Frontiers in Pharmacology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 10, 2025
Breast
cancer
is
the
most
commonly
diagnosed
worldwide.
Metal
metabolism
pivotal
for
regulating
cell
fate
and
drug
sensitivity
in
breast
cancer.
Iron
copper
are
essential
metal
ions
critical
maintaining
cellular
function.
The
accumulation
of
iron
triggers
distinct
death
pathways,
known
as
ferroptosis
cuproptosis,
respectively.
Ferroptosis
characterized
by
iron-dependent
lipid
peroxidation,
while
cuproptosis
involves
copper-induced
oxidative
stress.
They
increasingly
recognized
promising
targets
development
anticancer
drugs.
Recently,
compelling
evidence
demonstrated
that
interplay
between
plays
a
crucial
role
progression.
This
review
elucidates
converging
pathways
Moreover,
we
examined
value
genes
associated
with
clinical
diagnosis
treatment
cancer,
mainly
outlining
potential
co-targeting
approach.
Lastly,
delve
into
current
challenges
limitations
this
strategy.
In
general,
offers
an
overview
interaction
offering
valuable
perspectives
further
research
treatment.
Molecular Biomedicine,
Год журнала:
2023,
Номер
4(1)
Опубликована: Окт. 16, 2023
Abstract
Ferroptosis,
a
regulated
form
of
cellular
death
characterized
by
the
iron-mediated
accumulation
lipid
peroxides,
provides
novel
avenue
for
delving
into
intersection
metabolism,
oxidative
stress,
and
disease
pathology.
We
have
witnessed
mounting
fascination
with
ferroptosis,
attributed
to
its
pivotal
roles
across
diverse
physiological
pathological
conditions
including
developmental
processes,
metabolic
dynamics,
oncogenic
pathways,
neurodegenerative
cascades,
traumatic
tissue
injuries.
By
unraveling
intricate
underpinnings
molecular
machinery,
contributors,
signaling
conduits,
regulatory
networks
governing
researchers
aim
bridge
gap
between
intricacies
this
unique
mode
multifaceted
implications
health
disease.
In
light
rapidly
advancing
landscape
ferroptosis
research,
we
present
comprehensive
review
aiming
at
extensive
in
origins
progress
human
diseases.
This
concludes
careful
analysis
potential
treatment
approaches
carefully
designed
either
inhibit
or
promote
ferroptosis.
Additionally,
succinctly
summarized
therapeutic
targets
compounds
that
hold
promise
targeting
within
various
facet
underscores
burgeoning
possibilities
manipulating
as
strategy.
summary,
enriched
insights
both
investigators
practitioners,
while
fostering
an
elevated
comprehension
latent
translational
utilities.
revealing
basic
processes
investigating
possibilities,
crucial
resource
scientists
medical
aiding
deep
understanding
effects
situations.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 2091 - 2112
Опубликована: Март 1, 2024
Abstract:
Currently,
cancer
remains
one
of
the
most
significant
threats
to
human
health.
Treatment
cancers
challenging,
despite
implementation
diverse
therapies
in
clinical
practice.
In
recent
years,
research
on
mechanism
ferroptosis
has
presented
novel
perspectives
for
treatment.
Ferroptosis
is
a
regulated
cell
death
process
caused
by
lipid
peroxidation
membrane
unsaturated
fatty
acids
catalyzed
iron
ions.
The
rapid
development
bio-nanotechnology
generated
considerable
interest
exploiting
iron-induced
as
new
therapeutic
target
against
cancer.
This
article
provides
comprehensive
overview
advancements
at
intersection
and
bionanotechnology.
this
respect,
its
relation
are
summarized.
Furthermore,
feasibility
nano-drug
delivery
system
based
treatment
introduced
analyzed.
Secondly,
strategies
inducing
using
nanodrug
technology
discussed,
including
promoting
Fenton
reactions,
inhibiting
glutathione
peroxidase
4,
reducing
low
levels,
Xc
−
.
Additionally,
explores
potential
combined
involving
Finally,
application
prospects
challenges
nanoagents
discussed.
Keywords:
cancers,
ferroptosis,
system,
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Май 2, 2024
As
a
new
form
of
regulated
cell
death,
ferroptosis
has
unraveled
the
unsolicited
theory
intrinsic
apoptosis
resistance
by
cancer
cells.
The
molecular
mechanism
depends
on
induction
oxidative
stress
through
excessive
reactive
oxygen
species
accumulation
and
glutathione
depletion
to
damage
structural
integrity
Due
their
high
loading
tunability,
nanocarriers
can
escort
delivery
ferro-therapeutics
desired
site
enhanced
permeation
or
retention
effect
active
targeting.
This
review
shed
light
necessity
iron
in
growth
fascinating
features
regulating
cycle
metastasis.
Additionally,
we
discussed
ferroptosis-mediated
therapy
using
nanoplatforms
chemical
basis
overcoming
barriers
therapy.
