Colloids and Interface Science Communications,
Год журнала:
2022,
Номер
48, С. 100620 - 100620
Опубликована: Март 30, 2022
Diabetic
wounds
afflict
numerous
patients
due
to
poor
healing
and
risk
of
amputation,
mainly
caused
by
abnormal
inflammatory
conditions
peripheral
vascular
disease.
Herein,
we
designed
a
dual
functional
electrospun
membrane
consisting
polycaprolactone/sulfated
chitosan
nanofibers
polydopamine
(PDA)
nanoparticles
assist
diabetic
wound
healing.
The
endothelial
growth
factor
binds
with
sulfated
loaded
in
the
for
revascularization.
reactive
oxygen
species
(ROS)
scavenging
ability
PDA
sprayed
on
surface
is
verified
1,1-diphenyl-2-trinitrophenylhydrazine
method
(DPPH
method).
vivo
experiments
confirmed
could
alleviate
inflammation
promote
Such
anti-inflammatory
pro-angiogenic
effects
be
promising
candidate
chronic
care.
Advanced NanoBiomed Research,
Год журнала:
2022,
Номер
3(2)
Опубликована: Дек. 23, 2022
Diabetic
wound,
also
known
as
diabetic
foot
ulcer
(DFU),
is
a
form
of
chronic
lesion
that
disrupts
the
patient's
lifestyle
and,
in
severe
cases,
may
be
fatal.
Recent
endeavors
utilizing
enzymes,
particularly
nanozymes
conjunction
with
other
materials,
have
revealed
potential
to
treat
wounds.
Herein,
rational
structural
design
enzyme‐based
biomaterials
summarized
after
presenting
types
and
processes
enzymes
employed
wound
healing,
goal
better
understanding
interaction
between
biological
materials.
The
importance
enzyme
catalytic
activity,
coupled
new
therapeutic
treatment
strategies,
emphasized
use
for
healing.
This
review
represents
most
recent
development
innovation
healing
applications,
it
can
used
reference
guide
regenerative
biomedicines
from
nanoenzyme
biomaterials.
Pharmaceutical Science Advances,
Год журнала:
2023,
Номер
2, С. 100029 - 100029
Опубликована: Ноя. 23, 2023
Chronic
and
severe
inflammation
results
in
many
diseases
disorders
humans.
Currently,
available
conventional
anti-inflammatory
drugs
have
numerous
mild-to-severe
side
effects.
Thus,
there
is
a
need
for
safe,
effective,
affordable,
alternative
drugs.
This
study
aimed
to
evaluate
the
effect
of
sclareol
(SCL),
diterpene
alcohol
that
principal
ingredient
refined
oil
Salvia
sclarea
(L.),
through
vivo
silico
studies.
For
this,
we
examined
individual
combined
effects
SCL
(5,
10,
20
mg/kg)
standard
celecoxib
(CXB)
or
ketoprofen
(KPN)
at
42
mg/kg
(p.o.)
on
formalin-induced
inflammatory
Swiss
mice.
Additionally,
an
analysis
was
conducted
potential
mechanism
this
study.
potentiality
standards
interact
with
cyclooxygenase
(COX-1
COX-2)
receptors.
Our
findings
suggest
exhibits
dose-dependent
SCL-20
significantly
reduced
number
paw
licks
edema
diameters.
Moreover,
CXN-42
KPN-42
demonstrated
better
In
comparison
standards,
revealed
comparable
binding
interaction
COX-1
COX-2
receptors
molecular
docking
Furthermore,
displayed
remarkable
pharmacokinetic
characteristics.
conclusion,
dose-dependently
diameters
animals.
may
be
responsible
producing
by
interacting
Bioactive Materials,
Год журнала:
2023,
Номер
33, С. 460 - 482
Опубликована: Ноя. 29, 2023
Ischemic
cardiomyopathy
(ICM)
affect
millions
of
patients
globally.
Decellularized
extracellular
matrix
materials
(dECM)
have
components,
microstructure
and
mechanical
properties
similar
to
healthy
cardiac
tissues,
can
be
manufactured
into
various
forms
implantable
biomaterials
including
injectable
hydrogels
or
epicardial
patches,
which
been
extensively
reported
attenuate
pathological
left
ventricular
remodeling
maintain
heart
function.
Recently,
dECM
medical
devices
for
ICM
treatment
approved
clinical
use
studied
in
trials,
exhibiting
considerable
translation
potential.
Cells,
growth
factors
other
bioactive
agents
incorporated
with
different
improve
the
therapeutic
outcomes.
In
addition,
more
detailed
aspects
biological
effects
mechanisms
are
being
revealed.
This
review
summarized
recent
advances
from
variable
sources
repair,
extraction
matrix,
cell
integration,
smart
manufacturing
patch
materials,
their
applications.
Besides,
this
provides
an
outlook
on
cutting-edge
development
directions
field.
Materials & Design,
Год журнала:
2022,
Номер
222, С. 111069 - 111069
Опубликована: Авг. 17, 2022
Implant-associated
infection
(IAI)
and
insufficient
implant
osseointegration
are
two
primary
concerns
of
failure.
Polyetheretherketone
(PEEK),
though
widely
used
in
orthopedic
implants,
has
been
limited
clinical
applications
by
its
poor
osteogenic
activity,
inferior
antibacterial
ability,
improper
immunological
reactions.
In
this
study,
copper
(Cu),
a
multi-functional
bioactive
ion,
is
incorporated
into
the
polydopamine
(PDA)
coating
on
PEEK
surfaces
using
metal-catecholamine
assembling
strategy.
This
DA-CuII
induces
spatial
distribution
Cu,
exerting
biological
functions
simultaneously
through
passive
contact
active
release
Cu.
coated
exhibit
not
only
superior
abilities
osteogenesis,
angiogenesis,
antibiosis
but
also
possess
immunomodulatory
effects
to
enhance
macrophages-mediated
osteogenesis
activity.
Moreover,
mild
necessary
inflammatory
response,
exhibiting
excellent
ability
osseointegration.
Our
findings
suggest
that
potential
for
implants
provides
new
insight
novel
modification
strategies
materials.
Colloids and Interface Science Communications,
Год журнала:
2022,
Номер
48, С. 100620 - 100620
Опубликована: Март 30, 2022
Diabetic
wounds
afflict
numerous
patients
due
to
poor
healing
and
risk
of
amputation,
mainly
caused
by
abnormal
inflammatory
conditions
peripheral
vascular
disease.
Herein,
we
designed
a
dual
functional
electrospun
membrane
consisting
polycaprolactone/sulfated
chitosan
nanofibers
polydopamine
(PDA)
nanoparticles
assist
diabetic
wound
healing.
The
endothelial
growth
factor
binds
with
sulfated
loaded
in
the
for
revascularization.
reactive
oxygen
species
(ROS)
scavenging
ability
PDA
sprayed
on
surface
is
verified
1,1-diphenyl-2-trinitrophenylhydrazine
method
(DPPH
method).
vivo
experiments
confirmed
could
alleviate
inflammation
promote
Such
anti-inflammatory
pro-angiogenic
effects
be
promising
candidate
chronic
care.
