International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138493 - 138493
Опубликована: Дек. 1, 2024
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)
Опубликована: Фев. 20, 2025
The progression of malignant tumors leads to the development secondary in various organs, including bones, brain, liver, and lungs. This metastatic process severely impacts prognosis patients, significantly affecting their quality life survival rates. Research efforts have consistently focused on intricate mechanisms underlying this corresponding clinical management strategies. Consequently, a comprehensive understanding biological foundations tumor metastasis, identification pivotal signaling pathways, systematic evaluation existing emerging therapeutic strategies are paramount enhancing overall diagnostic treatment capabilities for tumors. However, current research is primarily metastasis within specific cancer types, leaving significant gaps our complex cascade, organ-specific tropism mechanisms, targeted treatments. In study, we examine sequential processes elucidate driving organ-tropic systematically analyze tumors, those tailored organ involvement. Subsequently, synthesize most recent advances technologies challenges opportunities encountered pertaining bone metastasis. Our objective offer insights that can inform future practice crucial field.
Язык: Английский
Процитировано
7
Heliyon, Год журнала: 2024, Номер 10(20), С. e38481 - e38481
Опубликована: Сен. 26, 2024
Язык: Английский
Процитировано
7
European Polymer Journal, Год журнала: 2024, Номер 220, С. 113427 - 113427
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
3
Frontiers in Oncology, Год журнала: 2025, Номер 15
Опубликована: Фев. 7, 2025
Iron-based nanomaterials (INMs), due to their particular magnetic property, excellent biocompatibility, and functionality, have been developed into powerful tools in both tumor diagnosis therapy. We give an overview here on how INMs such as iron oxide nanoparticles, element-doped nanocomposites, iron-based organic frameworks (MOFs) display versatility for imaging therapy improvement. In terms of imaging, improve the sensitivity accuracy techniques resonance (MRI) photoacoustic (PAI) support development multimodal platforms. Regarding treatment, play a key role advanced strategies immunotherapy, hyperthermia, synergistic combination therapy, which effectively overcome tumor-induced drug resistance reduce systemic toxicity. The integration with artificial intelligence (AI) radiomics further expands its capabilities precise identification, treatment optimization, amplifies monitoring. now link materials science computing clinical innovations enable next-generation cancer diagnostics therapeutics.
Язык: Английский
Процитировано
0
Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 20
Опубликована: Март 10, 2025
Quercetin (QUE) is a phytoestrogen with known antitumor properties; however, its hydrophobic nature and low bioavailability limit efficacy as an anticancer drug. To address this, we explored loading QUE onto non-toxic nanocarrier. This study focused on the biological activity of magnetic iron oxide nanoparticles coated polyethylene glycol (MAG@PEG) loaded (MAG@PEG@QUE) in MCF-7 cells. The MAG@PEG nanosystem was synthesized using hydrothermal method, incorporated by adding alcoholic solution to aqueous dispersion MAG@PEG. incorporation confirmed qualitatively FTIR spectroscopy quantitatively through UV-visible spectroscopy. Cytotoxicity studies showed that MAG@PEG@QUE, at concentration equivalent IC50 free QUE, significantly reduced cell proliferation viability while increasing apoptosis. cells treated MAG@PEG@QUE also displayed actin cytoskeleton alterations typical apoptotic Transmission electron microscopy revealed clusters within cellular vesicles. Targeted delivery these achieved static field, leading high intracellular accumulation selective death targeted areas, without affecting adjacent In conclusion, shows comparable effects has potential enhance QUE's for breast cancer treatment.
