Circulation Research,
Год журнала:
2023,
Номер
132(9), С. 1226 - 1245
Опубликована: Апрель 27, 2023
Kidney
disease
is
associated
with
adverse
consequences
in
many
organs
beyond
the
kidney,
including
heart,
lungs,
brain,
and
intestines.
The
kidney-intestinal
cross
talk
involves
intestinal
epithelial
damage,
dysbiosis,
generation
of
uremic
toxins.
Recent
studies
reveal
that
kidney
injury
expands
lymphatics,
increases
lymphatic
flow,
alters
composition
mesenteric
lymph.
like
blood
vessels,
are
a
route
for
transporting
potentially
harmful
substances
generated
by
architecture
actions
uniquely
suited
to
take
up
transport
large
macromolecules,
functions
differentiate
them
from
allowing
play
distinct
role
variety
physiological
pathological
processes.
Here,
we
focus
on
mechanisms
which
diseases
result
deleterious
changes
lymphatics
consider
novel
paradigm
vicious
cycle
detrimental
organ
talk.
This
concept
injury-induced
modulation
promotes
production
distribution
factors,
turn
contributes
progression
distant
systems.
Vaccines,
Год журнала:
2022,
Номер
10(11), С. 1946 - 1946
Опубликована: Ноя. 17, 2022
Vaccination
is
still
the
most
cost-effective
way
to
combat
infectious
illnesses.
Conventional
vaccinations
may
have
low
immunogenicity
and,
in
situations,
only
provide
partial
protection.
A
new
class
of
nanoparticle-based
has
shown
considerable
promise
addressing
majority
shortcomings
traditional
and
subunit
vaccines.
This
due
recent
breakthroughs
chemical
biological
engineering,
which
allow
for
exact
regulation
nanoparticle
size,
shape,
functionality,
surface
characteristics,
resulting
improved
antigen
presentation
robust
immunogenicity.
blend
physicochemical,
immunological,
toxicological
experiments
can
be
used
accurately
characterize
nanovaccines.
narrative
review
will
an
overview
current
scenario
nanovaccine.
ACS Nano,
Год журнала:
2023,
Номер
17(14), С. 13044 - 13061
Опубликована: Июль 6, 2023
Oral
drug
administration
has
been
a
popular
choice
due
to
patient
compliance
and
limited
clinical
resources.
Orally
delivered
drugs
must
circumvent
the
harsh
gastrointestinal
(GI)
environment
effectively
enter
systemic
circulation.
The
GI
tract
number
of
structural
physiological
barriers
that
limit
bioavailability
including
mucus,
tightly
regulated
epithelial
layer,
immune
cells,
associated
vasculature.
Nanoparticles
have
used
enhance
oral
drugs,
as
they
can
act
shield
prevent
early
degradation
while
also
increasing
uptake
transport
across
intestinal
epithelium.
Evidence
suggests
different
nanoparticle
formulations
may
be
transported
via
intracellular
mechanisms
cross
Despite
existence
significant
body
work
on
nanoparticles,
many
key
questions
remain:
What
causes
poor
drugs?
factors
contribute
ability
barriers?
Do
properties
such
size
charge
influence
type
endocytic
pathways
taken?
In
this
Review,
we
summarize
components
types
nanoparticles
developed
for
delivery.
particular,
focus
various
in
internalization
or
cargo
translocation
Understanding
gut
barrier,
characteristics,
lead
development
more
therapeutically
useful
carriers.
Nano-Micro Letters,
Год журнала:
2023,
Номер
15(1)
Опубликована: Июнь 3, 2023
Abstract
Immunotherapy
has
become
a
promising
research
“hotspot”
in
cancer
treatment.
“Soldier”
immune
cells
are
not
uniform
throughout
the
body;
they
accumulate
mostly
organs
such
as
spleen
and
lymph
nodes
(LNs),
etc.
The
unique
structure
of
LNs
provides
microenvironment
suitable
for
survival,
activation,
proliferation
multiple
types
cells.
play
an
important
role
both
initiation
adaptive
immunity
generation
durable
anti-tumor
responses.
Antigens
taken
up
by
antigen-presenting
peripheral
tissues
need
to
migrate
with
lymphatic
fluid
activate
lymphocytes
therein.
Meanwhile,
accumulation
retaining
many
functional
compounds
enhance
their
efficacy
significantly.
Therefore,
have
key
target
tumor
immunotherapy.
Unfortunately,
nonspecific
distribution
drugs
vivo
greatly
limits
activation
cells,
which
leads
unsatisfactory
effects.
efficient
nano-delivery
system
is
effective
strategy
maximize
drugs.
