ACS Applied Bio Materials,
Год журнала:
2022,
Номер
5(9), С. 4055 - 4085
Опубликована: Авг. 18, 2022
Currently,
the
clinic's
treatment
of
acute/chronic
wounds
is
still
unsatisfactory
due
to
lack
functional
and
appropriate
wound
dressings.
Intelligent
multifunctional
dressings
are
considered
most
advanced
modalities.
It
essential
design
develop
with
required
functions
according
microenvironment
in
clinical
treatment.
This
work
summarizes
characteristics
various
common
wounds,
such
as
acute
wound,
diabetic
burns
scalded
mucosal
ulcers
wound.
Furthermore,
factors
transformation
from
chronic
were
analyzed.
Then
we
focused
on
summarizing
how
researchers
fully
thoroughly
combined
complex
modern
technology
ensure
usability
value
dressing,
photothermal-sensitive
dressings,
dressing
(pH-sensitive
ROS-sensitive
osmotic
pressure
dressings),
hemostatic
guiding
tissue
regeneration
microneedle
3D/4D
printing
Finally,
revolutionary
development
transform
existing
into
needs
soon
possible
have
carried
out
a
reasonable
meaningful
outlook.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2022,
Номер
17(3), С. 353 - 384
Опубликована: Янв. 24, 2022
Bacterial
infection
and
the
ever-increasing
bacterial
resistance
have
imposed
severe
threat
to
human
health.
And
contamination
could
significantly
menace
wound
healing
process.
Considering
sophisticated
process,
novel
strategies
for
skin
tissue
engineering
are
focused
on
integration
of
bioactive
ingredients,
antibacterial
agents
included,
into
biomaterials
with
different
morphologies
improve
cell
behaviors
promote
healing.
However,
a
comprehensive
review
anti-bacterial
dressing
enhance
has
not
been
reported.
In
this
review,
various
as
dressings
will
be
discussed.
Different
kinds
agents,
including
antibiotics,
nanoparticles
(metal
metallic
oxides,
light-induced
agents),
cationic
organic
others,
their
recent
advances
summarized.
Biomaterial
selection
fabrication
structures
forms,
films,
hydrogel,
electrospun
nanofibers,
sponge,
foam
three-dimension
(3D)
printed
scaffold
regeneration,
elaborated
Current
challenges
future
perspectives
presented
in
multidisciplinary
field.
We
envision
that
provide
general
insight
elegant
design
further
refinement
dressing.
Materials Today Bio,
Год журнала:
2023,
Номер
19, С. 100582 - 100582
Опубликована: Фев. 16, 2023
Hydrogels
are
essential
biomaterials
due
to
their
favorable
biocompatibility,
mechanical
properties
similar
human
soft
tissue
extracellular
matrix,
and
repair
properties.
In
skin
wound
repair,
hydrogels
with
antibacterial
functions
especially
suitable
for
dressing
applications,
so
novel
hydrogel
dressings
have
attracted
widespread
attention,
including
the
design
of
components,
optimization
preparation
methods,
strategies
reduce
bacterial
resistance,
etc.
this
review,
we
discuss
fabrication
challenges
associated
crosslinking
methods
chemistry
materials.
We
investigated
advantages
limitations
(antibacterial
effects
mechanisms)
different
components
in
achieve
good
properties,
response
stimuli
such
as
light,
sound,
electricity
resistance.
Conclusively,
provide
a
systematic
summary
findings
(crosslinking
methods)
an
outlook
on
long-lasting
effects,
broader
spectrum,
diversified
forms,
future
development
prospects
field.
ACS Nano,
Год журнала:
2022,
Номер
16(11), С. 19491 - 19508
Опубликована: Ноя. 2, 2022
Chronic
wounds
are
characterized
by
long-term
inflammation
and
persistent
infection,
which
make
them
difficult
to
heal.
Therefore,
an
urgent
desire
is
develop
a
multifunctional
wound
dressing
that
can
prevent
infection
promote
healing
creating
favorable
microenvironment.
In
this
study,
curcumin-based
metal-organic
framework
(QCSMOF-Van),
loaded
with
vancomycin
coated
quaternary
ammonium
salt
chitosan
(QCS),
was
prepared.
Multifunctional
composite
hydrogels
were
conveniently
synthesized
combining
methacrylic
anhydride
modified
gelatin
oxidized
sodium
alginate
QCSMOF-Van
through
radical
polymerization
Schiff
base
reaction.
It
important
note
the
could
capture
bacteria
positive
charges
on
surface
of
QCS.
process,
due
synergistic
effect
broad-spectrum
antibacterial
Zn2+
vancomycin,
metabolism
well
inhibited,
efficient
capturing
rapid
killing
achieved.
The
precisely
regulate
balance
M1/M2
phenotypes
macrophages,
thereby
promoting
regeneration
nerves
blood
vessels,
promotes
chronic
wounds.
