Electrospun fibers with blank surface and inner drug gradient for improving sustained release

Biomaterials Advances, Год журнала: 2023, Номер 150, С. 213404 - 213404

Опубликована: Март 31, 2023

Язык: Английский

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Magnetic Microrobot Swarms with Polymeric Hands Catching Bacteria and Microplastics in Water

ACS Nano, Год журнала: 2024, Номер 18(20), С. 13171 - 13183

Опубликована: Май 8, 2024

The forefront of micro- and nanorobot research involves the development smart swimming micromachines emulating complexity natural systems, such as swarming collective behaviors typically observed in animals microorganisms, for efficient task execution. This study introduces magnetically controlled microrobots that possess polymeric sequestrant "hands" decorating a magnetic core. Under influence external fields, functionalized beads dynamically self-assemble from individual microparticles into well-defined rotating planes diverse dimensions, allowing modulation their propulsion speed, exhibiting motion. These mobile microrobotic swarms can actively capture free-swimming bacteria dispersed microplastics "on-the-fly", thereby cleaning aquatic environments. Unlike conventional methods, these be collected complex media release captured contaminants second vessel controllable manner, is, using ultrasound, offering sustainable solution repeated use decontamination processes. Additionally, residual water is subjected to UV irradiation eliminate any remaining bacteria, providing comprehensive solution. In summary, this shows microrobot design

Язык: Английский

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Magnetically driven microrobots: Recent progress and future development

Materials & Design, Год журнала: 2023, Номер 227, С. 111735 - 111735

Опубликована: Фев. 13, 2023

Microrobots have received extensive attention in the past few decades, and in-depth research of micro-nano processing technology materials has promoted further development microrobots. Researchers successfully achieved use chemical fuels, electric, sound, magnetic fields to promote movement Among many power sources, attracted wide because their advantages including remote wireless operation harmlessness human body. After decades development, magnetically driven microrobots been extensively studied cargo transportation, cell manipulation, toxic substance removal, micromanipulation. This article first summarizes driving methods recent years, then for manufacturing microrobots, shapes typical spiral, spherical, linear structures. that, are sorted out, application magnetic-driven biomedicine other years is summarized. Finally, prospects discussed.

Язык: Английский

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Nanoparticles from Microalgae and Their Biomedical Applications

Marine Drugs, Год журнала: 2023, Номер 21(6), С. 352 - 352

Опубликована: Июнь 7, 2023

Over the years, microalgae have been a source of useful compounds mainly used as food and dietary supplements. Recently, metabolites that can participate in synthesis several nanoparticles through inexpensive environmentally friendly routes alternative to chemical synthesis. Notably, occurrence global health threats focused attention on application medicinal field. In this review, we report influence secondary from marine freshwater cyanobacteria were applied therapeutics. addition, use isolated surface combat diseases has also addressed. Although studies proven beneficial effect high-value bioproducts their potential medicine, there is still room for understanding exact role human body translating lab-based research into clinical trials.

Язык: Английский

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Reconfigurable self-assembly of photocatalytic magnetic microrobots for water purification

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Ноя. 1, 2023

The development of artificial small-scale robotic swarms with nature-mimicking collective behaviors represents the frontier research in robotics. While microrobot swarming under magnetic manipulation has been extensively explored, light-induced self-organization micro- and nanorobots is still challenging. This study demonstrates interaction-controlled, reconfigurable, reversible, active self-assembly TiO

Язык: Английский

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Recent advances on stimuli-responsive biopolymer-based nanocomposites for drug delivery

Composites Part B Engineering, Год журнала: 2023, Номер 266, С. 111018 - 111018

Опубликована: Сен. 21, 2023

Язык: Английский

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Cell‐Based Micro/Nano‐Robots for Biomedical Applications: A Review

Small, Год журнала: 2023, Номер 20(1)

Опубликована: Авг. 31, 2023

Abstract Micro/nano‐robots are powerful tools for biomedical applications and applied in disease diagnosis, tumor imaging, drug delivery, targeted therapy. Among the various types of micro‐robots, cell‐based micro‐robots exhibit unique properties because their different cell sources. In combination with actuation methods, particularly externally propelled microrobots have enormous potential applications. This review introduces recent progress micro/nano‐robots. Different methods micro/nano‐robots summarized, templates introduced. Furthermore, focuses on precise control using external fields. Potential challenges, further prospects, clinical translations also discussed.

Язык: Английский

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Design and Control of the Magnetically Actuated Micro/Nanorobot Swarm toward Biomedical Applications

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(15)

Опубликована: Фев. 27, 2024

Recently, magnetically actuated micro/nanorobots hold extensive promises in biomedical applications due to their advantages of noninvasiveness, fuel-free operation, and programmable nature. While effectively promised various fields such as targeted delivery, most past investigations are mainly displayed magnetic control individual micro/nanorobots. Facing practical medical use, the required for development swarm a closed-loop manner. This review outlines recent developments micro/nanorobot swarms, including actuating fundamentals, designs, controls, applications. The fundamental principles interactions involved formation swarms discussed first. advances design artificial biohybrid along with devices methods used manipulation, presented. Furthermore, that have potential achieve clinical application introduced, imaging-guided therapy, embolization, biofilm eradication. By addressing challenges toward end this review, promise treatments future.

Язык: Английский

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Oral administration microrobots for drug delivery

Bioactive Materials, Год журнала: 2024, Номер 39, С. 163 - 190

Опубликована: Май 21, 2024

Oral administration is the most simple, noninvasive, convenient treatment. With increasing demands on targeted drug delivery, traditional oral treatment now facing some challenges: 1) biologics how to implement and ensure bioavailability not lower than subcutaneous injections; 2) How achieve therapy of drugs in gastrointestinal tract? Based these two issues, delivery microrobots have shown great application prospect due their characteristics flexible locomotion or driven ability. Therefore, this paper summarizes various developed recent years divides them into four categories according different driving modes: magnetic-controlled microrobots, anchored self-propelled biohybrid microrobots. As involve disciplines such as materials science, mechanical engineering, medicine, control systems, begins by introducing barriers that must overcome. Subsequently, it provides an overview typical involved design process To enhance readers' understanding working principles we present a guideline for designing Furthermore, current development status types reviewed, summarizing respective advantages limitations. Finally, considering significant concerns regarding safety clinical translation, discuss challenges prospections translation presented paper, providing corresponding suggestions addressing existing challenges.

Язык: Английский

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Nanomaterial-mediated modulation of the cGAS-STING signaling pathway for enhanced cancer immunotherapy

Acta Biomaterialia, Год журнала: 2024, Номер 176, С. 51 - 76

Опубликована: Янв. 17, 2024

Язык: Английский

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