Dissolving microneedles: Applications and growing therapeutic potential

Journal of Controlled Release, Год журнала: 2022, Номер 348, С. 186 - 205

Опубликована: Июнь 7, 2022

Microneedles are a rapidly developing method for the transdermal delivery of therapeutic compounds. All types microneedles, whether solid, hollow, coated, or dissolving function by penetrating stratum corneum layer skin producing microchannel through which agents may be delivered. To date, coated and hollow microneedles have been most successful, despite suffering from issues such as poor drug loading capabilities blocked pores. Dissolving on other hand, superior well positive attributes that make it an ideal system, including simple methods fabrication disposal, abundantly available materials. Indeed, dissolvable can even fabricated entirely agent itself thus eliminating requirement additional excipients. This focused review presents recent developments trends potential future directions. The advantages, disadvantages materials discussed. applications system in different areas both research literature clinical trials is highlighted. Applications cosmetics, vaccine delivery, diagnosis monitoring, cancer, pain inflammation, diabetes, hair scalp disorders inflammatory diseases presented. current observed microneedle landscape with particular emphasis contemporary commercial successes barriers impeding development commercialisation also

Язык: Английский

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Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications

Military Medical Research, Год журнала: 2023, Номер 10(1)

Опубликована: Март 28, 2023

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering (TE) regenerative medicine. In contrast to conventional biomaterials or synthetic materials, biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical biophysical cues that mimic the in vivo extracellular matrix (ECM). Additionally, such mechanical adaptability, microstructure interconnectivity, inherent bioactivity, making them ideal design living implants specific applications TE This paper provides an overview recent progress (BNBMs), including advances their preparation, functionality, potential future challenges. We highlight fabrication BNBMs outline general strategies functionalizing tailoring with various biological physicochemical characteristics native ECM. Moreover, we key functionalization versatile applications. Finally, conclude by offering our perspective open challenges developments this rapidly-evolving field.

Язык: Английский

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Advances in tannic acid-incorporated biomaterials: Infection treatment, regenerative medicine, cancer therapy, and biosensing

Chemical Engineering Journal, Год журнала: 2021, Номер 432, С. 134146 - 134146

Опубликована: Дек. 29, 2021

Язык: Английский

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Biomedical polymers: synthesis, properties, and applications

Science China Chemistry, Год журнала: 2022, Номер 65(6), С. 1010 - 1075

Опубликована: Апрель 24, 2022

Язык: Английский

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Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

Bioactive Materials, Год журнала: 2023, Номер 27, С. 303 - 326

Опубликована: Апрель 18, 2023

Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable delivery, diverse cargo loading capacity. Although microneedles are initially designed penetrate stratum corneum of skin for transdermal they, recently, have been used promote wound healing regeneration tissues organs the results promising. Despite there reviews about microneedles, few them focus on tissue regeneration. Here, we review recent advances in this field. We first give an overview microneedle system terms potential cargos (e.g., small molecules, macromolecules, nucleic acids, nanoparticles, extracellular vesicle, cells), structural designs multidrug structures, adhesive structures), material selection, release mechanisms. Then briefly summarize different fabrication methods, including their advantages limitations. finally progress microneedle-assisted skin, cardiac, bone, tendon, ocular, vascular, oral, hair, spinal cord, uterine tissues). expect that our article would serve guideline readers design systems according applications, structure design, achieving better efficacy.

Язык: Английский

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Microneedle system for tissue engineering and regenerative medicine

Exploration, Год журнала: 2023, Номер 3(1)

Опубликована: Янв. 21, 2023

Abstract Global increasing demand for high life quality and length facilitates the development of tissue engineering regenerative medicine, which apply multidisciplinary theories techniques to achieve structural reconstruction functional recovery disordered or damaged tissues organs. However, clinical performances adopted drugs, materials, powerful cells in laboratory are inescapably limited by currently available technologies. To tackle problems, versatile microneedles developed as new platform local delivery diverse cargos with minimal invasion. The efficient delivery, well painless convenient procedure endow good patient compliance clinic. In this review, we first categorize different microneedle systems models, then summarize their applications medicine mainly involving maintenance rehabilitation end, discuss advantages, challenges, prospects depth future translations.

Язык: Английский

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Down-Regulating Scar Formation by Microneedles Directly via a Mechanical Communication Pathway

ACS Nano, Год журнала: 2022, Номер 16(7), С. 10163 - 10178

Опубликована: Май 26, 2022

Excessive extracellular matrix deposition drives fibroblasts into a state of high mechanical stress, exacerbating pathological fibrosis and hypertrophic scar formation, leading to tissue dysfunction. This study reports minimally invasive convenient approach obtaining scarless using silk fibroin microneedle patch (SF MNs). We found that by tuning the MN size density only, biocompatible MNs significantly decreased elevation index in rabbit ear model increased ultimate tensile strength close regular skin. To advance our understanding this recent approach, we built fibroblast-populated collagen lattice system finite element MN-mediated cellular behavior fibroblasts. reduced generated contraction as indicated expression sensitive gene ANKRD1. Specifically, SF attenuated integrin-FAK signaling consequently down-regulated TGF-β1, α-SMA, I, fibronectin. It resulted low-stress microenvironment helps reduce formation significantly. Microneedles' physical intervention

Язык: Английский

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Wet‐Adhesive Elastomer for Liquid Metal‐Based Conformal Epidermal Electronics

Advanced Functional Materials, Год журнала: 2022, Номер 32(25)

Опубликована: Март 18, 2022

Abstract Wearable electronics are increasingly used in health monitoring and treatment different conditions. However, few devices can adhere conformally to the skin after sports showers (sweating, deformation, friction). Here, a facile method is presented by providing metal‐polymer conductor (MPC) made with polyethylene glycol (PEG) blended polydimethylsiloxane (PDMS) based adhesive (PPA) that encapsulates gallium‐based liquid metal alloy circuits as epidermal electronics. Adding PEG into PDMS prepolymer result softer wet‐adhesive elastomer bear larger deformation than itself. The soft for more 2 d. It has been demonstrated these meet needs of motion detection, electrophysiological signal detection wound healing during 48 h wearing shower. expected electronic excellent biosafety be widely solve existing problems medical adhesives human–machine interfaces.

Язык: Английский

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Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli‐Responsive, Toxicity, Immunogenicity, and Clinical Translation

Advanced Science, Год журнала: 2021, Номер 9(2)

Опубликована: Ноя. 19, 2021

Cancer is one of the top life-threatening dangers to human survival, accounting for over 10 million deaths per year. Bioactive glasses have developed dramatically since their discovery 50 years ago, with applications that include therapeutics as well diagnostics. A new system within bioactive glass family, mesoporous (MBGs), has evolved into a multifunctional platform, thanks MBGs easy-to-functionalize nature and tailorable textural properties-surface area, pore size, volume. Although yet meet potential in tumor treatment imaging practice, recently research shed light on distinguished capabilities promising theranostic systems cancer therapy. This review presents progress field MBG diagnosis therapy, including synthesis MBGs, mechanistic overview application drug monitoring, therapy ( particularly, targeted delivery stimuli-responsive nanoplatforms), immunological profile MBG-based nanodevices reference development novel therapeutics.

Язык: Английский

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Wearable and implantable devices for drug delivery: Applications and challenges

Biomaterials, Год журнала: 2022, Номер 283, С. 121435 - 121435

Опубликована: Фев. 23, 2022

Язык: Английский

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