End-to-end design of wearable sensors

Nature Reviews Materials, Год журнала: 2022, Номер 7(11), С. 887 - 907

Опубликована: Июль 22, 2022

Язык: Английский

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Antimicrobial Ionic Liquid‐Based Materials for Biomedical Applications

Advanced Functional Materials, Год журнала: 2021, Номер 31(42)

Опубликована: Июль 23, 2021

Abstract Excessive and unwarranted administration of antibiotics has invigorated the evolution multidrug‐resistant microbes. There is, therefore, an urgent need for advanced active compounds. Ionic liquids with short‐lived ion‐pair structures are highly tunable have diverse applications. Apart from their unique physicochemical features, newly discovered biological activities ionic fascinated biochemists, microbiologists, medical scientists. In particular, antimicrobial properties opened new vistas in overcoming current challenges associated combating antibiotic‐resistant pathogens. Discussions regarding liquid derivatives monomeric polymeric forms presented here. The mechanism parameters that affect activities, such as chain length, cation/anion type, cation density, polymerization, considered. potential applications biomedical arena, including regenerative medicine, biosensing, drug/biomolecule delivery, to stimulate scientific community further improve efficacy liquids.

Язык: Английский

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Stimuli-responsive transdermal microneedle patches

Materials Today, Год журнала: 2021, Номер 47, С. 206 - 222

Опубликована: Май 20, 2021

Microneedle (MN) patches consisting of miniature needles have emerged as a promising tool to perforate the

Язык: Английский

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Microneedles in Drug Delivery: Progress and Challenges

Micromachines, Год журнала: 2021, Номер 12(11), С. 1321 - 1321

Опубликована: Окт. 28, 2021

In recent years, an innovative transdermal delivery technology has attracted great interest for its ability to distribute therapeutics and cosmeceuticals several applications, including vaccines, drugs, biomolecules skin-related problems. The advantages of microneedle patch have been extensively evaluated in the latest literature; hence, academic publications this area are rising exponentially. Like all new technologies, application potential but is not without limitations. review, we will discuss possible limitations by highlighting areas where a deal improvements required. Emphasising these concerns early on should help scientists technologists address matters timely fashion use their resources wisely.

Язык: Английский

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Microneedle system for tissue engineering and regenerative medicine

Exploration, Год журнала: 2023, Номер 3(1)

Опубликована: Янв. 21, 2023

Abstract Global increasing demand for high life quality and length facilitates the development of tissue engineering regenerative medicine, which apply multidisciplinary theories techniques to achieve structural reconstruction functional recovery disordered or damaged tissues organs. However, clinical performances adopted drugs, materials, powerful cells in laboratory are inescapably limited by currently available technologies. To tackle problems, versatile microneedles developed as new platform local delivery diverse cargos with minimal invasion. The efficient delivery, well painless convenient procedure endow good patient compliance clinic. In this review, we first categorize different microneedle systems models, then summarize their applications medicine mainly involving maintenance rehabilitation end, discuss advantages, challenges, prospects depth future translations.

Язык: Английский

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Improved pharmacodynamics of epidermal growth factor via microneedles-based self-powered transcutaneous electrical stimulation

Nature Communications, Год журнала: 2022, Номер 13(1)

Опубликована: Ноя. 14, 2022

Epidermal growth factor is an excellent drug for promoting wound healing; however, its conventional administration strategies are associated with pharmacodynamic challenges, such as low transdermal permeability, reduction, and receptor desensitization. Here, we develop a microneedle-based self-powered transcutaneous electrical stimulation system (mn-STESS) by integrating sliding free-standing triboelectric nanogenerator microneedle patch to achieve improved epidermal pharmacodynamics. We show that the mn-STESS facilitates penetration utilization using microneedles pierce stratum corneum. More importantly, find it converts mechanical energy of finger into electricity mediates through microneedles. demonstrate applied acts "adjuvant" suppresses reduction glutathione upregulates expression in keratinocyte cells, successfully compensating Collectively, this work highlights promise adjuvants improving pharmacodynamics, creating combinatorial therapeutic traditional drugs.

Язык: Английский

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Bioinspired microneedle patches: Biomimetic designs, fabrication, and biomedical applications

Matter, Год журнала: 2022, Номер 5(2), С. 390 - 429

Опубликована: Фев. 1, 2022

Язык: Английский

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Microneedle biomedical devices

Nature Reviews Bioengineering, Год журнала: 2023, Номер 2(4), С. 324 - 342

Опубликована: Дек. 21, 2023

Язык: Английский

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Reactive Oxygen Species-Responsive Gel-Based Microneedle Patches for Prolonged and Intelligent Psoriasis Management

ACS Nano, Год журнала: 2023, Номер 17(5), С. 4346 - 4357

Опубликована: Фев. 27, 2023

Psoriasis is an inflammatory skin disease. Microneedle (MN) patches can improve psoriasis treatment outcomes by increasing local drug content in the skin. As frequently relapses, developing intelligent MN-based delivery systems with prolonged therapeutic levels and improved efficiency of great significance. Here, we designed detachable H2O2-responsive gel-based MN containing methotrexate (MTX) epigallocatechin gallate (EGCG) using EGCG as both cross-linkers for needle-composited materials anti-inflammatory drugs. The MNs had dual-mode release kinetics, which quickly released MTX diffusively sustainably way. Compared dissolving MNs, extended retention EGCG, leading to reactive oxygen species (ROS) scavenging effects. ROS-responsive that transdermally delivered antiproliferative drugs psoriasis-like prophylactic animal models.

Язык: Английский

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Multifunctional Silk Fibroin Methacryloyl Microneedle for Diabetic Wound Healing

Small, Год журнала: 2022, Номер 18(51)

Опубликована: Ноя. 4, 2022

Diabetic wound is one of the common complications in diabetic patients, which exhibits chronic, hard-to-heal characteristics. The healing process wounds impaired by several factors, including excessive oxidative stress, blocked angiogenesis, and bacterial infection. therapeutic effects traditional microneedle patches remain not satisfactory, due to their difficulty simultaneously targeting multiple targets treat wounds. As such, there an urgent need develop a multifunctional (MN) patch for promoting A MN with antioxidant, proangiogenesis, antibacterial capacities was fabricated target pathogenesis Silk fibroin methacryloyl, has excellent biocompatibility, stable mechanical properties, well processability, selected as base material patches. Prussian blue nanozymes (PBNs) vascular endothelial growth factor (VEGF) are encapsulated tips patches, Polymyxin layers Based on synergic properties these components, exhibit drug-sustained release, properties. developed accelerate healing, providing potential approach.

Язык: Английский

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