Cell Communication and Signaling,
Год журнала:
2023,
Номер
21(1)
Опубликована: Окт. 31, 2023
Abstract
Background
Cells
have
been
increasingly
known
to
release
extracellular
vesicles
(EVs)
the
environment
under
physiological
and
pathological
conditions.
A
plethora
of
studies
revealed
that
EVs
contain
cell-derived
biomolecules
are
found
in
circulation,
thereby
implicating
them
molecular
trafficking
between
cells.
Furthermore,
an
effect
on
function
disease
development
serve
as
biomarkers.
Main
body
Given
close
association
EV
circulation
vascular
disease,
this
review
aims
provide
a
brief
introduction
EVs,
with
specific
focus
cargoes
participating
mechanisms,
diagnosis,
engineering,
clinical
potential,
highlight
emerging
evidence
suggesting
promising
targets
diseases.
Despite
expansion
research
field,
some
noticeable
limitations
remain
for
translational
research.
Conclusion
This
makes
novel
contribution
summary
recent
advances
perspective
future
Theranostics,
Год журнала:
2023,
Номер
13(12), С. 4138 - 4165
Опубликована: Янв. 1, 2023
Neurodegenerative
diseases
are
characterized
by
the
progressive
loss
of
neurons
and
intricate
interactions
between
different
cell
types
within
affected
regions.Reliable
biomarkers
that
can
accurately
reflect
disease
activity,
diagnose,
monitor
progression
neurodegenerative
crucial
for
development
effective
therapies.However,
identifying
suitable
has
been
challenging
due
to
heterogeneous
nature
these
diseases,
affecting
specific
subsets
in
brain
regions.One
promising
approach
promoting
regeneration
recovery
involves
transplantation
mesenchymal
stem
cells
(MSCs).MSCs
have
demonstrated
ability
modulate
immune
system,
promote
neurite
outgrowth,
stimulate
angiogenesis,
repair
damaged
tissues,
partially
through
release
their
extracellular
vesicles
(EVs).MSC-derived
EVs
retain
some
therapeutic
characteristics
parent
MSCs,
including
regulate
facilitate
tissue
repair.This
review
aims
explore
potential
MSC-derived
as
an
emerging
strategy
highlighting
role
modulating
neuronal
recovery.By
elucidating
mechanisms
which
exert
effects,
we
advance
our
understanding
leverage
novel
treatment
approaches
field
diseases.
Theranostics,
Год журнала:
2024,
Номер
14(8), С. 3358 - 3384
Опубликована: Янв. 1, 2024
With
the
increase
in
aging
population,
occurrence
of
neurological
disorders
is
rising.Recently,
stem
cell
therapy
has
garnered
attention
due
to
its
convenient
sourcing,
minimal
invasiveness,
and
capacity
for
directed
differentiation.However,
there
are
some
disadvantages,
such
as
poor
quality
control,
safety
assessments,
ethical
logistical
issues.Consequently,
scientists
have
started
shift
their
from
cells
extracellular
vesicles
similar
structures
properties.Beyond
these
parallels,
can
enhance
biocompatibility,
facilitate
easy
traversal
barriers,
minimize
side
effects.Furthermore,
cell-derived
be
engineered
load
drugs
modify
surfaces
treatment
outcomes.In
this
review,
we
summarize
functions
native
vesicles,
subsequently
review
strategies
engineering
applications
Alzheimer's
disease,
Parkinson's
stroke,
discuss
challenges
solutions
associated
with
clinical
translation
vesicles.
Abstract
Intravenous
thrombolysis
with
recombinant
tissue
plasminogen
activator
(rtPA)
is
the
primary
treatment
for
ischemic
stroke.
However,
rtPA
can
substantially
increase
blood‐brain
barrier
(BBB)
permeability
and
susceptibility
to
hemorrhagic
transformation.
Herein,
mechanism
underlying
side
effects
of
investigated
demonstrated
that
ferroptosis
plays
an
important
role.
The
inhibitor,
liproxstatin‐1
(Lip)
proposed
alleviate
effects.
A
well‐designed
macrocyclic
carrier,
glucose‐modified
azocalix[4]arene
(GluAC4A),
prepared
deliver
Lip
site.
GluAC4A
bound
tightly
markedly
improved
its
solubility.
Glucose,
modified
at
upper
rim
GluAC4A,
imparts
BBB
targeting
drug
delivery
system
owing
presence
glucose
transporter
1
on
surface.
responsiveness
hypoxia
due
azo
groups
enabled
targeted
release
successfully
accumulation
in
brain,
Lip@GluAC4A
significantly
reduced
ferroptosis,
leakage,
neurological
deficits
induced
by
vivo.
These
findings
deepen
understanding
provide
a
novel
strategy
their
effective
mitigation,
which
great
significance
prognosis
patients
Journal of Neurology,
Год журнала:
2024,
Номер
271(7), С. 3928 - 3941
Опубликована: Май 23, 2024
The
benefits
and
risks
of
tenecteplase
(TNK)
versus
alteplase
(ALT)
have
recently
been
assessed
in
acute
ischemic
stroke
(AIS)
patients
undergoing
mechanical
thrombectomy
(MT)
with
diverse
results.
Due
to
its
high
fibrin
specificity
lack
excitotoxicity,
TNK
may
a
higher
efficacy
safety
profile.
This
study
aimed
evaluate
the
compared
ALT
AIS
prior
thrombectomy.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 22, 2024
Abstract
Stroke
is
a
leading
cause
of
mortality
and
long-term
disability
globally,
with
acute
ischemic
stroke
(AIS)
being
the
most
common
subtype.
Despite
significant
advances
in
reperfusion
therapies,
their
limited
time
window
associated
risks
underscore
necessity
for
novel
treatment
strategies.
Stem
cell-derived
extracellular
vesicles
(EVs)
have
emerged
as
promising
therapeutic
approach
due
to
ability
modulate
post-stroke
microenvironment
facilitate
neuroprotection
neurorestoration.
This
review
synthesizes
current
research
on
potential
stem
EVs
AIS,
focusing
origin,
biogenesis,
mechanisms
action,
strategies
enhancing
targeting
capacity
efficacy.
Additionally,
we
explore
innovative
combination
therapies
discuss
both
challenges
prospects
EV-based
treatments.
Our
findings
reveal
that
exhibit
diverse
effects
such
promoting
neuronal
survival,
diminishing
neuroinflammation,
protecting
blood-brain
barrier,
angiogenesis
neurogenesis.
Various
strategies,
including
modifications
cargo
modifications,
been
developed
improve
efficacy
EVs.
Combining
other
treatments,
therapy,
cell
transplantation,
nanomedicine,
gut
microbiome
modulation,
holds
great
promise
improving
outcomes.
However,
heterogeneity
need
standardized
protocols
EV
production
quality
control
remain
be
addressed.
represent
avenue
offering
address
limitations
Further
needed
optimize
translate
benefits
clinical
practice,
an
emphasis
ensuring
safety,
overcoming
regulatory
hurdles,
specificity
delivery
target
tissues.
Graphical
