Insight into extracellular vesicles in vascular diseases: intercellular communication role and clinical application potential DOI Creative Commons
Wenxiu Liu,

Meiqi Jin,

Qiuyan Chen

и другие.

Cell Communication and Signaling, Год журнала: 2023, Номер 21(1)

Опубликована: Окт. 31, 2023

Abstract Background Cells have been increasingly known to release extracellular vesicles (EVs) the environment under physiological and pathological conditions. A plethora of studies revealed that EVs contain cell-derived biomolecules are found in circulation, thereby implicating them molecular trafficking between cells. Furthermore, an effect on function disease development serve as biomarkers. Main body Given close association EV circulation vascular disease, this review aims provide a brief introduction EVs, with specific focus cargoes participating mechanisms, diagnosis, engineering, clinical potential, highlight emerging evidence suggesting promising targets diseases. Despite expansion research field, some noticeable limitations remain for translational research. Conclusion This makes novel contribution summary recent advances perspective future

Язык: Английский

New strategies of neurodegenerative disease treatment with extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) DOI Creative Commons
Chella Perumal Palanisamy, Jinjin Pei, Phaniendra Alugoju

и другие.

Theranostics, Год журнала: 2023, Номер 13(12), С. 4138 - 4165

Опубликована: Янв. 1, 2023

Neurodegenerative diseases are characterized by the progressive loss of neurons and intricate interactions between different cell types within affected regions.Reliable biomarkers that can accurately reflect disease activity, diagnose, monitor progression neurodegenerative crucial for development effective therapies.However, identifying suitable has been challenging due to heterogeneous nature these diseases, affecting specific subsets in brain regions.One promising approach promoting regeneration recovery involves transplantation mesenchymal stem cells (MSCs).MSCs have demonstrated ability modulate immune system, promote neurite outgrowth, stimulate angiogenesis, repair damaged tissues, partially through release their extracellular vesicles (EVs).MSC-derived EVs retain some therapeutic characteristics parent MSCs, including regulate facilitate tissue repair.This review aims explore potential MSC-derived as an emerging strategy highlighting role modulating neuronal recovery.By elucidating mechanisms which exert effects, we advance our understanding leverage novel treatment approaches field diseases.

Язык: Английский

Процитировано

70

Stem cell-derived extracellular vesicles in the therapeutic intervention of Alzheimer's Disease, Parkinson's Disease, and stroke DOI Creative Commons

W. Zhou,

Xudong Wang,

Yumeng Dong

и другие.

Theranostics, Год журнала: 2024, Номер 14(8), С. 3358 - 3384

Опубликована: Янв. 1, 2024

With the increase in aging population, occurrence of neurological disorders is rising.Recently, stem cell therapy has garnered attention due to its convenient sourcing, minimal invasiveness, and capacity for directed differentiation.However, there are some disadvantages, such as poor quality control, safety assessments, ethical logistical issues.Consequently, scientists have started shift their from cells extracellular vesicles similar structures properties.Beyond these parallels, can enhance biocompatibility, facilitate easy traversal barriers, minimize side effects.Furthermore, cell-derived be engineered load drugs modify surfaces treatment outcomes.In this review, we summarize functions native vesicles, subsequently review strategies engineering applications Alzheimer's disease, Parkinson's stroke, discuss challenges solutions associated with clinical translation vesicles.

Язык: Английский

Процитировано

12

Alleviating Recombinant Tissue Plasminogen Activator‐induced Hemorrhagic Transformation in Ischemic Stroke via Targeted Delivery of a Ferroptosis Inhibitor DOI Creative Commons
Yanqin Geng, Lina Qiu,

Yuan‐Qiu Cheng

и другие.

Advanced Science, Год журнала: 2024, Номер 11(24)

Опубликована: Апрель 22, 2024

Abstract Intravenous thrombolysis with recombinant tissue plasminogen activator (rtPA) is the primary treatment for ischemic stroke. However, rtPA can substantially increase blood‐brain barrier (BBB) permeability and susceptibility to hemorrhagic transformation. Herein, mechanism underlying side effects of investigated demonstrated that ferroptosis plays an important role. The inhibitor, liproxstatin‐1 (Lip) proposed alleviate effects. A well‐designed macrocyclic carrier, glucose‐modified azocalix[4]arene (GluAC4A), prepared deliver Lip site. GluAC4A bound tightly markedly improved its solubility. Glucose, modified at upper rim GluAC4A, imparts BBB targeting drug delivery system owing presence glucose transporter 1 on surface. responsiveness hypoxia due azo groups enabled targeted release successfully accumulation in brain, Lip@GluAC4A significantly reduced ferroptosis, leakage, neurological deficits induced by vivo. These findings deepen understanding provide a novel strategy their effective mitigation, which great significance prognosis patients

Язык: Английский

Процитировано

11

Signaling pathways in brain ischemia: Mechanisms and therapeutic implications DOI

Wen Lin,

Xiaosu Zhao, Jiawen Cheng

и другие.

