Engineered Regeneration,
Год журнала:
2024,
Номер
5(2), С. 210 - 227
Опубликована: Апрель 12, 2024
Following
myocardial
infarction
(MI),
cardiac
tissue
undergoes
irreversible
cellular
alterations,
with
cardiomyocytes
being
replaced
by
fibrotic
tissue.
In
order
to
improve
regeneration,
a
previously
characterized
chitosan-based
cryogel,
which
was
designed
our
group,
used.
The
treatment
regimen
involved
the
sequential
delivery
of
cryogel
loaded
specific
cytokines
and
growth
factors,
followed
separate
injection
pre-differentiated
cells.
Initially,
interleukin-10
transforming
factor-β
injected
into
infarcted
immediately
after
MI
induction,
targeting
acute
inflammatory
response.
On
day
four
post-MI,
second
administered,
this
time
utilizing
vascular
endothelial
factor
fibroblast
factor-2,
aimed
at
promoting
regeneration
angiogenesis.
Subsequently,
on
six
experimental
group
received
cardiomyocyte-like
cells,
smooth
muscle
purpose
these
in
synergy
repopulate
lost
populations,
thereby
enhancing
repair.
improved
increased
output,
ejection
fraction,
reduced
regions.
Thus,
enriched
anti-inflammatory
proangiogenic
factors
supplemented
offers
promising
platform
for
controlled
release
therapeutics,
substantial
repair
following
MI.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Май 31, 2024
Abstract
The
immune
response
holds
a
pivotal
role
in
cardiovascular
disease
development.
As
multifunctional
cells
of
the
innate
system,
macrophages
play
an
essential
initial
inflammatory
that
occurs
following
injury,
thereby
inducing
subsequent
damage
while
also
facilitating
recovery.
Meanwhile,
diverse
phenotypes
and
phenotypic
alterations
strongly
associate
with
distinct
types
severity
diseases,
including
coronary
heart
disease,
valvular
myocarditis,
cardiomyopathy,
failure,
atherosclerosis
aneurysm,
which
underscores
importance
investigating
macrophage
regulatory
mechanisms
within
context
specific
diseases.
Besides,
recent
strides
single-cell
sequencing
technologies
have
revealed
heterogeneity,
cell–cell
interactions,
downstream
therapeutic
targets
at
higher
resolution,
brings
new
perspectives
into
macrophage-mediated
potential
Remarkably,
myocardial
fibrosis,
prevalent
characteristic
most
cardiac
remains
formidable
clinical
challenge,
necessitating
profound
investigation
impact
on
fibrosis
In
this
review,
we
systematically
summarize
functional
plasticity
diseases
unprecedented
insights
introduced
by
technologies,
focus
different
causes
characteristics
especially
relationship
between
inflammation
(myocardial
infarction,
pressure
overload,
dilated
diabetic
cardiomyopathy
aging)
vascular
injury
(atherosclerosis
aneurysm).
Finally,
highlight
preclinical/clinical
targeting
strategies
translational
implications.
Materials Horizons,
Год журнала:
2023,
Номер
11(1), С. 37 - 101
Опубликована: Окт. 27, 2023
The
unique
network
characteristics
and
stimuli
responsiveness
of
supramolecular
hydrogels
have
rendered
them
highly
advantageous
in
the
field
wound
dressings,
showcasing
unprecedented
potential.
However,
there
are
few
reports
on
a
comprehensive
review
hydrogel
dressings
for
repair
hemostasis.
This
first
introduces
major
cross-linking
methods
hydrogels,
which
includes
hydrogen
bonding,
electrostatic
interactions,
hydrophobic
host-guest
metal
ligand
coordination
some
other
interactions.
Then,
we
advanced
materials
reported
recent
years
then
summarize
basic
principles
each
method.
Next,
classify
structures
before
outlining
their
forming
process
propose
potential
future
directions.
Furthermore,
also
discuss
raw
materials,
structural
design
principles,
material
used
to
achieve
functions
such
as
antibacterial
function,
tissue
adhesion,
substance
delivery,
anti-inflammatory
antioxidant
functions,
cell
behavior
regulation,
angiogenesis
promotion,
hemostasis
innovative
years.
Finally,
existing
problems
well
development
directions
strategy,
design,
discussed.
is
proposed
stimulate
further
exploration
by
researchers
future.
Bioengineering,
Год журнала:
2025,
Номер
12(2), С. 205 - 205
Опубликована: Фев. 19, 2025
Myocardial
infarction
(MI)
is
a
cardiovascular
disease
(CVD)
with
high
morbidity
and
mortality
worldwide,
which
serious
threat
to
human
life
health.
