Targeted delivery of factors and cells for improving cardiac tissue regeneration and heart function following myocardial infarction DOI Creative Commons
Kamila Raziyeva, Zharylkasyn Zharkinbekov,

Yevgeniy Kim

и другие.

Engineered Regeneration, Год журнала: 2024, Номер 5(2), С. 210 - 227

Опубликована: Апрель 12, 2024

Following myocardial infarction (MI), cardiac tissue undergoes irreversible cellular alterations, with cardiomyocytes being replaced by fibrotic tissue. In order to improve regeneration, a previously characterized chitosan-based cryogel, which was designed our group, used. The treatment regimen involved the sequential delivery of cryogel loaded specific cytokines and growth factors, followed separate injection pre-differentiated cells. Initially, interleukin-10 transforming factor-β injected into infarcted immediately after MI induction, targeting acute inflammatory response. On day four post-MI, second administered, this time utilizing vascular endothelial factor fibroblast factor-2, aimed at promoting regeneration angiogenesis. Subsequently, on six experimental group received cardiomyocyte-like cells, smooth muscle purpose these in synergy repopulate lost populations, thereby enhancing repair. improved increased output, ejection fraction, reduced regions. Thus, enriched anti-inflammatory proangiogenic factors supplemented offers promising platform for controlled release therapeutics, substantial repair following MI.

Язык: Английский

Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets DOI Creative Commons

Runkai Chen,

Hongrui Zhang,

Botao Tang

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Май 31, 2024

Abstract The immune response holds a pivotal role in cardiovascular disease development. As multifunctional cells of the innate system, macrophages play an essential initial inflammatory that occurs following injury, thereby inducing subsequent damage while also facilitating recovery. Meanwhile, diverse phenotypes and phenotypic alterations strongly associate with distinct types severity diseases, including coronary heart disease, valvular myocarditis, cardiomyopathy, failure, atherosclerosis aneurysm, which underscores importance investigating macrophage regulatory mechanisms within context specific diseases. Besides, recent strides single-cell sequencing technologies have revealed heterogeneity, cell–cell interactions, downstream therapeutic targets at higher resolution, brings new perspectives into macrophage-mediated potential Remarkably, myocardial fibrosis, prevalent characteristic most cardiac remains formidable clinical challenge, necessitating profound investigation impact on fibrosis In this review, we systematically summarize functional plasticity diseases unprecedented insights introduced by technologies, focus different causes characteristics especially relationship between inflammation (myocardial infarction, pressure overload, dilated diabetic cardiomyopathy aging) vascular injury (atherosclerosis aneurysm). Finally, highlight preclinical/clinical targeting strategies translational implications.

Язык: Английский

Процитировано

67

Supramolecular hydrogels for wound repair and hemostasis DOI

Shaowen Zhuo,

Yongping Liang,

Zhengying Wu

и другие.

Materials Horizons, Год журнала: 2023, Номер 11(1), С. 37 - 101

Опубликована: Окт. 27, 2023

The unique network characteristics and stimuli responsiveness of supramolecular hydrogels have rendered them highly advantageous in the field wound dressings, showcasing unprecedented potential. However, there are few reports on a comprehensive review hydrogel dressings for repair hemostasis. This first introduces major cross-linking methods hydrogels, which includes hydrogen bonding, electrostatic interactions, hydrophobic host-guest metal ligand coordination some other interactions. Then, we advanced materials reported recent years then summarize basic principles each method. Next, classify structures before outlining their forming process propose potential future directions. Furthermore, also discuss raw materials, structural design principles, material used to achieve functions such as antibacterial function, tissue adhesion, substance delivery, anti-inflammatory antioxidant functions, cell behavior regulation, angiogenesis promotion, hemostasis innovative years. Finally, existing problems well development directions strategy, design, discussed. is proposed stimulate further exploration by researchers future.

Язык: Английский

Процитировано

57

Physical strategies to engineer supramolecular composite hydrogels for advanced biomedical applications DOI

Sravan Baddi,

Auphedeous Y. Dang-i,

Fengli Gao

и другие.

Progress in Materials Science, Год журнала: 2025, Номер 151, С. 101428 - 101428

Опубликована: Янв. 9, 2025

Язык: Английский

Процитировано

4

IL-1 signaling pathway, an important target for inflammation surrounding in myocardial infarction DOI
Jianwu Huang,

Wenlong Kuang,

Zihua Zhou

и другие.

Inflammopharmacology, Год журнала: 2024, Номер unknown

Опубликована: Апрель 27, 2024

Язык: Английский

Процитировано

8

Research progress of injectable hydrogels in the treatment of bone tissue diseases DOI
Shengjie Zhang, Xiaohua Li, Chunxiao Li

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155139 - 155139

Опубликована: Авг. 24, 2024

Язык: Английский

Процитировано

8

Inflammatory Cell-Targeted Delivery Systems for Myocardial Infarction Treatment DOI Creative Commons
Wenyuan Zhang, Dan Peng, Shiqi Cheng

и другие.

