ACS Applied Nano Materials,
Год журнала:
2023,
Номер
6(9), С. 7123 - 7149
Опубликована: Апрель 25, 2023
Since
cancer
has
a
very
complex
pathophysiology,
existing
treatment
strategies
encounter
several
challenges
such
as
the
lack
of
specificity/selectivity,
induction
multidrug
resistance,
and
possible
side
effects/toxicity.
A
wide
variety
organic,
inorganic,
hybrid
nanosystems
have
been
designed
with
unique
magnetic,
thermal,
mechanical,
electrical,
optical
properties
for
targeted
therapy.
These
advanced
enhanced
bioavailability,
biocompatibility,
drug
loading
capacity
developed
therapy
to
reduce
toxicity
improve
targeting
properties.
In
this
context,
persist
their
clinical
translational
studies
enhancement
therapeutic
efficiency
well
optimization
synthesis
conditions
large-scale
production.
addition,
despite
promising
preclinical
results,
number
available
patients
is
still
low,
partly
due
understanding
differences
among
animal
model
species
humans
that
influence
behavior
functionality
these
nanosystems.
Regarding
this,
organ-on-a-chip
platforms
can
significantly
help
in
screening
delivery
aspects
cancer/tumor
cells
modeling
research;
organs-on-chip
approach
also
be
helpful
analyze
cancer–immune
interactions.
Future
should
focus
on
exploration
multifunctional
synergistic
chemo-photothermal,
photothermal/photodynamic,
immunotherapeutic
potentials
smart
theranostic
capabilities.
Herein,
recent
advancements
pertaining
applications
therapeutics
are
deliberated.
Current
obstacles
limitations
hindering
application
from
research
uses
discussed
while
providing
recommendations
more
efficient
adoption
nanomaterials
cancers.
Progress in Materials Science,
Год журнала:
2024,
Номер
144, С. 101292 - 101292
Опубликована: Апрель 6, 2024
The
prevalence
of
multidrug-resistant
(MDR)
bacterial
infections
has
emerged
as
a
serious
threat
to
clinical
treatment
and
global
human
health,
become
one
the
most
important
challenges
in
therapy.
Hence,
there
is
an
urgent
need
develop
safe,
effective,
new
antibacterial
strategies
based
on
multifunctional
nanomaterials
for
accurate
detection
MDR
infections.
Chemodynamic
therapy
(CDT)
emerging
therapeutic
strategy
that
uses
Fenton/Fenton-like
metal-based
nanocatalysts
convert
hydrogen
peroxide
(H2O2)
into
hydroxyl
radicals
(OH)
destroy
Despite
enormous
potential
CDT,
single
CDT
limitations
such
low
catalytic
efficacy
insufficient
production
H2O2.
In
this
regard,
can
be
combined
with
other
strategies,
photothermal
(PTT),
which
effectively
enhanced
by
PTT
heating
effect.
Thus,
rational
combination
nanoplatform
been
demonstrated
highly
efficient
achieving
better
This
review
summarizes
discusses
latest
advances
photothermal-enhanced
(PT/CDT)
infection
theranostics
well
advantages,
challenges,
future
research
directions
applications,
will
inspire
development
PT/CDT
Materials Horizons,
Год журнала:
2023,
Номер
11(3), С. 590 - 625
Опубликована: Ноя. 10, 2023
In
order
to
address
the
issue
of
bacterial
infection
during
transplantation
bone
implants,
four
types
implants
with
long-term
antimicrobial
functionality
have
been
constructed.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(5), С. 2298 - 2316
Опубликована: Янв. 26, 2024
Bacterial
infection
hampers
wound
repair
by
impeding
the
healing
process.
Concurrently,
inflammation
at
site
triggers
production
of
reactive
oxygen
species
(ROS),
causing
oxidative
stress
and
damage
to
proteins
cells.
This
can
lead
chronic
wounds,
posing
severe
risks.
Therefore,
eliminating
bacterial
reducing
ROS
levels
are
crucial
for
effective
healing.
Nanozymes,
possessing
enzyme-like
catalytic
activity,
convert
endogenous
substances
into
highly
toxic
substances,
such
as
ROS,
combat
bacteria
biofilms
without
inducing
drug
resistance.
However,
current
nanozyme
model
with
single
enzyme
activity
falls
short
meeting
complex
requirements
antimicrobial
therapy.
Thus,
developing
nanozymes
multiple
enzymatic
activities
is
essential.
Herein,
we
engineered
a
novel
metalloenzyme
called
Ru-procyanidin
nanoparticles
(Ru-PC
NPs)
diverse
aid
infections.
Under
acidic
conditions,
due
their
glutathione
(GSH)
depletion
peroxidase
(POD)-like
Ru-PC
NPs
combined
H2O2
exhibit
excellent
antibacterial
effects.
in
neutral
environment,
NPs,
catalase
(CAT)
decompose
O2,
alleviating
hypoxia
ensuring
sufficient
supply.
Furthermore,
possess
exceptional
antioxidant
capacity
through
superior
superoxide
dismutase
(SOD)
effectively
scavenging
excess
nitrogen
(RNS)
environment.
maintains
balance
system
prevents
inflammation.
also
promote
polarization
macrophages
from
M1
M2,
facilitating
More
importantly,
show
good
biosafety
negligible
toxicity.
