Sclareol exerts an anti-inflammatory effect, possibly through COXs inhibition pathway: In vivo and in silico studies

Pharmaceutical Science Advances, Journal Year: 2023, Volume and Issue: 2, P. 100029 - 100029

Published: Nov. 23, 2023

Chronic and severe inflammation results in many diseases disorders humans. Currently, available conventional anti-inflammatory drugs have numerous mild-to-severe side effects. Thus, there is a need for safe, effective, affordable, alternative drugs. This study aimed to evaluate the effect of sclareol (SCL), diterpene alcohol that principal ingredient refined oil Salvia sclarea (L.), through vivo silico studies. For this, we examined individual combined effects SCL (5, 10, 20 mg/kg) standard celecoxib (CXB) or ketoprofen (KPN) at 42 mg/kg (p.o.) on formalin-induced inflammatory Swiss mice. Additionally, an analysis was conducted potential mechanism this study. potentiality standards interact with cyclooxygenase (COX-1 COX-2) receptors. Our findings suggest exhibits dose-dependent SCL-20 significantly reduced number paw licks edema diameters. Moreover, CXN-42 KPN-42 demonstrated better In comparison standards, revealed comparable binding interaction COX-1 COX-2 receptors molecular docking Furthermore, displayed remarkable pharmacokinetic characteristics. conclusion, dose-dependently diameters animals. may be responsible producing by interacting

Language: Английский

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Tuning foreign body response with tailor-engineered nanoscale surface modifications: fundamentals to clinical applications

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(33), P. 7834 - 7854

Published: Jan. 1, 2023

The synergistic effect of nanotopography and chemistry in modulating different stages the foreign body response, impacting cell–protein–biomaterial interactions.

Language: Английский

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Decellularized extracellular matrix materials for treatment of ischemic cardiomyopathy

Bioactive Materials, Journal Year: 2023, Volume and Issue: 33, P. 460 - 482

Published: Nov. 29, 2023

Ischemic cardiomyopathy (ICM) affect millions of patients globally. Decellularized extracellular matrix materials (dECM) have components, microstructure and mechanical properties similar to healthy cardiac tissues, can be manufactured into various forms implantable biomaterials including injectable hydrogels or epicardial patches, which been extensively reported attenuate pathological left ventricular remodeling maintain heart function. Recently, dECM medical devices for ICM treatment approved clinical use studied in trials, exhibiting considerable translation potential. Cells, growth factors other bioactive agents incorporated with different improve the therapeutic outcomes. In addition, more detailed aspects biological effects mechanisms are being revealed. This review summarized recent advances from variable sources repair, extraction matrix, cell integration, smart manufacturing patch materials, their applications. Besides, this provides an outlook on cutting-edge development directions field.

Language: Английский

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Stimuli‐Sensitive Nanotherapies for the Treatment of Osteoarthritis

Macromolecular Bioscience, Journal Year: 2021, Volume and Issue: 21(11)

Published: Aug. 16, 2021

Abstract Osteoarthritis (OA) is a common chronic inflammatory disease in the joints. It one of leading causes disability with increasing morbidity, which has become serious clinical issues. Current treatments would only provide temporary relief due to lack early diagnosis and effective therapy, thus replacement joints may be needed when OA deteriorates. Although intra‐articular injection oral administration drugs are helpful for treatment, they suffering from systemic toxicity, short retention time joint, insufficient bioavailability. Nanomedicine potential improve drug delivery efficiency targeting ability. In this focused progress review, particle‐based loading systems that can achieve targeted triggered release summarized. Stimuli‐responsive nanocarriers sensitive endogenous microenvironmental signals such as reactive oxygen species, enzymes, pH, temperature, well external stimuli light therapy introduced review. Furthermore, associated imaging treatment The applications nanotherapies finally discussed.

Language: Английский

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Mussel-inspired dopamine-CuII coated polyetheretherketone surface with direct and immunomodulatory effect to facilitate osteogenesis, angiogenesis, and antibacterial ability

Materials & Design, Journal Year: 2022, Volume and Issue: 222, P. 111069 - 111069

Published: Aug. 17, 2022

Implant-associated infection (IAI) and insufficient implant osseointegration are two primary concerns of failure. Polyetheretherketone (PEEK), though widely used in orthopedic implants, has been limited clinical applications by its poor osteogenic activity, inferior antibacterial ability, improper immunological reactions. In this study, copper (Cu), a multi-functional bioactive ion, is incorporated into the polydopamine (PDA) coating on PEEK surfaces using metal-catecholamine assembling strategy. This DA-CuII induces spatial distribution Cu, exerting biological functions simultaneously through passive contact active release Cu. coated exhibit not only superior abilities osteogenesis, angiogenesis, antibiosis but also possess immunomodulatory effects to enhance macrophages-mediated osteogenesis activity. Moreover, mild necessary inflammatory response, exhibiting excellent ability osseointegration. Our findings suggest that potential for implants provides new insight novel modification strategies materials.

Language: Английский

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