Pharmacology & Therapeutics, Год журнала: 2023, Номер 251, С. 108541 - 108541

Опубликована: Окт. 1, 2023

Язык: Английский

Процитировано

22

M1-type microglia-derived exosomes contribute to blood–brain barrier damage DOI
Wen Jiang,

Yan Wu,

Ailan Pang

и другие.

Brain Research, Год журнала: 2024, Номер 1835, С. 148919 - 148919

Опубликована: Апрель 6, 2024

Язык: Английский

Процитировано

9

Efficacy and safety of intravenous tenecteplase compared to alteplase before mechanical thrombectomy in acute ischemic stroke: a meta-analysis DOI Creative Commons

Nihong Wu,

Thorsten R. Doeppner, Dirk M. Hermann

и другие.

Journal of Neurology, Год журнала: 2024, Номер 271(7), С. 3928 - 3941

Опубликована: Май 23, 2024

The benefits and risks of tenecteplase (TNK) versus alteplase (ALT) have recently been assessed in acute ischemic stroke (AIS) patients undergoing mechanical thrombectomy (MT) with diverse results. Due to its high fibrin specificity lack excitotoxicity, TNK may a higher efficacy safety profile. This study aimed evaluate the compared ALT AIS prior thrombectomy.

Язык: Английский

Процитировано

9

A New Perspective in the Treatment of Ischemic Stroke: Ferroptosis DOI
Lei Zhang,

Xin Yue Bai,

Ke Yao Sun

и другие.

Neurochemical Research, Год журнала: 2024, Номер 49(4), С. 815 - 833

Опубликована: Янв. 3, 2024

Язык: Английский

Процитировано

8

Exosomes: The endogenous nanomaterials packed with potential for diagnosis and treatment of neurologic disorders DOI
Xuelin Tang, Yuxuan He,

Jinchi Liu

и другие.

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 239, С. 113938 - 113938

Опубликована: Май 3, 2024

Язык: Английский

Процитировано

7

Advancing stroke therapy: innovative approaches with stem cell-derived extracellular vesicles DOI Creative Commons
Jiahao Song, Da Zhou, Lili Cui

и другие.

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 22, 2024

Abstract Stroke is a leading cause of mortality and long-term disability globally, with acute ischemic stroke (AIS) being the most common subtype. Despite significant advances in reperfusion therapies, their limited time window associated risks underscore necessity for novel treatment strategies. Stem cell-derived extracellular vesicles (EVs) have emerged as promising therapeutic approach due to ability modulate post-stroke microenvironment facilitate neuroprotection neurorestoration. This review synthesizes current research on potential stem EVs AIS, focusing origin, biogenesis, mechanisms action, strategies enhancing targeting capacity efficacy. Additionally, we explore innovative combination therapies discuss both challenges prospects EV-based treatments. Our findings reveal that exhibit diverse effects such promoting neuronal survival, diminishing neuroinflammation, protecting blood-brain barrier, angiogenesis neurogenesis. Various strategies, including modifications cargo modifications, been developed improve efficacy EVs. Combining other treatments, therapy, cell transplantation, nanomedicine, gut microbiome modulation, holds great promise improving outcomes. However, heterogeneity need standardized protocols EV production quality control remain be addressed. represent avenue offering address limitations Further needed optimize translate benefits clinical practice, an emphasis ensuring safety, overcoming regulatory hurdles, specificity delivery target tissues. Graphical

Язык: Английский

Процитировано

7

Progress on the pathological tissue microenvironment barrier-modulated nanomedicine DOI
Han Han, Lei Xing,

Bi‐Te Chen

и другие.

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 200, С. 115051 - 115051

Опубликована: Авг. 6, 2023

Язык: Английский

Процитировано

17