Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 11, 2024
In
recent
years,
the
incidence
of
cancer
has
been
increasing
year
by
year,
and
burden
disease
economic
caused
it
worsening.
Although
chemotherapy,
immunotherapy,
targeted
therapy
other
therapeutic
means
continue
to
progress,
they
still
inevitably
have
problems
such
as
high
toxicity
side
effects,
susceptibility
drug
resistance,
price.
Photothermal
photodynamic
demonstrated
considerable
advantages
in
imaging
treatment
due
their
minimally
invasive
selective
nature.
However,
development
constrained
challenges
related
delivery.
times,
delivery
systems
constructed
based
on
supramolecular
chemistry
subject
interest,
particularly
view
compatibility
with
permeability
long
retention
effect
tumors.
Furthermore,
advantage
dissociating
active
ingredient
under
pH,
light
stimuli
makes
them
unique
therapy.
This
paper
reviews
current
status
nanomedicines
therapy,
elucidating
faced
providing
a
theoretical
basis
for
efficient
precise
malignant
ACS Nano,
Год журнала:
2023,
Номер
17(9), С. 7953 - 7978
Опубликована: Апрель 18, 2023
Hydrogels,
as
one
of
the
most
feasible
soft
biomaterials,
have
gained
considerable
attention
in
therapeutic
applications
by
virtue
their
tunable
properties
including
superior
patient
compliance,
good
biocompatibility
and
biodegradation,
high
cargo-loading
efficiency.
However,
hydrogel
application
is
still
limited
some
challenges
like
inefficient
encapsulation,
easy
leakage
loaded
cargoes,
lack
controllability.
Recently,
nanoarchitecture-integrated
systems
were
found
to
be
therapeutics
with
optimized
properties,
extending
bioapplication.
In
this
review,
we
briefly
presented
category
hydrogels
according
synthetic
materials
further
discussed
advantages
Additionally,
various
nanoarchitecture
hybrid
biomedical
engineering
are
systematically
summarized,
cancer
therapy,
wound
healing,
cardiac
repair,
bone
regeneration,
diabetes
obesity
therapy.
Last,
current
challenges,
limitations,
future
perspectives
development
flexible
addressed.
Advanced Materials,
Год журнала:
2024,
Номер
36(21)
Опубликована: Фев. 16, 2024
Immunotherapy
represents
a
revolutionary
paradigm
in
cancer
management,
showcasing
its
potential
to
impede
tumor
metastasis
and
recurrence.
Nonetheless,
challenges
including
limited
therapeutic
efficacy
severe
immune-related
side
effects
are
frequently
encountered,
especially
solid
tumors.
Hydrogels,
class
of
versatile
materials
featuring
well-hydrated
structures
widely
used
biomedicine,
offer
promising
platform
for
encapsulating
releasing
small
molecule
drugs,
biomacromolecules,
cells
controlled
manner.
Immunomodulatory
hydrogels
present
unique
capability
augmenting
immune
activation
mitigating
systemic
toxicity
through
encapsulation
multiple
components
localized
administration.
Notably,
based
on
biopolymers
have
gained
significant
interest
owing
their
biocompatibility,
environmental
friendliness,
ease
production.
This
review
delves
into
the
recent
advances
bio-based
immunotherapy
synergistic
combinatorial
approaches,
highlighting
diverse
applications.
It
is
anticipated
that
this
will
guide
rational
design
field
immunotherapy,
fostering
clinical
translation
ultimately
benefiting
patients.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(9)
Опубликована: Янв. 21, 2024
Abstract
A
high
level
of
reduced
glutathione
is
a
major
factor
contributing
to
the
radioresistance
observed
in
solid
tumors.
To
address
this
associated
with
glutathione,
cinnamaldehyde
(CA)
polymer
prodrug,
referred
as
PDPCA,
fabricated.
This
prodrug
created
by
synthesizing
pendent
CA
acetal
linkages
hydrophobic
block,
forming
self‐assembled
into
core–shell
nanoparticle
aqueous
media.
Additionally,
it
encapsulates
all‐
trans
retinoic
acid
(ATRA)
for
synchronous
delivery,
resulting
PDPCA@ATRA.
