Chinese Journal of Plastic and Reconstructive Surgery,
Год журнала:
2023,
Номер
5(4), С. 185 - 194
Опубликована: Дек. 1, 2023
Diabetic
wounds
significantly
affect
patient
quality
of
life.
Microneedles
are
a
promising
treatment
to
accelerate
wound
healing
owing
their
high
drug-loading
capacity
and
efficient
drug
delivery;
however,
few
studies
date
have
comprehensively
reviewed
microneedles
for
diabetic
healing.
This
up-to-date
review
summarizes
the
research
progress
in
healing,
including
manufacturing
materials
techniques,
structures,
designs,
release
mechanisms,
delivery
substances,
specific
effects.
study
showed
that
most
designed
made
synthetic
polymers
and/or
natural
using
polydimethylsiloxane
micromolding.
The
geometric
structure
design
directly
influence
penetration
ability
capacity.
can
deliver
antibiotics,
hypoglycemic
agents,
traditional
Chinese
medicines,
metal
ions,
growth
factors,
exosomes,
stem
cells,
microorganisms,
thus
promoting
through
diverse
such
as
antibacterial,
anti-inflammatory,
antioxidant,
hypoglycemic,
angiogenic
activities,
at
different
stages
process.
In
conclusion,
systems
wounds.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(20)
Опубликована: Май 25, 2024
Acute
wounds
are
converted
to
chronic
due
advanced
age
and
diabetic
complications.
Nanozymes
catalyze
ROS
production
kill
bacteria
without
causing
drug
resistance,
while
microneedles
(MNs)
can
break
through
the
skin
barrier
deliver
drugs
effectively.
be
intergrateded
into
MNs
delivery
systems
improve
painless
delivery.
It
also
reduce
effective
dose
of
sterilization
increasing
efficiency
effectively
killing
wounded
preventing
resistance.
This
paper
describes
various
types
metal
nanozymes
from
previous
studies
compares
their
mutual
enhancement
with
nanozymes.
The
pooled
results
show
that
MNs,
material
innovation,
able
both
penetrate
scab
exert
additional
anti-inflammatory
bactericidal
effects.
catalytic
effect
some
accelerate
lysis
or
create
a
cascade
reaction
against
inflammation
infection.
However,
issue
increased
toxicity
associated
penetration
clinical
translation
remains
challenge.
study
reviews
latest
published
corresponding
challenges
use
combined
for
treatment
wounds,
providing
further
information
future
research.
Abstract
Diabetic
wounds
present
a
significant
challenge
in
clinical
treatment
and
are
characterized
by
chronic
inflammation,
oxidative
stress,
impaired
angiogenesis,
peripheral
neuropathy,
heightened
risk
of
infection
during
the
healing
process.
By
creating
small
channels
surface
skin,
microneedle
technology
offers
minimally
invasive
efficient
approach
for
drug
delivery
treatment.
This
article
begins
outlining
biological
foundation
normal
skin
wound
unique
pathophysiological
mechanisms
diabetic
wounds.
It
then
delves
into
various
types,
materials,
preparation
processes
microneedles.
The
focus
is
on
application
multifunctional
microneedles
treatment,
highlighting
their
antibacterial,
anti-inflammatory,
immunomodulatory,
antioxidant,
angiogenic
neural
repair
properties.
These
demonstrate
synergistic
therapeutic
effects
directly
influencing
microenvironment,
ultimately
accelerating
advancement
not
only
holds
promise
enhancing
outcomes
but
also
new
strategies
addressing
other
Advanced Materials,
Год журнала:
2023,
Номер
35(49)
Опубликована: Июнь 3, 2023
Bioadhesives
with
antimicrobial
properties
enable
easier
and
safer
treatment
of
wounds
as
compared
to
the
traditional
methods
such
suturing
stapling.
Composed
natural
or
synthetic
polymers,
these
bioadhesives
seal
facilitate
healing
while
preventing
infections
through
activity
locally
released
drugs,
nanocomponents,
inherently
polers.
Although
many
different
materials
strategies
are
employed
develop
bioadhesives,
design
biomaterials
necessitates
a
prudent
approach
achieving
all
required
including
optimal
adhesive
cohesive
properties,
biocompatibility,
can
be
challenging.
Designing
tunable
physical,
chemical,
biological
will
shed
light
on
path
for
future
advancement
properties.
In
this
review,
requirements
commonly
used
developing
discussed.
particular,
their
synthesis
experimental
clinical
applications
variety
organs
reviewed.
Advances
in
pave
way
better
management
increase
positive
outcomes.
Advanced Materials,
Год журнала:
2024,
Номер
36(30)
Опубликована: Май 13, 2024
Owing
to
the
increased
tissue
iron
accumulation
in
patients
with
diabetes,
microorganisms
may
activate
high
expression
of
iron-involved
metabolic
pathways,
leading
exacerbation
bacterial
infections
and
disruption
systemic
glucose
metabolism.
Therefore,
an
on-demand
transdermal
dosing
approach
that
utilizes
homeostasis
regulation
combat
antimicrobial
resistance
is
a
promising
strategy
address
challenges
associated
low
administration
bioavailability
antibiotic
treating
infected
diabetic
wounds.
Here,
it
aimed
propose
effective
therapy
based
on
hemoglobin
bionics
induce
disturbances
homeostasis.
The
preferred
"iron
cargo"
synthesized
by
protoporphyrin
IX
chelated
dopamine
gallium
(PDGa),
delivered
via
glucose/pH-responsive
microneedle
bandage
(PDGa@GMB).
PDGa@GMB
downregulates
levels
uptake
regulator
(Fur)
peroxide
response
(perR)
Staphylococcus
aureus,
nutrient
starvation
oxidative
stress,
ultimately
suppressing
iron-dependent
activities.
Consequently,
demonstrates
insusceptibility
genetic
while
maintaining
sustainable
effects
(>90%)
against
resistant
strains
both
S.
aureus
E.
coli,
accelerates
recovery
(<20
d).
Overall,
not
only
counteracts
but
also
holds
tremendous
potential
mediating
microbial-host
crosstalk,
synergistically
attenuating
pathogen
virulence
pathogenicity.
Advanced Materials Technologies,
Год журнала:
2024,
Номер
9(15)
Опубликована: Май 7, 2024
Abstract
Controllable
and
long‐term
release
remains
a
great
challenge
in
current
drug
delivery
systems.
Benefiting
from
their
efficient
loading
painless
administration,
microneedles
(MNs)
have
emerged
as
promising
platform
for
transdermal
delivery,
while
they
often
fail
to
achieve
tissue
adhesion
controllable
extended
release.
Here,
3D
printing
of
an
innovative
MN
patch
is
presented
with
succulent‐inspired
responsive
microstructures
light‐controllable
capability.
The
exhibits
reversible
shrink‐swell
volume
change
behavior
response
surrounding
humidity,
which
enables
sufficient
mechanical
strength
skin
penetration
under
the
shrinkage
conditions
when
swollen
tissues.
Moreover,
introduces
system,
achieved
through
integration
thiolated
heparin
(Hep‐SH)
sustained
growth
factor
graphene
oxide
(GO)
nanosheets
controlled
via
near
infrared
(NIR)
laser
irradiation.
patches
good
biocompatibility
can
promote
proliferation,
migration,
proangiogenesis
endothelial
cells
further
demonstrated.
Thus,
it
believed
that
such
flexible
be
candidates
well
other
related
engineering
applications.
