Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(9), P. 7127 - 7150
Published: Feb. 17, 2024
Language: Английский
Theranostics, Journal Year: 2023, Volume and Issue: 13(12), P. 4138 - 4165
Published: Jan. 1, 2023
Neurodegenerative diseases are characterized by the progressive loss of neurons and intricate interactions between different cell types within affected regions.Reliable biomarkers that can accurately reflect disease activity, diagnose, monitor progression neurodegenerative crucial for development effective therapies.However, identifying suitable has been challenging due to heterogeneous nature these diseases, affecting specific subsets in brain regions.One promising approach promoting regeneration recovery involves transplantation mesenchymal stem cells (MSCs).MSCs have demonstrated ability modulate immune system, promote neurite outgrowth, stimulate angiogenesis, repair damaged tissues, partially through release their extracellular vesicles (EVs).MSC-derived EVs retain some therapeutic characteristics parent MSCs, including regulate facilitate tissue repair.This review aims explore potential MSC-derived as an emerging strategy highlighting role modulating neuronal recovery.By elucidating mechanisms which exert effects, we advance our understanding leverage novel treatment approaches field diseases.
Language: Английский
Citations
66
Advanced Science, Journal Year: 2024, Volume and Issue: 11(24)
Published: April 22, 2024
Abstract Intravenous thrombolysis with recombinant tissue plasminogen activator (rtPA) is the primary treatment for ischemic stroke. However, rtPA can substantially increase blood‐brain barrier (BBB) permeability and susceptibility to hemorrhagic transformation. Herein, mechanism underlying side effects of investigated demonstrated that ferroptosis plays an important role. The inhibitor, liproxstatin‐1 (Lip) proposed alleviate effects. A well‐designed macrocyclic carrier, glucose‐modified azocalix[4]arene (GluAC4A), prepared deliver Lip site. GluAC4A bound tightly markedly improved its solubility. Glucose, modified at upper rim GluAC4A, imparts BBB targeting drug delivery system owing presence glucose transporter 1 on surface. responsiveness hypoxia due azo groups enabled targeted release successfully accumulation in brain, Lip@GluAC4A significantly reduced ferroptosis, leakage, neurological deficits induced by vivo. These findings deepen understanding provide a novel strategy their effective mitigation, which great significance prognosis patients
Language: Английский
Citations
11
Brain Research, Journal Year: 2024, Volume and Issue: 1835, P. 148919 - 148919
Published: April 6, 2024
Language: Английский
Citations
9
Theranostics, Journal Year: 2024, Volume and Issue: 14(8), P. 3358 - 3384
Published: Jan. 1, 2024
With the increase in aging population, occurrence of neurological disorders is rising.Recently, stem cell therapy has garnered attention due to its convenient sourcing, minimal invasiveness, and capacity for directed differentiation.However, there are some disadvantages, such as poor quality control, safety assessments, ethical logistical issues.Consequently, scientists have started shift their from cells extracellular vesicles similar structures properties.Beyond these parallels, can enhance biocompatibility, facilitate easy traversal barriers, minimize side effects.Furthermore, cell-derived be engineered load drugs modify surfaces treatment outcomes.In this review, we summarize functions native vesicles, subsequently review strategies engineering applications Alzheimer's disease, Parkinson's stroke, discuss challenges solutions associated with clinical translation vesicles.
Language: Английский
Citations
9
Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 251, P. 108541 - 108541
Published: Oct. 1, 2023
Language: Английский
Citations
21
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 200, P. 115051 - 115051
Published: Aug. 6, 2023
Language: Английский
Citations
17
Journal of Neurology, Journal Year: 2024, Volume and Issue: 271(7), P. 3928 - 3941
Published: May 23, 2024
The benefits and risks of tenecteplase (TNK) versus alteplase (ALT) have recently been assessed in acute ischemic stroke (AIS) patients undergoing mechanical thrombectomy (MT) with diverse results. Due to its high fibrin specificity lack excitotoxicity, TNK may a higher efficacy safety profile. This study aimed evaluate the compared ALT AIS prior thrombectomy.
Language: Английский
Citations
8
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: July 22, 2024
Abstract Stroke is a leading cause of mortality and long-term disability globally, with acute ischemic stroke (AIS) being the most common subtype. Despite significant advances in reperfusion therapies, their limited time window associated risks underscore necessity for novel treatment strategies. Stem cell-derived extracellular vesicles (EVs) have emerged as promising therapeutic approach due to ability modulate post-stroke microenvironment facilitate neuroprotection neurorestoration. This review synthesizes current research on potential stem EVs AIS, focusing origin, biogenesis, mechanisms action, strategies enhancing targeting capacity efficacy. Additionally, we explore innovative combination therapies discuss both challenges prospects EV-based treatments. Our findings reveal that exhibit diverse effects such promoting neuronal survival, diminishing neuroinflammation, protecting blood-brain barrier, angiogenesis neurogenesis. Various strategies, including modifications cargo modifications, been developed improve efficacy EVs. Combining other treatments, therapy, cell transplantation, nanomedicine, gut microbiome modulation, holds great promise improving outcomes. However, heterogeneity need standardized protocols EV production quality control remain be addressed. represent avenue offering address limitations Further needed optimize translate benefits clinical practice, an emphasis ensuring safety, overcoming regulatory hurdles, specificity delivery target tissues. Graphical
Language: Английский
Citations
7
Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(4), P. 815 - 833
Published: Jan. 3, 2024
Language: Английский
Citations
6
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 239, P. 113938 - 113938
Published: May 3, 2024
Language: Английский
Citations
5