Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 92, С. 105374 - 105374
Опубликована: Янв. 21, 2024
Язык: Английский
ACS Materials Letters, Год журнала: 2024, Номер 6(7), С. 2533 - 2547
Опубликована: Май 24, 2024
Contemporary options for multidrug-resistant bacteria infected diabetic foot ulcers (IDFUs) are predominantly nonspecific. These IDFU injuries often display prolonged inflammation and delayed tissue repair, mainly attributed to an overabundance of M1 macrophages in the hostile microenvironment. Although immunomodulatory hydrogels show promise IDFU-focused care, a targeted, safe transition from M2 using simplified techniques remains significant obstacle. Here, we introduce hybrid hydrogel (GGG) with inherent capabilities IDFUs. GGG is composed interpenetrating polymer networks featuring gallium-induced self-assembling glycyrrhizic acid photo-cross-linked gelatin methacryloyl matrix. Importantly, effectively decreases ratio conditions drug-resistant by disrupting iron metabolism scavenging reactive oxygen species, which contributes enhanced treatment results wounds. To sum up, strategy present provides straightforward, safe, highly effective therapeutic avenue managing
Язык: Английский
Процитировано
79
Advanced Materials, Год журнала: 2024, Номер 36(32)
Опубликована: Июнь 1, 2024
Abstract Burn wounds often bring high risks of delayed healing process and even death. Reactive oxygen species (ROS) play a crucial role in burn wound repair. However, the dynamic requires both generation ROS to inhibit bacteria subsequent reduction levels initiate promote tissue regeneration, which calls for more intelligent regulation dressing system. Hence, dual‐layered hydrogel (Dual‐Gel) tailored repair is designed: inner layer (Gel 2) first responds bacterial hyaluronidase (Hyal) deliver aggregation‐induced emission photosensitizer functionalized adipose‐derived stem cell nanovesicles, generate upon light irradiation eliminate bacteria; then outer 1) continuously starts long‐lasting consumption excess at site accelerate regeneration. Simultaneously, nanovesicles trapped burns also provide nutrients mobilize neighboring tissues thoroughly assist inflammation regulation, proliferation, migration, angiogenesis. In summary, this study develops an treatment approach on by programmatically regulating facilitating comprehensive
Язык: Английский
Процитировано
78
Advanced Science, Год журнала: 2023, Номер 10(14)
Опубликована: Март 22, 2023
Hard-healing diabetic wound brings burgeoning physical and mental burdens to patients. Current treatment strategies tend achieve multistage promotion real-time reporting facilitate management. Herein, a biomimetic enzyme cascade inverse opal microparticles system for healing, which is intergated with glucose oxidase (GOD) copper peroxide (CP). Such are composed of biofriendly hyaluronic acid methacryloyl (HAMA) pH-responsive acrylic (AA), provided abundant binding sites spaces chemical immobilizing doping enzymes metal bioinorganics. When the catalytic applied on sites, hyperglycemia environment would serve as hydrogen (H2 O2 ) generator through GOD catalysis, while acidic triggers decomposition CP, further catalyzing H2 generate reactive oxygen species (ROS). Additionally, distinctive structural color can visually reflect pH intelligently estimate healing state. It demonstrated that such microparticle systems exhibit excellent broad-spectrum antibacterial angiogenesis-promoting properties, well significant ability healing. These features indicate possess valuable potential in related field.
