Chinese Chemical Letters, Год журнала: 2023, Номер 35(7), С. 109129 - 109129
Опубликована: Сен. 21, 2023
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Фев. 21, 2024
Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management
Язык: Английский
Процитировано
158
Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 203, С. 115130 - 115130
Опубликована: Окт. 31, 2023
Язык: Английский
Процитировано
48
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5842 - 5842
Опубликована: Май 27, 2024
This study provides a brief discussion of the major nanopharmaceuticals formulations as well impact nanotechnology on future pharmaceuticals. Effective and eco-friendly strategies biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) outlined. paper discusses need use natural resources for “green” design new with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, preparation nanomaterials must be carefully considered. Therefore, safety long-term effects not overlooked. The testing represents an essential point their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent valuable, bioinspired model nanopharmaceutical that avoids using animals. Nanoformulations critical various fields, especially pharmacy, medicine, agriculture, material science, due unique properties advantages over conventional allows improved solubility, bioavailability, targeted drug delivery, controlled release, reduced toxicity. have transitioned from experimental stages being vital component clinical practice, significantly improving outcomes medical fields cancer treatment, infectious diseases, neurological disorders, personalized advanced diagnostics. Here key points highlighting importance. significant challenges, opportunities, directions mentioned final section.
Язык: Английский
Процитировано
27
Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 209, С. 115304 - 115304
Опубликована: Апрель 9, 2024
Язык: Английский
Процитировано
21
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(9), С. 3876 - 3900
Опубликована: Июнь 22, 2024
Despite the promising prospects of nanoparticles in oral drug delivery, process administration involves a complex transportation pathway that includes cellular uptake, intracellular trafficking, and exocytosis by intestinal epithelial cells, which are necessary steps for to enter bloodstream exert therapeutic effects. Current researchers have identified several crucial factors regulate interaction between including surface properties such as ligand modification, charge, hydrophilicity/hydrophobicity, protein corona formation, well holistic like particle size, shape, rigidity. Understanding these is essential enhancing transepithelial transport efficiency designing effective delivery systems. Therefore, this review provides comprehensive overview influence nanoparticles, elucidating underlying principles governing their impact on transport. The also outlines chosen parameters be considered subsequent design
Язык: Английский
Процитировано
21
ACS Nano, Год журнала: 2024, Номер 18(10), С. 7455 - 7472
Опубликована: Фев. 28, 2024
The epithelial mucosa is a key biological barrier faced by gastrointestinal, intraoral, intranasal, ocular, and vaginal drug delivery. Ligand-modified nanoparticles demonstrate excellent ability on this process, but their efficacy diminished the formation of protein coronas (PCs) when they interact with matrices. PCs are broadly implicated in affecting fate NPs vivo vitro, yet few studies have investigated formed during interactions mucosa, especially mucus. In study, we constructed transferrin modified (Tf-NPs) as model explored mechanisms effects that had subsequent impact transcellular transport Tf-NPs. mucus-secreting cells, Tf-NPs adsorbed more proteins from mucus layers, which masked, displaced, dampened active targeting Tf-NPs, thereby weakening endocytosis efficiencies. mucus-free intracellular trafficking, enhanced transcytosis related functions. Inspired soft artificial biomimetic membranes, used mucin an "active PC" to precoat (M@Tf-NPs), limited negative impacts "passive PCs" interface improved favorable routes endocytosis. M@Tf-NPs associated endoplasmic reticulum-Golgi functions, prompting exocytosis. summary, shielded against absorption also could be employed spear break through barrier. These findings offer theoretical foundation design platform enhance efficiency oral-administered nanomedicines.
Язык: Английский
Процитировано
20
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Ноя. 24, 2023
The oral delivery of nano-drug systems (Nano-DDS) remains a challenge. Taking inspirations from viruses, here we construct core-shell mesoporous silica nanoparticles (NPs, ~80 nm) with virus-like nanospikes (VSN) to simulate viral morphology, and further modified VSN L-alanine (CVSN) enable chiral recognition for functional bionics. By comparing the solid NPs, NPs VSN, demonstrate advantages CVSN on overcoming intestinal sequential barriers in both animals human via multiple biological processes. Subsequently, encapsulate indomethacin (IMC) into nanopores mimic gene package, wherein payloads are isolated bio-environments exist an amorphous form increase their stability solubility, while multi-sited anchor recognize mucosa enhance penetrability ultimately improve adsorption IMC. Encouragingly, also prove versatility as Nano-DDS.
Язык: Английский
Процитировано
26
Pharmaceutics, Год журнала: 2024, Номер 16(7), С. 852 - 852
Опубликована: Июнь 25, 2024
The disadvantages of some conventional drugs, including their low bioavailability, poor targeting efficiency, and important side effects, have led to the rational design drug delivery systems. In particular, introduction systems is a potential approach enhance uptake therapeutic agents deliver them at right time in amount concentration required site, as well open new strategies for effective illness treatment. this review, we provide basic understanding with an emphasis on use cyclodextrin-, polymer- surfactant-based These are very attractive because they biocompatible biodegradable nanomaterials multifunctional components. We also details considerations variety medical applications by employing several routes administration.
Язык: Английский
Процитировано
11
Nano Convergence, Год журнала: 2024, Номер 11(1)
Опубликована: Фев. 8, 2024
Abstract Inflammatory bowel disease (IBD), including Crohn’s and ulcerative colitis, is a family of chronic disorders along the gastrointestinal tract. Because its idiopathic nature, IBD does not have fundamental cure; current available therapies for are limited to prolonged doses immunomodulatory agents. While these treatments may reduce inflammation, therapeutic efficacy, inconsistency across patients, adverse side effects from aggressive medications remain as major drawbacks. Recently, excessive production accumulation neutrophil extracellular traps (NETs) also known NETosis been identified exacerbate inflammatory responses induce further tissue damage in IBD. Such discovery invited many researchers investigate NETs potential target. DNase-I natural agent that can effectively destroy and, therefore, potentially NETs-induced inflammations even without use drugs. However, low stability rapid clearance limitations applications. In this research, polymeric nanozymes were fabricated increase delivery efficacy DNase-I. was immobilized on surface nanoparticles maintain enzymatic properties while extending activity colon. Delivery using platform allowed enhanced with minimal toxicity. When administered animal models IBD, successfully alleviated various pathophysiological symptoms More importantly, nanozyme administration attenuated infiltration colon compared free or mesalamine.
Язык: Английский
Процитировано
10
The Science of The Total Environment, Год журнала: 2024, Номер 927, С. 172240 - 172240
Опубликована: Апрель 4, 2024
Язык: Английский
Процитировано
10