This
advanced
cascade
management
strategy
for
tissue
highlights
potential
in
dressings.
Abstract
Macrophages
are
highly
heterogeneous
and
exhibit
a
diversity
of
functions
phenotypes.
They
can
be
divided
into
pro‐inflammatory
macrophages
(M1)
anti‐inflammatory
(M2).
Diabetic
wounds
characterized
by
prolonged
inflammatory
phase
difficulty
in
healing
due
to
the
accumulation
wound.
Therefore,
hydrogel
dressings
with
macrophage
heterogeneity
regulation
function
hold
great
promise
promoting
diabetic
wound
clinical
applications.
However,
precise
conversion
M1
M2
simple
biosafe
approaches
is
still
challenge.
Here,
an
all‐natural
ability
regulate
developed
promote
angiogenesis
healing.
The
protocatechuic
aldehyde
hybridized
collagen‐based
exhibits
good
bioadhesive
antibacterial
properties
as
well
reactive
oxygen
species
scavenging
ability.
More
importantly,
able
convert
without
need
for
any
additional
ingredients
or
external
intervention.
This
safe
immunomodulatory
approach
shows
application
potential
shortening
repair
accelerating
Bioactive Materials,
Год журнала:
2022,
Номер
19, С. 360 - 375
Опубликована: Апрель 26, 2022
The
high
demand
for
rapid
wound
healing
has
spurred
the
development
of
multifunctional
and
smart
bioadhesives
with
strong
bioadhesion,
antibacterial
effect,
real-time
sensing,
wireless
communication,
on-demand
treatment
capabilities.
Bioadhesives
bio-inspired
structures
chemicals
have
shown
unprecedented
adhesion
strengths,
as
well
tunable
optical,
electrical,
bio-dissolvable
properties.
Accelerated
been
achieved
via
directly
released
growth
factors,
material
or
drug-induced
host
immune
responses,
delivery
curative
cells.
Most
recently,
integration
biosensing
modules
units
in
a
closed-loop
system
yielded
bioadhesives,
allowing
sensing
physiological
conditions
(e.g.,
pH,
temperature,
uric
acid,
glucose,
cytokine)
iterative
feedback
drastically
enhanced,
stage-specific
by
triggering
drug
to
avoid
infection
prolonged
inflammation.
Despite
advances
burgeoning
field,
challenges
still
exist
design
fabrication
integrated
systems,
particularly
chronic
wounds,
presenting
significant
opportunities
future
next-generation
materials
systems.
ACS Applied Materials & Interfaces,
Год журнала:
2021,
Номер
14(20), С. 23002 - 23021
Опубликована: Дек. 28, 2021
Although
reactive
oxygen
species
(ROS)
are
essential
for
cellular
processes,
excessive
ROS
could
be
a
major
cause
of
various
inflammatory
diseases
because
the
oxidation
proteins,
DNA,
and
membrane
lipids.
It
has
recently
been
suggested
that
amount
thus
regulated
to
treat
such
physiological
disorders.
A
ROS-scavenging
hydrogel
is
promising
candidate
therapeutic
applications
its
high
biocompatibility,
3D
matrix,
ability
modified.
Approaches
conferring
antioxidant
properties
normal
hydrogels
include
embedding
catalytic
nanoparticles,
modifying
polymer
chains
with
ROS-adsorbing
organic
moieties,
incorporating
ROS-labile
linkers
in
backbones.
Such
can
used
wound
healing,
cardiovascular
diseases,
bone
repair,
ocular
neurodegenerative
eliminate
oxidative
stress,
accelerate
regeneration
process,
show
synergetic
effects
other
drugs
or
molecules.
In
this
review,
mechanisms
by
which
generated
scavenged
body
outlined,
levels
resulting
stress
on
described.
Next,
mechanism
scavenging
explained
depending
agents
embedded
within
hydrogel.
Lastly,
recent
achievements
development
inflammation-associated
presented.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2021,
Номер
9
Опубликована: Сен. 20, 2021
Wound
healing
is
a
common
physiological
process
which
consists
of
sequence
molecular
and
cellular
events
that
occur
following
the
onset
tissue
lesion
in
order
to
reconstitute
barrier
between
body
external
environment.
The
inherent
properties
hydrogels
allow
damaged
heal
by
supporting
hydrated
environment
has
long
been
explored
wound
management
aid
autolytic
debridement.
However,
chronic
non-healing
wounds
require
added
therapeutic
features
can
be
achieved
incorporation
biomolecules
cells
promote
faster
better
outcomes.
In
recent
decades,
numerous
have
developed
modified
match
time
scale
for
distinct
stages
healing.
This
review
will
discuss
effects
various
types
on
pathophysiology,
as
well
ideal
characteristics
healing,
crosslinking
mechanism,
fabrication
techniques
design
considerations
hydrogel
engineering.
Finally,
several
challenges
related
adopting
future
perspectives
are
discussed.
