Smart Materials in Medicine,
Год журнала:
2023,
Номер
4, С. 578 - 589
Опубликована: Янв. 1, 2023
Mesenchymal
stem
cell
exosomes
(MSC-Exos)
are
a
type
of
vesicle
with
biological
function
secreted
by
mesenchymal
cells
(MSCs).
In
tissue
repair,
MSC-Exos
more
effective
than
MSCs,
and
they
can
be
used
as
cell-free
alternative
therapy
to
MSCs.
This
therapeutic
system
has
stable
membrane
structure
that
is
coated
proteins,
miRNAs,
mRNA,
lncRNA,
DNA,
other
macromolecular
active
substances.
These
molecules
have
powerful
effect
on
regeneration.
regulate
the
target
through
direct
recognition,
fusion,
secretion
communication
mediators.
Skin
wound
healing
consists
mainly
blood
coagulation,
inflammation
response,
proliferation,
remodeling.
By
regulating
four
stages
healing,
effectively
reduce
inflammation,
immune
promote
enhanced
migration
angiogenesis
remodeling,
thus
shortening
time
reducing
scar
formation.
A
variety
factors,
genetic
material
signaling
pathways
involved
in
this
process.
article
reviews
efficacy
mechanism
promoting
skin
repair.
ACS Nano,
Год журнала:
2023,
Номер
17(16), С. 15962 - 15977
Опубликована: Авг. 3, 2023
Treatment
of
diabetic
foot
ulcers
(DFU)
needs
to
reduce
inflammation,
relieve
hypoxia,
lower
blood
glucose,
promote
angiogenesis,
and
eliminate
pathogenic
bacteria,
but
the
therapeutic
efficacy
is
greatly
limited
by
diversity
synergy
drug
functions
as
well
DFU
microenvironment
itself.
Herein,
an
ultrasound-augmented
multienzyme-like
nanozyme
hydrogel
spray
was
developed
using
hyaluronic
acid
encapsulated
l-arginine
ultrasmall
gold
nanoparticles
Cu1.6O
coloaded
phosphorus
doped
graphitic
carbon
nitride
nanosheets
(ACPCAH).
This
possesses
five
types
enzyme-like
activities,
including
superoxide
dismutase
(SOD)-,
catalase
(CAT)-,
glucose
oxidase
(GOx)-,
peroxidase
(POD)-,
nitric
oxide
synthase
(NOS)-like
activities.
The
kinetics
reaction
mechanism
sonodynamic/sonothermal
synergistic
enhancement
SOD-CAT-GOx-POD/NOS
cascade
ACPCAH
are
fully
investigated.
Both
in
vitro
vivo
tests
demonstrate
that
this
can
be
activated
thus
accelerating
wound
healing
effectively.
study
highlights
a
competitive
approach
based
on
nanozymes
for
development
all-in-one
therapies.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(19), С. 22830 - 22842
Опубликована: Май 2, 2023
Antibiotic
resistance
reduces
the
effectiveness
of
infected
wound
healing,
and
it
is
necessary
to
develop
a
new
strategy
promote
healing
without
using
antibiotics.
Here,
we
Chlorin
e6
(Ce6)-loaded
zinc-metal-organic
framework
(MOF)
thermosensitive
hydrogel
(Ce6@MOF-Gel)
based
on
alginate
poly(propylene
glycol)
407,
which
enhances
antibacterial
effects
promotes
by
novel
combining
zinc-MOF
with
photodynamic
therapy
(PDT).
Zinc-MOF
can
realize
acid-responsive
release
Ce6
improve
performance
drug
destroying
integrity
bacterial
cell
membranes
enhancing
production
reactive
oxygen
species
(ROS).
Additionally,
Ce6@MOF-Gel
stability,
solubility,
properties
Ce6.
More
importantly,
inflammation
collagen
deposition
re-epithelialization
facilitate
healing.
Collectively,
MOF-based
provides
new,
efficient,
safe
way
for
accelerated
wounds.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Фев. 6, 2024
Inflammatory
skin
disorders
can
cause
chronic
scarring
and
functional
impairments,
posing
a
significant
burden
on
patients
the
healthcare
system.
Conventional
therapies,
such
as
corticosteroids
nonsteroidal
anti-inflammatory
drugs,
are
limited
in
efficacy
associated
with
adverse
effects.
Recently,
nanozyme
(NZ)-based
hydrogels
have
shown
great
promise
addressing
these
challenges.
NZ-based
possess
unique
therapeutic
abilities
by
combining
benefits
of
redox
nanomaterials
enzymatic
activity
water-retaining
capacity
hydrogels.
The
multifaceted
effects
include
scavenging
reactive
oxygen
species
other
inflammatory
mediators
modulating
immune
responses
toward
pro-regenerative
environment
enhancing
regenerative
potential
triggering
cell
migration
differentiation.
