Materials & Design,
Год журнала:
2024,
Номер
240, С. 112815 - 112815
Опубликована: Март 12, 2024
Establishing
a
phototheranostic
platform
constructed
by
the
second
near-infrared
(NIR-II)
region
has
proved
revolutionary
and
promising
strategy
for
cancer
treatment.
However,
antitumor
effectiveness
is
severely
limited
monotonicity
of
NIR-photothermal
therapy
(HPTT)
modality
tumor
thermotolerance
caused
production
heat
shock
proteins
(HSPs).
Here,
minimalistic
approach
used
to
construct
an
organic
nanoplatform
(IFT@PEG-GOX
NPs)
with
reciprocal
cyclic
promotion
hypothermia
starvation
treatments
NIR-II
imaging-guided
therapy.
After
enhanced
permeability
retention
(EPR)
effect
causes
IFT@PEG-GOX
NPs
accumulate
in
tumors,
glucose
oxidase
(GOx)-mediated
may
obstruct
adenosine
triphosphate
(ATP)
downregulation
(HSPs),
thereby
reducing
cells.
that,
sensitized
HPTT
was
activated
GOx's
catalytic
activity
increased
NIR
laser
irradiation.
Then,
there
would
be
subsequent,
intensified
inhibition
HSP
along
additional
amplification
GOx-mediated
starvation.
As
consequence,
HPTT/Starvation
(ST)
bidirectional
cycle
method
initiated,
leading
enhancing
impact
ST
significantly
better
suppression.
Advanced Materials,
Год журнала:
2024,
Номер
36(31)
Опубликована: Май 21, 2024
Fluorescence
imaging
(FLI)-guided
phototheranostics
using
emission
from
the
second
near-infrared
(NIR-II)
window
show
significant
potential
for
cancer
diagnosis
and
treatment.
Clinical
imaging-used
polymethine
ionic
indocyanine
green
(ICG)
dye
is
widely
adopted
NIR
fluorescence
imaging-guided
photothermal
therapy
(PTT)
research
due
to
its
exceptional
photophysical
properties.
However,
ICG
has
limitations
such
as
poor
photostability,
low
conversion
efficiency
(PCE),
short-wavelength
peak,
liver-targeting
issues,
which
restrict
wider
use.
In
this
study,
two
derivatives
are
transformed
into
neutral
merocyanines
(mCy)
achieve
much-enhanced
performance
NIR-II
phototheranostics.
Initial
designs
of
dyes
similar
drawbacks
in
terms
photostability
performance.
One
modified
molecules,
mCy890,
shows
significantly
improved
stability,
an
peak
over
1000
nm,
a
high
PCE
51%,
all
considerably
outperform
ICG.
vivo
studies
demonstrate
that
nanoparticles
mCy890
can
effectively
accumulate
at
tumor
sites
guided
by
imaging.
This
provides
valuable
insights
development
enhanced
Abstract
Solar
energy
is
a
primary
form
of
renewable
energy,
and
photothermal
conversion
direct
process
with
tunable
efficiency.
Among
various
kinds
materials,
porous
organic
polymers
(POP)
are
widely
investigated
owing
to
their
controllable
molecular
design,
tailored
structures,
good
absorption
solar
light,
low
thermal
conductivity.
A
variety
POP,
such
as
conjugated
microporous
(CMP),
covalent
frameworks
(COF),
hyper‐crosslinked
(HCP),
intrinsic
microporosity
(PIM),
ionic
(PIP),
developed
applied
in
applications
seawater
desalination,
latent
storage,
biomedical
fields.
In
this
review,
comprehensive
overview
the
recent
advances
POP
for
provided.
The
micro
structure
characteristics
macro
morphology
designed
heat
phototherapy
photodynamic
therapy,
drug
delivery.
Besides,
probe
into
underlying
mechanism
structural
design
constructing
excellent
performance
methodicalized.
Finally,
remaining
challenges
prospective
opportunities
future
development
energy‐driven
elucidated.
