A Dual-Targeted Nanocapsule Inhibitor Alleviates Severe Acute Pancreatitis via Cytokine and NLRP3 Inflammasome Regulation DOI Creative Commons
Ling Wu,

Shu-Ju Liao,

Yuhang Li

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 19, 2024

Abstract Severe acute pancreatitis (SAP), a special type of abdomen, lacks effective treatment methods for clinical diagnosis because its complex etiology and unclear pathogenesis. Herein, we engineered structurally controllable gold-doped Prussian blue analogues-based nanozyme by optimizing the preparation procedure as dual-targeted inhibitor NLRP3 inflammasome inflammatory cytokine pathways treating SAP. The as-synthesized nanomaterials with different structures, including nanocapsular (CaAuHCF), ultramicro nanocube (CAHCF-Au), (CaHCF) exhibit multienzyme-like activities, such peroxidase (POD), glutathione (GPx), superoxide dismutase (SOD), which are dependent on their structure. Density functional theory (DFT) simulations revealed underlying mechanisms differences in reactivity among compositions indicating that POD catalytic activity CaAuHCF nanocapsules plays leading role under physiological conditions. In vitro or vivo experiments confirmed can efficiently remove exogenous endogenous reactive oxygen species (ROS) at cellular level nontoxic. Importantly, not only is regulator mediate factors related to proinflammatory cell (IL-6, TNF-α, IL-1β) but also acts an activation effectively relieve symptoms SAP through preventing cleavage Gasdermin-D into Gasdermin-N via targeted inhibition cleaved Caspase-1 activation, thus suppressing pyroptosis pancreatic immune cells. Overall, our data highlight feasibility inhibitors cytokines provide potential nanozyme-based antioxidants treatment.

Язык: Английский

Nanomaterial-Based Repurposing of Macrophage Metabolism and Its Applications DOI Creative Commons

Tingting Meng,

Danfeng He,

Zhuolei Han

и другие.

Nano-Micro Letters, Год журнала: 2024, Номер 16(1)

Опубликована: Июль 15, 2024

Macrophage immunotherapy represents an emerging therapeutic approach aimed at modulating the immune response to alleviate disease symptoms. Nanomaterials (NMs) have been engineered monitor macrophage metabolism, enabling evaluation of progression and replication intricate physiological signal patterns. They achieve this either directly or by delivering regulatory signals, thereby mapping phenotype effector functions through metabolic repurposing customize fate for therapy. However, a comprehensive summary regarding NM-mediated visualization coordinated rewiring maintain phenotypic equilibrium is currently lacking. This review aims address gap outlining recent advancements in NM-based immunotherapy. We initially explore relationship between polarization, disease, before delving into NM innovations that visualize activity elucidate onset fine-tune its remodeling macrophage-centered Finally, we discuss prospects challenges immunotherapy, aiming accelerate clinical translation. anticipate will serve as valuable reference researchers seeking leverage novel intervention-matched immunomodulators macrophages other fields engineering.

Язык: Английский

Процитировано

9
Advancements in nanozymes research for the management of chronic wounds DOI

Duoduo Chen,

Guoxin Tan,

Shujian Tian

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 500, С. 157299 - 157299

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

8
Sprayable Hydrogel for pH-Responsive Nanozyme-Derived Bacteria-Infected Wound Healing DOI

Furong Chao,

Chengliang Cao, Yin Xu

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 20, 2025

Long-term inflammation and persistent bacterial infection are primary contributors to unhealed chronic wounds. The use of conventional antibiotics often leads bacteria drug resistance, diminishing wound healing effectiveness. Nanozymes have become a promising alternative antimicrobial materials due their low cost, easy synthesis, good stability. Herein, we develop novel sprayable hydrogel based on carboxymethyl chitosan (CMCS) oxidized hyaluronic acid (OHA), incorporating Au nanoparticle-carbon nitride (AuNPs-C3N4) nanozyme, glucose, Mn2+ for bacteria-infected healing. forms rapidly in situ upon spraying gradually degrades the area, releasing AuNPs-C3N4 which exhibits robust glucose oxidase-like (GOx-like) activity, initiating comprehensive catalytic cascade through Mn2+-mediated Fenton-like reaction that generates hydroxyl radicals (•OH) eliminate Staphylococcus aureus (S. aureus) Methicillin-resistant S. (MRSA). Computational results indicate interactions between AuNPs g-C3N4 maximize synergistic effects heterojunction, improving O2 adsorption facilitating electron-O2 optimize activity. Further experiments demonstrate can cover wounds situ, while CMCS promotes collagen production fibroblast proliferation, offering viable strategy

Язык: Английский

Процитировано

1
Engineering in NIR‐responsive photothermal materials and their application in wound healing administration DOI Creative Commons
A. Bassam, Meng-Xuan Du, Yuan Li

и другие.

