ACS Macro Letters,
Год журнала:
2025,
Номер
unknown, С. 284 - 291
Опубликована: Фев. 18, 2025
Understanding
the
dynamics
of
nanosheets
in
polymer
matrices
is
crucial
for
processing
nanocomposites
and
their
applications
drug
delivery.
In
this
work,
we
investigate
diffusion
thin
unentangled
melts
using
molecular
simulations.
We
show
that
smaller
than
a
characteristic
size
lc,
which
few
times
chain
size,
continuum
hydrodynamic
theory
based
on
macroscopic
viscosity
breaks
down
significantly
underestimates
coefficients.
For
with
sizes
l
<
derive
scaling
relationships
both
translational
rotational
coefficients
as
functions
further
reveal
dynamical
coupling
between
nanosheet
motion
modes
melt.
>
recovered.
Our
findings
reconcile
theories
nanoparticles
melts.
Chemical Reviews,
Год журнала:
2024,
Номер
124(9), С. 5505 - 5616
Опубликована: Апрель 16, 2024
The
recent
emergence
of
nanomedicine
has
revolutionized
the
therapeutic
landscape
and
necessitated
creation
more
sophisticated
drug
delivery
systems.
Polymeric
nanoparticles
sit
at
forefront
numerous
promising
designs,
due
to
their
unmatched
control
over
physiochemical
properties
such
as
size,
shape,
architecture,
charge,
surface
functionality.
Furthermore,
polymeric
have
ability
navigate
various
biological
barriers
precisely
target
specific
sites
within
body,
encapsulate
a
diverse
range
cargo
efficiently
release
this
in
response
internal
external
stimuli.
However,
despite
these
remarkable
advantages,
presence
wider
clinical
application
is
minimal.
This
review
will
provide
comprehensive
understanding
vehicles.
affecting
be
outlined
first,
followed
by
description
nanoparticle
designs
preparation
methods,
beginning
with
polymers
on
which
they
are
based.
meticulously
explore
current
performance
against
myriad
diseases
including
cancer,
viral
bacterial
infections,
before
finally
evaluating
advantages
crucial
challenges
that
determine
potential
decades
come.
Journal of Materials Research and Technology,
Год журнала:
2023,
Номер
27, С. 1739 - 1763
Опубликована: Окт. 4, 2023
Nature
is
still
the
main
focus
of
scientific
and
technological
research,
particularly
in
nanotechnology
because
its
remarkable
properties;
has
acquired
much
interest
recent
years.
This
review
focuses
on
up-to-date
overview
classification
nanoparticles,
characterization,
methods
preparation,
characterization
application
nanoparticles.
Initial
section
gives
insight
various
techniques
for
synthesis
encompassing
both
bottom-up
top-down
approaches.
Different
nanoparticles
are
discussed
details.
Highlighting
importance
controlling
shape,
size,
composition
to
develop
enhance
properties
These
include
enhanced
surface
area,
unique
optical,
electronic,
magnetic
characteristics,
as
well
improved
mechanical
properties.
Understanding
these
attributes
essential
harnessing
different
applications
effectively.
Broad
spectrum
also
discussed.
Additionally,
have
found
catalysis,
environmental
remediation,
antimicrobial
coatings,
contributing
sustainable
development
protection.
Overall,
represent
a
progressive
area
research
with
tremendous
potential
innovation
societal
impact.
Our
evaluation
will
serve
solid
reference,
assisting
community
comprehend
topic
better
by
showing
role
each
technique
comparable
manner.
As
field
constantly
evolving,
this
incorporates
latest
developments,
advancements
up
time
publication.
A
comprehensive
understanding
their
properties,
decisive
realizing
full
industrial
domains.
Chemical Reviews,
Год журнала:
2023,
Номер
123(11), С. 7326 - 7378
Опубликована: Март 13, 2023
Cancer
thermal
therapy,
also
known
as
hyperthermia
has
long
been
exploited
to
eradicate
mass
lesions
that
are
now
defined
cancer.
With
the
development
of
corresponding
technologies
and
equipment,
local
therapies
such
radiofrequency
ablation,
microwave
high-intensity
focused
ultrasound,
have
validated
effectively
ablate
tumors
in
modern
clinical
practice.
However,
they
still
face
many
shortcomings,
including
nonspecific
damages
adjacent
normal
tissues
incomplete
ablation
particularly
for
large
tumors,
restricting
their
wide
usage.
Attributed
versatile
physiochemical
properties,
biomaterials
specially
designed
potentiate
treatments
according
unique
working
principles.
Meanwhile,
biomaterial-based
delivery
systems
able
bridge
with
other
types
treatment
strategies
chemotherapy,
radiotherapy
immunotherapy.
Therefore,
this
review,
we
discuss
recent
progress
functional
reinforce
by
functioning
sensitizers
endow
more
efficient
tumor-localized
and/or
vehicles
synergize
therapeutic
modalities
combined
cancer
treatments.
Thereafter,
provide
a
critical
perspective
on
further
biomaterial-assisted
toward
applications.
Abstract
Over
the
past
several
decades,
mRNA
vaccines
have
evolved
from
a
theoretical
concept
to
clinical
reality.
These
offer
advantages
over
traditional
vaccine
techniques,
including
their
high
potency,
rapid
development,
low-cost
manufacturing,
and
safe
administration.
However,
until
recently,
concerns
instability
inefficient
distribution
of
in
vivo
limited
utility.
Fortunately,
recent
technological
advancements
mostly
resolved
these
concerns,
resulting
development
numerous
vaccination
platforms
for
infectious
diseases
various
types
cancer.
shown
promising
outcomes
both
animal
models
humans.
