As
a
kind
of
reactive
oxygen
species
(ROS)
mediated
therapy,
sonodynamic
therapy
(SDT)
has
attracted
great
interest
in
cancer
therapy.
However,
highly
efficient
and
biocompatible
sonosensitizers
are
urgently
required
to
improve
the
therapeutic
efficiency
SDT.
In
this
work,
Ti3C2-TiO2
MXenes
were
controlled
synthesized
as
good
through
interface
engineering
by
regulating
dissolved
concentration
aqueous
solution.
The
as-prepared
Ar-Ti3C2-TiO2
MXene
possessed
narrow
band
gap
2.37
eV
with
promoted
charge
carrier
transformation
electron-hole
separation.
Compared
pure
TiO2
sonosensitizers,
displayed
higher
US-triggered
generation
efficiency.
addition,
structurally
maintained
photothermal
conversion
laser
irradiation
could
greatly
pair
separation
further
increase
ROS
capability.
After
modification
arginyl–glycyl–aspartic
(RGD)
peptide,
Ar-Ti3C2-TiO2-RGD
efficiently
accumulate
tumor
sites
achieve
effective
PTT
enhanced
SDT
eliminate
tumors
after
intravenous
injection
without
causing
appreciable
long-term
toxicity.
Therefore,
work
presented
new
way
construct
safe
for
potential
clinical
translation.
Molecules,
Год журнала:
2023,
Номер
28(6), С. 2733 - 2733
Опубликована: Март 17, 2023
Rhenium
(Re)
is
widely
used
in
the
diagnosis
and
treatment
of
cancer
due
to
its
unique
physical
chemical
properties.
Re
has
more
valence
electrons
outer
shell,
allowing
it
exist
a
variety
oxidation
states
form
different
geometric
configurations
with
many
ligands.
The
luminescence
properties,
lipophilicity,
cytotoxicity
complexes
can
be
adjusted
by
changing
ligand
Re.
This
article
mainly
reviews
development
radionuclide
188Re
radiotherapy
some
innovative
applications
as
well
therapeutic
approaches
imaging
techniques
therapy.
In
addition,
current
application
future
challenges
opportunities
are
also
discussed.
Theranostics,
Год журнала:
2024,
Номер
14(6), С. 2464 - 2488
Опубликована: Янв. 1, 2024
Cancer
has
remained
a
formidable
challenge
in
medicine
and
claimed
an
enormous
number
of
lives
worldwide.Theranostics,
combining
diagnostic
methods
with
personalized
therapeutic
approaches,
shows
huge
potential
to
advance
the
battle
against
cancer.This
review
aims
provide
overview
theranostics
oncology:
exploring
its
history,
current
advances,
challenges,
prospects.We
present
fundamental
evolution
from
radiotherapeutics,
cellular
therapeutics,
nanotherapeutics,
showcasing
critical
milestones
last
decade.From
early
concept
targeted
drug
delivery
emergence
medicine,
benefited
advances
imaging
technologies,
molecular
biology,
nanomedicine.Furthermore,
we
emphasize
pertinent
illustrations
that
revolutionary
strategies
cancer
management
enhance
accuracy
therapies
customized
for
individual
patients,
thereby
facilitating
implementation
medicine.Finally,
describe
future
perspectives
on
emerging
topics,
field.
Abstract
Sonodynamic
therapy
(SDT),
featuring
noninvasive,
deeper
penetration,
low
cost,
and
repeatability,
is
a
promising
approach
for
deep‐seated
tumors.
However,
the
general
or
only
utilization
of
SDT
shows
efficiency
unsatisfactory
treatment
outcomes
due
to
complicated
tumor
microenvironment
(TME)
process.
To
circumvent
issues,
three
feasible
approaches
enhancing
SDT‐based
therapeutic
effects,
including
sonosensitizer
optimization,
strategies
conquering
hypoxia
TME,
combinational
are
summarized,
with
particular
focus
on
combination
other
modalities,
chemodynamic
therapy,
photodynamic
photothermal
chemotherapy,
starvation
gas
immunotherapy.
In
end,
current
challenges
in
tumors
discussed
enhanced
effects
provided.
It
envisioned
that
this
review
will
provide
new
insight
into
strategic
design
high‐efficiency
sonosensitizer‐derived
nanotheranostics,
thereby
augmenting
accelerating
potential
clinical
transformation.
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
7(4), С. 4441 - 4452
Опубликована: Фев. 7, 2024
Sonodynamic
therapy
(SDT)
is
a
promising
ultrasound
(US)-triggered
therapeutic
modality
for
anticancer
treatments
due
to
its
high
penetration,
safety,
and
noninvasiveness.
Its
efficiency
closely
related
the
performance
of
sonosensitizers
oxygen
concentration
tumor
microenvironment
(TME).
Herein,
inspired
by
adhesion
cocklebur,
rough-surface
sonosensitizer
gold
platinum
encapsulated
with
magnesium
silicate
loaded
glucose
oxidase
(AuPt@MgSiO3@GOx,
APMS-GOx)
an
enzymatic
cascade
activity
was
designed
improve
delivery
capability,
produce
reactive
species,
reduce
in
tissue.
The
rough
surface
APMS-GOx
can
ability
nanomaterials
deliver
areas.
reaction
induce
starvation
level
oxygen.
Adequate
not
only
alleviate
hypoxia
TME
but
also
further
convert
singlet
(1O2)
under
US
activation.
Moreover,
GOx
increases
involvement
US,
resulting
positive
effect
on
therapy.
Furthermore,
exhibits
near-infrared
absorption
properties,
providing
photoacoustic
imaging-guided
combination
breast
strategy.
Novel
inorganic
sonosensitizers
with
excellent
reactive
oxygen
species
(ROS)
generation
activity
and
multifunctionality
are
appealing
in
sonodynamic
therapy
(SDT).
Herein,
amorphous
bismuth
(Bi)-doped
CoFe-layered
double
hydroxide
(a-CoBiFe-LDH)
nanosheets
proposed
via
crystalline-to-amorphous
phase
transformation
strategy
as
a
new
type
of
bifunctional
sonosensitizer,
which
allows
ultrasound
(US)
to
trigger
ROS
for
magnetic
resonance
imaging
(MRI)-guided
SDT.
Importantly,
a-CoBiFe-LDH
exhibit
much
higher
(≈6.9
times)
than
that
traditional
TiO
