracellular
exome
vesicles
are
summarized.The
article
concluded
with
future
outlook
field.
Molecules,
Год журнала:
2021,
Номер
27(1), С. 146 - 146
Опубликована: Дек. 27, 2021
Cancer
is
a
group
of
disorders
characterized
by
uncontrolled
cell
growth
that
affects
around
11
million
people
each
year
globally.
Nanocarrier-based
systems
are
extensively
used
in
cancer
imaging,
diagnostics
as
well
therapeutics;
owing
to
their
promising
features
and
potential
augment
therapeutic
efficacy.
The
focal
point
research
remains
develop
new-fangled
smart
nanocarriers
can
selectively
respond
cancer-specific
conditions
deliver
medications
target
cells
efficiently.
Nanocarriers
loaded
cargos
the
tumour
site
either
passive
or
active
mode,
with
least
drug
elimination
from
delivery
systems.
This
review
chiefly
focuses
on
current
advances
allied
such
dendrimers,
liposomes,
mesoporous
silica
nanoparticles,
quantum
dots,
micelles,
superparamagnetic
iron-oxide
gold
nanoparticles
carbon
nanotubes,
list
few.
Exhaustive
discussion
crucial
topics
like
targeting,
surface
decorated
smart-nanocarriers
stimuli-responsive
nanotherapeutics
responding
temperature,
enzyme,
pH
redox
stimuli
have
been
covered.
Nano-Micro Letters,
Год журнала:
2022,
Номер
14(1)
Опубликована: Июль 18, 2022
As
the
indispensable
second
cellular
messenger,
calcium
signaling
is
involved
in
regulation
of
almost
all
physiological
processes
by
activating
specific
target
proteins.
The
importance
ions
(Ca
Chemical Science,
Год журнала:
2022,
Номер
13(15), С. 4239 - 4269
Опубликована: Янв. 1, 2022
Small-molecule
prodrugs
have
become
the
main
toolbox
to
improve
unfavorable
physicochemical
properties
of
potential
therapeutic
compounds
in
contemporary
anti-cancer
drug
development.
Many
approved
small-molecule
prodrugs,
however,
still
face
key
challenges
their
pharmacokinetic
(PK)
and
pharmacodynamic
(PD)
properties,
thus
severely
restricting
further
clinical
applications.
Self-assembled
emerged
as
they
could
take
advantage
benefits
both
prodrug
design
nanomedicine,
so
maximize
loading,
reduce
premature
leakage,
PK/PD
parameters
targeting
ability.
Notably,
temporally
spatially
controlled
release
drugs
at
cancerous
sites
be
achieved
by
encoding
various
activable
linkers
that
are
sensitive
chemical
or
biological
stimuli
tumor
microenvironment
(TME).
In
this
review,
we
comprehensively
summarized
recent
progress
made
development
single/multiple-stimulus-responsive
self-assembled
for
mono-
combinatorial
therapy.
A
special
focus
was
placed
on
conjugation
strategies
(polymer-drug
conjugates,
drug-drug
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Апрель 28, 2022
Cancer
has
become
a
main
public
health
issue
globally.
The
conventional
treatment
measures
for
cancer
include
surgery,
radiotherapy
and
chemotherapy.
Among
the
various
available
measures,
chemotherapy
is
still
one
of
most
important
treatments
patients.
However,
cancers
faces
many
problems
associated
with
lot
adverse
effects,
which
limit
its
therapeutic
potency,
low
survival
quality
discount
prognosis.
In
order
to
decrease
these
side
effects
improve
effectiveness
patient's
compliance,
more
targeted
are
needed.
Sustainable
controlled
deliveries
drugs
controllable
toxicities
expected
address
hurdles.
Chitosan
second
abundant
natural
polysaccharide,
excellent
biocompatibility
notable
antitumor
activity.
Its
biodegradability,
biocompatibility,
biodistribution,
nontoxicity
immunogenicity
free
have
made
chitosan
widely
used
polymer
in
pharmacology,
especially
oncotherapy.
Here,
we
make
brief
review
achievements
derivatives
pharmacology
special
focus
on
their
agents
delivery
applications,
immunomodulation,
signal
pathway
modulation
activity
highlight
role
treatment.
Despite
large
number
successful
studies,
commercialization
copolymers
big
challenge.
further
development
polymerization
technology
may
satisfy
unmet
medical
needs.
