GelMA-based bioactive hydrogel scaffolds with multiple bone defect repair functions: therapeutic strategies and recent advances

Biomaterials Research, Год журнала: 2023, Номер 27(1)

Опубликована: Фев. 9, 2023

Currently, the clinical treatment of critical bone defects attributed to various causes remains a great challenge, and repairing these with synthetic substitutes is most common strategy. In general, tissue engineering materials that mimic structural, mechanical biological properties natural have been extensively applied fill promote in situ regeneration. Hydrogels extracellular matrix (ECM)-like are materials, among which methacrylate-based gelatin (GelMA) hydrogels widely used because their tunable properties, excellent photocrosslinking capability good biocompatibility. Owing lack osteogenic activity, however, GelMA combined other types activities improve current composites. There three main aspects consider when enhancing regenerative performance composite materials: osteoconductivity, vascularization osteoinduction. Bioceramics, bioglass, biomimetic scaffolds, inorganic ions, bionic periosteum, growth factors two-dimensional (2D) nanomaterials combinations achieve enhanced regeneration activities. Three-dimensional (3D)-bioprinted scaffolds popular research topic (BTE), printed customized suitable for restoring large irregular due shape structural tunability, Herein, recent progress on GelMA-based hydrogel as multifunctional platforms plastic or orthopedic clinics systematically reviewed summarized. These strategies pave way design effective reconstruction biosafety. This review provides novel insights into development trends (BTE) correcting defects, contents summarized emphasized from perspectives (osteoconductivity, vascularization, osteoinduction 3D-bioprinting). addition, advantages deficiencies put forward, corresponding improvement measures presented prior application near future (created BioRender.com).

Язык: Английский

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Bacterial cellulose-based hydrogel with antibacterial activity and vascularization for wound healing

Carbohydrate Polymers, Год журнала: 2023, Номер 308, С. 120647 - 120647

Опубликована: Фев. 3, 2023

Язык: Английский

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Human urine-derived stem cell exosomes delivered via injectable GelMA templated hydrogel accelerate bone regeneration

Materials Today Bio, Год журнала: 2023, Номер 19, С. 100569 - 100569

Опубликована: Фев. 1, 2023

The key to critical bone regeneration in tissue engineering relies on an ideal bio-scaffold coated with a controlled release of growth factors. Gelatin methacrylate (GelMA) and Hyaluronic acid (HAMA) have been novel topic interest while introducing appropriate nano-hydroxyapatite (nHAP) improve its mechanical properties. And the exosomes derived from human urine-derived stem cells (human USCEXOs) also reported promote osteogenesis engineering. present study aimed design new GelMA-HAMA/nHAP composite hydrogel as drug delivery system. USCEXOs were encapsulated slow-released for better osteogenesis. characterization GelMA-based showed excellent performance vitro studies that USCEXOs/GelMA-HAMA/nHAP could marrow mesenchymal (BMSCs) angiogenesis endothelial progenitor (EPCs), respectively. Meanwhile, vivo results confirmed this significantly defect repair cranial rat model. In addition, we found can formation H-type vessels area, enhancing therapeutic effect. conclusion, our findings suggested controllable biocompatible may effectively by coupling angiogenesis.

Язык: Английский

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Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy

Advanced Science, Год журнала: 2023, Номер 11(1)

Опубликована: Ноя. 20, 2023

Abstract Deregulated inflammations induced by various factors are one of the most common diseases in people's daily life, while severe inflammation can even lead to death. Thus, efficient treatment has always been hot topic research medicine. In past decades, as a potential biomaterial, stimuli‐responsive hydrogels have focus attention for due their excellent biocompatibility and design flexibility. Recently, thanks rapid development nanotechnology material science, more efforts made develop safer, personal effective therapy some frequent but tough such sepsis, rheumatoid arthritis, osteoarthritis, periodontitis, ulcerative colitis. Herein, from recent studies articles, conventional emerging delivery anti‐inflammatory drugs summarized. And prospects clinical translation future also discussed further detail.

Язык: Английский

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Tunable Zeolitic Imidazolate Framework‐8 Nanoparticles for Biomedical Applications

Small Methods, Год журнала: 2023, Номер 8(3)

Опубликована: Ноя. 23, 2023

Abstract Zeolite imidazole framework‐8 (ZIF‐8) is the most prestigious one among zeolitic imidazolate framework (ZIF) with tunable dimensions and unique morphological features. Utilizing its synthetic adjustability structural regularity, ZIF‐8 exhibits enhanced flexibility, allowing for a wide range of functionalities, such as loading nanoparticle components while preserving biomolecules activity. Extensive efforts are made from investigating synthesis techniques to develop novel applications over decades. In this review, development recent progress various approaches briefly summarized. addition, interesting properties adjustable porosity, excellent thermal, chemical stabilities introduced. Further, five representative biomedical highlighted based on above physicochemical properties. Finally, remaining challenges offered insights into future outlook also discussed. This review aims understand co‐relationships between structures offering opportunity construct attractive materials promising characteristics.

