ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(5), С. 5582 - 5597
Опубликована: Янв. 23, 2024
The
tendon-bone
interface
has
a
complex
gradient
structure
vital
for
stress
transmission
and
pressure
buffering
during
movement.
However,
injury
to
the
tissue,
especially
tendon
cartilage
components,
often
hinders
complete
restoration
of
original
structure.
Here,
metal
ion
network
hydrogel
scaffold,
with
capability
targeting
multitissue,
was
constructed
through
photopolymerization
LHERHLNNN
peptide-modified
zeolitic
imidazolate
framework-8
(LZIF-8)
WYRGRL
magnesium
metal-organic
framework
(WMg-MOF)
within
which
could
facilitate
directional
migration
ions
form
dynamic
gradient,
thereby
achieving
integrated
regeneration
tissues.
LZIF-8
selectively
migrated
tendon,
releasing
zinc
enhance
collagen
secretion
promoting
repair.
Simultaneously,
WMg-MOF
cartilage,
induce
cell
differentiation
facilitating
regeneration.
Infrared
spectroscopy
confirmed
successful
peptide
modification
nano
ZIF-8
Mg-MOF.
Fluorescence
imaging
validated
that
LZIF-8/WMg-MOF
had
longer
retention,
indirectly
confirming
their
interface.
In
summary,
this
dual-targeted
scaffold
potential
synchronized
multitissue
at
compromised
interface,
offering
favorable
prospects
its
application
in
reconstruction
characterized
by
Biomaterials Research,
Год журнала:
2023,
Номер
27(1)
Опубликована: Фев. 9, 2023
Currently,
the
clinical
treatment
of
critical
bone
defects
attributed
to
various
causes
remains
a
great
challenge,
and
repairing
these
with
synthetic
substitutes
is
most
common
strategy.
In
general,
tissue
engineering
materials
that
mimic
structural,
mechanical
biological
properties
natural
have
been
extensively
applied
fill
promote
in
situ
regeneration.
Hydrogels
extracellular
matrix
(ECM)-like
are
materials,
among
which
methacrylate-based
gelatin
(GelMA)
hydrogels
widely
used
because
their
tunable
properties,
excellent
photocrosslinking
capability
good
biocompatibility.
Owing
lack
osteogenic
activity,
however,
GelMA
combined
other
types
activities
improve
current
composites.
There
three
main
aspects
consider
when
enhancing
regenerative
performance
composite
materials:
osteoconductivity,
vascularization
osteoinduction.
Bioceramics,
bioglass,
biomimetic
scaffolds,
inorganic
ions,
bionic
periosteum,
growth
factors
two-dimensional
(2D)
nanomaterials
combinations
achieve
enhanced
regeneration
activities.
Three-dimensional
(3D)-bioprinted
scaffolds
popular
research
topic
(BTE),
printed
customized
suitable
for
restoring
large
irregular
due
shape
structural
tunability,
Herein,
recent
progress
on
GelMA-based
hydrogel
as
multifunctional
platforms
plastic
or
orthopedic
clinics
systematically
reviewed
summarized.
These
strategies
pave
way
design
effective
reconstruction
biosafety.
This
review
provides
novel
insights
into
development
trends
(BTE)
correcting
defects,
contents
summarized
emphasized
from
perspectives
(osteoconductivity,
vascularization,
osteoinduction
3D-bioprinting).
addition,
advantages
deficiencies
put
forward,
corresponding
improvement
measures
presented
prior
application
near
future
(created
BioRender.com).
Materials Today Bio,
Год журнала:
2023,
Номер
19, С. 100569 - 100569
Опубликована: Фев. 1, 2023
The
key
to
critical
bone
regeneration
in
tissue
engineering
relies
on
an
ideal
bio-scaffold
coated
with
a
controlled
release
of
growth
factors.
Gelatin
methacrylate
(GelMA)
and
Hyaluronic
acid
(HAMA)
have
been
novel
topic
interest
while
introducing
appropriate
nano-hydroxyapatite
(nHAP)
improve
its
mechanical
properties.
And
the
exosomes
derived
from
human
urine-derived
stem
cells
(human
USCEXOs)
also
reported
promote
osteogenesis
engineering.
present
study
aimed
design
new
GelMA-HAMA/nHAP
composite
hydrogel
as
drug
delivery
system.
