MXenes-based nanomaterials for biosensing and biomedicine

Coordination Chemistry Reviews, Год журнала: 2023, Номер 479, С. 215002 - 215002

Опубликована: Янв. 10, 2023

Язык: Английский

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Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

Nano-Micro Letters, Год журнала: 2023, Номер 15(1)

Опубликована: Фев. 8, 2023

Gene therapy provides a promising approach in treating cancers with high efficacy and selectivity few adverse effects. Currently, the development of functional vectors safety effectiveness is intense focus for improving delivery nucleic acid drugs gene therapy. For this purpose, stimuli-responsive nanocarriers displayed strong potential overall efficiencies reducing effects via effective protection, prolonged blood circulation, specific tumor accumulation, controlled release profile drugs. Besides, synergistic could be achieved when combined other therapeutic regimens. This review summarizes recent advances various delivery. Particularly, responding to endogenous stimuli including pH, reactive oxygen species, glutathione, enzyme, etc., exogenous light, thermo, ultrasound, magnetic field, are introduced. Finally, future challenges prospects toward clinical translation well discussed. The major objective present biomedical cancer provide guidance developing novel nanoplatforms that clinically applicable.

Язык: Английский

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Small-size Ti3C2Tx MXene nanosheets coated with metal-polyphenol nanodots for enhanced cancer photothermal therapy and anti-inflammation

Acta Biomaterialia, Год журнала: 2023, Номер 159, С. 312 - 323

Опубликована: Янв. 25, 2023

Язык: Английский

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A Rational Design of Metal–Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns

Nano-Micro Letters, Год журнала: 2023, Номер 15(1)

Опубликована: Апрель 30, 2023

Metal-organic frameworks (MOFs) have attracted significant research interest in biomimetic catalysis. However, the modulation of activity MOFs by precisely tuning coordination metal nodes is still a challenge. Inspired metalloenzymes with well-defined structures, series containing halogen-coordinated copper (Cu-X MOFs, X = Cl, Br, I) are employed to elucidate their structure-activity relationship. Intriguingly, experimental and theoretical results strongly support that halogen atoms directly regulates enzyme-like activities Cu-X influencing spatial configuration electronic structure Cu active center. The optimal Cu-Cl MOF exhibits excellent superoxide dismutase-like specific one order magnitude higher than reported Cu-based nanozymes. More importantly, performing enzyme-mimicking catalysis, nanozyme can significantly scavenge reactive oxygen species alleviate oxidative stress, thus effectively relieving ocular chemical burns. Mechanistically, antioxidant antiapoptotic properties achieved regulating NRF2 JNK or P38 MAPK pathways. Our work provides novel way refine nanozymes engineering microenvironment and, more significantly, demonstrating potential therapeutic effect ophthalmic disease.

Язык: Английский

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Biomimetic Enzyme Cascade Structural Color Hydrogel Microparticles for Diabetic Wound Healing Management

Advanced Science, Год журнала: 2023, Номер 10(14)

Опубликована: Март 22, 2023

Hard-healing diabetic wound brings burgeoning physical and mental burdens to patients. Current treatment strategies tend achieve multistage promotion real-time reporting facilitate management. Herein, a biomimetic enzyme cascade inverse opal microparticles system for healing, which is intergated with glucose oxidase (GOD) copper peroxide (CP). Such are composed of biofriendly hyaluronic acid methacryloyl (HAMA) pH-responsive acrylic (AA), provided abundant binding sites spaces chemical immobilizing doping enzymes metal bioinorganics. When the catalytic applied on sites, hyperglycemia environment would serve as hydrogen (H2 O2 ) generator through GOD catalysis, while acidic triggers decomposition CP, further catalyzing H2 generate reactive oxygen species (ROS). Additionally, distinctive structural color can visually reflect pH intelligently estimate healing state. It demonstrated that such microparticle systems exhibit excellent broad-spectrum antibacterial angiogenesis-promoting properties, well significant ability healing. These features indicate possess valuable potential in related field.