Nano-Micro Letters,
Год журнала:
2025,
Номер
17(1)
Опубликована: Фев. 24, 2025
Abstract
Sonodynamic
therapy
(SDT)
as
an
emerging
modality
for
malignant
tumors
mainly
involves
in
sonosensitizers
and
low-intensity
ultrasound
(US),
which
can
safely
penetrate
the
tissue
without
significant
attenuation.
SDT
not
only
has
advantages
including
high
precision,
non-invasiveness,
minimal
side
effects,
but
also
overcomes
limitation
of
low
penetration
light
to
deep
tumors.
The
cytotoxic
reactive
oxygen
species
be
produced
by
utilization
combined
with
US
kill
tumor
cells.
However,
underlying
mechanism
been
elucidated,
its
unsatisfactory
efficiency
retards
further
clinical
application.
Herein,
we
shed
on
main
mechanisms
types
sonosensitizers,
organic
inorganic
sonosensitizers.
Due
development
nanotechnology,
many
novel
nanoplatforms
are
utilized
this
arisen
field
solve
barriers
enable
continuous
innovation.
This
review
highlights
potential
nanosonosensitizers
focus
enhanced
based
monotherapy
or
synergistic
that
difficult
reach
traditional
treatment,
especially
orthotopic
cancers.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 2, 2024
Abstract
Recent
advances
are
achieved
in
the
design
and
development
of
efficient
organic
photosensitizers
(PSs),
especially
with
fluorescence
imaging
navigation
second
near‐infrared
(NIR‐II,
1000–1700
nm)
region.
However,
there
simply
a
handful
NIR‐II
emissive
PSs
oxygen‐independent
capability
due
to
scarcity
high‐performance
NIR‐responsive
materials
targeted
delivery.
Herein,
NIR‐II‐emissive
nanomedicine
biomimetic
engineering
for
multiple
phototherapies
pancreatic
tumors
is
reported.
An
A‐D‐A‐type
conjugated
small‐molecule
TPC
designed
used
prepare
water‐dispersive
nanoparticles,
which
demonstrated
high
efficiency
type
I
II
photodynamic
performances,
good
photothermal
conversion
57%,
bright
emission
quantum
yield
9.8%
under
808
nm
light
irradiation.
With
cancer
cell
membrane
camouflage,
high‐resolution
bioimaging
whole‐body
blood
vessels
tumors.
Antitumor
experiments
tumor
elimination
biosafety
This
work
versatile
enhanced
tumor‐targeting
superior
phototheranostics,
providing
feasible
idea
evolution
theranostics.
Constructing
J-aggregated
organic
dyes
represents
a
promising
strategy
for
obtaining
biomedical
second
near-infrared
(NIR-II)
emissive
materials,
as
they
exhibit
red-shifted
spectroscopic
properties
upon
assembly
into
nanoparticles
(NPs)
in
aqueous
environments.
However,
currently
available
NIR-II
J-aggregates
primarily
rely
on
specific
molecular
backbones
with
intricate
design
strategies
and
are
susceptible
to
fluorescence
quenching
during
assembly.
A
facile
approach
constructing
bright
using
prevalent
donor-acceptor
(D-A)
molecules
is
still
lacking.
In
this
study,
we
present
method
that
transforms
D-A
by
simply
bending
the
molecule
through
introducing
methyl
group,
enabling
high-performance
phototheranostics.
The
TAA-BT-CN
exhibits
hypsochromic-shift
absorption
forming
H-aggregated
NPs,
while
designed
mTAA-BT-CN
bent
structure
demonstrates
bathochromic
shift
of
over
100
nm
leading
much
enhanced
emission
beyond
1100
nm.
With
respect
its
counterpart
aggregation-caused
(ACQ)
phenomenon,
NPs
7-fold
increase
owing
their
aggregation-induced
(AIE)
property
well
efficient
generation
heat
reactive
oxygen
species
under
808
light
excitation.
Finally,
employed
whole-body
blood
vessel
imaging
technology
imaging-guided
tumor
phototherapies.
