International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138493 - 138493
Published: Dec. 1, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: Feb. 20, 2025
The progression of malignant tumors leads to the development secondary in various organs, including bones, brain, liver, and lungs. This metastatic process severely impacts prognosis patients, significantly affecting their quality life survival rates. Research efforts have consistently focused on intricate mechanisms underlying this corresponding clinical management strategies. Consequently, a comprehensive understanding biological foundations tumor metastasis, identification pivotal signaling pathways, systematic evaluation existing emerging therapeutic strategies are paramount enhancing overall diagnostic treatment capabilities for tumors. However, current research is primarily metastasis within specific cancer types, leaving significant gaps our complex cascade, organ-specific tropism mechanisms, targeted treatments. In study, we examine sequential processes elucidate driving organ-tropic systematically analyze tumors, those tailored organ involvement. Subsequently, synthesize most recent advances technologies challenges opportunities encountered pertaining bone metastasis. Our objective offer insights that can inform future practice crucial field.
Language: Английский
Citations
3
Heliyon, Journal Year: 2024, Volume and Issue: 10(20), P. e38481 - e38481
Published: Sept. 26, 2024
Language: Английский
Citations
6
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: Feb. 7, 2025
Iron-based nanomaterials (INMs), due to their particular magnetic property, excellent biocompatibility, and functionality, have been developed into powerful tools in both tumor diagnosis therapy. We give an overview here on how INMs such as iron oxide nanoparticles, element-doped nanocomposites, iron-based organic frameworks (MOFs) display versatility for imaging therapy improvement. In terms of imaging, improve the sensitivity accuracy techniques resonance (MRI) photoacoustic (PAI) support development multimodal platforms. Regarding treatment, play a key role advanced strategies immunotherapy, hyperthermia, synergistic combination therapy, which effectively overcome tumor-induced drug resistance reduce systemic toxicity. The integration with artificial intelligence (AI) radiomics further expands its capabilities precise identification, treatment optimization, amplifies monitoring. now link materials science computing clinical innovations enable next-generation cancer diagnostics therapeutics.
Language: Английский
Citations
0
Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 20
Published: March 10, 2025
Quercetin (QUE) is a phytoestrogen with known antitumor properties; however, its hydrophobic nature and low bioavailability limit efficacy as an anticancer drug. To address this, we explored loading QUE onto non-toxic nanocarrier. This study focused on the biological activity of magnetic iron oxide nanoparticles coated polyethylene glycol (MAG@PEG) loaded (MAG@PEG@QUE) in MCF-7 cells. The MAG@PEG nanosystem was synthesized using hydrothermal method, incorporated by adding alcoholic solution to aqueous dispersion MAG@PEG. incorporation confirmed qualitatively FTIR spectroscopy quantitatively through UV-visible spectroscopy. Cytotoxicity studies showed that MAG@PEG@QUE, at concentration equivalent IC50 free QUE, significantly reduced cell proliferation viability while increasing apoptosis. cells treated MAG@PEG@QUE also displayed actin cytoskeleton alterations typical apoptotic Transmission electron microscopy revealed clusters within cellular vesicles. Targeted delivery these achieved static field, leading high intracellular accumulation selective death targeted areas, without affecting adjacent In conclusion, shows comparable effects has potential enhance QUE's for breast cancer treatment.
Language: Английский
Citations
0
European Polymer Journal, Journal Year: 2024, Volume and Issue: 220, P. 113427 - 113427
Published: Sept. 1, 2024
Language: Английский
Citations
3
Cancers, Journal Year: 2024, Volume and Issue: 16(18), P. 3210 - 3210
Published: Sept. 20, 2024
Ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation, has generated substantial interest in cancer therapy. Various methods have been developed to induce ferroptosis tumor cells, including approved drugs, experimental compounds, and nanomedicine formulations. Unlike apoptosis, presents unique molecular cellular features, representing promising approach for cancers resistant conventional treatments. Recent research indicates strong link between the immune microenvironment, suggesting potential trigger robust antitumor responses. Multiple metabolic pathways control ferroptosis, iron, lipid, redox metabolism. Thus, understanding interaction metabolism is crucial developing effective anticancer therapies. This review provides an in-depth discussion on combining inorganic nanoparticles with therapies such as phototherapy, chemotherapy, radiotherapy, immunotherapy, role these combination Furthermore, this paper explores future treatment using nanomedicine, focusing how can enhance cells boost immunity. The goal advance ferroptosis-based from laboratory clinical applications.
Language: Английский
Citations
1
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 8, 2024
Abstract Catalytic therapies, such as chemodynamic therapy and ferroptosis, harness the tumor microenvironment to enhance specificity penetration of treatments, thus improving targeted therapy. Despite these advancements, treatment effectiveness varies due individual differences, making precise monitoring drug activity dosage essential optimize Traditional imaging strategies, which monitor metal ion release or reactive oxygen species production, frequently fail well correlate with therapeutic outcome. Herein, this study have developed an integrated self‐monitoring catalytic platform that combines palladium‐ manganese‐based nanoparticles (PdMn NPs) caspase‐3 activated probe (Casp probe). Dual‐channel MRI fluorescent probe, responsive both low pH activity, significantly enhances accuracy real‐time evaluations, allowing for early reporting response (in 6 h), earlier than volume reduction (8 days). This approach improves assessment outcomes aligns shift toward individualized cancer protocols.
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 26, 2024
Abstract Hypertrophic scar (HS) remains a major challenge for clinicians due to unsatisfactory therapeutic performance. Although inducing apoptosis of HS fibroblasts (HSFs) has proved be an effective nonsurgical treatment strategy, potential chemotherapy resistance HSFs makes the development new and efficient strategies highly demanding. Herein, ferroptosis‐apoptosis combined strategy is developed through supramolecular self‐assembly between cucurbit[7]uril (CB[7]) two bioactive agents, dihydroartemisinin (DHA) gold nanoclusters (AuNCs). The resulting self‐assembled nanoparticles, named CAD NPs, showed high guest loading efficiency prominent pH‐responsive degradability in acidic lysosomes HSFs. Importantly, both DHA AuNCs act synergistically generate excessive reactive oxygen species lipid peroxidation, leading mitochondrial damage, ultimately concurrent ferroptosis on Upon further into hydrogel microneedles facilitate their transdermal delivery, these NPs superior antiscar effects shortening span 3 weeks improving appearance, as demonstrated at rabbit ear model HS. present assembly‐based provides innovative guideline efficiently treating well other diseases.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138493 - 138493
Published: Dec. 1, 2024
Language: Английский
Citations
0