Amorphous NiB@IrOx nanozymes trigger efficient apoptosis-ferroptosis hybrid therapy

Acta Biomaterialia, Год журнала: 2022, Номер 155, С. 575 - 587

Опубликована: Окт. 30, 2022

Язык: Английский

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Nanozymes: A comprehensive review on emerging applications in cancer diagnosis and therapeutics

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 256, С. 128272 - 128272

Опубликована: Ноя. 23, 2023

Язык: Английский

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L-Arginine self-delivery supramolecular nanodrug for NO gas therapy

Acta Biomaterialia, Год журнала: 2023, Номер 169, С. 517 - 529

Опубликована: Авг. 1, 2023

Язык: Английский

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Polydopamine reduced graphene oxide/ chitosan-based hydrogel for the therapy of diabetic wound

Materials Today Communications, Год журнала: 2024, Номер 39, С. 109319 - 109319

Опубликована: Май 27, 2024

Язык: Английский

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Autophagy inhibition mediated via an injectable and NO-releasing hydrogel for amplifying the antitumor efficacy of mild magnetic hyperthermia

Bioactive Materials, Год журнала: 2024, Номер 39, С. 336 - 353

Опубликована: Май 25, 2024

While mild hyperthermia holds great potential in the treatment of solid tumors, thermal stress-triggered self-repairing autophagy significantly compromises its efficacy. To circumvent this obstacle, an injectable hydrogel (NO-Gel) composed thermosensitive poly(ethylene glycol)-polypeptide copolymers modified with abundant NO donors on their side chains is developed. Meanwhile, ferrimagnetic Zn

Язык: Английский

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Current advances in nanozyme-based nanodynamic therapies for cancer

Acta Biomaterialia, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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Harnessing stimuli-responsive NO nanomaterials for advanced multi-disease therapy

Coordination Chemistry Reviews, Год журнала: 2025, Номер 533, С. 216540 - 216540

Опубликована: Фев. 27, 2025

Язык: Английский

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Hydrogel-enabled ROS-GSH modulation for sustained copper-mediated chemodynamic therapy of oral squamous cell carcinoma

Journal of Controlled Release, Год журнала: 2025, Номер 383, С. 113772 - 113772

Опубликована: Апрель 23, 2025

Язык: Английский

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Regenerative cerium oxide nanozymes alleviate oxidative stress for efficient dry eye disease treatment

Regenerative Biomaterials, Год журнала: 2022, Номер 9

Опубликована: Янв. 1, 2022

Abstract Dry eye disease (DED) is the most common in ophthalmic consultation except for refractive errors. Therefore, an exploration of valid and alternative therapeutic interventions essential to feed urgent medical need. It has been demonstrated that oxidative stress causes multiple adverse effects pathogenesis DED, thence alleviating effective strategy DED treatment. Herein, we developed a cerium oxide nanozyme combined with branched poly(ethylene imine)-graft-poly(ethylene glycol) (bPEI-g-PEG). Owing its stable hydrophilic chains on surface reducing cytotoxicity loads amines groups be ions through coordination bonds, modified nanozymes (referred as CNP@bPEI-g-PEG) are water soluble highly biocompatible. Meanwhile, due excellent antioxidant activity, CNP@bPEI-g-PEG can mimic activity superoxide dismutase catalase scavenge intracellular reactive oxygen species (ROS). Experimental studies firmly were auto-regenerative more active scavenging excessive ROS by cerium-element valence state recycling, recovering morphology corneal, conjunctival epithelium number goblet cells. The advanced combination may offer superior deal treatment DED.

Язык: Английский

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Piezoelectric Ba_0.85Sr_0.15TiO₃ Nanosonosensitizer with Nitric Oxide Delivery for Boosting Cancer Therapy

Small Methods, Год журнала: 2023, Номер 8(1)

Опубликована: Окт. 15, 2023

Abstract The efficacy of sonodynamic therapy (SDT) mainly relies on the sonosensitizers, which generate reactive oxygen species (ROS) upon ultrasound (US) stimulation. However, limited availability high‐efficiency sonosensitizers hampers therapeutic effectiveness SDT as a standalone modality. In this work, robust and gas cancer platform is constructed based strontium (Sr) doped barium titanate (BST) piezoelectric nanoparticles functionalized with L‐arginine (BST@LA). doping Sr into A site ABO 3 nanocrystals not only introduces vacancies enhance intrinsic piezoelectricity, but also narrows semiconductor band gap enhances charge carrier migration, all facilitate production superoxide anion (•O 2 − ) hydroxyl radical (•OH). addition, generated ROS promotes decomposition surface‐tethered LA, enabling controlled release nitric oxide (NO) at tumor site, thereby achieving combination effect. vivo experiments exhibit remarkable suppression rate (89.5%) in 4T1 mice model, demonstrating strategy. ion vacancy engineering to improve along synergistic therapy, provides promising avenues for improving therapy.

Язык: Английский

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