This
study
will
facilitate
flourishing
advancement
based
D-A-type
molecules.
Nano-Micro Letters,
Год журнала:
2024,
Номер
17(1)
Опубликована: Сен. 30, 2024
Abstract
Vaccinations
are
essential
for
preventing
and
treating
disease,
especially
cancer
nanovaccines,
which
have
gained
considerable
interest
recently
their
strong
anti-tumor
immune
capabilities.
Vaccines
can
prompt
the
system
to
generate
antibodies
activate
various
cells,
leading
a
response
against
tumor
tissues
reducing
negative
effects
recurrence
risks
of
traditional
chemotherapy
surgery.
To
enhance
flexibility
targeting
vaccines,
nanovaccines
utilize
nanotechnology
encapsulate
or
carry
antigens
at
nanoscale
level,
enabling
more
controlled
precise
drug
delivery
responses.
Cancer
function
by
encapsulating
tumor-specific
tumor-associated
within
nanomaterials.
The
small
size
these
nanomaterials
allows
T
dendritic
thereby
eliciting
potent
response.
In
this
paper,
we
focus
on
classification
carriers
roles
different
target
clinically
tested
discussing
strategies
effectively
inducing
cytotoxic
lymphocytes
responses
optimizing
antigen
presentation,
while
also
looking
ahead
translational
challenges
moving
from
animal
experiments
clinical
trials.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 7, 2024
Abstract
Organic
photothermal
materials
have
attracted
extensive
attention
due
to
their
designable
molecular
structure,
tunable
excited‐state
properties,
and
excellent
biocompatibility,
however,
the
development
of
near‐infrared
II
(NIR‐II)
absorbing
organic
with
high
conversion
efficiency
(PTCE)
molar
extinction
coefficient
(
ɛ
)
remains
challenging.
Herein,
a
novel
“electron‐donor
iteration”
strategy
is
proposed
construct
dendrimers
(CR‐DPA‐T,
CR‐(DPA)
2
‐T
3
‐T)
donor‐
π
‐acceptor‐
‐donor
(D
‐π‐
A‐
‐D)
features
diradical
characteristics.
Owing
enhanced
D–A
effect
intramolecular
motions,
absorption
capacity
increase
as
generation
grows.
Surprisingly,
an
performance
1064
×
PTCE
superb
value
2.85
10
4
in
NIR‐II
region
achieved
for
nanoparticles
(CR‐(DPA)
NPs)
compared
most
reported
counterparts.
Besides,
NPs
exhibit
superior
antitumor
efficacy
by
synergistic
therapy
(PTT)
immunotherapy,
efficiently
inhibiting
growth
both
primary
distant
tumors.
To
best
knowledge,
dendrimer
first
time
reported,
universal
donor
engineering
offered
develop
NIR‐II‐absorbing
immunotherapy.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Авг. 1, 2024
Abstract
Surgery
remains
the
standard
treatment
for
spinal
metastasis.
However,
uncontrolled
intraoperative
bleeding
poses
a
significant
challenge
adequate
surgical
resection
and
compromises
outcomes.
In
this
study,
we
develop
thrombin
(Thr)-loaded
nanorobot-hydrogel
hybrid
superstructure
by
incorporating
nanorobots
into
regenerated
silk
fibroin
nanofibril
hydrogels.
This
with
superior
thixotropic
properties
is
injected
percutaneously
dispersed
metastasis
of
hepatocellular
carcinoma
(HCC)
easy
characteristics,
before
surgery
in
mouse
model.
Under
near-infrared
irradiation,
self-motile
penetrate
deep
tumor,
releasing
Thr
controlled
manner.
Thr-induced
thrombosis
effectively
blocks
tumor
vasculature
reduces
bleeding,
inhibiting
growth
postoperative
recurrence
Au
nanorod-mediated
photothermal
therapy.
Our
minimally
invasive
platform
provides
novel
preoperative
therapeutic
strategy
HCC
controlling
growth,
potentially
reduced
complications
enhanced
operative
