Bioorganic Chemistry, Год журнала: 2024, Номер 153, С. 107791 - 107791
Опубликована: Сен. 3, 2024
Язык: Английский
Theranostics, Год журнала: 2023, Номер 13(12), С. 4138 - 4165
Опубликована: Янв. 1, 2023
Neurodegenerative diseases are characterized by the progressive loss of neurons and intricate interactions between different cell types within affected regions.Reliable biomarkers that can accurately reflect disease activity, diagnose, monitor progression neurodegenerative crucial for development effective therapies.However, identifying suitable has been challenging due to heterogeneous nature these diseases, affecting specific subsets in brain regions.One promising approach promoting regeneration recovery involves transplantation mesenchymal stem cells (MSCs).MSCs have demonstrated ability modulate immune system, promote neurite outgrowth, stimulate angiogenesis, repair damaged tissues, partially through release their extracellular vesicles (EVs).MSC-derived EVs retain some therapeutic characteristics parent MSCs, including regulate facilitate tissue repair.This review aims explore potential MSC-derived as an emerging strategy highlighting role modulating neuronal recovery.By elucidating mechanisms which exert effects, we advance our understanding leverage novel treatment approaches field diseases.
Язык: Английский
Процитировано
71
Theranostics, Год журнала: 2024, Номер 14(8), С. 3358 - 3384
Опубликована: Янв. 1, 2024
With the increase in aging population, occurrence of neurological disorders is rising.Recently, stem cell therapy has garnered attention due to its convenient sourcing, minimal invasiveness, and capacity for directed differentiation.However, there are some disadvantages, such as poor quality control, safety assessments, ethical logistical issues.Consequently, scientists have started shift their from cells extracellular vesicles similar structures properties.Beyond these parallels, can enhance biocompatibility, facilitate easy traversal barriers, minimize side effects.Furthermore, cell-derived be engineered load drugs modify surfaces treatment outcomes.In this review, we summarize functions native vesicles, subsequently review strategies engineering applications Alzheimer's disease, Parkinson's stroke, discuss challenges solutions associated with clinical translation vesicles.
Язык: Английский
Процитировано
12
Advanced Science, Год журнала: 2024, Номер 11(24)
Опубликована: Апрель 22, 2024
Abstract Intravenous thrombolysis with recombinant tissue plasminogen activator (rtPA) is the primary treatment for ischemic stroke. However, rtPA can substantially increase blood‐brain barrier (BBB) permeability and susceptibility to hemorrhagic transformation. Herein, mechanism underlying side effects of investigated demonstrated that ferroptosis plays an important role. The inhibitor, liproxstatin‐1 (Lip) proposed alleviate effects. A well‐designed macrocyclic carrier, glucose‐modified azocalix[4]arene (GluAC4A), prepared deliver Lip site. GluAC4A bound tightly markedly improved its solubility. Glucose, modified at upper rim GluAC4A, imparts BBB targeting drug delivery system owing presence glucose transporter 1 on surface. responsiveness hypoxia due azo groups enabled targeted release successfully accumulation in brain, Lip@GluAC4A significantly reduced ferroptosis, leakage, neurological deficits induced by vivo. These findings deepen understanding provide a novel strategy their effective mitigation, which great significance prognosis patients
Язык: Английский
Процитировано
11
Pharmacology & Therapeutics, Год журнала: 2023, Номер 251, С. 108541 - 108541
Опубликована: Окт. 1, 2023
Язык: Английский
Процитировано
23
Brain Research, Год журнала: 2024, Номер 1835, С. 148919 - 148919
Опубликована: Апрель 6, 2024
Язык: Английский
Процитировано
9
Journal of Neurology, Год журнала: 2024, Номер 271(7), С. 3928 - 3941
Опубликована: Май 23, 2024
The benefits and risks of tenecteplase (TNK) versus alteplase (ALT) have recently been assessed in acute ischemic stroke (AIS) patients undergoing mechanical thrombectomy (MT) with diverse results. Due to its high fibrin specificity lack excitotoxicity, TNK may a higher efficacy safety profile. This study aimed evaluate the compared ALT AIS prior thrombectomy.
Язык: Английский
Процитировано
9
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Июль 22, 2024
Abstract Stroke is a leading cause of mortality and long-term disability globally, with acute ischemic stroke (AIS) being the most common subtype. Despite significant advances in reperfusion therapies, their limited time window associated risks underscore necessity for novel treatment strategies. Stem cell-derived extracellular vesicles (EVs) have emerged as promising therapeutic approach due to ability modulate post-stroke microenvironment facilitate neuroprotection neurorestoration. This review synthesizes current research on potential stem EVs AIS, focusing origin, biogenesis, mechanisms action, strategies enhancing targeting capacity efficacy. Additionally, we explore innovative combination therapies discuss both challenges prospects EV-based treatments. Our findings reveal that exhibit diverse effects such promoting neuronal survival, diminishing neuroinflammation, protecting blood-brain barrier, angiogenesis neurogenesis. Various strategies, including modifications cargo modifications, been developed improve efficacy EVs. Combining other treatments, therapy, cell transplantation, nanomedicine, gut microbiome modulation, holds great promise improving outcomes. However, heterogeneity need standardized protocols EV production quality control remain be addressed. represent avenue offering address limitations Further needed optimize translate benefits clinical practice, an emphasis ensuring safety, overcoming regulatory hurdles, specificity delivery target tissues. Graphical
Язык: Английский
Процитировано
9
Neurochemical Research, Год журнала: 2024, Номер 49(4), С. 815 - 833
Опубликована: Янв. 3, 2024
Язык: Английский
Процитировано
8
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Май 1, 2024
Abstract Stem cells (SCs) have been used therapeutically for decades, yet their applications are limited by factors such as the risk of immune rejection and potential tumorigenicity. Extracellular vesicles (EVs), a key paracrine component stem cell potency, overcome drawbacks cell-free therapeutic agent play an important role in treating various diseases. However, EVs derived from two-dimensional (2D) planar culture SCs low yield face challenges large-scale production, which hinders clinical translation EVs. Three-dimensional (3D) culture, given its ability to more realistically simulate vivo environment, can not only expand large quantities, but also improve activity EVs, changing content improving effects. In this review, we briefly describe advantages EV-related applications, provide overview 3D finally focus on specific future perspectives different SCs. Graphical
Язык: Английский
Процитировано
7
Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 239, С. 113938 - 113938
Опубликована: Май 3, 2024
Язык: Английский
Процитировано
7