The
PDPCA@ATRA
nanoparticles
accumulate
reactive
oxygen
species
through
both
endogenous
and
exogenous
pathways,
enhancing
ferroptosis
depleting
glutathione.
approach
demonstrates
efficacy
overcoming
tumor
vivo
vitro,
promoting
ferroptosis,
cytotoxic
T
lymphocyte
(CTL)
response
lung
tumors
anti‐PD‐1
(αPD‐1)
immunotherapy.
Furthermore,
study
reveals
that
promote
NRF2‐GPX4
signaling
pathway,
suggesting
potential
further
investigation
combination
radiotherapy
αPD‐1
immune
checkpoint
inhibitors
cancer
treatment.
Cancer
immunotherapy,
encompassing
both
experimental
and
standard-of-care
therapies,
has
emerged
as
a
promising
approach
to
harnessing
the
immune
system
for
tumor
suppression.
Experimental
strategies,
including
novel
immunotherapies
preclinical
models,
are
actively
being
explored,
while
established
treatments,
such
checkpoint
inhibitors
(ICIs),
widely
implemented
in
clinical
settings.
This
comprehensive
review
examines
historical
evolution,
underlying
mechanisms,
diverse
strategies
of
cancer
highlighting
its
applications
ongoing
advancements.
The
delves
into
essential
components
anticancer
immunity,
dendritic
cell
activation,
T
priming,
surveillance,
addressing
challenges
posed
by
evasion
mechanisms.
Key
immunotherapeutic
vaccines,
oncolytic
viruses,
adoptive
transfer,
ICIs,
discussed
detail.
Additionally,
role
nanotechnology,
cytokines,
chemokines,
adjuvants
enhancing
precision
efficacy
were
explored.
Combination
particularly
those
integrating
immunotherapy
with
radiotherapy
or
chemotherapy,
exhibit
synergistic
potential
but
necessitate
careful
management
reduce
side
effects.
Emerging
factors
influencing
outcomes,
heterogeneity,
gut
microbiota
composition,
genomic
epigenetic
modifications,
also
examined.
Furthermore,
molecular
mechanisms
therapeutic
resistance
analyzed,
focus
on
contributions
noncoding
RNAs
alterations,
along
innovative
intervention
strategies.
emphasizes
recent
advancements,
particular
attention
biomarker-driven
approaches
aimed
at
optimizing
patient
prognosis.
Challenges
immunotherapy-related
toxicity,
limited
solid
tumors,
production
constraints
highlighted
critical
areas
future
research.
Advancements
personalized
therapies
delivery
systems
proposed
avenues
enhance
treatment
effectiveness
accessibility.
By
incorporating
insights
from
multiple
disciplines,
this
aims
deepen
understanding
application
ultimately
fostering
more
effective
accessible
solutions.
Materials Advances,
Год журнала:
2024,
Номер
5(10), С. 4112 - 4130
Опубликована: Янв. 1, 2024
Peptide
nanofibers
have
exhibited
a
remarkable
ability
to
enhance
immune
response
induction.
Herein,
we
explore
the
peptide
nanofibers'
transformative
potential,
providing
comprehensive
examination
of
their
application
in
vaccine
development.
Interdisciplinary materials,
Год журнала:
2023,
Номер
2(5), С. 689 - 713
Опубликована: Сен. 1, 2023
Abstract
Chirality
is
an
omnipresent
structural
feature
found
in
nature.
The
transfer
and
amplification
of
chirality
are
widely
recognized
phenomena.
In
appropriate
solvents,
chiral
molecules
can
self‐assemble
into
diverse
supramolecular
nanomaterials
with
unique
properties.
the
past
two
decades,
there
has
been
a
growing
number
reported
nanomaterials.
Significant
advancements
have
made
within
these
materials,
as
well
their
regulation
applications.
Therefore,
it
essential
to
summarize
progress
this
field.
Here
we
present
comprehensive
overview
latest
nanomaterials,
ranging
from
This
review
aims
deepen
our
understanding
fundamental
origins
inherent
while
also
providing
reference
for
expanding
potential