Язык: Английский
Процитировано
0
Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13
Опубликована: Апрель 30, 2025
A notable increase in cancer-related fatalities and morbidity worldwide is attributed to drug resistance. The factors contributing resistance include efflux via ABC transporters, apoptosis evasion, epigenetic alterations, DNA repair mechanisms, the tumor microenvironment, among others. Systemic toxicities associated with conventional cancer diagnostics therapies have led development of alternative approaches, such as nanotechnology, enhance diagnostic precision improve therapeutic outcomes. Nanomaterial, including carbon nanotubes, dendrimers, polymeric micelles, liposomes, shown significant benefits diagnosis treatment due their unique physicochemical properties, biocompatibility, stability, enhanced permeability, retention characteristics, targeted delivery. Building on these advantages, this review conducted through comprehensive analysis recent literature explore principal mechanisms resistance, potential nanomaterials revolutionize selective delivery treatment. Additionally, strategies employed by overcome tumors, pump inhibition, multidrug loading, gene silencing are discussed detail. Furthermore, we examine challenges that limit application impede transition clinical use.
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Май 3, 2025
Reactive oxygen species (ROS)-mediated pyroptosis provides a robust strategy for overcoming apoptosis resistance in breast cancer therapy. Nevertheless, the low efficiency of remains an undeniable challenge. Overcoming this obstacle necessitates creation innovative approaches and nanocatalysts to boost ROS generation. Herein, distinct lanthanum-doped BiFeO3 (La-BFO) piezoelectric nanozymes are rationally designed engineered specific cell through inducing amplified production releasing La ions. The introduction reduces recombination rate electron-hole pairs narrowing bandgap creating vacancy BFO, improving harmful generation efficiency. Importantly, released ions robustly disrupt lysosomal membrane, ultimately pyroptosis, combination with ROS-induced biological effect. In vitro vivo antineoplastic results confirm desirable therapeutic effect on combating tumor. Especially, iron bismuth elemental components endow nanocomposites dual-mode computed tomography/magnetic resonance imaging ability, guaranteeing potential guidance monitoring.
Язык: Английский
Процитировано
0
Medical Oncology, Год журнала: 2025, Номер 42(7)
Опубликована: Июнь 4, 2025
Язык: Английский
Процитировано
0
Cancers, Год журнала: 2024, Номер 16(18), С. 3210 - 3210
Опубликована: Сен. 20, 2024
Ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation, has generated substantial interest in cancer therapy. Various methods have been developed to induce ferroptosis tumor cells, including approved drugs, experimental compounds, and nanomedicine formulations. Unlike apoptosis, presents unique molecular cellular features, representing promising approach for cancers resistant conventional treatments. Recent research indicates strong link between the immune microenvironment, suggesting potential trigger robust antitumor responses. Multiple metabolic pathways control ferroptosis, iron, lipid, redox metabolism. Thus, understanding interaction metabolism is crucial developing effective anticancer therapies. This review provides an in-depth discussion on combining inorganic nanoparticles with therapies such as phototherapy, chemotherapy, radiotherapy, immunotherapy, role these combination Furthermore, this paper explores future treatment using nanomedicine, focusing how can enhance cells boost immunity. The goal advance ferroptosis-based from laboratory clinical applications.
Язык: Английский
Процитировано
2
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 8, 2024
Abstract Catalytic therapies, such as chemodynamic therapy and ferroptosis, harness the tumor microenvironment to enhance specificity penetration of treatments, thus improving targeted therapy. Despite these advancements, treatment effectiveness varies due individual differences, making precise monitoring drug activity dosage essential optimize Traditional imaging strategies, which monitor metal ion release or reactive oxygen species production, frequently fail well correlate with therapeutic outcome. Herein, this study have developed an integrated self‐monitoring catalytic platform that combines palladium‐ manganese‐based nanoparticles (PdMn NPs) caspase‐3 activated probe (Casp probe). Dual‐channel MRI fluorescent probe, responsive both low pH activity, significantly enhances accuracy real‐time evaluations, allowing for early reporting response (in 6 h), earlier than volume reduction (8 days). This approach improves assessment outcomes aligns shift toward individualized cancer protocols.
Язык: Английский
Процитировано
2