Язык: Английский
Процитировано
60
ACS Nano, Год журнала: 2024, Номер 18(19), С. 12295 - 12310
Опубликована: Май 2, 2024
Immune checkpoint blockade (ICB) has brought tremendous clinical progress, but its therapeutic outcome can be limited due to insufficient activation of dendritic cells (DCs) and infiltration cytotoxic T lymphocytes (CTLs). Evoking immunogenic cell death (ICD) is one promising strategy promote DC maturation elicit T-cell immunity, whereas low levels ICD induction solid tumors restrict durable antitumor efficacy. Herein, we report a genetically edited membrane-coated cascade nanozyme (gCM@MnAu) for enhanced cancer immunotherapy by inducing activating the stimulator interferon genes (STING) pathway. In tumor microenvironment (TME), gCM@MnAu initiates reaction generates abundant hydroxyl (•OH), resulting in improved chemodynamic therapy (CDT) boosted activation. addition, released Mn
Язык: Английский
Процитировано
34
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)
Опубликована: Май 9, 2024
Hydrogels have emerged as promising candidates for biomedical applications, especially in the field of antibacterial therapeutics, due to their unique structural properties, highly tunable physicochemical and excellent biocompatibility. The integration stimuli-responsive functions into hydrogels holds potential enhance properties therapeutic efficacy, dynamically responding different external or internal stimuli, such pH, temperature, enzymes, light. Therefore, this review describes applications hydrogel dressings responsive stimuli therapy. collaborative interaction between materials is discussed. This synergistic approach, contrast conventional materials, not only amplifies effect but also alleviates adverse side effects diminishes incidence multiple infections drug resistance. provides a comprehensive overview current challenges outlines future research directions hydrogels. It underscores imperative ongoing interdisciplinary aimed at unraveling mechanisms wound healing. understanding crucial optimizing design implementation Ultimately, aims offer scientific guidance development practical clinical application dressings.
Язык: Английский
Процитировано
32
Bioactive Materials, Год журнала: 2024, Номер 44, С. 131 - 151
Опубликована: Окт. 15, 2024
Язык: Английский
Процитировано
28
Nano-Micro Letters, Год журнала: 2024, Номер 16(1)
Опубликована: Июль 2, 2024
Abstract Chronic diabetic wounds confront a significant medical challenge because of increasing prevalence and difficult-healing circumstances. It is vital to develop multifunctional hydrogel dressings, with well-designed morphology structure enhance flexibility effectiveness in wound management. To achieve these, we propose self-healing dressing based on structural color microspheres for The microsphere comprised photothermal-responsive inverse opal framework, which was constructed by hyaluronic acid methacryloyl, silk fibroin methacryloyl black phosphorus quantum dots (BPQDs), further re-filled dynamic hydrogel. filler formed Knoevenagel condensation reaction between cyanoacetate benzaldehyde-functionalized dextran (DEX-CA DEX-BA). Notably, the composite can be applied arbitrarily, they adhere together upon near-infrared irradiation leveraging BPQDs-mediated photothermal effect thermoreversible stiffness change Additionally, eumenitin vascular endothelial growth factor were co-loaded their release behavior regulated same mechanism. Moreover, effective monitoring drug process achieved through visual variations. system has demonstrated desired capabilities controllable efficient These characteristics suggest broad prospects proposed clinical applications.
Язык: Английский
Процитировано
22
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(5), С. 1126 - 1148
Опубликована: Янв. 1, 2024
This review highlights the latest progress of smart hydrogel dressings for bandaging, monitoring and therapy diabetic wounds.
Язык: Английский
Процитировано
21
Biomaterials, Год журнала: 2025, Номер unknown, С. 123134 - 123134
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
9
Small, Год журнала: 2023, Номер 20(22)
Опубликована: Дек. 15, 2023
Hemorrhage remains a critical challenge in various medical settings, necessitating the development of advanced hemostatic materials. Hemostatic hydrogels have emerged as promising solutions to address uncontrolled bleeding due their unique properties, including biocompatibility, tunable physical characteristics, and exceptional capabilities. In this review, comprehensive overview preparation biomedical applications is provided. Particularly, with materials forms are introduced. Additionally, trauma management, surgical procedures, wound care, etc. summarized. Finally, limitations future prospects discussed evaluated. This review aims highlight hemorrhage management offer insights into clinically relevant
Язык: Английский
Процитировано
29