Ultrasmall metal alloy nanozymes mimicking neutrophil enzymatic cascades for tumor catalytic therapy

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Фев. 22, 2024

Abstract Developing strategies that emulate the killing mechanism of neutrophils, which involves enzymatic cascade superoxide dismutase (SOD) and myeloperoxidase (MPO), shows potential as a viable approach for cancer therapy. Nonetheless, utilizing natural enzymes therapeutics is hindered by various challenges. While nanozymes have emerged treatment, developing SOD-MPO in one nanozyme remains challenge. Here, we develop possessing both SOD- MPO-like activities through alloying Au Pd, exhibits highest activity when ratio Pd 1:3, attributing to high d-band center adsorption energy anions, determined theoretical calculations. The 1 3 alloy exhibit excellent tumor therapeutic performance safety female tumor-bearing mice, with attributed their tumor-specific ability renal clearance caused ultrasmall size. Together, this work develops AuPd mimic neutrophil cascades catalytic treatment tumors.

Язык: Английский

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Antioxidant and Prooxidant Nanozymes: From Cellular Redox Regulation to Next‐Generation Therapeutics

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(33)

Опубликована: Апрель 21, 2023

Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted tremendous interest in recent years owing to their ability replace natural enzymes various biomedical applications, such as biosensing, therapeutics, drug delivery, and bioimaging. In particular, the nanozymes capable of regulating cellular redox status by mimicking antioxidant mammalian cells are great therapeutic significance oxidative-stress-mediated disorders. As distinction physiological oxidative stress (oxidative eustress) pathological distress) occurs at a fine borderline, it is challenge design that can differentially sense two extremes cells, tissues organs mediate appropriate chemical reactions. this Review, we summarize advances development redox-active applications. We primarily highlight prooxidant disease model systems, cancer, neurodegeneration, cardiovascular diseases. The future perspectives emerging area research challenges associated applications described.

Язык: Английский

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A Rational Design of Metal–Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns

Nano-Micro Letters, Год журнала: 2023, Номер 15(1)

Опубликована: Апрель 30, 2023

Metal-organic frameworks (MOFs) have attracted significant research interest in biomimetic catalysis. However, the modulation of activity MOFs by precisely tuning coordination metal nodes is still a challenge. Inspired metalloenzymes with well-defined structures, series containing halogen-coordinated copper (Cu-X MOFs, X = Cl, Br, I) are employed to elucidate their structure-activity relationship. Intriguingly, experimental and theoretical results strongly support that halogen atoms directly regulates enzyme-like activities Cu-X influencing spatial configuration electronic structure Cu active center. The optimal Cu-Cl MOF exhibits excellent superoxide dismutase-like specific one order magnitude higher than reported Cu-based nanozymes. More importantly, performing enzyme-mimicking catalysis, nanozyme can significantly scavenge reactive oxygen species alleviate oxidative stress, thus effectively relieving ocular chemical burns. Mechanistically, antioxidant antiapoptotic properties achieved regulating NRF2 JNK or P38 MAPK pathways. Our work provides novel way refine nanozymes engineering microenvironment and, more significantly, demonstrating potential therapeutic effect ophthalmic disease.

Язык: Английский

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Single‐Atom Nanozymes for Catalytic Therapy: Recent Advances and Challenges

Advanced Functional Materials, Год журнала: 2024, Номер 34(16)

Опубликована: Янв. 4, 2024

Abstract As a powerful tool, nanozyme catalysts broaden the avenues to implement bio‐inspired solutions for addressing many important concerns, covering energy, healthcare, environment, and more. Recent endeavors, characterized by atomic precision, have enabled extensive exploration of single‐atom nanozymes (SAzymes) with high catalytic activity, superior substrate selectivity, integrated multifunctionalities, thus becoming an emerging field that bridges nanotechnology biology. This review provides brief outline progress summarizes latest research advances regarding SAzymes in biomedical therapeutics, mainly including tumor therapy, wound antibacterial tissue anti‐inflammatory focus on their prototypical synthesis therapeutic mechanisms. Finally, current challenges future perspectives engineering advanced are also discussed outlooked. It is anticipated this area shall provide useful guidance therapy.

Язык: Английский

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Research progress of nanozymes in colorimetric biosensing: Classification, activity and application

Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150612 - 150612

Опубликована: Март 21, 2024

Язык: Английский

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