In
vivo
models
have
confirmed
efficacy
inhibiting
promoting
The
focus
this
work
highlights
quadruple
its
potential
reduce
bacteria-infected
Abstract
Infectious
diseases
present
significant
challenges
to
global
health,
thereby
extensively
affecting
both
human
society
and
the
economy.
In
recent
years,
functional
probes
have
demonstrated
remarkable
potential
as
crucial
biomedical
media
for
research
treatment
of
infectious
diseases.
Their
applications
in
realm
include
pathogen
detection,
exploration
biological
mechanisms,
development
anti‐infective
drugs.
This
review
provides
a
concise
introduction
severity,
classification,
pathogenesis
Subsequently,
we
examined
distinctiveness
design
strategies
diagnosing
treating
diseases,
shedding
light
on
their
rationale
using
typical
examples.
We
discuss
current
status
associated
with
clinical
implementation
probes.
Furthermore,
explored
prospects
these
diagnosis
aims
offer
novel
insights
into
diagnostic
broaden
disease
treatment.
Most
nanozymes
in
development
for
medical
applications
only
exhibit
single-enzyme-like
activity,
and
are
thus
limited
by
insufficient
catalytic
activity
dysfunctionality
complex
pathological
microenvironments.
To
overcome
the
impediments
of
substrate
availabilities
concentrations,
some
metal-based
may
mimic
two
or
more
activities
natural
enzymes
to
catalyze
cascade
reactions
multiple
substrates
simultaneously,
thereby
amplifying
catalysis.
Metal-based
with
multienzyme-like
(MNMs)
adapt
dissimilar
conditions
exert
different
enzyme-like
effects.
These
can
synergize
realize
"self-provision
substrate,"
which
upstream
catalysts
produce
downstream
limitation
microenvironment.
Consequently,
MNMs
potent
antitumor,
antibacterial,
anti-inflammatory
effects
preclinical
models.
This
review
summarizes
cellular
underlying
mechanisms
MNMs.
Their
potential
utility
optimization
strategy
from
perspective
clinical
requirements
also
discussed,
aim
provide
a
theoretical
reference
design,
development,
therapeutic
application
their
ACS Applied Materials & Interfaces,
Год журнала:
2022,
Номер
14(45), С. 50677 - 50691
Опубликована: Ноя. 3, 2022
Various
injury
defense
and
repair
functions
are
performed
by
the
skin.
Free
radicals
secreted
after
cause
oxidative
stress
inflammatory
responses,
which
make
wound
healing
difficult.
However,
current
metal
nanomaterials
for
do
not
have
sufficient
catalytic
activity
or
complex
material
design
cannot
properly
fit
wounds.
Therefore,
it
is
imperative
to
develop
more
effective
therapeutic
approaches.
This
study
investigated
effect
of
Ni4Cu2
hollow
nanospheres
composited
with
F127
hydrogel
on
promoting
applying
them
exhibited
a
superior
spatial
structure,
contained
many
sites,
could
be
synthesized
in
simple
manner.
In
vitro
experiments
showed
that
had
superoxide
dismutase-like
promoted
fibroblast
migration,
angiogenesis,
macrophage
polarization.
F127,
thermosensitive,
nontoxic,
phase-change
porous
material,
has
proven
an
choice
injectable
sprayable
medical
dressings.
were
mixed
without
significantly
affecting
its
performance.
addition
adapting
complex,
irregular
gaps
acute
wounds,
mixture
lengthened
nanozyme
release
time,
enhanced
healing.
Based
animal
experiments,
Ni4Cu2/F127
composite
effectively
healing,
epithelial
regeneration,
formation
skin
appendages
such
as
hair
follicles
mice.
Furthermore,
was
nontoxic
animals
high
biological
safety.
The
provided
innovative
strategy
hydrogels
treatment
Abstract
Endogenous
electric
field
is
ubiquitous
in
a
multitude
of
important
living
activities
such
as
bone
repair,
cell
signal
transduction,
and
nerve
regeneration,
signifying
that
regulating
the
organisms
highly
beneficial
to
maintain
organism
health.
As
an
emerging
promising
research
direction,
piezoelectric
nanomedicine
materdicine
precisely
activated
by
ultrasound
with
synergetic
advantages
deep
tissue
penetration,
remote
spatiotemporal
selectivity,
mechanical‐electrical
energy
interconversion,
have
been
progressively
utilized
for
disease
treatment
repair
participating
modulation
endogenous
field.
This
specific
utilizing
effect
typically
regarded
“sonopiezoelectric
nanomedicine”.
comprehensive
review
summarizes
discusses
substantially
employed
sonopiezoelectric
nanomaterials
nanotherapies
provide
insight
into
internal
mechanism
corresponding
biological
behavior/effect
biomaterials
versatile
treatments.
primarily
focuses
on
biosensing,
drug
delivery,
tumor
therapy,
antimicrobia,
further
illuminates
underlying
mechanism.
In
addition,
challenges
developments/prospects
are
analyzed
promoting
clinical
translation.
It
earnestly
expected
this
kind
nanomedicine/biomaterials‐enabled
technology
will
provoke
investigation
promote
development
next‐generation
multifunctional
materdicine.