USCEXOs
were
encapsulated
slow-released
for
better
osteogenesis.
characterization
GelMA-based
showed
excellent
performance
vitro
studies
that
USCEXOs/GelMA-HAMA/nHAP
could
marrow
mesenchymal
(BMSCs)
angiogenesis
endothelial
progenitor
(EPCs),
respectively.
Meanwhile,
vivo
results
confirmed
this
significantly
defect
repair
cranial
rat
model.
In
addition,
we
found
can
formation
H-type
vessels
area,
enhancing
therapeutic
effect.
conclusion,
our
findings
suggested
controllable
biocompatible
may
effectively
by
coupling
angiogenesis.
Abstract
Deregulated
inflammations
induced
by
various
factors
are
one
of
the
most
common
diseases
in
people's
daily
life,
while
severe
inflammation
can
even
lead
to
death.
Thus,
efficient
treatment
has
always
been
hot
topic
research
medicine.
In
past
decades,
as
a
potential
biomaterial,
stimuli‐responsive
hydrogels
have
focus
attention
for
due
their
excellent
biocompatibility
and
design
flexibility.
Recently,
thanks
rapid
development
nanotechnology
material
science,
more
efforts
made
develop
safer,
personal
effective
therapy
some
frequent
but
tough
such
sepsis,
rheumatoid
arthritis,
osteoarthritis,
periodontitis,
ulcerative
colitis.
Herein,
from
recent
studies
articles,
conventional
emerging
delivery
anti‐inflammatory
drugs
summarized.
And
prospects
clinical
translation
future
also
discussed
further
detail.
Abstract
Zeolite
imidazole
framework‐8
(ZIF‐8)
is
the
most
prestigious
one
among
zeolitic
imidazolate
framework
(ZIF)
with
tunable
dimensions
and
unique
morphological
features.
Utilizing
its
synthetic
adjustability
structural
regularity,
ZIF‐8
exhibits
enhanced
flexibility,
allowing
for
a
wide
range
of
functionalities,
such
as
loading
nanoparticle
components
while
preserving
biomolecules
activity.
Extensive
efforts
are
made
from
investigating
synthesis
techniques
to
develop
novel
applications
over
decades.
In
this
review,
development
recent
progress
various
approaches
briefly
summarized.
addition,
interesting
properties
adjustable
porosity,
excellent
thermal,
chemical
stabilities
introduced.
Further,
five
representative
biomedical
highlighted
based
on
above
physicochemical
properties.
Finally,
remaining
challenges
offered
insights
into
future
outlook
also
discussed.
This
review
aims
understand
co‐relationships
between
structures
offering
opportunity
construct
attractive
materials
promising
characteristics.
Bioactive Materials,
Год журнала:
2024,
Номер
38, С. 346 - 373
Опубликована: Май 9, 2024
Gelatin
methacryloyl
(GelMA)
hydrogels
is
a
widely
used
bioink
because
of
its
good
biological
properties
and
tunable
physicochemical
properties,
which
has
been
in
variety
tissue
engineering
regeneration.
However,
pure
GelMA
limited
by
the
weak
mechanical
strength
lack
continuous
osteogenic
induction
environment,
difficult
to
meet
needs
bone
repair.
Moreover,
are
unable
respond
complex
stimuli
therefore
adapt
physiological
pathological
microenvironments.
This
review
focused
on
functionalization
strategies
hydrogel
based
bioinks
for
The
synthesis
process
was
described
details,
various
functional
methods
requirements
regeneration,
including
strength,
porosity,
vascularization,
differentiation,
immunoregulation
patient
specific
repair,
etc.
In
addition,
response
smart
GelMA-based
external
physical
stimulation
internal
microenvironment
stimulation,
as
well
achieve
both
disease
treatment
regeneration
presence
common
diseases
(such
inflammation,
infection,
tumor)
also
briefly
reviewed.
Finally,
we
emphasized
current
challenges
possible
exploration
directions
Bioactive Materials,
Год журнала:
2024,
Номер
41, С. 239 - 256
Опубликована: Июль 24, 2024
Periodontitis
is
a
chronic
inflammatory
disease
caused
by
plaque
that
destroys
the
alveolar
bone
tissues,
resulting
in
tooth
loss.