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Abstract Wound healing is a complex process that involves multiple stages and susceptible to various challenges, such as infection, insufficient blood flow, the body's inadequate response process, which can be life‐threatening for patient. In current medical landscape, traditional treatments often struggle meet high standards of modern care. Therefore, it crucial actively explore develop new drugs or advanced technologies enhance bacterially infected wounds. recent years, several physical methods effectively accelerate wound have garnered widespread attention interest. Among these, Photothermal therapy (PTT) has been extensively utilized in treatment bacterial infections due its non‐invasive, low toxicity, ease use. The photothermal agents (PTAs) serve core material PTT, their efficacy significantly influenced by specific PTAs employed. Selecting appropriate essential achieving desired therapeutic effect. This relies on PTAs's ability efficiently convert wavelengths light energy into heat upon absorption, thereby generating thermal effect at site. Consequently, properties PTAs, including conversion efficiency, biocompatibility, stability within organism, are critical factors determine outcome. review introduces organic, inorganic, organic‐inorganic hybrid PTT healing, highlighting main applications management years. Finally, we briefly discuss limitations prospects this field.

Язык: Английский

Процитировано

1
Metal-organic frameworks: synthesis, properties, wound dressing, challenges and scopes in advanced wound dressing DOI
Muhammad Umar Aslam Khan,

Muhammad Azhar Aslam,

Tooba Yasin

и другие.

Biomedical Materials, Год журнала: 2024, Номер 19(5), С. 052001 - 052001

Опубликована: Июль 8, 2024

Abstract Wound healing is a critical but complex biological process of skin tissue repair and regeneration resulting from various systems working together at the cellular molecular levels. Quick wound problems associated with traditional techniques are being overcome multifunctional materials. Over time, this research area has drawn significant attention. Metal-organic frameworks (MOFs), owning to their peculiar physicochemical characteristics, now considered promising class well-suited porous materials for in addition other applications. This detailed literature review provides an overview latest developments MOFs We have discussed synthesis, essential biomedical properties, wound-healing mechanism, MOF-based dressing materials, The possible major challenges limitations been discussed, along conclusions future perspectives. addresses MOFs-based several angles covers most current subject. readers may discover how advanced discipline by producing more inventive, useful, successful dressings. It influences development generations biomaterials wounds.

Язык: Английский

Процитировано

7
Intelligent Carbon Dots with Switchable Photo‐Activated Oxidase‐Mimicking Activity and pH Responsive Antioxidant Activity Adaptive to the Wound Microenvironment for Selective Antibacterial Therapy DOI Creative Commons
He Li, Zhi Li,

Meiqi Gu

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Сен. 3, 2024

Abstract Intelligent antibacterial agent with controllable activities adaptive to the wound microenvironment is appealing reduce drug resistance and enhance efficiency. In this study, celery chosen as carbon source construct celery‐based dots (CECDs) double activities, i.e., reactive oxygen species (ROS)‐production ROS‐clearance activities. The ROS‐production capability of CECDs dependent on oxidase (OXD)‐mimicking activity, which only photo‐activated thus artificially controlled by light avoid production excess ROS. Meanwhile, optimal OXD‐mimicking activity occurrs at pH 5, close microenvironmental bacterial infection site, will efficacy. On other hand, exhibit antioxidant neutral or weak alkaline pH, assist healing wound. Thus, conversion ability can be dynamically intelligently switched automatically different stages treatment (from acid neutral/weak basic). proposed exert adorable selective against Gram‐positive bacteria satisfactory therapeutic effect infected mice. This study paves a new avenue design intelligent nanoagent sensitive condition, reducing assisting precise medicine.

Язык: Английский

Процитировано

5
Facile and straightforward fabrication of antimicrobial Cu-Ce oxide nanoagent for repair of acutely infected wounds DOI Creative Commons
Jinhui Lin, Zhaowei Wang,

Jiangshan Hu

и другие.

Materials & Design, Год журнала: 2025, Номер unknown, С. 113901 - 113901

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Chitosan-based hydrogel incorporated with polydopamine and protoporphyrin for photothermal-oxidation sterilization of bacteria-infected wound therapy DOI
Xiao Wang, Xiaojing Zhang, Wenjing Zhao

и другие.

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 678, С. 89 - 100

Опубликована: Сен. 13, 2024

Язык: Английский

Процитировано

4
Enhanced antioxidant activity of CeO2/Ti3C2Tx nanocomposites for cardiovascular protection DOI
Yanjie Hou,

Jialing Liu,

Guannan Zhang

и другие.

Inorganic Chemistry Communications, Год журнала: 2025, Номер 174, С. 114006 - 114006

Опубликована: Янв. 27, 2025

Язык: Английский

Процитировано

0
Enzyme-like CeO2 Nanomaterials with Different Structure–Activity for Ulcerative Colitis Therapy DOI Creative Commons
Bo Su, Zihao Xu, Mengdan Shen

и другие.

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Язык: Английский

Процитировано

0