Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Ноя. 23, 2023
Acute
pancreatitis
(AP)
is
a
common
and
life-threatening
digestive
disorder.
However,
its
diagnosis
treatment
are
still
impeded
by
our
limited
understanding
of
etiology,
pathogenesis,
clinical
manifestations,
as
well
the
available
detection
methods.
Fortunately,
progress
microenvironment-targeted
nanoplatforms
has
shown
their
remarkable
potential
to
change
status
quo.
The
pancreatic
inflammatory
microenvironment
typically
characterized
low
pH,
abundant
reactive
oxygen
species
(ROS)
enzymes,
overproduction
cells,
hypoxia,
which
exacerbate
pathological
development
AP
but
also
provide
targeting
sites
for
nanoagents
achieve
early
treatment.
This
review
elaborates
various
targets
summarizes
in
detail
prospects
application
functional
nanomaterials
specific
targets.
Additionally,
it
presents
challenges
future
trends
develop
multifunctional
targeted
effective
AP,
providing
valuable
reference
research.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(25)
Опубликована: Апрель 13, 2023
Diabetic
wounds
are
characterized
by
drug-resistant
bacterial
infections,
biofilm
formation,
impaired
angiogenesis
and
perfusion,
oxidative
damage
to
the
microenvironment.
Given
their
complex
nature,
diabetic
remain
a
major
challenge
in
clinical
practice.
Reactive
oxygen
species
(ROS),
which
have
been
shown
trigger
hyperinflammation
excessive
cellular
apoptosis,
play
pivotal
role
pathogenesis
of
wounds.
ROS-scavenging
nanosystems
recently
emerged
as
smart
multifunctional
nanomedicines
with
broad
synergistic
applicability.
The
documented
anti-inflammatory
pro-angiogenic
ability
treatments
predestines
these
promising
options
for
treatment
Yet,
this
context,
therapeutic
applicability
efficacy
be
elucidated.
Herein,
ROS
is
deciphered,
properties
strengths
capacity
summarized.
In
addition,
current
challenges
such
potential
future
directions
discussed
through
clinical-translational
lens.
Bioactive Materials,
Год журнала:
2024,
Номер
35, С. 181 - 207
Опубликована: Фев. 2, 2024
Peptide
molecules
have
design
flexibility,
self-assembly
ability,
high
biocompatibility,
good
biodegradability,
and
easy
functionalization,
which
promote
their
applications
as
versatile
biomaterials
for
tissue
engineering
biomedicine.
In
addition,
the
functionalization
of
self-assembled
peptide
nanomaterials
with
other
additive
components
enhances
stimuli-responsive
functions,
promoting
function-specific
that
induced
by
both
internal
external
stimulations.
this
review,
we
demonstrate
recent
advance
in
molecular
design,
self-assembly,
functional
tailoring,
biomedical
peptide-based
nanomaterials.
The
strategies
on
synthesis
single,
dual,
multiple
various
dimensions
are
analyzed,
regulation
active
such
metal/metal
oxide,
DNA/RNA,
polysaccharides,
photosensitizers,
2D
materials,
others
discussed.
designed
temperature-,
pH-,
ion-,
light-,
enzyme-,
ROS-responsive
abilities
drug
delivery,
bioimaging,
cancer
therapy,
gene
antibacterial,
well
wound
healing
dressing
presented
This
comprehensive
review
provides
detailed
methodologies
advanced
techniques
from
biology,
materials
science,
nanotechnology,
will
guide
inspire
level
peptides
specific
functions
applications.
International Journal of Nanomedicine,
Год журнала:
2023,
Номер
Volume 18, С. 1537 - 1560
Опубликована: Март 1, 2023
Abstract:
Diabetes
mellitus
(DM)
induced
wound
healing
impairment
remains
a
serious
health
problem
and
burden
on
the
clinical
obligation
for
high
amputation
rates.
Based
features
of
microenvironment,
biomaterials
loading
specific
drugs
can
benefit
diabetic
treatment.
Drug
delivery
systems
(DDSs)
carry
diverse
functional
substances
to
site.
Nano-drug
(NDDSs),
benefiting
from
their
related
nano
size,
overcome
limitations
conventional
DDSs
application
are
considered
as
developing
process
in
treatment
field.
Recently,
number
finely
designed
nanocarriers
efficiently
various
(bioactive
non-bioactive
factors)
have
emerged
circumvent
constraints
faced
by
traditional
DDSs.
This
review
describes
recent
advances
nano-drug
involved
mitigating
diabetes
mellitus-based
non-healing
wounds.
Keywords:
drug
system,
nanotechnology,
healing,
nanoparticles
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(26)
Опубликована: Фев. 26, 2024
Abstract
Chronic
inflammation
and
excessive
reactive
oxygen
species
(ROS)
can
impair
diabetic
wound
healing.
Regulatory
T
cells
(Tregs)
have
emerged
as
a
promising
target
to
promote
healing
by
regulating
the
immune
system
supporting
tissue
repair
through
secretion
of
growth
factors
cytokines.
However,
an
effective
strategy
for
on‐demand
recruitment
Tregs
is
still
lacking.
Here,
ROS‐scavenging
Tregs‐recruiting
hydrogel
patch
developed
sequential
release
C─C
motif
chemokine
22
(CCL22)
triggered
ROS
in
bed.
The
prepared
crosslinking
gelatin
with
cleavable
linker
together
CCL22
(RSG‐CCL22).
RSG‐CCL22
presented
desirable
physical
properties
suitable
skin
regeneration
purposes.
In
addition,
scavenging
feature
RSG
suppresses
differentiation
helper
17
(Th17)
protects
recruited
from
apoptosis
oxidative
stress,
which
maximizes
their
function
accelerating
closure
promoting
hair
follicle
full‐thickness
defect
mouse
model.
Therefore,
proposed
approach
provides
new
therapeutic
via
functional
ROS‐triggered
delivery.
Chemical Engineering Journal,
Год журнала:
2024,
Номер
489, С. 150992 - 150992
Опубликована: Апрель 4, 2024
The
emergence
of
multifunctional
wound
dressings
for
cutaneous
tissue
injuries
represents
a
paradigm
shift
in
care,
offering
advanced
solutions
that
transcend
traditional
protection.
Inspired
by
the
recent
advances
nano-reinforcement
and
mussel-inspired
chemistry,
an
innovative
bioadhesive
self-healing
hydrogel
was
developed
using
dopamine-grafted
oxidized
sodium
alginate/gelatin
containing
Myrtus
communis
L.
extract@ZIF-8
NPs
(MC@ZIF-8/DA-OSA/Gel)
through
dual
cross-linking.
resulting
optimized
demonstrated
good
physicochemical,
hemostatic
properties,
rapid
self-repair,
firm
adhesion
to
tissues.
In
vitro
analysis
confirmed
excellent
cytocompatibility
cultured
fibroblasts.
Notably,
incorporation
MC@ZIF-8
into
enhanced
antioxidant
antibacterial
activities.
Applying
engineered
at
injury
site
significantly
accelerated
healing
process
mouse
model
injury,
as
evident
increased
thickness
improved
collagen
disposition.
Moreover,
local
increase
CD31+
cells
COL1A+
strands
indicated
vascularization,
fibroblast
proliferation
compared
other
groups.
Overall,
our
results
demonstrate
potential
efficacy
system
wound-covering
material,
suggesting
it
could
be
effective
treating
various
forms
acute
chronic
wounds
well.
