Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson’s Disease DOI Open Access
Matthew Miller,

Harold E. Landis,

Robert E. Miller

и другие.

Опубликована: Авг. 14, 2024

Intercellular adhesion molecule 1 (ICAM-1/CD54), a transmembrane glycoprotein, has been considered as one of the most important molecules during leukocyte recruitment. It is encoded by ICAM1 gene and plays central role in inflammation. It’s crucial many inflammatory diseases such ulcerative colitis rheumatoid arthritis are well established. Given that neuroinflammation, underscored microglial activation, key element neurodegenerative Parkinson’s disease (PD), we investigated whether ICAM-1 this progressive neurological condition if so, elucidate underpinning mechanisms. Specifically, were interested potential interaction between ICAM-1, glial cells ferroptosis, an iron-dependent form cell death recently implicated PD. We conclude there exist direct indirect (via T cells) influences on ferroptosis further elucidation these interactions can suggest novel intervention for devastating disease.

Язык: Английский

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease DOI Creative Commons
Érica Novaes Soares, Ana Carla dos Santos Costa,

Gabriel de Jesus Ferrolho

и другие.

Cells, Год журнала: 2024, Номер 13(6), С. 474 - 474

Опубликована: Март 7, 2024

Parkinson’s disease (PD) is a progressive neurodegenerative characterized by resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) the primary neurotransmitter involved in this disease, but cholinergic imbalance has been implicated. Current intervention PD focused on replenishing central DA, which provides remarkable temporary symptomatic relief does not address neuronal loss progression of disease. It well established nicotinic receptors (nAChRs) can regulate DA release nicotine itself may have neuroprotective effects. Recent studies identified nAChRs nonneuronal cell types, including glial cells, where they inflammatory responses. Given crucial role neuroinflammation dopaminergic degeneration involvement microglia astrocytes response, provide novel therapeutic target prevention and/or treatment PD. In review, following brief discussion PD, we focus cells and, specifically, their pathology treatment.

Язык: Английский

Процитировано

9
Heavy Metal Interactions with Neuroglia and Gut Microbiota: Implications for Huntington’s Disease DOI Creative Commons
Yousef Tizabi, Samia Bennani,

Nacer El Kouhen

и другие.

Cells, Год журнала: 2024, Номер 13(13), С. 1144 - 1144

Опубликована: Июль 3, 2024

Huntington’s disease (HD) is a rare but progressive and devastating neurodegenerative characterized by involuntary movements, cognitive decline, executive dysfunction, neuropsychiatric conditions such as anxiety depression. It follows an autosomal dominant inheritance pattern. Thus, child who has parent with the mutated huntingtin (mHTT) gene 50% chance of developing disease. Since HTT protein involved in many critical cellular processes, including neurogenesis, brain development, energy metabolism, transcriptional regulation, synaptic activity, vesicle trafficking, cell signaling, autophagy, its aberrant aggregates lead to disruption numerous pathways neurodegeneration. Essential heavy metals are vital at low concentrations; however, higher concentrations, they can exacerbate HD disrupting glial–neuronal communication and/or causing dysbiosis (disturbance gut microbiota, GM), both which neuroinflammation further Here, we discuss detail interactions iron, manganese, copper glial–neuron GM indicate how this knowledge may pave way for development new generation disease-modifying therapies HD.

Язык: Английский

Процитировано

5
Ferroptosis as an emerging target in sickle cell disease DOI Creative Commons
Vitor Fortuna, Jaqueline Costa Lima,

Gabriel F. Oliveira

и другие.

Current Research in Toxicology, Год журнала: 2024, Номер 7, С. 100181 - 100181

Опубликована: Янв. 1, 2024

Sickle cell disease (SCD) is an inherited hemoglobin disorder marked by red blood sickling, resulting in severe anemia, painful episodes, extensive organ damage, and shortened life expectancy. In SCD, increased iron levels can trigger ferroptosis, a specific type of death characterized reactive oxygen species (ROS) lipid peroxide accumulation, leading to damage impairments. The intricate interplay between iron, inflammation, oxidative stress SCD underscores the necessity thoroughly understanding these processes for development innovative therapeutic strategies. This review highlights importance balancing complex interactions among various factors exploitation knowledge developing novel therapeutics this devastating disease.

Язык: Английский

Процитировано

4
Status epilepticus alters hippocampal ultrastructure in kainic acid rat model DOI
Mzia G. Zhvania,

Irina Sharikadze,

Nadezhda Japaridze

и другие.

Tissue and Cell, Год журнала: 2025, Номер 94, С. 102789 - 102789

Опубликована: Фев. 10, 2025

Язык: Английский

Процитировано

0
Structural analysis and bioavailability study of low-molecular-weight chondroitin sulfate‑iron complexes prepared by photocatalysis-Fenton reaction DOI
Qianqian Du, Haoran Song, Chunhong Yan

и другие.