This
study
highlights
potential
as
alternative
approach
conventional
techniques
cancer
treatment.
review
article
aims
provide
thorough
detailed
examination
vaccines,
mechanisms
action
applications
immunotherapy.
Additionally,
will
analyze
current
state
technology
highlight
future
directions
implementation
this
platform
mainstream
therapeutic
option.
The
also
discuss
challenges
limitations
such
stability
distribution,
suggest
ways
overcome
issues.
By
providing
comprehensive
overview
critical
analysis
contribute
advancement
innovative
Acta Pharmaceutica Sinica B,
Год журнала:
2023,
Номер
13(11), С. 4391 - 4416
Опубликована: Май 20, 2023
Owing
to
the
inherent
shortcomings
of
traditional
therapeutic
drugs
in
terms
inadequate
efficacy
and
toxicity
clinical
treatment,
nanomedicine
designs
have
received
widespread
attention
with
significantly
improved
reduced
non-target
side
effects.
Nanomedicines
hold
tremendous
theranostic
potential
for
treating,
monitoring,
diagnosing,
controlling
various
diseases
are
attracting
an
unfathomable
amount
input
research
resources.
Against
backdrop
exponentially
growing
number
publications,
it
is
imperative
help
audience
get
a
panorama
image
activities
field
nanomedicines.
Herein,
this
review
elaborates
on
development
trends
nanomedicines,
emerging
nanocarriers,
vivo
fate
safety
their
extensive
applications.
Moreover,
challenges
obstacles
hindering
translation
nanomedicines
also
discussed.
The
elaboration
aspects
may
enlighten
readers
set
route
future
endeavors.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Фев. 14, 2024
Abstract
Despite
recent
advancements
in
cancer
treatment,
this
disease
still
poses
a
serious
threat
to
public
health.
Vaccines
play
an
important
role
preventing
illness
by
preparing
the
body's
adaptive
and
innate
immune
responses
combat
diseases.
As
our
understanding
of
malignancies
their
connection
system
improves,
there
has
been
growing
interest
priming
fight
more
effectively
comprehensively.
One
promising
approach
involves
utilizing
nanoparticle
systems
for
antigen
delivery,
which
shown
potentiate
as
vaccines
and/or
adjuvants.
In
review,
we
comprehensively
summarized
immunological
mechanisms
while
focusing
specifically
on
applications
various
types
nanoparticles
field
immunotherapy.
By
exploring
these
breakthroughs,
hope
identify
significant
challenges
obstacles
making
nanoparticle-based
adjuvants
feasible
clinical
application.
This
review
serves
assess
breakthroughs
vaccinations
shed
light
prospects
potential
barriers.
doing
so,
aim
inspire
future
immunotherapies
that
harness
nanotechnology
deliver
effective
targeted
treatments.
Graphical
abstract
Abstract
Recently,
the
field
of
nanomedicine
has
witnessed
substantial
advancements
in
development
nanocarriers
for
targeted
drug
delivery,
emerges
as
promising
platforms
to
enhance
therapeutic
efficacy
and
minimize
adverse
effects
associated
with
conventional
chemotherapy.
Notably,
deformable
have
garnered
considerable
attention
due
their
unique
capabilities
size
changeable,
tumor‐specific
aggregation,
stimuli‐triggered
disintegration,
morphological
transformations.
These
present
significant
opportunities
revolutionizing
delivery
strategies,
by
responding
specific
stimuli
or
environmental
cues,
enabling
achieved
various
functions
at
tumor
site,
including
size‐shrinkage
penetration,
aggregative
retention
effect,
disintegrating
enable
controlled
release,
shape‐changing
improve
cellular
uptake,
allowing
personalized
treatment
approaches
combination
therapies.
This
review
provides
an
overview
recent
developments
applications
enhancing
therapy,
underscores
diverse
design
strategies
employed
create
elucidates
remarkable
potential
therapy.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(4), С. 1984 - 2021
Опубликована: Янв. 1, 2024
In
this
review,
we
focus
on
nanoscale
polymer
discs,
toroids,
and
platelets.
We
illustrate
design
rules,
group
compositions
discuss
commonly
used
self-assembly
strategies.
summarise
look
ahead
to
potential
applications
of
these
nanomaterials.
Abstract
Immune
checkpoint
inhibitors
(ICIs)
have
shown
remarkable
success
in
cancer
treatment.
However,
patients
without
sufficient
antitumor
immunity,
numerous
data
indicate
that
blocking
the
negative
signals
elicited
by
immune
checkpoints
is
ineffective.
Drugs
stimulate
activation‐related
pathways
are
emerging
as
another
route
for
improving
immunotherapy.
In
addition,
development
of
nanotechnology
presents
a
promising
platform
tissue
and
cell
type‐specific
delivery
improved
uptake
immunomodulatory
agents,
ultimately
leading
to
enhanced
immunotherapy
reduced
side
effects.
this
review,
we
summarize
discuss
latest
developments
nanoparticles
(NPs)
immuno‐oncology
therapy
with
focus
on
lipid‐based
NPs
(lipid‐NPs),
including
characteristics
advantages
various
types.
Using
agonists
targeting
stimulation
interferon
genes
(STING)
transmembrane
protein
an
exemplar,
review
potential
lipid‐NPs
augment
STING
agonist
therapy.
Furthermore,
present
recent
findings
underlying
mechanisms
how
pathway
activation
fosters
immunity
regulates
tumor
microenvironment
provide
summary
distinct
preclinical
studies
clinical
trials.
Ultimately,
conduct
critical
assessment
obstacles
future
directions
utilization
enhance