Nano-delivery
systems
shown
beneficial
improving
biodistribution
enhancing
lymphoid
tissues,
exhibiting
powerful
prospects
achieving
delivery
LNs.
Herein,
physiological
barriers
were
summarized
factors
affecting
discussed
thoroughly.
Moreover,
developments
reviewed
transformation
targeting
nanocarriers
discussed.
Abstract
Immunotherapy
has
emerged
as
a
potent
strategy
in
cancer
treatment,
with
many
approved
drugs
and
modalities
the
development
stages.
Despite
its
promise,
immunotherapy
is
not
without
limitations,
including
side
effects
suboptimal
efficacy.
Using
nanoparticles
(NPs)
delivery
vehicles
to
target
lymph
nodes
(LNs)
can
improve
efficacy
of
reduce
patients.
In
this
context,
paper
reviews
LN‐targeted
immunotherapeutic
NP
strategies,
mechanisms
transport
during
LN
targeting,
their
related
biosafety
risks.
targeting
LNs
involves
either
passive
influenced
by
physical
properties,
or
active
facilitated
affinity
ligands
on
surfaces,
while
alternative
methods,
such
intranodal
injection
high
endothelial
venule
(HEV)
have
uncertain
clinical
applicability
require
further
research
validation.
NPs
for
increase
biocompatibility,
but
risks
toxicity,
organ
accumulation,
oxidative
stress
remain,
although
strategies
biodegradable
biomacromolecules,
polyethylene
glycol
(PEG)
coating,
impurity
addition
mitigate
these
Additionally,
work
concludes
future‐oriented
discussion,
offering
critical
insights
into
field.
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Июнь 3, 2022
The
lymphatics
transport
material
from
peripheral
tissues
to
lymph
nodes,
where
immune
responses
are
formed,
before
being
transported
into
systemic
circulation.
With
key
roles
in
and
fluid
homeostasis,
lymphatic
dysregulation
is
linked
diseases,
including
lymphedema.
Fluid
within
the
interstitium
passes
initial
vessels
a
valve
system
prevents
backflow.
Additionally,
endothelial
cells
produce
chemokines,
such
as
CCL21,
that
direct
migration
of
dendritic
lymphocytes.
As
result,
an
attractive
delivery
route
for
transporting
modulatory
treatments
nodes
immunotherapies
potentiated
addition
alternative
method
reaching
In
this
review,
we
discuss
physiology
mechanisms
used
materials
nodes.
We
then
summarize
nanomaterial-based
strategies
take
advantage
functions
delivering
therapeutics
or
also
describe
opportunities
targeting
modulate
functions.
Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 565 - 565
Опубликована: Фев. 8, 2023
Lymph
nodes
are
organs
that
control
immune
cells
and
provide
a
major
pathway
for
primary
tumors
to
metastasize.
A
nanoparticles-based
strategy
has
several
advantages
make
it
suitable
achieving
effective
lymphatic
delivery.
First,
the
size
of
nanoparticles
can
be
tailored
meet
range
appropriate
migration.
In
addition,
functionalized
target
interest
delivery
drugs
or
imaging
probes.
Existing
lymph
node
contrast
agents
map
all
regardless
metastasis
status;
however,
by
using
nanoparticles,
is
possible
selectively
metastases.
Moreover,
specifically
deliver
anticancer
metastatic
nodes.
this
review,
we
introduce
use
mapping,
in
particular
highlighting
design
considerations
detecting
Furthermore,
assess
trends
node-targeting
clinical
practice
suggest
future
directions
nanoparticles.
Polymers,
Год журнала:
2023,
Номер
15(7), С. 1615 - 1615
Опубликована: Март 24, 2023
Mucus
is
a
viscoelastic
gel
that
acts
as
protective
barrier
for
epithelial
surfaces.
The
mucosal
vehicles
and
adjuvants
need
to
pass
through
the
mucus
layer
make
drugs
vaccine
delivery
by
routes
possible.
mucoadhesion
of
polymer
particle
significantly
increases
contact
time
between
formulations
mucosa;
then,
particles
can
penetrate
epithelium
reach
mucosa-associated
lymphoid
tissues.
This
review
presents
key
findings
have
aided
in
understanding
mucopenetration
while
exploring
influence
physicochemical
characteristics
on
mucus-polymer
interactions.
We
describe
polymer-based
designed
with
mucoadhesive
or
mucopenetrating
properties
discuss
impact
polymers
local
systemic
immune
responses
after
immunization.
In
future
research,
more
attention
paid
design
development
could
lead
effective
vaccines.
