Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence

Metabolites, Год журнала: 2025, Номер 15(2), С. 124 - 124

Опубликована: Фев. 13, 2025

Neurodegenerative diseases comprise a group of chronic, usually age-related, disorders characterized by progressive neuronal loss, deformation structure, or loss function, leading to substantially reduced quality life. They remain significant focus scientific and clinical interest due their increasing medical social importance. Most neurodegenerative present intracellular protein aggregation extracellular deposition (plaques), such as α-synuclein in Parkinson's disease amyloid beta (Aβ)/tau aggregates Alzheimer's. Conventional treatments for conditions incur high costs are related the development several adverse effects. In addition, many patients irresponsive them. For these reasons, there is growing tendency find new therapeutic approaches help patients. This review intends investigate some phytocompounds' effects on diseases. These generally increased oxidative stress inflammation, so phytocompounds can prevent treat To achieve our aim provide critical assessment current literature about phytochemicals targeting neurodegeneration, we reviewed reputable databases, including PubMed, EMBASE, COCHRANE, seeking trials that utilized against conditions. A few investigated humans, after screening, 13 were ultimately included following PRISMA guidelines. compounds include polyphenols (flavonoids luteolin quercetin, phenolic acids rosmarinic acid, ferulic caffeic other like resveratrol), alkaloids (such berberine, huperzine A, caffeine), terpenoids ginkgolides limonene). The gathered evidence underscores caffeine, ginkgolides, primarily anti-inflammatory, antioxidant, neuroprotective, counteracting neuroinflammation, oxidation, synaptic dysfunctions, which crucial aspects intervention various conditions, Alzheimer's dementias, depression, neuropsychiatric disorders. summary, they show use improvements cognition, memory, disinhibition, irritability/lability, aberrant behavior, hallucinations, mood

Язык: Английский

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Nobiletin and Eriodictyol Suppress Release of IL-1β, CXCL8, IL-6, and MMP-9 from LPS, SARS-CoV-2 Spike Protein, and Ochratoxin A-Stimulated Human Microglia

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 636 - 636

Опубликована: Янв. 14, 2025

Neuroinflammation is involved in various neurological and neurodegenerative disorders which the activation of microglia one key factors. In this study, we examined anti-inflammatory effects flavonoids nobiletin (5,6,7,8,3′,4′-hexamethoxyflavone) eriodictyol (3′,4′,5,7-tetraxydroxyflavanone) on human cell line stimulated by either lipopolysaccharide (LPS), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) full-length Spike protein (FL-Spike), or mycotoxin ochratoxin A (OTA). Human were preincubated with (10, 50, 100 µM) for h, following which, they 24 h. The inflammatory mediators interleukin-1 beta (IL-1β), chemokine (C-X-C motif) ligand 8 (CXCL8), IL-6, matrix metalloproteinase-9 (MMP-9) quantified culture supernatant enzyme-linked immunosorbent assay (ELISA). Both significantly inhibited LPS, FL-Spike, OTA-stimulated release IL-1β, CXCL8, MMP-9 at 50 µM, while, most cases, was also effective 10 pronounced reductions µM. These findings suggest that both are potent inhibitors pathogen-stimulated microglial mediators, highlighting their potential therapeutic application neuroinflammatory diseases, such as long COVID.

Язык: Английский

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Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression

Neuroscience, Год журнала: 2025, Номер 569, С. 161 - 183

Опубликована: Фев. 7, 2025

Язык: Английский

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Pre-clinical evidence for mitochondria as a therapeutic target for luteolin: a mechanistic view

Chemico-Biological Interactions, Год журнала: 2025, Номер unknown, С. 111492 - 111492

Опубликована: Март 1, 2025

Язык: Английский

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TMF Attenuates Cognitive Impairment and Neuroinflammation by Inhibiting the MAPK/NF-κB Pathway in Alzheimer’s Disease: A Multi-Omics Analysis

Marine Drugs, Год журнала: 2025, Номер 23(2), С. 74 - 74

Опубликована: Фев. 7, 2025

The rising prevalence of Alzheimer's disease (AD) underscores the urgent need for novel therapeutic agents derived from natural sources. Among flavonoids, 3',4',5,7-tetramethoxyflavone (TMF), a structural analog luteolin, has gained attention its favorable pharmacokinetics and potential neuroprotective properties. Despite significant effects TMF, efficacy mechanism action in AD remain unclear. This study explored TMF's pharmacological models, highlighting ability to improve memory cognitive deficits APP/PS1 mice. TMF reduced Aβ plaques, NFTs formation, glial activation while suppressing neuroinflammation through MAPK/NF-κB pathway. Further analysis LPS-induced BV2 cells revealed reduce microglial activation. These findings highlight anti-neuroinflammatory activity suggesting as treatment AD.

Язык: Английский

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A Comprehensive Review on the Neuropharmacological Effects of Phoenix dactylifera and the Potential Role of Its Phenolic Constituents

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106141 - 106141

Опубликована: Фев. 1, 2025

Язык: Английский

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Preparation, characterization and in vitro evaluation of anticancer and antioxidant effects of luteolin-loaded nanocapsules

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106754 - 106754

Опубликована: Фев. 1, 2025

Язык: Английский

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Evidence construction of Fufang Xueshuantong Capsule against retinal vein occlusion: A meta-analysis and network pharmacology

European Journal of Integrative Medicine, Год журнала: 2025, Номер unknown, С. 102452 - 102452

Опубликована: Апрель 1, 2025

Язык: Английский

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CURRENT CONCEPTS IN LONG-COVID BRAIN FOG AND POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME

Annals of Allergy Asthma & Immunology, Год журнала: 2024, Номер 133(5), С. 522 - 530

Опубликована: Авг. 23, 2024

Язык: Английский

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Role of Plant Phytochemicals: Resveratrol, Curcumin, Luteolin and Quercetin Indemyelination, Neurodegeneration, and Epilepsy

Antioxidants, Год журнала: 2024, Номер 13(11), С. 1364 - 1364

Опубликована: Ноя. 7, 2024

Polyphenols are an important group of biologically active compounds present in almost all food sources plant origin and primarily known for their anti-inflammatory antioxidative capabilities. Numerous studies have indicated broad spectrum pharmacological properties correlations between increased supply the human diet lower prevalence various disorders. The positive effects polyphenols application mostly discussed terms cardiovascular system well-being. However, recent years, they also increasingly mentioned as prophylactic therapeutic factors context neurological diseases, being able to suppress progression such disorders soothe accompanying symptoms. Among over 8000 compounds, that been identified, most widely examined comprise resveratrol, curcumin, luteolin quercetin. This review focuses on vitro assessments, animal models clinical trials, reflecting actual state knowledge, polyphenols' medicinal capabilities epilepsy, demyelinating neurodegenerative diseases central nervous system.

Язык: Английский

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