Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(11), P. 5864 - 5879
Published: Oct. 8, 2024
Despite
the
advancements
in
cancer
therapy,
delivering
active
pharmaceutical
ingredients
(APIs)
using
nanoparticles
remains
challenging
due
to
failed
conveyance
of
required
drug
payload,
poor
targeting
ability,
and
biodistribution,
hampering
their
clinical
translation.
Recently,
appropriate
design
materials
with
intrinsic
therapeutic
functionalities
has
garnered
enormous
interest
development
various
intelligent
nanoplatforms.
In
this
study,
we
demonstrate
fabrication
transition
metal
(molybdenum,
Mo)-doped
manganese
dioxide
(MnO2)
nanoarchitectures,
exhibiting
diagnostic
(magnetic
resonance
imaging,
MRI)
(chemodynamic
CDT)
functionalities.
The
facile
hydrothermal
approach-assisted
Mo-doped
MnO2
flower-like
nanostructures
offered
tailorable
morphologies
altered
dimensions,
precise
effects,
exceptional
biocompatibility,
biodegradability
tumor
microenvironment.
resultant
defects
doped
Mo
species
exhibited
peroxidase
oxidase
activities,
improving
glutathione
(GSH)
oxidation.
two
sets
variable
valence
ion
pairs
(Mn2+/Mn4+
Mo5+/Mo6+)
interplay
could
substantially
improve
Fenton-like
reaction
generate
toxic
hydroxyl
radicals
(•OH),
thus
achieving
CDT-assisted
antitumor
effects.
As
inherent
T1-MRI
agents,
these
displayed
excellent
MRI
efficacy
vitro.
Together,
believe
that
conformational
nanoarchitectures
states
potentiate
drugless
therapy
pharmaceutics.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
39, P. 336 - 353
Published: May 25, 2024
While
mild
hyperthermia
holds
great
potential
in
the
treatment
of
solid
tumors,
thermal
stress-triggered
self-repairing
autophagy
significantly
compromises
its
efficacy.
To
circumvent
this
obstacle,
an
injectable
hydrogel
(NO-Gel)
composed
thermosensitive
poly(ethylene
glycol)-polypeptide
copolymers
modified
with
abundant
NO
donors
on
their
side
chains
is
developed.
Meanwhile,
ferrimagnetic
Zn
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(6), P. 2447 - 2474
Published: March 18, 2024
The
clinical
efficacy
of
current
cancer
therapies
falls
short,
and
there
is
a
pressing
demand
to
integrate
new
targets
with
conventional
therapies.
Autophagy,
highly
conserved
self-degradation
process,
has
received
considerable
attention
as
an
emerging
therapeutic
target
for
cancer.
With
the
rapid
development
nanomedicine,
nanomaterials
have
been
widely
utilized
in
therapy
due
their
unrivaled
delivery
performance.
Hence,
considering
potential
benefits
integrating
autophagy
nanotechnology
therapy,
we
outline
latest
advances
autophagy-based
nanotherapeutics.
Based
on
brief
background
related
nanotherapeutics
impact
tumor
progression,
feasibility
treatment
demonstrated.
Further,
developed
modulate
are
reviewed
from
perspective
cell
signaling
pathways,
including
modulation
mammalian
rapamycin
(mTOR)
pathway,
autophagy-related
(ATG)
its
complex
expression,
reactive
oxygen
species
(ROS)
mitophagy,
interference
autophagosome-lysosome
fusion,
inhibition
hypoxia-mediated
autophagy.
In
addition,
combination
which
nano-autophagy
combined
chemotherapy,
phototherapy,
immunotherapy
also
described.
Finally,
prospects
challenges
efficient
envisioned.
Regenerative Biomaterials,
Journal Year:
2022,
Volume and Issue:
9
Published: Jan. 1, 2022
Abstract
Dry
eye
disease
(DED)
is
the
most
common
in
ophthalmic
consultation
except
for
refractive
errors.