Язык: Английский

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Near‐Infrared Light‐Triggered MXene Nanocomposite for Tumor‐Specific Mild Photothermal‐Enhanced Chemodynamic Therapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(44)

Опубликована: Май 20, 2024

Abstract Mild photothermal therapy (PTT) is an emerging and elegant approach with minimal adverse effects, demonstrating itself as effective treatment for cancer. However, potential challenges may arise from the overexpression of heat shock protein 90 (HSP90) reliance on monotherapy. Here, a near‐infrared (NIR) light‐triggered MXene nanocomposite (FA@MXene/CuO 2 /GA) developed to synergistically combine mild PTT chemodynamic (CDT) remarkably tumor eradication without any notable tissue damage. Under irradiation NIR light, effectively enhances by suppressing HSP90 expression through release gambogic acid (GA) due excellent performance Ti 3 C nanosheets well tumor‐targeting ability biocompatibility surface‐modified FA‐PEG‐SH. The copper‐based catalyst CuO in this system releases Cu 2+ acid‐triggered manner within microenvironment, activating Fenton‐like reaction generate hydroxyl radicals, simultaneous production H O serves alleviate deficiency endogenous tumor. Overall, current work showcases remarkable synergistic anticancer effect CDT, also proposes new avenues research utilizing nanomaterials treatment.

Язык: Английский

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Peroxidase-like manganese oxide nanoflowers-delaminated Ti3C2 MXene for ultrasensitive dual-mode and real-time detection of H2O2 released from cancer cells

Microchemical Journal, Год журнала: 2024, Номер unknown, С. 111796 - 111796

Опубликована: Сен. 1, 2024

Язык: Английский

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Review of Ti₃C₂T_x MXene Nanosheets and their Applications

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(9), С. 9847 - 9867

Опубликована: Май 1, 2024

MXene Ti3C2Tx is a two-dimensional (2D) nanosheet material from the family formed by selective etching of aluminum atoms in ternary carbide Ti3AlC2 sheet. This process results 2D with titanium and fluorine on surface. has several attractive properties for various applications, such as excellent electrical conductivity mechanical good chemical stability. also large surface area can be easily functionalized introducing different groups onto its Some notable applications include supercapacitors batteries owing to high area. been explored catalyst reactions, including hydrogen evolution CO2 reduction. The main emphasis this review centered around exploring electrical, magnetic, optical characteristics MXenes. Additionally, it provides concise overview approaches used synthesizing these materials, specifically top-down bottom-up methods. Furthermore, thoroughly examines significant MXenes across multiple fields, encompassing biology, water remediation, sensors, catalysis, energy storage, membrane separation, wearable electronics. considers challenges that arise when working offers insights into potential future directions perspectives field. Overall, promising widespread application research ongoing.

Язык: Английский

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MXenes in healthcare: synthesis, fundamentals and applications

Chemical Society Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Since their discovery over a decade ago, MXenes have transformed the field of "materials for healthcare", stimulating growing interest in healthcare-related applications. These developments also driven significant advancements MXenes' synthesis. This review systematically examines synthesis and applications sensing biomedical fields, underscoring pivotal role addressing critical challenges modern healthcare. We describe experimental by combining appropriate laboratory modules with mechanistic principles underlying each step. In addition, we provide extensive details on parameters, considerations, essential instructions successful Various healthcare including sensing, imaging, synergistic therapies, regenerative medicine, wearable devices been explored. further highlight emerging trends MXenes, viz., as nanovehicles drug delivery, vectors gene therapy, tools immune profiling. By identifying important parameters that define utility applications, this outlines strategies to regulate profile, thereby serving valuable guide design application-specific properties. The final section integrates research theoretical studies comprehensive understanding field. It technologies, such artificial intelligence (AI) machine learning (ML), accelerating material discovery, structure-property optimization, automation. Complemented detailed supplementary information synthesis, stability, biocompatibility, environmental impact, insights, offers profound knowledge base diverse family 2D materials. Finally, compared potential other materials underscore existing prioritize interdisciplinary collaboration. synthesizing key from its current (especially 2018 onward), provides cohesive assessment MXene foundations prospects sector.

Язык: Английский

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Nanomaterials Enhanced Sonodynamic Therapy for Multiple Tumor Treatment

Nano-Micro Letters, Год журнала: 2025, Номер 17(1)

Опубликована: Фев. 24, 2025

Abstract Sonodynamic therapy (SDT) as an emerging modality for malignant tumors mainly involves in sonosensitizers and low-intensity ultrasound (US), which can safely penetrate the tissue without significant attenuation. SDT not only has advantages including high precision, non-invasiveness, minimal side effects, but also overcomes limitation of low penetration light to deep tumors. The cytotoxic reactive oxygen species be produced by utilization combined with US kill tumor cells. However, underlying mechanism been elucidated, its unsatisfactory efficiency retards further clinical application. Herein, we shed on main mechanisms types sonosensitizers, organic inorganic sonosensitizers. Due development nanotechnology, many novel nanoplatforms are utilized this arisen field solve barriers enable continuous innovation. This review highlights potential nanosonosensitizers focus enhanced based monotherapy or synergistic that difficult reach traditional treatment, especially orthotopic cancers.

Язык: Английский

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