Perspectives on recent advancements in energy harvesting, sensing and bio-medical applications of piezoelectric gels

Chemical Society Reviews, Год журнала: 2023, Номер 52(17), С. 6191 - 6220

Опубликована: Янв. 1, 2023

This review highlights the recent progress in piezoelectric gels (also known as PiezoGels) comprised of polymers, ceramic oxides and supramolecular materials used for energy harvesting, sensing wound dressing.

Язык: Английский

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Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Advanced Functional Materials, Год журнала: 2024, Номер 34(23)

Опубликована: Янв. 7, 2024

Abstract The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized play an important role in homeostasis regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes holds promise as external intervention enhance synthesis extracellular matrix, thereby accelerating Hence, electroactive biomaterials considered a biomimetic approach ensure functional recovery integrating physiological signals, including electrical, biochemical, mechanical signals. This review will discuss endogenous bioelectricity tissue, effects ES on cellular behaviors. Then, recent advances materials their applications are systematically overviewed, with focus advantages disadvantages repair performances modulation cell fate. Finally, significance mimicking electrophysiological microenvironment target emphasized future development challenges strategies proposed.

Язык: Английский

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Surface Oxygen Vacancies and Corona Polarization of Bi₄Ti₃O₁₂ Nanosheets for Synergistically Enhanced Sonopiezoelectric Therapy

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(32), С. 22348 - 22359

Опубликована: Авг. 1, 2024

Sonopiezoelectric therapy, an ultrasound-activated piezoelectric nanomaterial for tumor treatment, has emerged as a novel alternative modality. However, the limited catalytic efficiency is serious bottleneck its practical application. Excellent catalysts with high coefficients, good deformability, large mechanical impact surface area, and abundant catalytically active sites still need to be developed urgently. In this study, classical ferroelectric material, bismuth titanate (Bi4Ti3O12, BTO), selected sonopiezoelectric sensitizer therapy. BTO generates electron–hole pairs under ultrasonic irradiation, which can react substrates in sonocatalytic-driven redox reaction. Aiming further improve activity of BTO, modification oxygen vacancies treatment corona polarization are envisioned study. Notably, reduces bandgap inhibits recombination. Additionally, immobilized built-in electric field on promoting separation electrons holes. Consequently, these modifications greatly sonocatalytic situ generation cytotoxic ROS CO, effectively eradicating tumor.

Язык: Английский

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Unleashing the Potential of Electroactive Hybrid Biomaterials and Self-Powered Systems for Bone Therapeutics

Nano-Micro Letters, Год журнала: 2024, Номер 17(1)

Опубликована: Окт. 17, 2024

The incidence of large bone defects caused by traumatic injury is increasing worldwide, and the tissue regeneration process requires a long recovery time due to limited self-healing capability. Endogenous bioelectrical phenomena have been well recognized as critical biophysical factors in remodeling regeneration. Inspired bioelectricity, electrical stimulation has widely considered an external intervention induce osteogenic lineage cells enhance synthesis extracellular matrix, thereby accelerating With ongoing advances biomaterials energy-harvesting techniques, electroactive self-powered systems biomimetic approaches ensure functional recapitulating natural electrophysiological microenvironment healthy tissue. In this review, we first introduce role bioelectricity endogenous electric field summarize different techniques electrically stimulate Next, highlight latest progress exploring hybrid such triboelectric piezoelectric-based nanogenerators photovoltaic cell-based devices their implementation engineering. Finally, emphasize significance simulating target tissue's propose opportunities challenges faced bioelectronics for repair strategies.