Therefore,
an
exploration
of
valid
and
alternative
therapeutic
interventions
essential
to
feed
urgent
medical
need.
It
has
been
demonstrated
that
oxidative
stress
causes
multiple
adverse
effects
pathogenesis
DED,
thence
alleviating
effective
strategy
DED
treatment.
Herein,
we
developed
a
cerium
oxide
nanozyme
combined
with
branched
poly(ethylene
imine)-graft-poly(ethylene
glycol)
(bPEI-g-PEG).
Owing
its
stable
hydrophilic
chains
on
surface
reducing
cytotoxicity
loads
amines
groups
be
ions
through
coordination
bonds,
modified
nanozymes
(referred
as
CNP@bPEI-g-PEG)
are
water
soluble
highly
biocompatible.
Meanwhile,
due
excellent
antioxidant
activity,
CNP@bPEI-g-PEG
can
mimic
activity
superoxide
dismutase
catalase
scavenge
intracellular
reactive
oxygen
species
(ROS).
Experimental
studies
firmly
were
auto-regenerative
more
active
scavenging
excessive
ROS
by
cerium-element
valence
state
recycling,
recovering
morphology
corneal,
conjunctival
epithelium
number
goblet
cells.
The
advanced
combination
may
offer
superior
deal
treatment
DED.
Small Methods,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Oct. 15, 2023
Abstract
The
efficacy
of
sonodynamic
therapy
(SDT)
mainly
relies
on
the
sonosensitizers,
which
generate
reactive
oxygen
species
(ROS)
upon
ultrasound
(US)
stimulation.
However,
limited
availability
high‐efficiency
sonosensitizers
hampers
therapeutic
effectiveness
SDT
as
a
standalone
modality.
In
this
work,
robust
and
gas
cancer
platform
is
constructed
based
strontium
(Sr)
doped
barium
titanate
(BST)
piezoelectric
nanoparticles
functionalized
with
L‐arginine
(BST@LA).
doping
Sr
into
A
site
ABO
3
nanocrystals
not
only
introduces
vacancies
enhance
intrinsic
piezoelectricity,
but
also
narrows
semiconductor
band
gap
enhances
charge
carrier
migration,
all
facilitate
production
superoxide
anion
(•O
2
−
)
hydroxyl
radical
(•OH).
addition,
generated
ROS
promotes
decomposition
surface‐tethered
LA,
enabling
controlled
release
nitric
oxide
(NO)
at
tumor
site,
thereby
achieving
combination
effect.
vivo
experiments
exhibit
remarkable
suppression
rate
(89.5%)
in
4T1
mice
model,
demonstrating
strategy.
ion
vacancy
engineering
to
improve
along
synergistic
therapy,
provides
promising
avenues
for
improving
therapy.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(29), P. 34427 - 34435
Published: July 14, 2023
Photothermal
therapy
(PTT)
has
emerged
as
a
promising
strategy
for
the
treatment
of
tumors.
However,
intrinsic
self-repair
mechanism
cells
and
nonspecific
photothermal
effect
agents
can
result
in
poor
outcomes
normal
tissue
injury.
To
address
this
issue,
we
developed
dual
light
activatable
perylenediimide
derivative
(P-NO)
nitric
oxide-enhanced
PTT.
P-NO
self-assemble
into
nanoparticles
aqueous
solutions.
The
are
capable
releasing
both
NO
molecule
(P-NH)
upon
green
irradiation.
simultaneous
release
P-NH
activates
inhibits
cell
protection
autophagy,
thereby
improving
therapeutic
efficacy
PTT
under
near-infrared
(NIR)
light.
Moreover,
switch
on
NIR
fluorescence
allows
real-time
monitoring
P-NH.
Remarkably,
mouse
subcutaneous
tumor
model,
significant
ablation
be
achieved
following
activated
gas
therapy.
This
work
offers
straightforward
approach
to
constructing
perylenediimide-based
enhancing
effectiveness