Carbohydrate Polymers, Год журнала: 2024, Номер 342, С. 122435 - 122435

Опубликована: Июнь 25, 2024

Язык: Английский

Процитировано

2
Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson’s Disease DOI Creative Commons
Matthew Miller,

Harold E. Landis,

Robert E. Miller

и другие.

Cells, Год журнала: 2024, Номер 13(18), С. 1554 - 1554

Опубликована: Сен. 15, 2024

Intercellular adhesion molecule 1 (ICAM-1/CD54), a transmembrane glycoprotein, has been considered as one of the most important molecules during leukocyte recruitment. It is encoded by ICAM1 gene and plays central role in inflammation. Its crucial many inflammatory diseases such ulcerative colitis rheumatoid arthritis are well established. Given that neuroinflammation, underscored microglial activation, key element neurodegenerative Parkinson’s disease (PD), we investigated whether ICAM-1 this progressive neurological condition and, if so, to elucidate underpinning mechanisms. Specifically, were interested potential interaction between ICAM-1, glial cells, ferroptosis, an iron-dependent form cell death recently implicated PD. We conclude there exist direct indirect (via cells T cells) influences on ferroptosis further elucidation these interactions can suggest novel intervention for devastating disease.

Язык: Английский

Процитировано

2
Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease DOI Open Access
Érica Novaes Soares, Ana Carla dos Santos Costa,

Gabriel de Jesus Ferrolho

и другие.

Опубликована: Март 4, 2024

Parkinson’s disease (PD) is a progressive neurodegenerative characterized by resting tremor, bradykinesia, rigidity, postural instability, that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) the primary neurotransmitter involved in this disease, but cholinergic imbalance has been implicated. Current intervention PD focused on replenishing central DA, which provides remarkable temporary symptomatic relief does not address neuronal loss and progression of disease. It well established nicotinic receptors (nAChRs) can regulate DA release nicotine itself may have neuroprotective effects. Recent studies identified nAChRs nonneuronal cell types including glial cells, where they inflammatory responses. Given crucial role neuroinflammation dopaminergic degeneration, involvement microglia astrocytes response, provide novel therapeutic target prevention and/or treatment PD. In review, following brief discussion PD, we focus cells specifically their pathology treatment.

Язык: Английский

Процитировано

1
Heavy Metals Interactions with Neuroglia and Gut Microbiota: Implications for Huntington’s Disease DOI Open Access
Yousef Tizabi, Samia Bennani,

Nacer El Kouhen

и другие.

Опубликована: Июнь 12, 2024

Huntington’s disease (HD) is a rare but progressive and devastating neurodegenerative characterized by involuntary movements, cognitive decline, executive dysfunction, neuropsychiatric conditions such as anxiety depression. It follows an autosomal dominant inheritance pattern. Thus, child who has parent with the mutated huntingtin (mHTT) gene 50% chance of developing disease. Since HTT protein involved in many critical cellular processes including neurogenesis, brain development, energy metabolism, transcriptional regulation, synaptic activity, vesicle trafficking, cell signaling, autophagy, its aberrant aggregates lead to disruption numerous pathways neurodegeneration. Essential heavy metals are vital at low concentrations, however, higher can exacerbate HD disrupting glial-neuronal communication, and/or causing dysbiosis (disturbance gut microbiota, GM), both which neuroinflammation further Here, we discuss detail interactions iron, manganese copper glial-neuron communication GM indicate how this knowledge may pave way for development new generation disease-modifying therapies HD.

Язык: Английский

Процитировано

1
Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson’s Disease DOI Open Access
Matthew Miller,

Harold E. Landis,

Robert E. Miller

и другие.

Опубликована: Авг. 14, 2024

Intercellular adhesion molecule 1 (ICAM-1/CD54), a transmembrane glycoprotein, has been considered as one of the most important molecules during leukocyte recruitment. It is encoded by ICAM1 gene and plays central role in inflammation. It’s crucial many inflammatory diseases such ulcerative colitis rheumatoid arthritis are well established. Given that neuroinflammation, underscored microglial activation, key element neurodegenerative Parkinson’s disease (PD), we investigated whether ICAM-1 this progressive neurological condition if so, elucidate underpinning mechanisms. Specifically, were interested potential interaction between ICAM-1, glial cells ferroptosis, an iron-dependent form cell death recently implicated PD. We conclude there exist direct indirect (via T cells) influences on ferroptosis further elucidation these interactions can suggest novel intervention for devastating disease.

Язык: Английский

Процитировано

1