This
review
highlights
current
state
art
NZ-engineered
(NZ@hydrogels)
for
regeneration
applications.
It
also
discusses
underlying
chemo-mechano-biological
mechanisms
behind
their
effectiveness.
Additionally,
challenges
future
directions
this
ground,
particularly
clinical
translation,
addressed.
insights
provided
aid
design
engineering
novel
hydrogels,
offering
new
possibilities
targeted
personalized
skin-care
therapies.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(5), С. 2298 - 2316
Опубликована: Янв. 26, 2024
Bacterial
infection
hampers
wound
repair
by
impeding
the
healing
process.
Concurrently,
inflammation
at
site
triggers
production
of
reactive
oxygen
species
(ROS),
causing
oxidative
stress
and
damage
to
proteins
cells.
This
can
lead
chronic
wounds,
posing
severe
risks.
Therefore,
eliminating
bacterial
reducing
ROS
levels
are
crucial
for
effective
healing.
Nanozymes,
possessing
enzyme-like
catalytic
activity,
convert
endogenous
substances
into
highly
toxic
substances,
such
as
ROS,
combat
bacteria
biofilms
without
inducing
drug
resistance.
However,
current
nanozyme
model
with
single
enzyme
activity
falls
short
meeting
complex
requirements
antimicrobial
therapy.
Thus,
developing
nanozymes
multiple
enzymatic
activities
is
essential.
Herein,
we
engineered
a
novel
metalloenzyme
called
Ru-procyanidin
nanoparticles
(Ru-PC
NPs)
diverse
aid
infections.
Under
acidic
conditions,
due
their
glutathione
(GSH)
depletion
peroxidase
(POD)-like
Ru-PC
NPs
combined
H2O2
exhibit
excellent
antibacterial
effects.
in
neutral
environment,
NPs,
catalase
(CAT)
decompose
O2,
alleviating
hypoxia
ensuring
sufficient
supply.
Furthermore,
possess
exceptional
antioxidant
capacity
through
superior
superoxide
dismutase
(SOD)
effectively
scavenging
excess
nitrogen
(RNS)
environment.
maintains
balance
system
prevents
inflammation.
also
promote
polarization
macrophages
from
M1
M2,
facilitating
More
importantly,
show
good
biosafety
negligible
toxicity.
In
vivo
models
have
confirmed
efficacy
inhibiting
promoting
The
focus
this
work
highlights
quadruple
its
potential
reduce
bacteria-infected
Abstract
Bacterial
infections
are
a
significant
obstacle
to
the
healing
of
acute
and
chronic
wounds,
such
as
diabetic
ulcers
burn
injuries.
Traditional
antibiotics
primary
treatment
for
bacterial
infections,
but
they
present
issues
antibiotic
resistance,
limited
efficacy,
potential
side
effects.
This
challenge
leads
exploration
nanozymes
alternative
therapeutic
agents.
Nanozymes
nanomaterials
with
enzyme‐like
activities.
Owing
their
low
production
costs,
high
stability,
scalability,
multifunctionality,
have
emerged
prominent
focus
in
antimicrobial
research.
Among
various
types
nanozymes,
metal‐based
offer
several
benefits,
including
broad‐spectrum
activity
robust
catalytic
properties.
Specifically,
copper‐based
(CuNZs)
shown
considerable
promoting
wound
healing.
They
exhibit
strong
effects,
reduce
inflammation,
enhance
tissue
regeneration,
making
them
highly
advantageous
use
care.
review
describes
dual
functions
CuNZs
combating
infection
facilitating
repair.
Recent
advancements
design
synthesis
CuNZs,
evaluating
promotion,
biosafety
both
vitro
vivo
on
basis
core
components,
critically
important.
Abstract
Chronic
diabetic
wounds
remain
a
worldwide
challenge
for
both
the
clinic
and
research.
Given
vicious
circle
of
oxidative
stress
inflammatory
response
as
well
impaired
angiogenesis
wound
tissues,
healing
process
is
disturbed
poorly
responds
to
current
treatments.
In
this
work,
nickel‐based
metal‐organic
framework
(MOF,
Ni‐HHTP)
with
excellent
antioxidant
activity
proangiogenic
function
developed
accelerate
chronic
wounds.
The
Ni‐HHTP
can
mimic
enzymatic
catalytic
activities
enzymes
eliminate
multi‐types
reactive
species
through
electron
transfer
reactions,
which
protects
cells
from
stress‐related
damage.
Moreover,
Ni‐based
MOF
promote
cell
migration
by
activating
transforming
growth
factor‐β1
(TGF‐β1)
in
vitro
reprogram
macrophages
anti‐inflammatory
phenotype.
Importantly,
effectively
promotes
suppressing
enhancing
vivo.
This
study
reports
versatile
promising
MOF‐based
nanozyme
healing,
may
be
extended
combination
other
dressings
enhance
management
or
non‐healing