Язык: Английский

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Catalytic Biomaterials

Accounts of Materials Research, Год журнала: 2024, Номер 5(3), С. 271 - 285

Опубликована: Фев. 16, 2024

ConspectusCatalytic biomaterials, an emerging frontier in biomaterials research, offer tremendous potential to circumvent the limitations of traditional treatment approaches, such as low specificity and adverse effects. By harnessing intrinsic physicochemical properties materials, catalytic especially nanoscale (termed nanomedicine), can directly engage with a range biogenic substrates initiate various chemical or biochemical reactions vivo. Chemically designed nanozymes emulate endogenous enzymes regulating intracellular redox homeostasis, offering distinct advantages over their natural counterparts, design flexibility, adjustable functionalities, robust stability harsh conditions, cost-effective production. The extensively investigated mimicked by include peroxidases, oxidases, superoxide dismutases, catalase, glutathione peroxidase. To improve enzyme-mimicking activities properties, composition, size, morphology, exposed crystal facets, surface chemistry, are finely tuned for reactive oxygen species (ROS)-producing pro-oxidative ROS-eliminating antioxidative applications. As interdisciplinary research catalysis biomedicine deepens, cutting-edge concepts catalysis, including single-atom photocatalysis, electrocatalysis, piezoelectric thermoelectric have gradually merged biomaterials. resultant be activated spatiotemporally light, ultrasound, magnetic fields, heat, etc., beyond scope aforementioned endogenously responsive nanozymes. Given semiconductor nature these externally defect engineering heterojunction strategies utilized enhance separation suppress recombination electron–hole pairs modulating bandgap structures. Consequently, efficacy rationally engineered generating scavenging ROS profoundly improved. Apart from ROS-centered applications, content has also been extended transformation substrates, depletion, glucose/lactate consumption, gas production inorganic nanocatalysts. Collectively, which purposefully influence cellular homeostasis regulate cell signaling pathways, assumed play pivotal role addressing spectrum pathophysiological disorders associated oxidative stress dysfunctions, cancer, inflammation, immunomodulation, neurodegeneration, cardiovascular diseases. connections among nanomedicine, nanozymes, we present our insights here clarify distinctions. Catalytic broader scope, spanning nanoscale, microscale, macroscale that possess specific activities. involved encompass both enzyme-mimetic well endogenously/exogenously initiated nanomedicine emphasizes integration nanotechnology therapeutic Nanozymes specifically focus on nanomaterials. Thus, utilize term "catalytic biomaterials" describe this fast-evolving field anticipate will motivate deeper between materials science, medicine.In Account, provide concise introduction fundamental understanding categorizing them into three groups based action mechanisms. Then, highlight group's work fabrication diverse biomedical cancer therapy, antibacterial, anti-inflammation, tissue engineering, regenerative medicine Our primary is deliberate tailor-made application sophisticated scenarios. biological effects arising elucidated. Furthermore, perspectives clinical translation discussed. We envision rapid development could spur evolution highly effective therapeutic/regenerative approaches minimal toxicity wide medical conditions.

Язык: Английский

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Piezoelectric materials for bone implants: opportunities and challenges

Nano Energy, Год журнала: 2025, Номер unknown, С. 110841 - 110841

Опубликована: Март 1, 2025

Язык: Английский

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Neuroregulation during Bone Formation and Regeneration: Mechanisms and Strategies

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

The skeleton is highly innervated by numerous nerve fibers. These fibers, in addition to transmitting information within the bone and mediating sensations, play a crucial role regulating tissue formation regeneration. Traditional engineering (BTE) often fails achieve satisfactory outcomes when dealing with large-scale defects, which frequently related lack of effective reconstruction neurovascular network. In recent years, increasing research has revealed critical nerves metabolism. Nerve fibers regulate cells through neurotransmitters, neuropeptides, peripheral glial cells. Furthermore, also coordinate vascular immune systems jointly construct microenvironment favorable for As signaling driver formation, neuroregulation spans entire process physiological activities from embryonic postmaturity remodeling repair. However, there currently comprehensive summaries these regulatory mechanisms. Therefore, this review sketches out function during Then, we elaborate on mechanisms coupling neuromodulation immunity. Finally, discuss several novel strategies neuro-bone (NBTE) based bone, focusing coordinated regeneration tissue.

Язык: Английский

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Bioimaging and prospects of night pearls‐based persistence phosphors in cancer diagnostics

Exploration, Год журнала: 2024, Номер 4(4)

Опубликована: Янв. 23, 2024

Abstract Inorganic persistent phosphors feature great potential for cancer diagnosis due to the long luminescence lifetime, low background scattering, and minimal autofluorescence. With prominent advantages of near‐infrared light, such as deep penetration, high resolution, autofluorescence, tissue absorption, can be used bioimaging. We focus on highlighting inorganic phosphors, emphasizing synthesis methods applications in diagnostics. Typical synthetic high‐temperature solid state, thermal decomposition, hydrothermal/solvothermal, template are proposed obtain small‐size biological organisms. The mechanisms with different excitation discussed effective matrixes including galliumate, germanium, aluminate, fluoride explored. Finally, current directions where continue optimized how further overcome challenges summarized.

Язык: Английский

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A review on external physical stimuli with biomaterials for bone repair

Chemical Engineering Journal, Год журнала: 2024, Номер 496, С. 153749 - 153749

Опубликована: Июль 4, 2024

Язык: Английский

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Oxygen Vacancy Piezoelectric Nanosheets Constructed by a Photoetching Strategy for Ultrasound “Unlocked” Tumor Synergistic Therapy

Nano Letters, Год журнала: 2024, Номер 24(26), С. 8008 - 8016

Опубликована: Июнь 24, 2024

Piezoelectric dynamic therapy (PzDT) is an effective method of tumor treatment by using piezoelectric polarization to generate reactive oxygen species. In this paper, two-dimensional Cu-doped BiOCl nanosheets with surface vacancies are produced the photoetching strategy. Under ultrasound, a built-in electric field generated promote electron and hole separation. The separated carriers achieve O

Язык: Английский

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