Poor
eradication
of
pathogenic
microorganisms,
persistent
malignant
inflammation
and
impaired
osteo-/angiogenesis
are
currently
primary
challenges
to
control
progression
rebuild
damaged
bone.
However,
existing
treatments
for
periodontitis
fail
comprehensively
address
these
issues.
Herein,
an
injectable
composite
hydrogel
(SFD/CS/ZIF-8@QCT)
encapsulating
quercetin-modified
zeolitic
imidazolate
framework-8
(ZIF-8@QCT)
developed.
This
possesses
thermo-sensitive
adhesive
properties,
which
can
provide
excellent
flowability
post-injection
stability,
resist
oral
fluid
washout
as
well
achieve
effective
tissue
adhesion.
Inspirationally,
it
observed
SFD/CS/ZIF-8@QCT
exhibits
rapid
localized
hemostatic
effect
following
implantation,
then
virtue
sustained
release
zinc
ions
quercetin
exerts
collective
functions
including
antibacterial,
immunomodulation,
pro-osteo-/angiogenesis
pro-recruitment,
ultimately
facilitating
regeneration.
Notably,
our
study
also
demonstrates
inhibition
PDLSCs
under
due
strong
energy
metabolism
powerful
activation
oxidative
stress
autophagy,
whereas
synergistic
effects
released
reversing
biological
processes.
Overall,
presents
innovative
insights
into
advancement
biomaterials
regenerate
periodontitis.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Янв. 4, 2024
Abstract
Periodontitis
is
a
chronic
inflammatory
disease
caused
by
the
local
microbiome
and
host
immune
response,
resulting
in
periodontal
structure
damage
even
tooth
loss.
Scaling
root
planning
combined
with
antibiotics
are
conventional
means
of
nonsurgical
treatment
periodontitis,
but
they
insufficient
to
fully
heal
periodontitis
due
intractable
bacterial
attachment
drug
resistance.
Novel
effective
therapeutic
options
clinical
therapy
remain
scarce.
Nanotherapeutics
achieve
stable
cell
targeting,
oral
retention
smart
release
great
flexibility
changing
chemical
composition
or
physical
characteristics
nanoparticles.
Meanwhile,
protectiveness
high
surface
area
volume
ratio
nanoparticles
enable
loading,
ensuring
remarkable
efficacy.
Currently,
combination
advanced
novel
strategies
most
active
research
treatment.
In
this
review,
we
first
introduce
pathogenesis
then
summarize
state-of-the-art
nanotherapeutic
based
on
triple
concerto
antibacterial
activity,
immunomodulation
periodontium
regeneration,
particularly
focusing
mechanism
ingenious
design
nanomedicines.
Finally,
challenges
prospects
nano
for
discussed
from
perspective
current
problems
future
development
trends.
Graphical
Molecular Pharmaceutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 18, 2024
Hydrogels,
composed
of
hydrophilic
polymer
networks,
have
emerged
as
versatile
materials
in
biomedical
applications
due
to
their
high
water
content,
biocompatibility,
and
tunable
properties.
They
mimic
natural
tissue
environments,
enhancing
cell
viability
function.
Hydrogels'
physical
properties
allow
for
tailored
antibacterial
biomaterial,
wound
dressings,
cancer
treatment,
engineering
scaffolds.
Their
ability
respond
physiological
stimuli
enables
the
controlled
release
therapeutics,
while
porous
structure
supports
nutrient
diffusion
waste
removal,
fostering
regeneration
repair.
In
healing,
hydrogels
provide
a
moist
environment,
promote
migration,
deliver
bioactive
agents
antibiotics,
healing
process.
For
therapy,
they
offer
localized
drug
delivery
systems
that
target
tumors,
minimizing
systemic
toxicity
improving
therapeutic
efficacy.
Ocular
therapy
benefits
from
hydrogels'
capacity
form
contact
lenses
maintain
prolonged
with
eye
surface,
treatment
outcomes
various
diseases.
mucosal
delivery,
facilitate
administration
therapeutics
across
barriers,
ensuring
sustained
improved
bioavailability
drugs.
Tissue
sees
scaffolds
extracellular
matrix,
supporting
growth
differentiation
repairing
damaged
tissues.
Similarly,
bone
regeneration,
loaded
factors
stem
cells
osteogenesis
accelerate
healing.
This
article
highlights
some
recent
advances
use
applications,
driven
by
be
engineered
specific
needs
interactive
biological