Nano Today, Journal Year: 2023, Volume and Issue: 48, P. 101755 - 101755
Published: Jan. 14, 2023
Language: Английский
Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(33)
Published: April 21, 2023
Nanozymes, nanomaterials with enzyme-mimicking activity, have attracted tremendous interest in recent years owing to their ability replace natural enzymes various biomedical applications, such as biosensing, therapeutics, drug delivery, and bioimaging. In particular, the nanozymes capable of regulating cellular redox status by mimicking antioxidant mammalian cells are great therapeutic significance oxidative-stress-mediated disorders. As distinction physiological oxidative stress (oxidative eustress) pathological distress) occurs at a fine borderline, it is challenge design that can differentially sense two extremes cells, tissues organs mediate appropriate chemical reactions. this Review, we summarize advances development redox-active applications. We primarily highlight prooxidant disease model systems, cancer, neurodegeneration, cardiovascular diseases. The future perspectives emerging area research challenges associated applications described.
Language: Английский
Citations
61
Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)
Published: April 30, 2023
Metal-organic frameworks (MOFs) have attracted significant research interest in biomimetic catalysis. However, the modulation of activity MOFs by precisely tuning coordination metal nodes is still a challenge. Inspired metalloenzymes with well-defined structures, series containing halogen-coordinated copper (Cu-X MOFs, X = Cl, Br, I) are employed to elucidate their structure-activity relationship. Intriguingly, experimental and theoretical results strongly support that halogen atoms directly regulates enzyme-like activities Cu-X influencing spatial configuration electronic structure Cu active center. The optimal Cu-Cl MOF exhibits excellent superoxide dismutase-like specific one order magnitude higher than reported Cu-based nanozymes. More importantly, performing enzyme-mimicking catalysis, nanozyme can significantly scavenge reactive oxygen species alleviate oxidative stress, thus effectively relieving ocular chemical burns. Mechanistically, antioxidant antiapoptotic properties achieved regulating NRF2 JNK or P38 MAPK pathways. Our work provides novel way refine nanozymes engineering microenvironment and, more significantly, demonstrating potential therapeutic effect ophthalmic disease.
Language: Английский
Citations
59
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(16)
Published: Jan. 4, 2024
Abstract As a powerful tool, nanozyme catalysts broaden the avenues to implement bio‐inspired solutions for addressing many important concerns, covering energy, healthcare, environment, and more. Recent endeavors, characterized by atomic precision, have enabled extensive exploration of single‐atom nanozymes (SAzymes) with high catalytic activity, superior substrate selectivity, integrated multifunctionalities, thus becoming an emerging field that bridges nanotechnology biology. This review provides brief outline progress summarizes latest research advances regarding SAzymes in biomedical therapeutics, mainly including tumor therapy, wound antibacterial tissue anti‐inflammatory focus on their prototypical synthesis therapeutic mechanisms. Finally, current challenges future perspectives engineering advanced are also discussed outlooked. It is anticipated this area shall provide useful guidance therapy.
Language: Английский
Citations
59
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150612 - 150612
Published: March 21, 2024
Language: Английский
Citations
59
Nano Today, Journal Year: 2023, Volume and Issue: 48, P. 101755 - 101755
Published: Jan. 14, 2023
Language: Английский
Citations
58