Inflammatory
immune
responses
are
initiated
immediately
after
MI,
unbalanced
inflammation
post-MI
can
lead
cardiac
dysfunction,
scarring,
ventricular
remodeling,
emphasizing
the
critical
need
for
an
effective
inflammation-regulating
treatment.
With
development
of
novel
therapies,
drug
delivery
system
specific
inflammatory
cells
offers
significant
potential.
In
this
review,
we
introduce
fibroblasts
involved
in
MI
summarize
newly
developed
systems
related
use
injectable
hydrogels,
patches,
nanoparticles,
extracellular
vesicles
(EVs).
Finally,
highlight
recent
trends
cell-targeting
involving
different
strategies
that
facilitate
treatment
MI.
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2025,
Номер
39(3)
Опубликована: Март 1, 2025
ABSTRACT
Resveratrol
alleviates
liver
fibrosis
in
mice
by
upregulating
IL‐10
to
reprogram
the
macrophage
phenotype;
however,
mechanism
remains
be
elucidated.
Building
on
our
previous
work,
this
study,
we
aimed
determine
role
of
TLR2/MyD88/ERK
and
NF‐κB/NLRP3
inflammasome
pathways
mediating
effects
resveratrol
polarization.
We
investigated
expression
cytokines
these
a
mouse
model
resveratrol‐treated
macrophages.
The
results
showed
that
TLR2,
MyD88,
ERK,
NF‐κB1
tissues
was
increased
fourth
week
after
treatment
with
but
decreased
fifth
week.
Similar
were
obtained
for
pathway.
also
both
macrophages
elevated
24
h
reduced
36
resveratrol.
Immunofluorescence
nucleocytoplasmic
separation
assays
inhibited
translocation
NF‐κB
from
cytoplasm
nucleus
macrophages,
associated
inhibition
Silencing
ERK.
In
conclusion,
are
involved
effect
polarization
subsequent
modulation
fibrosis.
acts
as
common
cytokine
coordinates
crosstalk
between
two
pathways.
Our
findings
highlight
potential
members
therapeutic
targets
toward
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(45), С. 61551 - 61564
Опубликована: Сен. 30, 2024
In
this
study,
we
synthesized
mesoporous
polydopamine
nanoparticles
(MPDA
NPs)
using
an
emulsion-induced
interface
assembly
strategy
and
loaded
epigallocatechin
gallate
(EGCG)
into
MPDA
NPs
via
electrostatic
attraction
to
form
EGCG@MPDA
NPs.
the
post
myocardial
infarction
(MI)
environment,
these
interventions
specifically
aimed
eliminate
reactive
oxygen
species
(ROS)
facilitate
repair
of
MI.
We
further
combined
them
with
a
thermosensitive
chitosan
(CS)
hydrogel
construct
injectable
composite
(EGCG@MPDA/CS
hydrogel).
Utilizing
Heliyon,
Год журнала:
2024,
Номер
10(15), С. e35447 - e35447
Опубликована: Июль 30, 2024
The
causal
relationship
between
inflammatory
cytokines
and
cardiovascular
diseases
(CVDs)
has
not
been
fully
elucidated.
Exploring
this
circulating
CVDs
is
crucial
for
early
clinical
diagnosis
effective
treatment.
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 7, 2025
Abstract
Activation
of
p38
mitogen-activated
protein
kinase
plays
an
important
role
in
the
progression
ventricular
muscle
inflammation
after
myocardial
ischemia-reperfusion
(MI/R).
The
inhibition
activation
ischemic
myocardium
can
reduce
remodeling
post-MI.
However,
owing
to
dynamic
change
MI,
clinical
therapeutic
effect
inhibitors
is
insufficient.
Herein,
we
describe
design
a
hydrogelator
Nap-Phe-Phe-Thr-Gly-Tyr-OH
(Nap-TGY)
coassemble
inhibitor
SB202190
(SB),
responsive
supramolecular
hydrogel
(Gel
Nap-TGY+SB)
for
local
administration
and
release
SB
efficiently
improve
inflammatory
microenvironment.
Under
overexpression
myocardium,
Nap-TGY
phosphorylated
yield
hydrophilic
Nap-Phe-Phe-Thr(H2PO3)-Gly-Tyr(H2PO3)
(Nap-TpGYp),
triggering
disassembly
inhibitor.
Injection
into
significantly
reduces
phosphorylation,
mitigates
inflammation,
enhances
angiogenesis.
These
findings
suggest
novel
strategy
cardiomyopathy
through
modulation
(MAPK)
pathway.
