Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 100, С. 106105 - 106105
Опубликована: Авг. 28, 2024
Язык: Английский
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 99, С. 105838 - 105838
Опубликована: Июнь 3, 2024
Язык: Английский
Процитировано
11
Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 209, С. 115319 - 115319
Опубликована: Апрель 21, 2024
Язык: Английский
Процитировано
10
Journal of Material Science and Technology, Год журнала: 2024, Номер 200, С. 227 - 242
Опубликована: Март 30, 2024
Язык: Английский
Процитировано
9
Advanced Materials, Год журнала: 2024, Номер 36(38)
Опубликована: Июль 26, 2024
Abstract In recent years, advancements in microbial sequencing technology have sparked an increasing interest the bacteria residing within solid tumors and its distribution functions various tumors. Intratumoral critically modulate tumor oncogenesis development through DNA damage induction, chronic inflammation, epigenetic alterations, metabolic immune regulation, while also influencing cancer treatment efficacy by affecting drug metabolism. response to these discoveries, a variety of anti‐cancer therapies targeting microorganisms emerged. These approaches encompass oncolytic therapy utilizing tumor‐associated bacteria, design biomaterials based on intratumoral use bacterial components for delivery systems, comprehensive strategies aimed at eradication tumor‐promoting bacteria. Herein, this review article summarizes patterns different tumors, examines their impact evaluates current therapeutic centered Furthermore, challenges prospects developing drugs that target communities are explored, promising new directions treatment.
Язык: Английский
Процитировано
9
Advanced Materials Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 5, 2025
Abstract Rapid advances in the development of nanotechnology recent years have led to functional magnetic nanoparticle types (MNPs) with different properties. The diverse applications these nanoparticles make them a desirable candidate for use biomedical areas due their exclusive chemical and physical present work is conducted study vitro biocompatibility CoFe 2 O 4 @shell surface coatings (shell: ascorbic acid (AA), dextran (DEX), polyethyleneimine (PEI). cytotoxicity coated screened toward glioma cancer line (C6) fibroblast cell (L929) using an MTT assay. NPs are synthesized co‐precipitation method together hydrothermal synthesis characterized regarding structural properties state‐of‐the‐art techniques. Results showed particles consistent crystal structure average crystallite size range 16–18 nm. For NPs, only slight increase Hc found except @PEI NPs. comparative analysis cytotoxic effects on L929 cells shows that samples much more specific brain tumor cells, especially it also indicates significant efficacy cells.
Язык: Английский
Процитировано
1
Aggregate, Год журнала: 2025, Номер unknown
Опубликована: Янв. 15, 2025
ABSTRACT Colorectal cancer (CRC) screening and early diagnosis is an effective strategy for reducing CRC mortality. However, the current detection methods involve exorbitant costs complex procedures, which are inconvenient large‐scale screening. Given its high prevalence in malignant tissues feces of patients, Fusobacterium nucleatum ( F. ) has emerged as a crucial biomarker CRC. Herein, we propose ‐specific recognition diagnosis. A novel nanobioprobe (AIE‐Pep) with aggregation‐induced emission (AIE) characteristics was synthesized by conjugating red/near‐infrared (NIR) emissive AIE luminogen (AIEgen) FadA‐targeting peptide (ASANWTIQYND). The robust binding affinity between FadA on allows AIE‐Pep NPs to adhere selectively , emits strong red/NIR fluorescence. In model orthotopic CRC, can precisely localize around Moreover, demonstrated limit (LOD) 82.97 CFU/mL could significantly differentiate mice from those normal mice. Overall, this study presents pivotal approach specifically identifying holds immense potential
Язык: Английский
Процитировано
1
Acta Biomaterialia, Год журнала: 2024, Номер 183, С. 278 - 291
Опубликована: Июнь 3, 2024
Язык: Английский
Процитировано
7
Carbohydrate Polymers, Год журнала: 2024, Номер 346, С. 122666 - 122666
Опубликована: Авг. 28, 2024
Язык: Английский
Процитировано
7
Exploration, Год журнала: 2023, Номер 4(1)
Опубликована: Дек. 22, 2023
Abstract Colorectal cancer (CRC) is generally characterized by a high prevalence of Fusobacterium nucleatum ( F. ), spindle‐shaped, Gram‐negative anaerobe pathogen derived from the oral cavity. This tumor‐resident microorganism has been closely correlated with occurrence, progression, chemoresistance and immunosuppressive microenvironment CRC. Furthermore, can specifically colonize CRC tissues through adhesion on its surface, forming biofilms that are highly resistant to commonly used antibiotics. Accordingly, it crucial develop efficacious non‐antibiotic approaches eradicate for treatment. In recent years, various antimicrobial strategies, such as natural extracts, inorganic chemicals, organic polymers, inorganic‐organic hybrid materials, bacteriophages, probiotics, vaccines, have proposed combat biofilms. review summarizes latest advancements in anti‐ research, elucidates mechanisms employed these systems, discusses benefits drawbacks each technology. Additionally, this also provides an outlook specificity, potential clinical implications, challenges, future improvements strategies treatment
Язык: Английский
Процитировано
14
Nano Today, Год журнала: 2024, Номер 56, С. 102288 - 102288
Опубликована: Май 6, 2024
Язык: Английский
Процитировано
6