Язык: Английский

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Strategies of functionalized GelMA-based bioinks for bone regeneration: Recent advances and future perspectives

Bioactive Materials, Год журнала: 2024, Номер 38, С. 346 - 373

Опубликована: Май 9, 2024

Gelatin methacryloyl (GelMA) hydrogels is a widely used bioink because of its good biological properties and tunable physicochemical properties, which has been in variety tissue engineering regeneration. However, pure GelMA limited by the weak mechanical strength lack continuous osteogenic induction environment, difficult to meet needs bone repair. Moreover, are unable respond complex stimuli therefore adapt physiological pathological microenvironments. This review focused on functionalization strategies hydrogel based bioinks for The synthesis process was described details, various functional methods requirements regeneration, including strength, porosity, vascularization, differentiation, immunoregulation patient specific repair, etc. In addition, response smart GelMA-based external physical stimulation internal microenvironment stimulation, as well achieve both disease treatment regeneration presence common diseases (such inflammation, infection, tumor) also briefly reviewed. Finally, we emphasized current challenges possible exploration directions

Язык: Английский

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A five-in-one novel MOF-modified injectable hydrogel with thermo-sensitive and adhesive properties for promoting alveolar bone repair in periodontitis: Antibacterial, hemostasis, immune reprogramming, pro-osteo-/angiogenesis and recruitment

Bioactive Materials, Год журнала: 2024, Номер 41, С. 239 - 256

Опубликована: Июль 24, 2024

Periodontitis is a chronic inflammatory disease caused by plaque that destroys the alveolar bone tissues, resulting in tooth loss. Poor eradication of pathogenic microorganisms, persistent malignant inflammation and impaired osteo-/angiogenesis are currently primary challenges to control progression rebuild damaged bone. However, existing treatments for periodontitis fail comprehensively address these issues. Herein, an injectable composite hydrogel (SFD/CS/ZIF-8@QCT) encapsulating quercetin-modified zeolitic imidazolate framework-8 (ZIF-8@QCT) developed. This possesses thermo-sensitive adhesive properties, which can provide excellent flowability post-injection stability, resist oral fluid washout as well achieve effective tissue adhesion. Inspirationally, it observed SFD/CS/ZIF-8@QCT exhibits rapid localized hemostatic effect following implantation, then virtue sustained release zinc ions quercetin exerts collective functions including antibacterial, immunomodulation, pro-osteo-/angiogenesis pro-recruitment, ultimately facilitating regeneration. Notably, our study also demonstrates inhibition PDLSCs under due strong energy metabolism powerful activation oxidative stress autophagy, whereas synergistic effects released reversing biological processes. Overall, presents innovative insights into advancement biomaterials regenerate periodontitis.

Язык: Английский

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New insights into nanotherapeutics for periodontitis: a triple concerto of antimicrobial activity, immunomodulation and periodontium regeneration

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 4, 2024

Abstract Periodontitis is a chronic inflammatory disease caused by the local microbiome and host immune response, resulting in periodontal structure damage even tooth loss. Scaling root planning combined with antibiotics are conventional means of nonsurgical treatment periodontitis, but they insufficient to fully heal periodontitis due intractable bacterial attachment drug resistance. Novel effective therapeutic options clinical therapy remain scarce. Nanotherapeutics achieve stable cell targeting, oral retention smart release great flexibility changing chemical composition or physical characteristics nanoparticles. Meanwhile, protectiveness high surface area volume ratio nanoparticles enable loading, ensuring remarkable efficacy. Currently, combination advanced novel strategies most active research treatment. In this review, we first introduce pathogenesis then summarize state-of-the-art nanotherapeutic based on triple concerto antibacterial activity, immunomodulation periodontium regeneration, particularly focusing mechanism ingenious design nanomedicines. Finally, challenges prospects nano for discussed from perspective current problems future development trends. Graphical

Язык: Английский

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Hydrogels as a Potential Biomaterial for Multimodal Therapeutic Applications

Molecular Pharmaceutics, Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

Hydrogels, composed of hydrophilic polymer networks, have emerged as versatile materials in biomedical applications due to their high water content, biocompatibility, and tunable properties. They mimic natural tissue environments, enhancing cell viability function. Hydrogels' physical properties allow for tailored antibacterial biomaterial, wound dressings, cancer treatment, engineering scaffolds. Their ability respond physiological stimuli enables the controlled release therapeutics, while porous structure supports nutrient diffusion waste removal, fostering regeneration repair. In healing, hydrogels provide a moist environment, promote migration, deliver bioactive agents antibiotics, healing process. For therapy, they offer localized drug delivery systems that target tumors, minimizing systemic toxicity improving therapeutic efficacy. Ocular therapy benefits from hydrogels' capacity form contact lenses maintain prolonged with eye surface, treatment outcomes various diseases. mucosal delivery, facilitate administration therapeutics across barriers, ensuring sustained improved bioavailability drugs. Tissue sees scaffolds extracellular matrix, supporting growth differentiation repairing damaged tissues. Similarly, bone regeneration, loaded factors stem cells osteogenesis accelerate healing. This article highlights some recent advances use applications, driven by be engineered specific needs interactive biological

Язык: Английский

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Recent progress of MOF-based antibacterial hydrogels

Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150641 - 150641

Опубликована: Март 26, 2024

Язык: Английский

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