Bioengineering, Год журнала: 2025, Номер 12(2), С. 205 - 205

Опубликована: Фев. 19, 2025

Myocardial infarction (MI) is a cardiovascular disease (CVD) with high morbidity and mortality worldwide, which serious threat to human life health. Inflammatory immune responses are initiated immediately after MI, unbalanced inflammation post-MI can lead cardiac dysfunction, scarring, ventricular remodeling, emphasizing the critical need for an effective inflammation-regulating treatment. With development of novel therapies, drug delivery system specific inflammatory cells offers significant potential. In this review, we introduce fibroblasts involved in MI summarize newly developed systems related use injectable hydrogels, patches, nanoparticles, extracellular vesicles (EVs). Finally, highlight recent trends cell-targeting involving different strategies that facilitate treatment MI.

Язык: Английский

Процитировано

1

Resveratrol Alleviates Liver Fibrosis by Targeting Cross‐Talk Between TLR2/MyD88/ERK and NF‐κB/NLRP3 Inflammasome Pathways in Macrophages DOI
Jie Lei, Qiufei Xie, Qingping Li

и другие.

Journal of Biochemical and Molecular Toxicology, Год журнала: 2025, Номер 39(3)

Опубликована: Март 1, 2025

ABSTRACT Resveratrol alleviates liver fibrosis in mice by upregulating IL‐10 to reprogram the macrophage phenotype; however, mechanism remains be elucidated. Building on our previous work, this study, we aimed determine role of TLR2/MyD88/ERK and NF‐κB/NLRP3 inflammasome pathways mediating effects resveratrol polarization. We investigated expression cytokines these a mouse model resveratrol‐treated macrophages. The results showed that TLR2, MyD88, ERK, NF‐κB1 tissues was increased fourth week after treatment with but decreased fifth week. Similar were obtained for pathway. also both macrophages elevated 24 h reduced 36 resveratrol. Immunofluorescence nucleocytoplasmic separation assays inhibited translocation NF‐κB from cytoplasm nucleus macrophages, associated inhibition Silencing ERK. In conclusion, are involved effect polarization subsequent modulation fibrosis. acts as common cytokine coordinates crosstalk between two pathways. Our findings highlight potential members therapeutic targets toward

Язык: Английский

Процитировано

1

Drug-Loaded Mesoporous Polydopamine Nanoparticles in Chitosan Hydrogels Enable Myocardial Infarction Repair through ROS Scavenging and Inhibition of Apoptosis DOI
Tianhu Wang, Yabin Wang,

Yingjie Zhang

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(45), С. 61551 - 61564

Опубликована: Сен. 30, 2024

In this study, we synthesized mesoporous polydopamine nanoparticles (MPDA NPs) using an emulsion-induced interface assembly strategy and loaded epigallocatechin gallate (EGCG) into MPDA NPs via electrostatic attraction to form EGCG@MPDA NPs. the post myocardial infarction (MI) environment, these interventions specifically aimed eliminate reactive oxygen species (ROS) facilitate repair of MI. We further combined them with a thermosensitive chitosan (CS) hydrogel construct injectable composite (EGCG@MPDA/CS hydrogel). Utilizing

Язык: Английский

Процитировано

5

Causal effects of Inflammatory cytokines on Cardiovascular diseases: Insights from genetic evidence DOI Creative Commons
Yuxiu Chen, Aifang Zhong

Heliyon, Год журнала: 2024, Номер 10(15), С. e35447 - e35447

Опубликована: Июль 30, 2024

The causal relationship between inflammatory cytokines and cardiovascular diseases (CVDs) has not been fully elucidated. Exploring this circulating CVDs is crucial for early clinical diagnosis effective treatment.

Язык: Английский

Процитировано

3

Sustained Release of Dual p38 Inhibitors via Supramolecular Hydrogels to Enhance Cardiac Repair after MI/R Injury DOI Creative Commons
Di Wang,

Aoxue Xu,

Haitao Su

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Фев. 7, 2025

Abstract Activation of p38 mitogen-activated protein kinase plays an important role in the progression ventricular muscle inflammation after myocardial ischemia-reperfusion (MI/R). The inhibition activation ischemic myocardium can reduce remodeling post-MI. However, owing to dynamic change MI, clinical therapeutic effect inhibitors is insufficient. Herein, we describe design a hydrogelator Nap-Phe-Phe-Thr-Gly-Tyr-OH (Nap-TGY) coassemble inhibitor SB202190 (SB), responsive supramolecular hydrogel (Gel Nap-TGY+SB) for local administration and release SB efficiently improve inflammatory microenvironment. Under overexpression myocardium, Nap-TGY phosphorylated yield hydrophilic Nap-Phe-Phe-Thr(H2PO3)-Gly-Tyr(H2PO3) (Nap-TpGYp), triggering disassembly inhibitor. Injection into significantly reduces phosphorylation, mitigates inflammation, enhances angiogenesis. These findings suggest novel strategy cardiomyopathy through modulation (MAPK) pathway.

Язык: Английский

Процитировано

0